• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2006.05a
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• pp.1027-1031
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• 2006

Recently, mobile-type analysis system when emergency patient can check his blood condition in the transportation or vessel has being required. Under the present system, it takes lots off-time to know the blood analysis result of patient, so, it may lead to a dangerous situation. But, in this study, analysis time makes to fall down to $1{\sim}min$. to emergency treatment patient more quickly, and you can check the information by wireless PC through Bluetooth base. It is able to measure in about 7minutes from 25minutes of warming-up time in existing facilities by testing temperature peculiarity curve, to operate system without error even minute temperature change by adoption DUAL heating. And Bluetooth base was adopted to reduce power consumption and be able to hospital networking by keeping and sending analyzed data when it needs.

• Proceedings of the Korea Society of Information Technology Applications Conference
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• 2005.11a
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• pp.335-338
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• 2005

In this paper, we propose a downlink power control scheme to apply in the unequal error protection multi-code CDMA mobile medicine system. The mobile medicine system contains (i) blood pressure and body temperature measurement value, (ii) ECG medical signals measured by the electrocardiogram device, (iii) mobile patient's history, (iv) G.729 audio signal, MPEG-4 CCD sensor video signal, and JPEG2000 medical image. By the help of the multi-code CDMA spread spectrum communication system with downlink power control scheme and unequal error protection strategy, it is possible to transmit mobile medicine media and meet the quality of service. Numerical analysis and simulation results show that the system is a well transmission platform in mobile medicine.

• Journal of the Korean Society of Visualization
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• v.10 no.2
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• pp.25-31
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• 2012

High-performance smartphones, equipped with a digital camera and an application software, can render conventional bench-top laboratory instruments mobile at affordable costs. As the smartphone-based devices are portable and wireless, they have wide applications especially in providing point-of-care (POC) tests in resource-constrained areas. We developed a hand-held diagnostic system, Mobile SmartScope, which consists of a small optical unit integrated with a smartphone. The performance of the SmartScope was favorably compared with that of conventional light microscopy in detecting and quantifying red blood cells. We also evaluated the fluorescence detection limit of the SmartScope incorporated with a blue light-emitting diode and appropriate optical filters by using fluorescently labeled microbeads for intensity calibration.

• Journal of Digital Convergence
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• v.12 no.4
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• pp.335-342
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• 2014

According to the recent trends in the growing elderly population, the chronically ill have increased. Thus the importance of the health care issues for them has emerged. In this paper, we want to implement a chronic disease management system using smart mobile devices. Proposed chronic disease management system is consisted of the biometric sensor, smart mobile devices, the patient management server, patient management DB, and patient symptoms analysis agent. The biometric sensor detects a biological information. Smart mobile devices receive the patient information from the sensor and transmit the information to the patient management server. The patient management server, patient management DB, and patient symptoms agent analysis agent analyze to process data delivered through a wireless communication network. Bio-signals includes modules of ECG, blood pressure, blood sugar and PPG. We are able to determine the current health status by monitoring measured biometric data through chronically ill health management system. We will focus on the individual service to be appropriate for a patient group in a mobile environment.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2006.05a
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• pp.1032-1036
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• 2006

In this study, we implement the potable blood gas analyzer measuring pH, $pCO_2\;and\;pO_2$ of the arterial blood. The implemented system by this study is divided into hardware and software part and also the hardware portion is parted by mechanism and electronic circuit mit. The system program is composed of operating, washing, correcting and measuring program. And to correct the system, two-point calibration method is used, one-point calibration method is also added for more accuracy, and system program is coded. For verifying the implemented system, We examine to response property of each electrode. And evaluate accuracy of the system using standard reagent and was construed as statistical.

• Journal of Korean Biological Nursing Science
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• v.23 no.3
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• pp.170-179
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• 2021

Purpose: The aim of this study was to identify core keywords and topic groups in the 'Diabetes mellitus and mobile applications' field of research for better understanding research trends in the past 20 years. Methods: This study was a text-mining and topic modeling study including four steps such as 'collecting abstracts', 'extracting and cleaning semantic morphemes', 'building a co-occurrence matrix', and 'analyzing network features and clustering topic groups'. Results: A total of 789 papers published between 2002 and 2021 were found in databases (Springer). Among them, 435 words were extracted from 118 articles selected according to the conditions: 'analyzed by text network analysis and topic modeling'. The core keywords were 'self-management', 'intervention', 'health', 'support', 'technique' and 'system'. Through the topic modeling analysis, four themes were derived: 'intervention', 'blood glucose level control', 'self-management' and 'mobile health'. The main topic of this study was 'self-management'. Conclusion: While more recent work has investigated mobile applications, the highest feature was related to self-management in the diabetes care and prevention. Nursing interventions utilizing mobile application are expected to not only effective and powerful glycemic control and self-management tools, but can be also used for patient-driven lifestyle modification.

• Journal of Biomedical and Translational Research
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• v.19 no.4
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• pp.130-139
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• 2018

This study aimed to analyze a high-performance liquid chromatography (HPLC) separation using a pentafluorophenyl column of parent drug hydroxychloroquine (HCQ) and its active metabolite, desethylhydroxchloroquine (DHCQ) applying to determine bioequivalence of two different formulations administered to patients. A rapid, simple, sensitive and specific liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed and validated for bioanalysis of HCQ and its metabolite DHCQ in human whole blood using deuterium derivative $hydroxychloroquine-D_4$ as an internal standard (IS). A triple-quadrupole mass spectrometer was operated using electrospray ionization in multiple reaction monitoring (MRM) mode. Sample preparation involves a two-step precipitation of protein techniques. The removed protein blood samples were chromatographed on a pentafluorophenyl (PFP) column ($50mm{\times}4.6mm$, $2.6{\mu}m$) with a mobile phase (ammonium formate solution containing dilute formic acid) in an isocratic mode at a flow rate of 0.45 mL/min. The standard curves were found to be linear in the range of 2 - 500 ng/mL for HCQ; 2 - 2,000 ng/mL for DHCQ in spite of lacking a highly sensitive MS spectrometry system. Results of intra- and inter-day precision and accuracy were within acceptable limits. A run time of 2.2 min for HCQ and 2.03 min for DHCQ in blood sample facilitated the analysis of more than 300 human whole blood samples per day. Taken together, we concluded that the assay developed herein represents a highly qualified technology for the quantification of HCQ in human whole blood for a parallel design bioequivalence study in a healthy male.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.25 no.4
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• pp.304-310
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• 1999

This study was designed to find the effect of Minocycline loaded microcapsule applied locally to tissue by measuring drug concentration in tissue and serum by HPLC and to achieve optimal drug delivery system and duration to a specific target site. Control group were administrated minocycline intramuscularly twice a day with $0.2{\mu}g/100g$ for 1 to 10 days. In experimental group, surgical wound was created on Rt. cheek and then minocycline loaded microcapsule was applied into the space between superficial and deep layer of masseter muscle. Animals were sacrificed at 1, 3, 5, 7, 10 days after initial administration, blood was obtained from heart and right masseter muscle was excised. Blood sample was centrifuged at 3000rpm for 15min. Tissue sample was homogenized, left at room temperature for 48hr and centrifuged at 4000g for 5min. Supernatant was completely dried and dissolved in distilled water. Analysis was conducted using a ${\mu}Bondapack$ C18 column. The mobile phase was 0.2M Ammonium Oxalate/0.1M EDTA/DMF=11/4/5 solution, which was injected into the column and detected with photodiode detector at 344nm wavelength. The results were as follows : 1. This method was reliable, could be replicated and suitable for minocycline analysis in tissue as well as serum. 2. In tissue, concentration of minocycline of experimental group was higher than that of control group for 5days. 3. Except 1 day, concentration of minocycline in serum of experimental group was lower than that of control group. 4. Concentration of minocycline in tissue was much higher than that in serum. From these results, minocycline loaded microcapsule might be effective tool for local drug delivery system might be useful for treatment of infections of oral and maxillofacial region and management of infected surgical wound, minimizing systemic effects.

• Journal of Internet Computing and Services
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• v.23 no.3
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• pp.87-95
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• 2022

Recently, with the development of smart technology, in medical information platform, patient's biometric data is measured in real time and accumulated into database, and it is possible to determine the patient's emergency situations. Medical staff can easily access patient information after simple authentication using a mobile terminal. However, in accessing medical information using the mobile terminal, it is necessary to study authentication in consideration of the patient situations and mobile terminal. In this paper, we studied on medical information platforms based on big data processing and edge computing for supporting automatic authentication in emergency situations. The automatic authentication system that we had studied is an authentication system that simultaneously performs user authentication and mobile terminal authentication in emergency situations, and grants upper-level access rights to certified medical staff and mobile terminal. Big data processing and analysis techniques were applied to the proposed platform in order to determine emergency situations in consideration of patient conditions such as high blood pressure and diabetes. To quickly determine the patient's emergency situations, edge computing was placed in front of the medical information server so that the edge computing determine patient's situations instead of the medical information server. The medical information server derived emergency situation decision values using the input patient's information and accumulated biometric data, and transmit them to the edge computing to determine patient-customized emergency situation. In conclusion, the proposed medical information platform considers the patient's conditions and determine quick emergency situations through big data processing and edge computing, and enables rapid authentication in emergency situations through automatic authentication, and protects patient's information by granting access rights according to the patient situations and the role of the medical staff.

• The Journal of the Korea Contents Association
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• v.11 no.12
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• pp.112-121
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• 2011

It has become general common sense through numerous researches that exercise provides positive impacts on physical and mental health. And it has been reported that regular exercise adjusts obesity by reducing body fat and lipid levels found in the blood and ultimately, it improves human quality of life. In this study, indices for managing swimming exercise therapy were induced through prior researches and weighted value was measured by modelling correlations between indices by using fuzzy ANP (Analytic Network Process) technique. With the determined results, users can be provided with real-time individualized exercise prescription without space constraint. And patient management system was intended to be realized so that tailor-made management per patient can be established on real-time through mobile equipments such as portable phone, smart phone, notebook and etc.