• Journal of KSNVE
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• v.10 no.5
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• pp.859-864
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• 2000

An effective and new method of reducing the noise of a HDD by structural modification of cover was investigated in this study. The correlation between the noise characteristics of the HDD and the vibration characteristics of the cover, which is the main source of the HDD noise, is found from experiments. A theoretical analysis is performed to find the modification method of the cover, and this modification method is applied the real cover of the HDD. The modification reduces the vibration of the cover transferred from driving motor. The effect of the modification is verified through noise tests.

• Proceedings of the Earthquake Engineering Society of Korea Conference
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• 1997.10a
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• pp.201-208
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• 1997

In most seismic codes such as the Uniform Building Code(UBC), the response modification factor(or the force reduction factor)is used to reflect the capability of a structure in dissipating energy through inelastic behavior. The response modification factor is assigned according to structural system type. Ductile systems such as special moment-resisting steel frames are assigned larger values of the response modification factor, and are consequently designed for smaller seismic design forces. Therefore, structural damage may occur during a severe earthquake. To ensure safety of the structures, the suitability of the response modification factor used in aseismic design procedures shall be evaluated. The object of this study is to develop a method for the evaluating of the response modification factor. The validity of the evaluating method has been examined for several cases of different structures and different earthquake excitations.

• Animal cells and systems
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• v.12 no.3
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• pp.117-125
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• 2008

One of the interesting trends in genome research is the study about epigenetic modification above single gene level. Epigenetics refers study about heritable change in the genome, which accompany modification in DNA or Chromatin besides DNA sequence alteration. We used to have the idea that the coding potential of the genome lies within the arrangement of the four bases A, T, G, C; However, additional information that affects phenotype is stored in the distribution of the modified base 5-methylcytosine. This form of information storage is flexible enough to be adapted for different somatic cell types, yet is stable enough to be retained during mitosis and/or meiosis. Epigenetic modification is a modification of the genome, as opposed to being part of the genome, so is known as "epigenetics"(Greek for "upon" genetics). This modification could be methylation on Cytosine base or post translational modification on histone protein(methylation, acetylation, phosphorylation, Sumoylation)($Dimitrijevi\hat{E}$ et al 2005). In this review, we would like to focus on the relationship of DNA methylation and cancer.

• Journal of the Korea institute for structural maintenance and inspection
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• v.5 no.1
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• pp.169-175
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• 2001

Bridge load rating calculations provide a basis for determining the safe load capacity of bridge. Load rating requires engineering judgement in determining a rating value that is applicable to maintaining the safe use of the bridge and arriving at posting and permit decisions. Load testing is an effective means in calculating the rating value of bridge. In Korea, load carrying capacity of bridge is modified by response modification factor that is determined from comparisons of measured values and analysis results. The response modification factor may be corrupted by vehicle location error that is defined as the gap of test vehicle location between load testing and analysis. In this study, the effects of vehicle location error to structural response and response modification factor are investigated, and a new method for evaluating response modification factor is proposed. The random data analysis shows that the proposed method is less sensitive to vehicle location error than the present method.

• Steel and Composite Structures
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• v.14 no.6
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• pp.621-636
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• 2013

Response modification factor is one of the seismic design parameters to consider nonlinear performance of building structures during strong earthquake, in conformity with the point that many seismic design codes led to reduce the loads. In the present paper it's tried to evaluate the response modification factors of dual moment resistant frame with buckling restrained braced (BRB). Since, the response modification factor depends on ductility and overstrength; the nonlinear static analysis, nonlinear dynamic analysis and linear dynamic analysis have been done on building models including multi-floors and different brace configurations (chevron V, invert V, diagonal and X bracing). The response modification factor for each of the BRBF dual systems has been determined separately, and the tentative value of 10.47 has been suggested for allowable stress design method. It is also included that the ductility, overstrength and response modification factors for all of the models were decreased when the height of the building was increased.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2004.11a
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• pp.666-669
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• 2004

Substructures position is considered as design parameter to obtain optimal structural changes to raise its dynamic characteristics. In conventional SDM (structural dynamics modification) method, the layout of modifying substructures position is first fixed and at that condition the structural optimization is performed by using the substructures size and/or material property as design parameters. But in this paper as a design variable substructures global translational and rotational position is treated. For effective structural modification the eigenvalue sensitivity with respect to that design parameter is derived based on measured frequency response function. The optimal structural modification is calculated by combining eigenvalue sensitivities and eigenvalue reanalysis technique iteratively. Numerical examples are presented to the case of beam stiffener optimization to raise the natural frequency of plate.

• BMB Reports
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• v.52 no.2
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• pp.113-118
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• 2019

The small ubiquitin-related modification molecule (SUMO), one of the post-translational modification molecules, is involved in a variety of cellular functions where it regulates protein activity and stability, transcription, and cell cycling. Modulation of protein SUMOylation or deSUMOylation modification has been associated with regulation of carcinogenesis in breast cancer. In the dynamic processes of SUMOylation and deSUMOylation in a variety of cancers, SUMO proteases (SENPs), reverse SUMOylation by isopeptidase activity and SENPs are mostly elevated, and are related to poor patient prognosis. Although underlying mechanisms have been suggested for how SENPs participate in breast cancer tumorigenesis, such as through regulation of target protein transactivation, cancer cell survival, cell cycle, or other post-translational modification-related machinery recruitment, the effect of SENP isoform-specific inhibitors on the progression of breast cancer have not been well evaluated. This review will introduce the functions of SENP1 and SENP2 and the underlying signaling pathways in breast cancer for use in discovery of new biomarkers for diagnosis or therapeutic targets for treatment.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.4 no.1
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• pp.103-117
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• 1997

This study was designed to investigate the effects of behavior medication and aerobic exercise on the degree of obesity, eating behavior, depression and self esteem among adolescent girls who were overweight and obese. Forty seven subjects were selected from one girl's middle school located in Seoul. Seventeen girls received the behavior modification program by joining 60-90 minute group session weekly. Behavior modification, in this study, consisted of self-monitoring, changing patterns of life style and attitudes, teaching nutrition and physical activities, and asking personal help. The aerobic exercise program was given to 16 girls 3 times per week with 60 minutes each time. Forteen girls received both behavior modification and aerobic exercise. These interventions continued for 8 weeks. Changes after intervention were examined twice after 4 weeks and 8 weeks for degree of obesity and once after 8 weeks only for eating behavior, depression and self esteem. The results were as follows ; 1. Degree of obesity was significantly decreased after 4 weeks and 8 weeks in 3 groups. Degree of obesity after 4 weeks and 8 weeks were not significantly different among 3 groups. 2. The mean score of eating behavior related to obesity decresed significantly after intervention in the behavior modification group only. There was significant difference in eating behavior among 3 groups after intervention. 3. The behavior modification group showed no significant changes in depression and self esteem after intervention. In the aerobic exercise group and group who participated in both behavior modification and aerobic exercise, the level of depression decreased significantly and the level of self esteem increased significantly. There were no significant differences in the level of depression and self esteem among 3 groups after intervention. These findings indicate that behavior modification might be effective in decreasing degree of obesity and eating behavior related to obesity, aerobic exercise be effective in decreasing degree of obesity and the level of depression, and also in increasing the level of self esteem.

• Journal of the Korean housing association
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• v.26 no.3
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• pp.65-76
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• 2015

With a rapidly aging population, the proportion of elderly households with low income has been increasing. Despite the poor housing environment, it is not easy to improve their housing environment due to the high cost of modification. However, as many elderly want to keep living in their current houses, it is urgent to improve their housing environment. The purpose of this study was to develop the guidelines on home modification for low-income elderly. This study set the scope of home modification categories through literature analysis in advance to develop the guidelines. Based on the literature analysis and small group workshops, the primary and secondary guidelines were derived and a total of 169 final guidelines were produced based on the scope of home modification categories. Those guidelines were composed of the categories by space, divided into mandatory and recommended by details. Those guidelines proposed in this study were classified and composed under the objective standards, so that they were systemic and objective based on the verification of experts. They are considered to get closer to the user's demand on the basis of the demand of low income elderly for home modification and the improvement categories under the system to support home modification for low income elderly at home and abroad. In addition, as the standards to apply each guideline, separated into mandatory and recommended, was suggested, those guidelines may help expand the scope of improvement under the economic conditions for home modification.

• Korean Institute of Interior Design Journal
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• v.26 no.1
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• pp.25-32
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• 2017

As the elderly population increases rapidly, existing houses many elderly reside are under poor conditions that they work as a factor to impede on the independent living of elderly people. Thus, improving existing housing environment to suit the needs of elderly life has been required. Academics has been continuously researched on the field considering the importance of elderly housing modification and the importance on the research of this field is projected to be greater with the coming of aging society. Hence, this study has a purpose on analyzing trends of previous studies related to housing modification for the elderly published in Korean academic journals in depth. This study is a content analysis study and analyzed the trend of previous studies with academic journal field, purpose of study, research subject, research area, research method, research content as analysis categories. As a result, previous studies was published the most in natural science academic journals and main stream of research was to suggest direction of housing modification by conducting surveys on actual conditions and needs of single elderly families and to suggest improving the directions of policies related to modification. On the other hand, empirical studies needed to execute housing modification such as standard and method of housing modification and supporting tools are still at minimal level that researches on this field should be conducted additionally. This study is expected to be used as basis to examine the current state of previous studies on housing modification for the elderly and to seek further research directions.