• BMB Reports
• /
• v.36 no.5
• /
• pp.488-492
• /
• 2003

Neurofilament-L (NF-L) is a major element of neuronal cytoskeletons and known to be important for neuronal survival in vivo. Since oxidative stress might play a critical role in the pathogenesis of neurodegenerative diseases, we investigated the role of copper and peroxide in the modification of NF-L. When disassembled NF-L was incubated with copper ion and hydrogen peroxide, then the aggregation of protein was proportional to copper and hydrogen peroxide concentrations. Dityrosine crosslink formation was obtained in copper-mediated NF-L aggregates. The copper-mediated modification of NF-L was significantly inhibited by thiol antioxidants, N-acetylcysteine, glutathione, and thiourea. A thioflavin-T binding assay was performed to determine whether the copper/$H_2O_2$ system-induced in vitro aggregation of NF-L displays amyloid-like characteristics. The aggregate of NF-L displayed thioflavin T reactivity, which was reminiscent of amyloid. This study suggests that copper-mediated NF-L modification might be closely related to oxidative reactions which may play a critical role in neurodegenerative diseases.

• Journal of KSNVE
• /
• v.6 no.3
• /
• pp.317-323
• /
• 1996

This paper proposes the method of experimental structural dynamic modification of fixture for environmental vibration test control. This method can predict the responses at any points on the fixture utilizing the experimental data, and structural dynamic modification of fixture is made using the predicted responses for the spectra at the specimen attachment points to meet the specified reference spectrum. From the results of controlling the fixture before and after modification by conventional control method and optimal reference spectrum, which has been previously reported by the authors, the proposed method is shown to be an effective one.

• Proceedings of the Korean Society of Tribologists and Lubrication Engineers Conference
• /
• 2002.05a
• /
• pp.259-266
• /
• 2002

The basic concept of 'tooth profile modification' is to change a part of the involute profile to reduce the load in that area and appropriate profile modifications can help gears to run quietly and resist scoring, pitting and tooth breakage. In this study, the modification of tooth profile to make a smooth transmission of the normal loads in spur gears has been developed. The modified tooth profile has been determined by the total deflection at contact points. We use the AGMA Standard to design basic gear profile, We also developed a gear design Program using tooth profile modification

• Transactions of the Korean Society of Machine Tool Engineers
• /
• v.12 no.1
• /
• pp.72-77
• /
• 2003

The stable driving condition of high speed gear is approached by shape modifications of a gear tooth. Recently, many gear designers are using FEM for the design and the manufacture of a high precision gear. In this paper, it is aimed to drive in stable sound level through the modification of the tooth and the shape of a gear. The simulation is used to understand the effect of holes for the decrement of weight and the stress variation for the tooth modification. Beam elements used to simulate the same condition as a real gear drive by FEM. The driven gear is simulated to 60,000rpm for the tooth modification.

• Proceedings of the Korean Society of Precision Engineering Conference
• /
• 2004.10a
• /
• pp.254-259
• /
• 2004

The research on surface modification technology has been advanced to change the properties of engineering material. Ion implantation is a novel surface modification technology to enhance the mechanical, chemical and electronic properties of mechanical parts. In this research, nitrogen ions are implanted into aluminum for mold to improve endurance and life span. To analyze modification of surface properties, micro hardness, friction coefficient, wear resistance, contact angle, and surface roughness were measured. Hardness of ion implanted specimens was higher than untreated specimen and friction coefficient was also improved. In this experiment, it can be expected that nitrogen ion implantation can contribute to enhance the mechanical properties of material and ion implantation technology may also be applied to other materials.

• Journal of the Korean earth science society
• /
• v.26 no.4
• /
• pp.329-335
• /
• 2005

The purpose of this study is to suggest the modification of activities to introduce the nature of science in earth science classrooms. A small modification can turn ordinary textbook activities into the nature of science activities. Since earth science could provide a good basis for the tentative, creative, and socially and culturally embedded nature of science, as well as appropriate understanding about scientific methods, careful modification of earth science activities could be effective for students to understand the nature of science. Considering which aspects of the nature of science are appropriate, along with the possible change in the activity, teachers will be able to modify textbook activities effectively. An example modification of H-R diagram activity was also suggested.

• The Journal of Korean Medicine
• /
• v.24 no.1
• /
• pp.9-28
• /
• 2003

Objects : The aim of this study was evaluate the effect of the Saengsig taken along with Behavior Modification Therapy, Methods : We examined the body compositions of 20 obese patients who were treated with Saengsig and Behavior Modification Therapy for 2 months by Inbody 2.0. Results : Changes of body composition due to Saengsig with Behavior Modification Therapy were reduction of body weight by $3.14{\pm}1.33{\;}kg$, lean body mass by $0.14{\pm}1.48{\;}kg$, fat mass by $3.00{\pm}1.53kg$ and BMI by $1.30{\pm}0.54$ Conclusion : Fat mass and body fat rate were significantly reduced after treatment with Saengsig with Behavior Modification Therapy.

• Journal of the Korean Society for Precision Engineering
• /
• v.25 no.9
• /
• pp.103-108
• /
• 2008

In-plane shear tests were performed to investigate the shear property change of FRP by plasma modification. Graphite/epoxy prepreg was used as a test material and plasma source was a microwave (2.4GHz) type. Plasma was induced by oxygen gas and its flow rate was kept $4{\sim}5$sccm with low vacuum state of $10^{-3}$ Torr. Prepreg was stacked unidirectionally ($[0^0]_8$) after plasma modification. Wettability was determined by measuring a contact angle. The results showed that the contact angle was decreased from $86^0$ to $45^0$ after plasma modification. Shear strength was also improved by ${\sim}10%$. SEM examination was made on the fracture surface and functional group produced by the plasma modification was investigated by XPS.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
• /
• 2002.11b
• /
• pp.599-604
• /
• 2002

Substructures position is considered as design parameter to obtain optimal structural changes to raise its dynamic characteristics. In conventional SDM (structural dynamics modification) method, the layout of modifying substructures position is first fixed and at that condition the structural optimization is performed by using the substructures size and/or material property as design parameters. But in this paper as a design variable substructures global translational and rotational position is treated. For effective structural modification the eigenvalue sensitivity with respect to that design parameter is derived based on measured frequency response function. The optimal structural modification is calculated by combining eigenvalue sensitivities and eigenvalue reanalysis technique iteratively. Numerical examples are presented to the case of beam stiffener optimization to raise the natural frequency of plate.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
• /
• 2002.11b
• /
• pp.25-30
• /
• 2002

To reduce the vibration of a gear driving system, the modification of gear tooth from the orignal involute gear profile is usually done in gear manufacturers. The quantity of tooth modification has been decided on the basis of the interference between two gear teeth during gear meshing and the elastic deformation due to loading. However, the dynamic characteristics with tooth modification has to be investigated to avoid the instability to the variation of gear meshing stiffness and the nonlinearity due to gear backlash which results in sub- or super-harmonics in its responses. This research shows the dynamic characteristics with various tooth modifications in its type and quantity.