• Title/Summary/Keyword: N-acetyl glycylglycine methyl ester

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Designing of Antiepileptic Ligands by Esterification and Acetylation of Dipeptides

  • Vishwakarma, K.K.;Saraf, S.K.;Uppadhyay, R.K.;Kohli, D.V.
    • Archives of Pharmacal Research
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    • v.15 no.3
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    • pp.204-207
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    • 1992
  • Glycylglycine, alanylalanine and alanylglycine were synthesized, their free carboxylic and amino groups were converted to methyl esters of N-acetylglycyglycine, N-acetylalanylglycine and N-acetylalanylalanine. The synthesized compounds were evaluated for antiepileptic activity, plasmaprotein binding, $TD_{50}$ and potentiating effect of phenobarbitone sodium.

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