• Journal of Trauma and Injury
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• v.27 no.4
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• pp.178-185
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• 2014

Purpose: The aim of this study was to assess the clinical efficacy of combined treatment with local anesthesia and ketamine procedural sedation for pediatric facial laceration repair in the Emergency Department (ED). Methods: Patients aged 1 to 5 years receiving ketamine for facial laceration repair were prospectively enrolled in a double-blind, randomized, and controlled study at an ED. All patients were to receive intravenous ketamine (2 mg/kg). The local anesthesia group (LA group) received a local anesthetic along with ketamine, whereas the no local anesthesia group (NLA group) received only ketamine. The total time of sedation, the patients' movements and groans, adverse events, and the satisfaction ratings of physicians, nurses, and parents were recorded. Results: A total of 186 patients were randomized (NLA group: 90, LA group: 96). The total time of sedation (30.5 minutes for the NLA group, 32.6 minutes for the LA group; p=0.660), patients' groans (26 (28.9%) versus 23 (24.0%); 0.446) and movements (27 (30%) versus 35 (36.5%); p=0.350) was not affected by the addition of local anesthesia. Other adverse events were similar between the two groups. Also, the satisfaction ratings of physicians (median 4 for the NLA group versus 4 for the LA group (p=0.796)), nurses (2 versus 2.5 (p=0.400)), and parents (4 versus 4 (p=0.199)) were equivalent between the two groups. Conclusion: In this study, we found that local anesthesia was not required along with ketamine sedation for pediatric facial laceration repair.

• Structural Engineering and Mechanics
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• v.67 no.1
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• pp.53-67
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• 2018

The changes of parameters of pressure and velocity of propagation of elastic pressure and shear waves in uniformly deformed solid compressible media are studied within the nonclassically linearized approach (NLA) of nonlinear elastodynamics to create a new theoretical basis of the geomechanical interpretation of various groups of geophysical observational and experimental data. The cases of small and large deformations are considered while their describing by various elastic potentials, i.e., problems considering the physical and geometric nonlinearity. Convenient analytical formulae are obtained to calculate the indicated parameters in the deformed isotropic media within the nonclassical linear and nonlinear solution in the NLA. Specific numerical experiments are conducted in case of overall compression of various materials. It is shown that the method (generally accepted in the studies of mechanics of standard constructional materials) of additional linearization (relative to the pressure parameter) in the basic correlations of the NLA introduces substantial quantitative and qualitative errors into the results at significant preliminary deformations. The influences of the physical and geometric nonlinearity on the studied characteristics of the medium are large in various materials and differ qualitatively. The contribution of nonlinear components to the values of the considered parameters prevails over linear components at large deformations. When certain critical values of compression deformations in the medium are achieved, elastic waves with actual velocity cannot propagate in it. The values of the critical deformations for pressure and shear waves differ within different elastic potentials and variants of the theory of initial deformations.

• Korean Journal of Biological Psychiatry
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• v.8 no.1
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• pp.111-115
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• 2001

An association study with Korean alcoholic patients(n=50) and normal controls(n=53) was performed to find the relationship between catechol-O-methyltransferase(COMT) gene polymorphism and alcoholism using polymerase chain reaction-restriction fragment length polymorphism. When we compared the allele and genotype frequencies of Nla III COMT gene polymorphism in alcoholism and normal controls, there was no significant difference between two groups. Our results do not support an association between the Nla III polymorphism of COMT gene and alcoholism.

• Journal of Pharmaceutical Investigation
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• v.29 no.2
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• pp.87-92
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• 1999

Drug delivery to the brain may be achieved by producing chimeric peptide, attaching the drug to protein 'vectors' which are transported into the brain from the blood by a receptor-mediated transcytosis through the blood-brain barrier (BBB). Since the BBB expresses high concentrations of transferrin receptor, and it was reported that anti-transferrin receptor mouse monoclonal antibody (OX26) undergoes transcytosis through the BBB, it is logical to assume that a drug delivery system via transferrin receptor-mediated transcytosis is a promising strategy. In the present study, therefore, we tested feasibility of several OX26 based vectors for the brain delivery of a model drug. Avidin-based delivery vectors such as OX26-streptavidin (OX26-SA), OX26-neutralite avidin (OX26-NLA) were chemically synthesized vectors and OX26 immunoglobulin G 3 type $C_{H}3$ fusion avidin $(OX26\;IgG3C_H3-AV)$ was genetically engineered. To improve the efficiency of producing chimeric peptide, we used avidin-biotin technology. Pharmacokinetics of $[^3H]biotin$ bound to OX26-SA, OX26-NLA and $OX26\;IgG3C_H3-AV$ was determined by intravenous injection technique, and their stabilities in plasma were analyzed using HPLC. The brain delivery of $[^3H]biotin$ bound to OX26-SA, OX26-NLA and OX26\;$IgG3C_{H}3-AV$ (expressed as %ID/g brain) was $0.22{\pm}0.01$, $0.18{\pm}0.01$ and $0.25{\pm}0.09$, respectively. The areas under the plasma concentration versus time curve (AUC) for OX26-SA, OX26-NLA, $OX26\;IgG3C_H3-AV$ from time zero to 60 min were $209{\pm}10$, $195{\pm}9$, $134{\pm}29\;%ID\;min/ml$ respectively and their total clearances $(CL_{tot})$ were $1.00{\pm}0.09$, $1.08{\pm}0.07$ and $1.54{\pm}0.29\;ml/min/kg$, espectively. These results showed that these vectors possess preferable pharmaceutical (e.g., resonable stability) and pharmacokinetics (e.g., significant brain uptake and enhanced AUC) for brain delivery. Therefore, these vectors may be broadly useful in the brain delivery of drugs that are not transported into the brain to a significant extent.

• Journal of Korean Library and Information Science Society
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• v.42 no.2
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• pp.85-103
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• 2011

Bibliographic Network has been a goal about not only to support resource sharing within libraries but also to pursue economic efficiency of cataloging. But nowadays, as resources in diverse media and format have been poured out, printed resources based union catalog should change to new resources finding system which include diverse type of resources. This study analyzes changing factors of bibliographic network and strategies for LC, NII, OCLC, NLA who try to turn over a new service. Finally basis on these findings, suggest task for Korean new generation bibliographic network service which is focused on introducing new collaborating model and developing new resource finding system.

• Journal of Korean Library and Information Science Society
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• v.35 no.3
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• pp.175-204
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• 2004

Digital information resource requires detailed metadata to ensure its long-term preservation and accessibility for future generations. This paper illuminated the characteristics of digital information resources, the concept of digital preservation and the necessity of metadata for long-term preservation of digital information resources. And this paper examined the 16 elements of RLG metadata for preserving digital information and the Reference Model for an Open Archival Information System(OATS) to support the interoperability of digital archiving. And then this study investigated concretely element sets of the preservation metadata for digital information resources in the Cedars and OCLC/RLG embodied within the OAIS framework. As result of the study, the paper suggested basic plan required to provide preservation metadata elements to preserve digital information resources in Korea.

• Journal of Information Management
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• v.43 no.3
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• pp.139-160
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• 2012

The document delivery service has been influenced by the changing digital information environment and the copyright law. This paper proposes the key points for the improved documents delivery service through trend analysis of BL(The Great Britain), NLA(Australia), subito(German speaking countries), JST(Japan), KISTI(Korea) and KERIS(Korea) and copyright law in each country. The purpose of this study is providing with the clues for developing strategies that can satisfy the users' needs in document delivery service for libraries and information centers.

• International Journal of Knowledge Content Development & Technology
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• v.10 no.4
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• pp.47-64
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• 2020

The study investigated the role of libraries in curtailing the spread of COVID-19 pandemic in Nigeria. Six research objectives were raised to guide the conduct of the study. The survey type of the descriptive research design was employed. The population of the study comprised of 139 selected librarians in Nigeria. The complete enumerative sampling technique was adopted to study the entire 139 librarians. The instrument for data collection was an online survey questionnaire designed by the researchers using SurveyMonkey and administered to the respondents via the Nigerian Library Association (NLA) WhatsApp group and the NLA Google group. The data collected were analyzed using descriptive statistics. The study revealed that among the services delivered by Nigerian libraries amidst the global pandemic are COVID-19 awareness and sensitization creation, provision of digital contents to patron, organizing online streaming programs and connecting patrons/citizens to accurate and reliable data on COVID-19 cases around the world. The study further revealed that these services are delivered frequently despite the low level of Nigerian libraries' preparedness for global pandemic. The study concluded that, Nigerian libraries, through their services, are potent weapon for promoting positive change, development, orientation, and re-orientation in the society. By creating COVID-19 awareness/sensitization (especially in rural areas), libraries are able to contribute significantly to the fight against the pandemic.

• The korean journal of orthodontics
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• v.19 no.1 s.27
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• pp.169-185
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• 1989

The purpose of this study was to establish Korean norms that will be valuable aids for diagnosis in orthognathic surgery patients. Lateral cephalometric measurements were established for adult Koreans (60 males, 62 females) with normal occlusion and acceptable profiles. The results were as follows: 1. Means, standard deviation and sexual differentiation were included within each measurement. 2. In skeletal measurements, FH to SN and SN to mandibular plane measurements in females were larger than those in males while all linear measurements in males were larger than those in males were larger than those in females. 3. Significant differences were observed between male and female groups on all of the items that showed vertical relationship in dental measurements. And the measurements of ADH, PDH and overbite in males were larger than those in females while the measurements of incisor exposure in females were larger than those in males. 4. In all measurements of soft tissue except NLA, that is, of FCA, UFH, ULL and LLL, males were larger than those in females.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.38A no.1
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• pp.79-87
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• 2013

A new modulation technique - correlative encoded FSK (CEFSK) - for use in power and bandwidth limited digital communication system is proposed. CEFSK is free of ISI and generates output signals which have a smooth and continuous phase transition and a reduced envelope fluctuation by keeping correlation between amplitude and phases of two subsequent symbols. In comparison to conventional one-bit differential detected (1DD) GFSK, the performance of the 1DD-CEFSK in a non-linearly amplified (NLA) channel impaired by additive white Gaussian noise (AWGN), ISI and IM, is analyzed via computer simulation. The simulation result shows that, in an NLA single-channel, 1DD-CEFSK provides a signal-to-noise ratio (SNR) advantage of up to 1.2dB and 0.8dB at BER of $1{\times}10^{-4}$ when input back-off (IBO) of HPA is -1.0dB and -3.0dB, respectively. For the same channel environment with multi-channel, 1DD-CEFSK outperforms 1DD-GFSK by 1.1dB in SNR, regardless of the value of IBO.