• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.6
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• pp.1546-1551
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• 2005

This Study was designed to investigate the effects of Nelumbinis Rhizomatis Nodus (NRN) on the change of cerebral hemodynamics [regional cerebral blood flow (rCBF), pial arterial diameter (PAD) and mean arterial blood pressure (MABP)] in normal and cerebral ischemic rats. And, this study was designed to investigate the inhibition of lactate dehydrogenase activity in neuronal cells The results were as follows NRN significantly increased rCBF and PAD in a dose-dependent manner, and NRN increased MABP in a dose-dependent manner. This results suggested that NRN significantly increased rCBF by dilating PAD. Both rCBF and PAD were significantly and stably increased by NRN (10 mg/kg, i.p.) during the period of cerebral reperfusion, which contrasted with the findings of rapid and marked increase in control group. NRN significantly inhibited lactate dehydrogenase activity in neuronal cells. This results suggested that NRN prevented the neuronal death. It is suggested that NRN had an anti-ischemic effect through the improvement of cerebral hemodynamics and inhibitive effect on the brain damage.

• The Journal of Pediatrics of Korean Medicine
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• v.22 no.2
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• pp.141-153
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• 2008

Objectives : This study was designed to investigate the effects of Nelumbinis Rhizomatis Nodus(NRN) on production levels of Blood Glucose and Serum Lipid Levels. Methods : This study is about changes of blood glucose levels, body weights, levels of food and water uptake, levels of total cholesterol in the body, triglyceride, Creatinine, and BUN production by NRN extract. Results : Treatment with NRN regulated blood glucose levels effectively, but treatment with NRN did not affect body weights, food and water uptake. In addition, treating with NRN also lowered levels of total cholesterol, which is important for diabetes, and also lowered levels of triglyceride, too. Serum Creatinine levels were not affected, but serum BUN levels were lowered by treating with NRN, which were elevated in diabetes. Conclusions : These results demonstrate that NRN is effective to treat DM level and also has anti-hyperlipidemic effect.

• Journal of Life Science
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• v.29 no.11
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• pp.1192-1199
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• 2019

The intention of this study was to confirm the possible use of an ethanol extracts of Nelumbinis Rhizomatis Nodus (NRN) as a cosmetic material. To this end, we extracted NRN with 70% ethanol and performed biological activity evaluation of whitening efficacy and wrinkle reduction. We performed cellular tyrosinase inhibition and melanin contents assay to check the whitening activity of NRN and carried out a toxicity evaluation of NRN via an MTT assay and the amounts of associated proteins that affect melanin production in a melanoma cell line (B16F10). And collagenase inhibitory assay was performed for the evaluation of anti-wrinkle of samples. In addition, a toxicity evaluation using an MTT assay and matrix metalloprotease (MMP-1) and procollagen synthesis inhibition by NRN were evaluated in a fibroblast cell line (CCD-986sk). Western blot results for the whitening activity evaluation revealed that the levels of two proteins related to melanin production, tyrosinase-related protein-1 (TRP-1) and tyrosinase-related protein-2 (TRP-2), were decreased in a dose-dependent manner. Moreover, collagenase inhibition activity at a concentration of $500{\mu}g/ml$ NRN by measuring epigallocatechin-3-gallate (EGCG) was increased by more than 80% compared to the control group. Meanwhile, procollagen synthesis was reduced by 68.8% in the UVB-induced CCD- 986sk cells group whereas collagen synthesis recovered by 80.2% with $25{\mu}g/ml$ NRN. The MMP-1 expression rate showed 20.2% reduction at $25{\mu}g/ml$. The results of the experiments verified the whitening and wrinkle suppression effects of NRN and confirmed that it could be used as a safe natural cosmetic material in the future.

• Journal of Fisheries and Marine Sciences Education
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• v.22 no.2
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• pp.218-230
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• 2010

This study was conducted to determine the effect of the noise level on the boarding environment in a stern trawl ship, KAYA(GT: 1,737 tons, Pukyong National University). We measured the noise level at a working, an accommodation and a teaching area, and an engine space on January 9, 2010 while the KAYA was sailing on a liner sea route. At the working area, the ranges of the noise rating number(NRN) and the NRN determination frequency(FNRN) were from 44 to 73 and from 1000 to 2000Hz, respectively. The results were generally satisfied the criteria of the International Maritime Organization(IMO). The noise level at the area, except the radio room(w2), was exceeded the criteria(50dB(A)) for the efficient studying and working. The noise level at the engine control room and the machine workshop was respectively exceeded 1.2dB and 9.5dB than the criteria caused the conversation disturbance (70dB(A)). At the accommodation, NRN and FNRN were from 49 to 54 and from 1000 to 4000Hz, respectively. The noise level was below the criteria of IMO, but above 40dB(A) caused the sleep disturbance. At the teaching area, NRN and FNRN were from 44 to 63 and from 500 to 2000Hz, respectively. The noise level was exceeded than the criteria(50dB(A)) for the efficient studying. At the engine space, NRN and FNRN were from 95 to 100 and from 2000 to 4000Hz, respectively. The noise level was above the criteria of IMO(90dB(A)) for the residence, while it was not exceeded 110dB(A) for the transient.

• Convergence Security Journal
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• v.16 no.7
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• pp.3-11
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• 2016

With repid development of optical networking technology, Software-Defined Network (SDN) and Network Function Virtualization (NFV), high performance networking service, collaboration platform that enables collaborative research globally, drastically National Research Network (NRN) including Internet Service has changed. Therefore we compared and analyzed several world-class NRNs and took a view of future development strategy of the NRN. Also we suggest high speed security environment in super high bandwidth network with 40Gbps and 100Gbps optical transmission technology, network separation of NRN with Science DMZ to support high performance network transmission for science big data, building security environment for last-mile in campus network that supports programmability of IDS using BRO framework.

• Journal of Korean Society of Environmental Engineers
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• v.31 no.12
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• pp.1123-1128
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• 2009

Noise radiated from medical treatment at dental clinic will affect the patients. On such point of view, We investigated the noise characteristics in case of medical treatment (scaling, tooth eliminating) and non-medical examination (idling) and also evaluated the degree of indoor noise using the evaluation index such as PSIL, NRN and made up a questionnaire about the reactions to noise. As a result of noise evaluation, it shows that the range of noise level is 67.7~78.3 dB(A) and frequency is very high (above 4 k Hz) and respondents are affected by noise (unpleasantness, hesitation to visit dental clinic, shivering with noise, being astonishment). Analysis by PSIL showed that it was no problem to conversation between worker and patient. But it exceeded the noise permit level in working space by NR-curve. To relieve a fear of noise in patients, they are considered to offer the ear protection, choose the low noisevibration equipment and use the masking effect. They are of great advantage to dental clinics to i prove dental service and competitiveness.

• Journal of the Korean GEO-environmental Society
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• v.15 no.8
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• pp.5-11
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• 2014

In this study, chemical analysis and ecotoxicity tests of leachate from disposal site for foot-and-mouth disease carcasses (FMD leachate) were conducted to collect fundamental data that will be used to develop environmental risk assessment tools for FMD leachate. For chemical analysis, concentration of $Cl^-$, $NH{_4}{^+}-N$, Korea standard method indicators for detection of leachate released from animal carcasses burial site into groundwater and NRN (Ninhydrin-Reactive Nitrogens), a newly suggested screening test indicator to detect groundwater contamination by FMD leachate, were assessed. For ecotoxicity tests, luminescent bacteria (V. fischeri), micro-algae (P. subcapitata) and water flea (D. magna) were selected as test species. Correlation analysis between the concentration of $Cl^-$, $NH{_4}{^+}-N$, NRN and the toxicity to V. fischeri was performed to identify the better indicators to monitor FMD leachate contamination. From regression analysis, the concentration of the indicators in FMD leachate contaminated sample that induced halfmaximal toxic effect to V. fischeri was evaluated. Results obtained from this study can be applied to assess the risk by FMD leachate and to establish the guideline to manage risk in relation to FMD leachate.

• Journal of the Korea Society of Computer and Information
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• v.23 no.12
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• pp.163-170
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• 2018

This study was conducted to investigate the effects of noise from dental clinics on workers and to establish a reduction plan. The noise generated by the treatment instrument(Ultrasonic scaler, Hand piece, 3-way syringe, Suction, Compressor) was measured in order to determine the characteristics(level, frequency) of the noise during medical treatment(Oral prophylaxis, Conservation treatment, Prosthesis treatment, Implant Scaling, Tooth eliminating). We also assessed the noise levels in dental clinic using evaluation indicators such as NR-curves and NRN. The results of the analysis showed that the noise generated during the treatment was 85dB(A) ~ 70dB(A) and that the high frequency component was dominant, which would affect the workers working at the dental clinic. The NR-curve analysis showed NR-67 to NR-83 and the high frequency components of 4kHz to 8kHz were predominant and far exceeded noise levels in the workplace. To minimize the noise damage of workers and to provide high quality medical service, it is necessary to establish countermeasures such as wearing a soundproof and periodic hearing tests.

• Proceedings of the Korea Information Processing Society Conference
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• 2015.10a
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• pp.355-356
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• 2015

ICT 및 연구관리환경의 다변화와 발전방향에 비추어, 연구망을 효율적으로 운영관리하기 위한 시스템의 구현 및 운영환경을 NFV기반으로 구축하고, 발전하기 위한 NFVI 구성방안을 연구하고자 한다.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.5
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• pp.2516-2523
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• 2013

Noise occurred when medical treatment in dental clinic will affect the patients. This study was measured the noise level and frequency in case of medical examination and also has evaluated the degree of indoor noise using the NR-curve, NRN and a distance to conversation between worker and patients using the PSIL. It shows that noise level was 69.3~81.5dB(A) and frequency was very high (more than 4K(Hz)) and analysis by NR-curve showed that it was exceed the noise permit level and distance to conversation was less than 1meter by PSIL. To remedy a fear of noise in patients and provide a conversational satisfaction, it's considered that choosing the low noise-vib. equipment, using the masking effect and set the room to explain. So It is possible to improve their competitiveness.