• Journal of Korea Multimedia Society
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• v.19 no.12
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• pp.1909-1918
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• 2016

This paper presents a unified framework for joint Convolutional Neural Network (CNN) based vehicle detection by leveraging multi-spectral image pairs. With the observation that under challenging environments such as night vision and limited light source, vehicle detection in a single color image can be more tractable by using additional far-infrared (FIR) image, we design joint CNN architecture for both RGB and FIR image pairs. We assume that a score map from joint CNN applied to overall image can be considered as confidence of vehicle existence. To deal with various scale ratios of vehicle candidates, multi-scale images are first generated scaling an image according to possible scale ratio of vehicles. The vehicle candidates are then detected on local maximal on each score maps. The generation of overlapped candidates is prevented with non-maximal suppression on multi-scale score maps. The experimental results show that our framework have superior performance than conventional methods with a joint framework of multi-spectral image pairs reducing false positive generated by conventional vehicle detection framework using only single color image.

• The KIPS Transactions:PartD
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• v.17D no.6
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• pp.463-470
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• 2010

We presented a very fast and robust method of text line segmentation based on the DCT blocks of color image without decompression and binary transformation processes. Using DC and another three primary AC coefficients from block DCT we created a gray-scale image having reduced size by 8x8. In order to detect and locate white strips between text lines we analyzed horizontal and vertical projection profiles of the image and we applied a direct markov model to recover the missing white strips by estimating hidden periodicity. We presented performance results. The results showed that our method was 40 - 100 times faster than traditional method.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.12 no.3
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• pp.186-191
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• 2019

In this paper, we propose a implementation approach of the high-speed feature extraction algorithm. The proposed method is based on the block type classification algorithm which reduces the computation time when target macro block is divided to smooth block type that has no image features. It is quantitatively identified that occurs at 29.5% of the total image using 200 standard test images with $64{\times}64$ macro block size. This means that within a standard test image containing various image information, 29.5% can reduce the complexity of the operation. When the proposed approach is applied to the Canny edge detection, the required latency of the edge detection can be completely eliminated, such as 2D derivative filter, gradient magnitude/direction computation, non-maximal suppression, adaptive threshold calculation, hysteresis thresholding. Also, it is expected that operation time of the feature detection can be reduced by applying block type classification algorithm to various feature extraction algorithms in this way.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.16 no.7
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• pp.2131-2153
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• 2022

To achieve accurate detection of tuberculosis (TB) areas in chest radiographs, we design a chest X-ray TB area detection algorithm. The algorithm consists of two stages: the chest X-ray TB classification network (CXTCNet) and the chest X-ray TB area detection network (CXTDNet). CXTCNet is used to judge the presence or absence of TB areas in chest X-ray images, thereby excluding the influence of other lung diseases on the detection of TB areas. It can reduce false positives in the detection network and improve the accuracy of detection results. In CXTCNet, we propose a channel attention mechanism (CAM) module and combine it with DenseNet. This module enables the network to learn more spatial and channel features information about chest X-ray images, thereby improving network performance. CXTDNet is a design based on a sparse object detection algorithm (Sparse R-CNN). A group of fixed learnable proposal boxes and learnable proposal features are using for classification and location. The predictions of the algorithm are output directly without non-maximal suppression post-processing. Furthermore, we use CLAHE to reduce image noise and improve image quality for data preprocessing. Experiments on dataset TBX11K show that the accuracy of the proposed CXTCNet is up to 99.10%, which is better than most current TB classification algorithms. Finally, our proposed chest X-ray TB detection algorithm could achieve AP of 45.35% and AP50 of 74.20%. We also establish a chest X-ray TB dataset with 304 sheets. And experiments on this dataset showed that the accuracy of the diagnosis was comparable to that of radiologists. We hope that our proposed algorithm and established dataset will advance the field of TB detection.

• Molecules and Cells
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• v.38 no.4
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• pp.373-379
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• 2015

Pyruvate kinase M2 isoform (PKM2), a rate-limiting enzyme in the final step of glycolysis, is known to be associated with the metabolic rewiring of cancer cells, and considered an important cancer therapeutic target. Herein, we report a novel PKM2 activator, PA-12, which was identified via the molecular docking-based virtual screening. We demonstrate that PA-12 stimulates the pyruvate kinase activity of recombinant PKM2 in vitro, with a half-maximal activity concentration of $4.92{\mu}M$, and effectively suppresses both anchorage-dependent and -independent growth of lung cancer cells in non-essential amino acid-depleted medium. In addition, PA-12 blocked the nuclear translocalization of PKM2 in lung cancer cells, resulting in the inhibition of hypoxia response element (HRE)-mediated reporter activity as well as hypoxia-inducible factor 1 (HIF-1) target gene expression, eventually leading to the suppression of cell viability under hypoxia. We also verified that the effects of PA-12 were dependent on PKM2 expression in cancer cells, demonstrating the specificity of PA-12 for PKM2 protein. Taken together, our data suggest that PA-12 is a novel and potent PKM2 activator that has therapeutic implications for lung cancer.