• 대한한의학회지
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• 제44권3호
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• pp.102-116
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• 2023

Objectives: To provide a case report of effective use of Korean herbal medicine treatment to reduce the development and progression of normal-tension glaucoma(NTG). Methods: This case involved a 52-year-old patient who had a history of excimer laser surgery at the age of 25 and was using prescriptions such as Cosopts2 and Xalatan for eye drops. We treated this patient with Korean herbal medicine treatment for 2 years and assessed the progression of NTG based on the optical coherence tomography test results that he recevied at the ophthalmology clinic every 6 months. Results: During the two years of treatment with Korean herbal medicine, it was observed that the progression of NTG was halted. However, after discontinuing the Korean herbal treatment, the progression resumed. Conclusion: Korean herbal medicine treatment was found to be effective in treating normal tension glaucoma, and a minimum treatment period of two years is necessary for an accurate evaluation of NTG.

• 한국식생활문화학회지
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• 제35권2호
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• pp.224-232
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• 2020

Glaucoma is one of the leading causes of blindness worldwide and is characterized by degeneration of the optic nerve. Elevated intraocular pressure (IOP) is the major contributing factor to optic nerve damage. However, some patients develop glaucoma even with normal IOP. Other factors, including age, race, myopia, and nutrition, can affect glaucoma risk. Dietary fat intake and serum fatty acid composition are closely related with the fatty acid profile of the retina and thus can modulate glaucoma risk. In this study, we collected serum samples from 34 glaucoma patients (26 primary open angle glaucoma (POAG) and 8 normal tension glaucoma (NTG)) and 45 healthy controls and analyzed their serum phospholipid fatty acid concentrations. The results show that the ratio of oleic acid to stearic acid (OA/SA), which is an indicator of stearoyl-CoA desaturase activity, was higher in POAG patients when compared to normal controls. The ratio of eicosapentaenoic acid to arachidonic acid (EPA/AA), which is an indirect marker of eicosanoid biosynthesis, was also higher in glaucoma patients (p=0.048). These results imply that dietary fatty acid intake and serum fatty acid profile can influence glaucoma risk. Additional study is necessary to identify the relationship between fatty acids and glaucoma.

• 대한안과학회지
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• 제58권8호
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• pp.960-967
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• 2017

목적: 갑상샘눈병증과 정상안, 정상안압녹내장 환자의 황반하 맥락막 두께를 비교해 보고자 한다. 대상과 방법: 정상군 70안, 갑상샘눈병증군 74안, 정상안압녹내장군 60안을 대상으로 하였다. 모든 환자는 스펙트럼영역 빛간섭단층촬영의 Enhanced Depth Imaging 방법으로 중심와 맥락막두께를 측정하였다. 평균 중심와 맥락막 두께는 중심와아래, 중심와 아래에서 각각 1.5 mm 비측 및 이측의 세 지점의 평균으로 정의하였다. 일반화 추정 방정식을 통하여 맥락막 두께에 미치는 변수를 알아보았다. 결과: 평균 중심와 맥락막 두께는 정상 $252.07{\pm}55.05{\mu}m$, 갑상샘눈병증 $281.01{\pm}60.06{\mu}m$, 정상안압녹내장 $241.66{\pm}55.00{\mu}m$로 유의한 차이를 보였다(p=0.013). 중심와아래, 비측, 이측 중심와 맥락막 모두 정상안압녹내장에서 갑상샘눈병증에 비해 얇았다(p=0.014, 0.012, and 0.034). 갑상샘눈병증에서 나이, 성별, 굴절률, 안압을 보정한 후에도 정상안압녹내장군에 비해 맥락막 두께가 유의하게 두꺼웠다(${\beta}=32.61$, p=0.017). 결론: 갑상샘눈병증군에서 정상안압녹내장군과 정상군보다 유의하게 두꺼운 맥락막을 보였고 평균 망막신경섬유층 두께는 정상안압녹내장군이 갑상샘눈병증군보다 유의하게 얇았다. 갑상샘눈병증 환자에서의 두꺼운 맥락막이 녹내장 진행에 있어 어떠한 효과를 가지는지 향후 추가적인 연구가 필요할 것으로 보인다.