• The korean journal of orthodontics
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• v.19 no.1 s.27
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• pp.77-93
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• 1989

The purpose of the present study were to disclose whether the depth of the mandibular antegonial notch can be used as an indicator of mandibular growth potential. The patients composed of 76 samples and were classified following 3 groups, based on the depth of mandibular antegonial notch : Deep notch group (more than 3mm), Neutral notch group (1-3mm), Shallow notch group (less than 1mm). For each case, the first lateral cephalograms were taken prior to the start of treatment and the second films 3-4 years after. The results were as follows; 1. Deep notch group had a shorter corpus, less ramus height and greater genial angle than did Shallow notch group. 2. Deep notch group had a more retrusive mandibular position than Shallow notch group. 3. Deep notch group had longer total anterior facial height and longer anterior lower facial height group. 4. Deep notch group grow vertical clockwise growth pattern, while Shallow notch group grow horizontal counterclockwise growth pattern. 5. Deep notch group had less mandibular growth than Shallow notch group during observation period.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.66 no.11
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• pp.1568-1574
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• 2017

This paper studied cogging torque reduction effect for sloping notch applied two notches on stator teeth. We have confirmed accuracy of FEM(Finite Element Method) through comparison previous model using asymmetric notch for experiment and 3D FEM results, and then cogging torque comparison of previous model and sloping notch model. Also the sloping notch model has been modified to step-sloping notch model to consider manufactur. The modification method of sloping notch changed the degree of slope of notch (a)(Notch(a) sloping Deg) and the degree of Slope of notch (b)(Notch(b) Sloping Deg). When Cogging torque is case of minimum, Notch (a) Sloping Deg is $-12[^{\circ}]$ and Notch(b) Sloping Deg $12[^{\circ}]$. In this case, cogging torque was about 23.9[mNm]. Cogging torque of previous model is about 40.8[mNm], so sloping notch model is less than previous model by 41.42[%]. Also, if sloping notch model is changed to step-sloping notch model, cogging torque of step-sloping notch model is about 24.82[mNm], Therefore the difference between the two cogging torque is about 3.85[%], so step-sloping notch model can be applied when considering manufacture.

• Journal of Biosystems Engineering
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• v.1 no.1
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• pp.64-72
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• 1976

This experimental work was carried out to investigate the fatigue bending strength on various shapes and sizes of notches of the domestically manufactured steel plate. The notch types tested were a circular hole, U-and V-notches. The S-N diagram for different notch shapes were discussed in relation to plan bending strength and stress concentration factor of notches .The results of the experiments are summarized as follows : (1) The difference between stress concentration factor and notch factor was greater as the radium of notch root became smaller, and these values approached to an identical value as the radium of notch root increased. (2) It was shown that the plane bending fatigue limit of bar without notch for the hotrolled steel having the tensile strength of 33.1kg/$mm^2$was 17.0kg/$mm^2$. (3) U-and V-notch had a greater effect of stress concentration factor on the endurance limit, but O-hole showed the same effect only for $\o\pm2mm$. (4) For the same radius of notch root, U-notch showed a lower value of fatigue limit compared to V-notch and O-hole.

• The korean journal of orthodontics
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• v.19 no.1 s.27
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• pp.123-135
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• 1989

This study was undertaken to investigate the relationship between the depth of antegonial notch and the craniofacial morphology, and to predict the mandibular growth direction & potential in class III malocclusion. The computerized analyses were carried out on longitudinal lateral cephalometric radiographs of 50 children with class III malocclusion, divided into two groups ; 30 deep notch subjects (more than 2.6mm) and 20 shallow notch subjects (less than 1.5mm). The conclusions were as follows: 1. The mandibular growth direction in deep notch group was more vertically directed than in shallow notch group. 2. Deep notch group had shorter anterior & posterior cranial base than shallow notch group. 3. There was not significant difference between deep & shallow notch groups in the amount of mandibular growth during treatment period. 4. Notch depth increased in both deep & shallow notch groups during treatment period.

• Journal of Korean Neurosurgical Society
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• v.61 no.4
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• pp.441-449
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• 2018

Objective : Notch receptors are heterodimeric transmembrane proteins that regulate cell fate, such as differentiation, proliferation, and apoptosis. Dysregulated Notch pathway signaling has been observed in glioblastomas, as well as in other human malignancies. Nerve growth factor (NGF) is essential for cell growth and differentiation in the nervous system. Recent reports suggest that NGF stimulates glioblastoma proliferation. However, the relationship between NGF and Notch1 in glioblastomas remains unknown. Therefore, we investigated expression of Notch1 in a glioblastoma cell line (U87-MG), and examined the relationship between NGF and Notch1 signaling. Methods : We evaluated expression of Notch1 in human glioblastomas and normal brain tissues by immunohistochemical staining. The effect of NGF on glioblastoma cell line (U87-MG) was evaluated by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. To evaluate the relationship between NGF and Notch1 signaling, Notch1 and Hes1 expression were evaluated by reverse transcription polymerase chain reaction (RT-PCR) and Western blot analysis, respectively. To confirm the effects of NGF on Notch1 signaling, Notch1 and Hes1 small interfering RNAs (siRNAs) were used. Results : In immunohistochemistry, Notch1 expression was higher in glioblastoma than in normal brain tissue. MTT assay showed that NGF stimulates U87-MG cells in a dose-dependent manner. RT-PCR and Western blot analysis demonstrated that Notch1 and Hes1 expression were increased by NGF in a dose-dependent manner. After transfection with Notch1 and Hes1 siRNAs, there was no significant difference between controls and 100 nM $NGF-{\beta}$, which means that U87-MG cell proliferation was suppressed by Notch1 and Hes1 siRNAs. Conclusion : These results indicate that NGF stimulates glioblastoma cell proliferation via Notch1 signaling through Hes 1.

• Development and Reproduction
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• v.16 no.4
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• pp.371-378
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• 2012

Notch signaling plays fundamental roles in various animal development. It has been suggested that Hr-Notch, a Notch homologue in the ascidian Halocynthia roretzi, is involved in the formation of peripheral neurons by suppressing the neural fates and promoting the epidermal differentiation. However, roles of Notch signaling remain controversial in the formation of nervous system in ascidian embryos. To precisely investigate functions of Notch signaling, we have isolated and characterized Hr-Numb, a Numb homologue which is a negative regulator of Notch signaling, in H. roretzi. Maternal expression of Hr-Numb mRNAs was detected in egg cytoplasm and the transcripts were inherited by the animal blastomeres. Its zygotic expression became evident by the early neurula stage and the transcripts were detected in dorsal neural precursor cells. Suppression of Hr-Numb function by an antisense morpholino oligonucleotide resulted in larvae with defect in brain vesicle and palps formation. Similar results have been obtained by overexpression of the constitutively activated Hr-Notch forms. Therefore, these results suggest that Hr-Numb is involved in Notch signaling during ascidian embryogenesis.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2003.06a
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• pp.1358-1361
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• 2003

In this study, intrinsic static/dynamic fracture toughness of Al 7175-T74 are evaluated from the apparent static/dynamic toughness of notched specimen. The notch/crack critical average stress fracture model is suggested to establish the relationship to predict the intrinsic fracture toughness from the apparent fracture toughness of a notched specimen. The notch/crack critical average stress fracture model is established using the relation between the notch root radius and the effective distance calculated by finite element analysis. It is conclude that the true fracture toughness can be estimated from test results of apparent fracture toughness measured by using a notched specimen. Also, critical notch root radius can be predicted by notch/crack critical average stress fracture model.

• BMB Reports
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• v.48 no.8
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• pp.431-437
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• 2015

Notch signaling plays a pivotal role in cell fate determination, cellular development, cellular self-renewal, tumor progression, and has been linked to developmental disorders and carcinogenesis. Notch1 is activated through interactions with the ligands of neighboring cells, and acts as a transcriptional activator in the nucleus. The Notch1 intracellular domain (Notch1-IC) regulates the expression of target genes related to tumor development and progression. The Notch1 protein undergoes modification after translation by posttranslational modification enzymes. Phosphorylation modification is critical for enzymatic activation, complex formation, degradation, and subcellular localization. According to the nuclear cycle, Notch1-IC is degraded by E3 ligase, FBW7 in the nucleus via phosphorylation-dependent degradation. Here, we summarize the Notch signaling pathway, and resolve to understand the role of phosphorylation in the regulation of Notch signaling as well as to understand its relation to cancer. [BMB Reports 2015; 48(8): 431-437]

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.10 no.3
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• pp.159-166
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• 2010

As Power Line has been already installed over 60% of a residential area all over the world, Broadband Service has been possible using high-speed PLC(Power Line Communication) without new access line installed for Internet access. Because of such reason, PLC is researched as the most suitable service for Last Mile Solution. But, Power Line is designed for transmitting electric power, so peripheral Wireless Communication System is affected by a leak of electric wave. In this paper, we propose a High Performance Notch Filter algorithm in comparison with a existing notch filter for reduction of interference between existing Wireless Communication Service and Power Line Service. In addition, we implement the Notch Filter emulator appling a High Performance Notch Filter and using a embedded board.

• Tunnel and Underground Space
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• v.17 no.3 s.68
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• pp.216-224
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• 2007

Blasting, using shock and dynamic energy of explosive, is very effective tunnel excavation method. But it had serious problem which is the blast vibration and over-break. In recent study, pre-cracked excavation method using notch hole reduced blast vibration and over-break in tunnel, so we performed study about developing notch bit system for making notch hole. In order to make notch hole effectively we had perform drilling experiments changing length and height of notch and in order to improve speed and precision of drilling we had developed notch bit system which consists of drilling bit, notch bit, adapter and notch guide.