• Biomolecules & Therapeutics
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• v.16 no.3
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• pp.173-178
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• 2008

Several lines of evidence indicate that scopolamine as a nonselective muscarinic antagonist disrupts object recognition performance and spatial working memory when administered systemically. In the present study, we investigated the different effects of scopolamine on acquisition, consolidation, and retrieval phases of object recognition performance and spatial working memory using the object recognition and the Morris water maze tasks in mice. In the acquisition phase test, scopolamine decreased recognition index on object recognition task and the trial 1 to trial 2 differences on Morris water maze task. In the consolidation and retrieval phase tests, scopolamine also decreased recognition index on object recognition task, where as scopolamine did not exhibited any effects on the Morris water maze task.

• JSTS:Journal of Semiconductor Technology and Science
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• v.16 no.2
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• pp.251-254
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• 2016

An energy-efficient object matching accelerator is proposed for mobile object recognition based on matching prediction scheme. Conventionally, vocabulary tree has been used to save the external memory bandwidth in object matching process but involved massive internal memory transactions to examine each object in a database. In this paper, a novel object matching accelerator is proposed based on matching predictions to reduce unnecessary internal memory transactions by mitigating non-target object examinations, thereby improving the energy-efficiency. Experimental results show a 26% reduction in power-delay product compared to the prior art.

• Animal cells and systems
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• v.12 no.1
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• pp.11-14
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• 2008

Finding a way to strengthen human cognitive functions, such as learning and memory, has been of great concern since the moment people realized that these functions can be affected and even altered by certain chemicals. Since then, plenty of endeavors have been made to look for safe ways of improving cognitive performances without adverse side-effects. Unfortunately, most of these efforts have turned out to be unsuccessful until now. In this study, we examine the effect of a natural compound, idesolide, on hippocampus-dependent recognition memory. We demonstrate that idesolide is effective in the enhancement of recognition memory, as measured by a novel object recognition task. Thus, idesolide might serve as a novel therapeutic medication for the treatment of memoryrelated brain anomalies such as mild cognitive impairment(MCI) and Alzheimer's disease.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.14 no.10
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• pp.4098-4116
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• 2020

Mobile devices such as smartphones are very attractive targets for augmented reality (AR) services, but their limited resources make it difficult to increase the number of objects to be recognized. When the recognition process is scaled to a large number of objects, it typically requires significant computation time and memory. Therefore, most large-scale mobile AR systems rely on a server to outsource recognition process to a high-performance PC, but this limits the scenarios available in the AR services. As a part of realizing large-scale standalone mobile AR, this paper presents a solution to the problem of accuracy, memory, and speed for large-scale object recognition. To this end, we design our own basic feature and realize spatial locality, selective feature extraction, rough pose estimation, and selective feature matching. Experiments are performed to verify the appropriateness of the proposed method for realizing large-scale standalone mobile AR in terms of efficiency and accuracy.

• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.2
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• pp.471-476
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• 2006

Chongmyung-tang(CMT, 聰明湯), oriental herbal medicine which consists of Polygaglae Radix(遠志), Acori Graminei Rhizoma(石菖蒲) and Hoelen(白茯神) has effect on amnesia, dementia. In order to evaluate effect of CMT on memory and learning in mice, CMT extract was used for studies. This paper describes the effects of CMT extract on memory and learning processes by using the passive and active avoidance performance tests, novel object recognition task and water maze task. The CMT extract ameliorated the memory retrieval deficit induced by ethanol in the passive avoidance responses but did not affect ambulatory activity of normal mice. These results suggest that CMT has an ameliorating effect on memory retrieval impairment. CMT extract decreased spontaneous motor activity(SMA) in the latter sessions of memory registration in active avoidance responses. These results suggest that CMT has partly transquilizing or antianxiety effects. In novel object recognition task to measure visual recognition memory, CMT-administered mice enhanced in long term memory for 1-3 days. In water maze task to measure spatial learning, which requires the activation of NMDA receptors in the hippocampus, spatial learning in CMT-administered mice was faster than in wild-type mice. These results suggest that CMT enhances memory and activates NMDA receptors.

• Toxicological Research
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• v.24 no.3
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• pp.183-188
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• 2008

The behavioral phenotypes of out-bred ICR mice were compared with those of in-bred C57BL/6 and BALB/c mice. In particular, this study examined the locomotor activity and two forms of hippocampus-dependent learning paradigms, passive avoidance and object recognition memory. The basal open-field activity of the ICR strain was greater than that of the C57BL/6 and BALB/c strains. In the passive avoidance task, all the mice showed a significant increase in the cross-over latency when tested 24 hours after training. The strength of memory retention in the ICR mice was relatively weak and measurable, as indicated by the shorter cross-over latency than the C57BL/6 and BALB/c mice. In the object recognition memory test, all strains had a significant preference for the novel object during testing. The index for the preference of a novel object was lower for the ICR and BALB/c mice. Nevertheless, the variance and the standard deviation in these strains were comparable. Overall, these results confirm the strain differences on locomotor activity and hippocampus-dependent learning and memory in mice.

• Korean Journal of Cognitive Science
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• v.19 no.2
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• pp.125-142
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• 2008

This study investigated the effects of space- and object-based attention on spatial and visual working memory, by measuring recognition of working memory on the spatial Stroop task including two modalities of attention resource. The similarity condition of stimulus arrangement between working memory task and spatial stroop task was manipulated in order to examine the effects of space-based attention on spatial rehearsal during working memory task, while Stroop rendition was manipulated in order to examine the effects of object-based attention on object rehearsal during working memory task. The results showed that in a condition that stimulus arrangement was highly similar for the spatial working memory task and the spatial Stroop task, recognition accuracy of the spatial working memory was high, but it was not significantly different with the Stroop conditions. In contrast, the recognition accuracy of visual working memory in the incongruent Stroop condition was lower than that in the congruent Stroop condition, but it was not significantly different with the similarity conditions (25% vs. 75%). The results indicated that selective attention has effects on working memory only when resource modality of working memory is the same as that of selective attention.

• Toxicological Research
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• v.31 no.1
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• pp.17-23
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• 2015

Excessive manganese (Mn) in the brain promotes a variety of abnormal behaviors, including memory deficits, decreased motor skills and psychotic behavior resembling Parkinson's disease. Hereditary hemochromatosis (HH) is a prevalent genetic iron overload disorder worldwide. Dysfunction in HFE gene is the major cause of HH. Our previous study has demonstrated that olfactory Mn uptake is altered by HFE deficiency, suggesting that loss of HFE function could alter manganese-associated neurotoxicity. To test this hypothesis, Hfe-knockout ($Hfe^{-/-}$) and wild-type ($Hfe^{+/+}$) mice were intranasally-instilled with manganese chloride ($MnCl_2$ 5 mg/kg) or water daily for 3 weeks and examined for memory function. Olfactory Mn diminished both short-term recognition and spatial memory in $Hfe^{+/+}$ mice, as examined by novel object recognition task and Barnes maze test, respectively. Interestingly, $Hfe^{-/-}$ mice did not show impaired recognition memory caused by Mn exposure, suggesting a potential protective effect of Hfe deficiency against Mn-induced memory deficits. Since many of the neurotoxic effects of manganese are thought to result from increased oxidative stress, we quantified activities of anti-oxidant enzymes in the prefrontal cortex (PFC). Mn instillation decreased superoxide dismutase 1 (SOD1) activity in $Hfe^{+/+}$ mice, but not in $Hfe^{-/-}$ mice. In addition, Hfe deficiency up-regulated SOD1 and glutathione peroxidase activities. These results suggest a beneficial role of Hfe deficiency in attenuating Mn-induced oxidative stress in the PFC. Furthermore, Mn exposure reduced nicotinic acetylcholine receptor levels in the PFC, indicating that blunted acetylcholine signaling could contribute to impaired memory associated with intranasal manganese. Together, our model suggests that disrupted cholinergic system in the brain is involved in airborne Mn-induced memory deficits and loss of HFE function could in part prevent memory loss via a potential up-regulation of anti-oxidant enzymes in the PFC.

• 제어로봇시스템학회:학술대회논문집
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• 1997.10a
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• pp.40-43
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• 1997

This paper presents a 3D object recognition method for generation of 3D environmental map or obstacle recognition of mobile robots. An active light source projects a stripe pattern of light onto the object surface, while the camera observes the projected pattern from its offset point. The system consists of a laser unit and a camera on a pan/tilt device. The line segment in 2D camera image implies an object surface plane. The scaling, filtering, edge extraction, object extraction and line thinning are used for the enhancement of the light stripe image. We can get faithful depth informations of the object surface from the line segment interpretation. The performance of the proposed method has demonstrated in detail through the experiments for varies type objects. Experimental results show that the method has a good position accuracy, effectively eliminates optical noises in the image, greatly reduces memory requirement, and also greatly cut down the image processing time for the 3D object recognition compared to the conventional object recognition.

• Journal of Radiation Protection and Research
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• v.37 no.3
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• pp.123-128
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• 2012

Evidence suggests that even low-dose irradiation can lead to progressive cognitive decline and memory deficits, which implicates, in part, hippocampal dysfunction in both humans and experimental animals. This study examined whether diethyldithiocarbamate (DDC) could attenuate memory impairment, using passive avoidance and object recognition test, and suppression of hippocampal neurogenesis, using the TUNEL assay and immunohistochemical detection with markers of neurogenesis (Kiel 67 (Ki-67) and doublecortin (DCX)) in adult mice treated with gamma radiation (0.5 or 2 Gy). DDC was administered intraperitonially at a dosage of 1,000 $mg{\cdot}kg^{-1}$ of body weight at 30 min. before irradiation. In passive avoidance and object recognition memory test, the mice, trained for 1 day after acute irradiation (2 Gy) showed significant memory deficits compared with the sham controls. The number of TUNEL-positive apoptotic nuclei in the dentate gyrus (DG) was increased 12 h after irradiation. In addition, the number of Ki-67- and DCX-positive cells were significantly decreased. DDC treatment prior to irradiation attenuated the memory defect, and blocked the apoptotic death. DDC may attenuate memory defect in a relatively low-dose exposure of radiation in adult mice, possibly by inhibiting a detrimental effect of irradiation on hippocampal neurogenesis.