• Journal of Oral Medicine and Pain
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• v.35 no.4
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• pp.237-243
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• 2010

Acanthosis nigricans usually has the characteristics that involve the development of darker pigmented patches and thickened skin with velvety texture on the body folds, and papillomatosis on lip and intraoral regions including tongue, gingiva, mucosa, palate. Malignant acanthosis nigricans, a type of acanthosis nigricans, occurs most commonly in association with underlying malignancy and characterically appears with three characteristic mucocutaneous lesion : especially of the lips and eyelids, hyperkeratosis of the palms and soles, the sign of Leser-Trelat. In the present report, the patient had typical clinical and histological findings of oral acanthosis nigricans, as well as past medical history associated with malignant gastric adenocarcinoma.