• 제목/요약/키워드: Organic matrix-free

검색결과 23건 처리시간 0.043초

Organic matrix-free imaging mass spectrometry

  • Kim, Eunjin;Kim, Jisu;Choi, Inseong;Lee, Jeongwook;Yeo, Woon-Seok
    • BMB Reports
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    • 제53권7호
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    • pp.349-356
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    • 2020
  • Mass spectrometry (MS) is an ideal tool for analyzing multiple types of (bio)molecular information simultaneously in complex biological systems. In addition, MS provides structural information on targets, and can easily discriminate between true analytes and background. Therefore, imaging mass spectrometry (IMS) enables not only visualization of tissues to give positional information on targets but also allows for molecular analysis of targets by affording the molecular weights. Matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) MS is particularly effective and is generally used for IMS. However, the requirement for an organic matrix raises several limitations that get in the way of accurate and reliable images and hampers imaging of small molecules such as drugs and their metabolites. To overcome these problems, various organic matrix-free LDI IMS systems have been developed, mostly utilizing nanostructured surfaces and inorganic nanoparticles as an alternative to the organic matrix. This minireview highlights and focuses on the progress in organic matrix-free LDI IMS and briefly discusses the use of other IMS techniques such as desorption electrospray ionization, laser ablation electrospray ionization, and secondary ion mass spectrometry.

토양-휴민의 물리화학적 특성 및 PAHs의 결합 특성 연구

  • 임동민;신현상
    • 한국지하수토양환경학회:학술대회논문집
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    • 한국지하수토양환경학회 2006년도 총회 및 춘계학술발표회
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    • pp.16-19
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    • 2006
  • Humin is the insoluble fraction of humic materials and play an important roles in the irreversible sorption of hydrophobic organic contaminants onto soil particles. However, there have been limited knowledge about the sorption and chemical properties of humin due to the difficulties in its separation from the inorganic matrix(mainly clays and oxides). In this study, do-ashed humin was isolated from a soil sample after removing free lipid and alkali-soluble humic fractions followed by dissolution of mineral matrix with 2% HF, and characterized by elemental analysis, C-13 NMR spectroscopic method. Sorption behavior of 1-naphthol with humin was also investigated from aqueous solution. C-13 NMR spectra indicate that humin molecules are mainly made up of aliphatic carbon including carbohydrate, methylene chain etc.. Sorption intensity for 1-naphthol was increased as organic carbon content of humin increased and log Koc values for the 1-naphthol sorption were determined to be ${\sim}3.12$

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Biodegradable Inorganic-Organic Composite Artiticial Bone Substitue -Part2. Collagen purification and its physical and biological properties-

  • Hwal Suh
    • 대한의용생체공학회:의공학회지
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    • 제15권3호
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    • pp.341-346
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    • 1994
  • To develop an artificial bone substitute that is gradually degraded and replaced by the regenerated natural bone, the authors designed a composite that is consisted of calcium phosphate and collagen. To use as the structural matrix of the composite, collagen was purified from human umbilical cord. The obtained collagen was treated by pepsin to remove telopeptides, and finally, the immune-free atel- ocollagen was produced. The cross linked atelocollagen was highly resistant to the collagenase induced collagenolysis. The cross linked collagen demonstrated an improved tensile strength.

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Controller with Voltage-Compensated Driver for Lighting Passive Matrix Organic Light Emitting Diodes Panels

  • Juan, Chang Jung;Tsai, Ming Jong
    • 한국정보디스플레이학회:학술대회논문집
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    • 한국정보디스플레이학회 2004년도 Asia Display / IMID 04
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    • pp.673-675
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    • 2004
  • This study proposes controller with voltage-compensated drivers for producing gray-scaled pictures on passive matrix organic light emitting diodes (PMOLEDs) panels. The controller includes voltage type drivers so the output impedance of the driver is far less than that of the current-type driver. Its low output impedance provides better electron-optical properties than those of traditional current drivers. A free running clock and a group of counters are applied to the gray-scaled function so that phase lock loop (PLL) circuit can be reduced in the controller. A pre-charge function is used to enhance performance of the luminance of an active OLED pixel. As a result, distribution of the low gray level portion is achieved linear relationship with input data. In this work, the digital part of the proposed controller is implemented using FPGA chips, and analog parts are combined with a digital-analog converter (DAC) and analog switches. A still image is displayed on a $48^{\ast}64$ PMOLEDs panel to assess the luminance performance fir the controller. Based on its cost requirement and luminance performance, the controller is qualified to join the market for driving PMOLEDs panels.

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Ag계 도체 및 RuO2계 저항체 페이스트의 특성에 미치는 무연계 글라스 프릿트 조성의 영향 (Effect of Lead Free Glass Frit Compositions on Properties of Ag System Conductor and RuO2 Based Resistor Pastes)

  • 구본급
    • 한국전기전자재료학회논문지
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    • 제24권3호
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    • pp.200-207
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    • 2011
  • Abstract: The effect of lead free glass frit compositions on the properties of thick film conductor and resistor pastes were investigated. Two types lead free frits, HBF-A(without $Bi_2O_3$) and HBF-B(with $Bi_2O_3$) were made from $SiO_2$, $B_2O_3$, $Al_2O_3$, CaO, MgO, $Na_2O$, $K_2O$, ZnO, MnO, $ZrO_2$, $Bi_2O_3$. And Ag based conductor pastes and $RuO_2$ based resistor paste were prepared by mixed with these frits and functional phase(Ag and $RuO_2$), and organic vehicle. The properties of thick film conductor and resistor sintered at $850^{\circ}C$ were studied after printing on $Al_2O_3$ substrate. The morphology of the sintered films surface were SEM and EDS were carried out to analysis the chemical composition on resistor surface and state of Ru atom in frit matrix.

산거울 추출물의 Elastase 활성 저해 및 Matrix Metalloproteinase-1 발현 억제 효과 (Inhibitory Effects of Carex humilis Extract on Elastase Activity and Matrix Metalloproteinase-1 Expression)

  • 박선희;이강혁;한창성;김기호;김영희
    • 대한화장품학회지
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    • 제36권2호
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    • pp.129-136
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    • 2010
  • 본 연구에서는 산거울 추출물의 항주름 활성을 연구하기 위하여 항산화, 엘라스타제 활성 억제, Matrix metalloproteinase-1 (MMP-1) mRNA 발현 및 단백질의 생성 억제 관련 실험을 진행하였다. 산거울의 뿌리부분을 95 % 에탄올로 추출하고 유기 용매로 분획하여 각 추출물 분획물에 대한 항산화 활성과 엘라스타제 억제 효능을 측정한 결과, EtOAc 분획이 각각 SC50=4.89 ${\mu}g/mL$, IC50=23.5 ${\mu}g/mL$ 로 가장 우수한 결과를 나타내었다. 따라서 활성이 가장 좋은 EtOAc 분획물로 부터 실리카겔 컬럼 크로마토그래피를 이용하여 활성물질을 분리하고, 분리된 물질이 ${\alpha}$-viniferin임을 분광학적 분석결과로 확인하였다. RT-PCR을 이용한 MMP-1 mRNA 발현능 평가에서 EtOAc 분획물과 ${\alpha}$-viniferin은 각각 50 ~ 60 % (10 ~ 100 ${\mu}g/mL$), 약 60 ~ 75 % (0.5 ~ 2 ${\mu}g/mL$)의 저해효과를 나타내었으며, Western-blot을 이용한 MMP-1 단백질 생성을 평가한 결과에서 역시 EtOAc 분획물과 ${\alpha}$-viniferin은 같은 농도에서 각각 50 ~ 65 %와 55 ~ 65 % 저해 효과를 나타내었다. 결론적으로, ${\alpha}$-viniferin을 함유한 산거울의 EtOAc 분획층의 주름 개선용 기능성 화장품 개발을 위한 소재로 개발 가능성을 확인하였다.

강변여과에서의 은나노입자의 영향 : 실험실규모 컬럼 실험 (Effect of silver nanoparticles on the performance of riverbank filtration: Column study)

  • 이동현;노진형;김현철;최재원;최일환;맹승규
    • 상하수도학회지
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    • 제29권1호
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    • pp.77-88
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    • 2015
  • Soil column experiments were evaluated effects of silver nanoparticles (i.e., 0, 2.5, 5, and 10 mg/L) on the microbial viability which is strongly associated with the degradation of organic matter, pharmaceutically active compounds(PhACs) and biological oxidation of nitrogenous compounds during river bank filtration. The addition of silver nanoparticles resulted in almost no change in the aqueous matrix. However, the intact cell concentration decreased with addition of silver nanoparticles from 2.5 to 10 mg/L, which accounted for 76% to 82% reduction compared to that of control (silver nanoparticles free surface water). The decrease in adenosine triphosphate was more pronounced; thus, the number and active cells in aqueous phase were concurrently decreased with added silver nanoparticles. Based on the florescence excitation-emission matrix and liquid chromatograph - organic carbon detection analyses, it shows that the removal of protein-like substances was relatively higher than that of humic-like substances, and polysaccharide was substantially reduced. But the extent of those substances removed during soil passage was decreased with the increasing concentration of silver nanoparticles. The attenuation of ionic PhACs ranged from 55% to 80%, depending on the concentration of silver nanoparticles. The attenuation of neutral PhACs ranged between 72% and 77%, which was relatively lower than that observed for the ionic PhACs. The microbial viability was affected by silver nanoparticles, which also resulted in inhibition of nitrifiers.

저온 플라즈마 처리를 이용한 파라 아라미드 섬유의 표면 개질 효과 및 역학적 특성(2) (Surface Modification Effect and Mechanical Property of para-aramid Fiber by Low-temperature Plasma Treatment)

  • 박성민;손현식;심지현;김주용;김태경;배진석
    • 한국염색가공학회지
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    • 제27권1호
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    • pp.18-26
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    • 2015
  • para-aramid fibers were treated by atmosphere air plasma to improve the interfacial adhesion. The wettability of plasma-treated aramid fiber was observed by means of dynamic contact angle surface free energy measurement. Surface roughness were investigated with the help of scanning electron microscopy and atomic force microscopy. The tensile test of aramid fiber roving was carried out to determine the effect of plasma surface treatments on the mechanical properties of the fibers. A pull-out force test was carried out to observe the interfacial adhesion effect with matrix material. It was found that surface modification and a chemical component ratio of the aramid fibers improved wettability and adhesion characterization. After oxygen plasma, it was indicated that modified the surface roughness of aramid fiber increased mechanical interlocking between the fiber surface and vinylester resin. Consequently the oxygen plasma treatment is able to improve fiber-matrix adhesion through excited functional group and etching effect on fiber surface.

Preparation and Characterizations of C60/Polystyrene Composite Particle Containing Pristine C60 Clusters

  • Kim, Jung-Woon;Kim, Kun-Ji;Park, Soo-Yeon;Jeong, Kwang-Un;Lee, Myong-Hoon
    • Bulletin of the Korean Chemical Society
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    • 제33권9호
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    • pp.2966-2970
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    • 2012
  • Fullerene/polystyrene ($C_{60}$/PS) nano particle was prepared by using emulsion polymerization. Styrene and fullerene were emulsified in aqueous media in the presence of poly(N-vinyl pyridine) as an emulsion stabilizer, and polymerization was initiated by water soluble radical initiator, potassium persulfate. The obtained nano particles have an average diameter in the range of 400-500 nm. The fullerene contents in the nano particle can be controlled up to 15 wt % by varying the feed ratio, which was confirmed by themogravimetric analysis (TGA) and elemental analysis (EA). The structure and morphologies of the $C_{60}$/PS nano particles were examined by various analytical techniques such as dynamic light scattering (DLS), scanning electron microscope (SEM), transmission electron microscope (TEM), electron diffraction (ED) pattern, X-ray powder diffraction (XRD), and UV spectroscopy. Unlike conventional $C_{60}$/PS particles initiated by organic free radical initiators, in which the fullerene is copolymerized forming a covalent bond with styrene monomer, the prepared $C_{60}$/PS nano particles contain pristine fullerene as secondary particles homogeneously distributed in the polystyrene matrix.

Atomic Layer Deposition for Display Applications

  • Park, Jin-Seong
    • 한국진공학회:학술대회논문집
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    • 한국진공학회 2013년도 제45회 하계 정기학술대회 초록집
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    • pp.76.1-76.1
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    • 2013
  • Atomic Layer Deposition (ALD) has remarkably developed in semiconductor and nano-structure applications since early 1990. Now, the advantages of ALD process are well-known as controlling atomic-level-thickness, manipulating atomic-level-composition control, and depositing impurity-free films uniformly. These unique properties may accelerate ALD related industries and applications in various functional thin film markets. On the other hand, one of big markets, Display industry, just starts to look at the potential to adopt ALD functional films in emerging display applications, such as transparent and flexible displays. Unlike conventional ALD process strategies (good quality films and stable precursors at high deposition processes), recently major display industries have suggested the following requirements: large area equipment, reasonable throughput, low temperature process, and cost-effective functional precursors. In this talk, it will be mentioned some demands of display industries for applying ALD processes and/or functional films, in terms of emerging display technologies. In fact, the AMOLED (active matrix organic light emitting diode) Television markets are just starting at early 2013. There are a few possibilities and needs to be developing for AMOLED, Flexible and transparent Display markets. Moreover, some basic results will be shown to specify ALD display applications, including transparent conduction oxide, oxide semiconductor, passivation and barrier films.

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