• Title, Summary, Keyword: Orthopaedics

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IGF1 potentiates BMP9-induced osteogenic differentiation in mesenchymal stem cells through the enhancement of BMP/Smad signaling

  • Chen, Liang;Zou, Xiang;Zhang, Ran-Xi;Pi, Chang-Jun;Wu, Nian;Yin, Liang-Jun;Deng, Zhong-Liang
    • BMB Reports
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    • v.49 no.2
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    • pp.122-127
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    • 2016
  • Engineered bone tissue is thought to be the ideal alternative for bone grafts in the treatment of related bone diseases. BMP9 has been demonstrated as one of the most osteogenic factors, and enhancement of BMP9-induced osteogenesis will greatly accelerate the development of bone tissue engineering. Here, we investigated the effect of insulin-like growth factor 1 (IGF1) on BMP9-induced osteogenic differentiation, and unveiled a possible molecular mechanism underling this process. We found that IGF1 and BMP9 are both detectable in mesenchymal stem cells (MSCs). Exogenous expression of IGF1 potentiates BMP9-induced alkaline phosphatase (ALP), matrix mineralization, and ectopic bone formation. Similarly, IGF1 enhances BMP9-induced endochondral ossification. Mechanistically, we found that IGF1 increases BMP9-induced activation of BMP/Smad signaling in MSCs. Our findings demonstrate that IGF1 can enhance BMP9-induced osteogenic differentiation in MSCs, and that this effect may be mediated by the enhancement of the BMP/Smad signaling transduction triggered by BMP9.

Correlation between Preoperative Magnetic Resonance Imaging Signal Intensity Changes and Clinical Outcomes in Patients Surgically Treated for Cervical Myeloradiculopathy

  • Chikhale, Chaitanya Baban;Khurjekar, Ketan Shripad;Kumar Shyam, Ashok;Sancheti, Parag Kantilal
    • Asian Spine Journal
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    • v.11 no.2
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    • pp.174-180
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    • 2017
  • Study Design: This was a single surgeon, single center-based retrospective study with prospective data collection. Purpose: To assess the correlation between T2-weighted magnetic resonance imaging (MRI) signal intensity (SI) changes and factors such as age, duration of symptoms, baseline modified Japanese Orthopedic Association (mJOA) score and to determine its prognostic value in predicting recovery after surgery. Overview of Literature: Whether intramedullary cord T2-weighted MRI SI changes can predict operative outcomes of cervical myeloradiculopathy remains debatable, with only a few prospective studies analyzing the same. Methods: Forty-six consecutive patients who underwent cervical myeloradiculopathy were included and were followed up for an average of 1 year. Preoperative T2-weighted MRI SI grading was performed for all patients. The correlation between MRI SI changes and age, duration of symptoms, preoperative mJOA score, and mJOA score at 1-year follow-up were analyzed. Results: Fifteen patients had single-level (21.73%) or double-level (10.86%) prolapsed discs; 54.34% had degenerative cervical spondylosis with canal stenosis or multilevel disc prolapse and 13.07% had ossified posterior longitudinal ligaments. The mean age was $56.17{\pm}9.53years$ (range, 35-81 years). The mean baseline mJOA score was $10.83{\pm}2.58$ (range, 6-16), which postoperatively improved to $13.59{\pm}2.28$ (range, 8-17; p<0.001). There was a statistically significant correlation between mJOA score at 1 year and MRI T2 SI grading (p=0.017). Conclusions: Patients with longer symptom durations had high grades of intramedullary cord T2-weighted MRI SI changes. Age and preoperative neurological status were not significantly correlated with the existence of intramedullary cord SI changes. However, patients without or with mild and diffuse intramedullary cord T2-weighted MRI SI changes had better postoperative neurological recovery than those with sharp and focal SI changes.

Socket Pressure Distribution of the Uni-Lateral Trans-Femoral Amputee with a Suction Socket (흡착식 소켓을 착용한 일측 대퇴절단환자의 소켓내부압력분포)

  • Chang, Y.H.;Kim, Y.H.;Yang, G.T.;Lim, S.H.;Mun, M.S.
    • Proceedings of the KOSOMBE Conference
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    • v.1997 no.05
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    • pp.249-252
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    • 1997
  • A study on static and dynamic socket pressure distributions on a trans-femoral amputee with a suction socket was performed in order to assess an optimal socket fitting and function. Even for the amputee's static neutral position, pressure concentrations were observed in the lateral, medial, and posterior planes of the socket. During free walking, a significant movement of pressure concentration areas was observed. Large socket pressure was observed in the lateral, medial-anterior and posterior walls during mid-stance or push-off period. Socket pressure measurement will be one of the good tool to determine the optimal socket-limb interface.

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Plantar-Pressure Distributions on Hallux Valgus Patients (엄지발가락외반증 환자의 발바닥압력분포)

  • Yang, G.T.;Kim, Y.H.;Park, Si-Bog;Lim, S.H.;Chang, Y.H.;Mun, M.S.
    • Proceedings of the KOSOMBE Conference
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    • v.1997 no.05
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    • pp.241-244
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    • 1997
  • 23 hallux valgus patients were evaluated with clinical examinations and plantar pressure distribution measurements. A masking method for detailed plantar pressure distribution analyses was suggested. With higher grade of hallux valgus, pressure, contact length & area, and impulse on metartasus were significantly increased. Localized pressure concentration is very important in foot diseases and appropriate plantar pressure distributions should be considered on any shoe design.

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