• 여성건강간호학회지
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• 제15권4호
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• pp.362-371
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• 2009

Purpose: This study was implemented to investigate the level of awareness of osteoporosis among urban women. Methods: A survey was conducted with a sample size of 434 adult females who resided in metropolises in Korea such as Seoul, Gyeonggi-do, Pusan, Gyeongsangnam-do, Kangwondo, Jeju-do and Jeollanam-do. Osteoporosis Awareness Scale was consisted of five areas with total number of 31 questions. The questionnaire's scale was 1 to 4 point, 4 point being the highest understanding level. The collected data were analyzed using descriptive statistics method. Results: The average awareness level of subjects was 2.38 and significant different depending on participants' age, education level, previous encounter with any information about osteoporosis, preventive behavior of osteoporosis, bone mineral density test, fracture history, diet control experience, and regular exercise. In osteoporosis awareness level by five areas, preventive behaviors 2.76 resulted in the highest score and characteristics of osteoporosis 2.51, bone physiology 2.46, improving bone health 2.38, and risk factors 1.80 followed respectively. Conclusion: We should implement bone health programs from a various perspective in order to raise women's osteoporosis awareness. In addition, We need follow-up studies on whether or not the increase on awareness level actually would result in changing in their behavior.

• 성인간호학회지
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• 제21권3호
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• pp.303-313
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• 2009

Purpose: The purpose of this study was to investigate bone mineral density(BMD) and identify risk factors of osteoporosis in Korean postmenopausal women. Methods: The subjects consisted of 328 women. The BMD of the calcaneus were measured with peripheral dual energy x-ray absorptiometry. The risk factors were collected by a self-report standardized questionnaire. The differences among the osteoporosis, osteopenia, and normal group were compared by one way analysis of variance test, Scheffe's multiple comparison tests and Logistic regression. Results: The average age was 65 years old and the average T-score was 28.7% with osteoporosis. The Risk factors of osteoporosis were inclined by 24% in age (OR = 1.24, CI = 1.16 ~ 1.31), 53% in menarchal age (OR = 1.53, CI = 1.24 ~ 1.88), 3.5 times in vegetarian (OR = 3.52, CI = 1.66 ~ 7.47), 2 times in small-bowel disease (OR = 2.01, CI= 1.03 ~ 3.94), 5.3 times in arthritis (OR = 5.33, CI = 1.61 ~ 17.67), 5.5 times in eating disorder (OR = 5.50, CI = 1.43 ~ 21.17), 6 times in health perception (OR = 6.08, CI = 2.30 ~ 16.06). The Risk factors of osteoporosis were reduced by 10% in weight (OR = 0.90. CI = 0.83 ~ 0.97), and 10% in menopausal age (OR = 0.90. CI = 0.84 ~ 0.98). Conclusion: The risk factors of osteoporosis were in the general characteristics, menstrual history, history of disease, life style & diet, and health perception. Eating disorder and health perception are highest on the risk factor of osteoporosis in Korean postmenopausal women.

• 대한간호학회지
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• 제31권2호
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• pp.194-205
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• 2001

The purpose of the study was to identify the effect of structured patients education had on prevention of osteoporosis, with fracture and the resulting of life style changes in patients. In this study, a non equivalent control group pre and a post test design was employed. Data were collected through an interview process using questionnaires from April to December of 1999. The subjects, consisting of 59 patients with fractures and over 40 years of age, were diagnosed in K University Hospital. This study tested the patients knowledge at three times. The times were before the program 2 weeks into the program, and 6 months after education program. Life style change related to prevention of osteoporosis was shown twice (before and 6 months after the education program) in the experimental group, and control group went without it. The instruments used for this study were developed by literature review according to a reliability test. Data was analyzed using X2 test and t test to determine similarities between the experimental and control groups. The hypothesis was tested using repeated measures of ANOVA, t-test and Pearson correlation coefficients. The results of the study were summarized as follows: 1. The first hypothesis was accepted: a higher level of knowledge about osteoporosis was found in experimental groups who received education than to the control group during the period (F=19.82, p=.0001). 2. The second hypothesis was accepted: a higher level of life style changes about osteoporosis on experimental group were recorded than as compared to control group (t=3.55, p=.001). 3. The third hypothesis was accepted: the higher the knowledge about osteoporosis the higher the level of performance of life style changes about prevention of osteoporosis (r=.600, p=.0001). In conclusion, structured patient education in patient with fractures improved the level of knowledge about osteoporosis and more likely undergo of life style changes 6 months after the education program. Also reeducation would be needed 6 months after program ends. That is structured patient education in pamphlet form would be very effective in nursing intervention that may to result in life style changes. Therefore further research is needed to reinforce the education material and to generalize the education effect.

• 약학회지
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• 제52권5호
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• pp.331-344
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• 2008

Recently, the FDA (Food and Drug Administration) of the United States and many advanced countries remark biomarkers and surrogate endpoints as a critical path tool on model based drug development. Economic, technical and social profit on model based drug development like a reduction of the length of research and development have been achieved. Therefore we summarize previous studies about biomarkers and surrogate endpoints and suggest a development direction of therapeutic agents. In diabetes mellitus (DM) and osteoporosis, there are remarkable increases in number of patients and most of patients take medicine during their whole lifetime. For this reason, many patients with DM and osteoporosis have a tolerance on their medicine. We expect that research and development on biomarkers and surrogate endpoints will contribute to new drug development on DM and osteoporosis. Biomarkers for DM are blood levels of glucose, insulin, ${HbA}_{1c}$, CRP, alpha-glucosidase, adiponectin and DPP-4. Among these, validated surrogate endpoints for DM are blood levels of glucose, insulin and ${HbA}_{1c}$ Biomarkers for osteoporosis are BMD, BMC, trabecular volume, ICTP, DPD, osteocalcin, the activity of osteoclast and production of osteoblast. The validated surrogate endpoints for osteoporosis are BMD only. This review summarizes all suggested biomarkers and surrogate endpoints in DM and osteoporosis. The biomarkers are classified by drugs, and the method of validation for surrogate endpoints is suggested. This information would contribute to suggest a direction of DM and osteoporosis therapeutic agent development.

• 융합정보논문지
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• 제9권12호
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• pp.71-80
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• 2019

본 연구는 노인요양시설 간호제공자의 골다공증 관련 지식과 골다공증 예방활동을 파악하기 위한 서술적 조사연구이다. 연구대상자는 S시와 Y시의 노인요양시설 4곳에서 근무 중인 간호제공자 142명이며 자료 수집기간은 2019년 7월 1일부터 7월 20일까지이다. 연구 자료는 SPSS 24.0 Version을 이용하였으며 t-test, ANOVA, Pearson's correlation coefficient를 실시하였다. 연구결과, 간호제공자의 골다공증 관련 지식은 중간수준으로 간호제공자의 학력, 골다공증 관리 교육 경험, 입소자 수, 노인 뼈 건강 중요도 인식에 따라 차이를 보였으며, 골다공증의 예방활동은 골다공증 관리 교육 경험, 노인 뼈 건강 중요도 인식에 따라 차이를 보였다. 연구대상자의 골다공증 관련 지식과 골다공증 예방활동은 정적 상관이 있었다. 따라서 노인 요양시설 간호제공자의 노인 골다공증 관리와 노인 뼈 건강 중요도 인식을 향상시키기 위한 교육 프로그램의 개발과 그에 따른 교육이 필요하며, 향후 교육의 효과를 확인하는 추가연구가 필요하다.

• Journal of Genetic Medicine
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• 제19권2호
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• pp.63-75
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• 2022

Purpose: Osteoporosis is a common calcium and metabolic skeletal disease which is characterized by decreased bone mass, microarchitectural deterioration of bone tissue and impaired bone strength, thereby leading to enhanced risk of bone fragility. In this study, we aimed to identify novel genes for susceptibility to osteoporosis and/or bone density. Materials and Methods: To identify differentially expressed genes (DEGs) between control and osteoporosis-induced cells, annealing control primer-based differential display reverse-transcription polymerase chain reaction (RT-PCR) was carried out in pre-osteoblast MC3T3-E1 cells. Expression levels of the identified DEGs were evaluated by quantitative RT-PCR. Association studies for the quantitative bone density analysis and osteoporosis case-control analysis of single nucleotide polymorphism (SNPs) were performed in Korean women (3,570 subjects) from the Korean Association REsource (KARE) study cohort. Results: Comparison analysis of expression levels of the identified DEGs by quantitative RT-PCR found seven genes, Anxa6, Col5a1, Col6a2, Eno1, Myof, Nfib, and Scara5, that showed significantly different expression between the dexamethason-treated and untreated MC3T3-E1 cells and between the ovariectomized osteoporosis-induced mice and sham mice. Association studies revealed that there was a significant association between the SNPs in the five genes, ANXA6, COL5A1, ENO1, MYOF, and SCARA5, and bone density and/or osteoporosis. Conclusion: Using a whole-genome comparative expression analysis, gene expression evaluation analysis, and association analysis, we found five genes that were significantly associated with bone density and/or osteoporosis. Notably, the association P-values of the SNPs in the ANXA6 and COL5A1 genes were below the Bonferroni-corrected significance level.

• 지역사회간호학회지
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• 제14권4호
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• pp.629-638
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• 2003

Purpose: This study investigated the effects of knowledge and health belief on osteoporosis preventive health behaviors. Methods: The subjects of this study were 266 middle-aged women. Data were collected using a self-reporting questionnaire with 101 questions. The period of data collection was from the 3rd of January to the 28th of February 2003. Data were analyzed using SPSS 10.0 PC+ program. Results: The results were summarized as follows: 1. The average score of knowledge about osteoporosis was 16.93 out of 27. Particularly, middle-aged women had knowledge more about osteoporosis prevention measures than about risk factors. 2. Knowledge, self efficacy and barriers were significantly correlated with osteoporosis preventive health behaviors. 3. As for the relationship between subjects' general characteristics and their health preventive behaviors, the size of living district, economic status, BMI. family history of osteoporosis and perception of health status were found to have significant effects on health preventive behaviors. Conclusions: According to the results presented above, preventive health behaviors may be promoted by increasing knowledge and perceived self-efficacy as well as decreasing individuals' perceived barriers through health education.

• 지역사회간호학회지
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• 제22권2호
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• pp.111-120
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• 2011

Purpose: The purpose of this study was to investigate osteoporosis knowledge, health beliefs, and influencing factors on health behaviors among female college students. Methods: Using the Osteoporosis Quiz, the Health belief Scale, and the Health Behavior Questionnaire, data were collected from 314 female college students from 4 universities located in Chungcheong providence. Results: The mean scores of knowledge and health belief were $12.7{\pm}3.81$ and $90.9{\pm}12.66$, respectively. There was a statistically significant correlation between osteoporosis knowledge and health belief (p<.001). Also, a statistically significant correlation was found between health belief and health behavior (p<.001). According to the regression model, knowledge, perceived benefit, perceived barrier, family history of osteoporosis, and health interest explained 6.7% of total variance in health behavior. Conclusion: Female college students should be taught to be aware of the importance of proper dietary intake and regular exercise as a way to maintain or promote the health of their bones so that they can prevent osteoporosis.

• 대한간호학회지
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• 제41권6호
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• pp.758-767
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• 2011

Purpose: This study was done to examine the threshold value of estimated height loss at which the risk of osteoporosis increases and to verify its discriminative ability in the detection of osteoporosis. Methods: It was conducted based on epidemiological descriptive methods on 732 Korean women at a public healthcare center in Seoul between July and November 2010. ANOVA, Pearson correlation, logistic regression analysis and receiver operating characteristics (ROC) curve were used for data analysis. Results: There was an age-related correlation between bone mineral density (lumbar spine: F=37.88, p<.001; femur: F=54.27, p<.001) and estimated height loss (F=27.68, p<.001). Estimated height loss increased significantly with decreasing bone mineral density (lumbar spine: r=-.23, p<.001; femur: r=-.34, p<.001). The odds ratio for the point at which the estimated height loss affects the occurrence of osteoporosis was found to increase at a cut-off value of 2 cm and the area under ROC curve was .71 and .82 in lumbar spine and femur, respectively. Conclusion: The optimal cut-off value of the estimated height loss for detection of osteoporosis was 2 cm. Height loss is therefore a useful indicator for the self-assessment and prognosis of osteoporosis.

• 대한디지털의료영상학회논문지
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• 제10권2호
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• pp.5-10
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• 2008

Thanks to recent development of science and technology, economic standard has been improved and life expectation has been gradually increased. Accordingly, disease aspect and demand for health have been changed in the concept from conventional center of disease to health improvement As the health issue in middle and senior age has also been vital in the national health, osteoporosis, one of the physical maladies occuring in these age group, is on the rise as a matter of important concern so that the researches on the osteoporosis have being accomplished actively in several medical domains. Research has been earned out for 735 examined objects, who have received medical examination of bone mineral density in the volunteer medical service of Daegu and Kyungbuk province for recent 4 years. The result indicated that serious osteoporosis prevailed over osteoporosis for male while osteopenia was majority to osteoporosis and that abnormal bone mineral density was more prominent than normal bone mineral density for both male and female. This study is to present basic data which is indispensible to preparation of senior citizen dominated society afterward, investigating the prevalence rate of osteoporosis.