• Korean journal of food and cookery science
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• v.30 no.5
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• pp.588-595
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• 2014

To develop a variety of salted vegetables, this study investigated the quality properties and sensory characteristics of pak-choi Baikkimchi with 0, 1, 3, 5 and 7% (w/w) red pepper seed during 50 days at $10^{\circ}C$. The pH of pak-choi Baikkimchi decreased little for the first days but decreased significantly after day 20. The larger amount of the red pepper seed kept pH the less affected. The total acidity of pak-choi Baikkimchi increased within 20 days. Lactic acid bacteria count, pak-choi Baikkimchi with 0% red pepper seed decreased after 30 days' increase, while pak-choi Baikkimchi with 3% and 5% red pepper decreased significantly after 20 days' increase. Hunter's color L value increased during storage but a and b value decreased. Pak-choi Baikkimchi with 0%, 5% and 7% red pepper seed on day 10, pak-choi Baikkimchi with 1% 3% red pepper seed on day 20. Flavor preference was higher on day 20 of storage. In taste analysis, pak-choi Baikkimchi with 3% and 7% red pepper seed higher preference on day 10 and with 5% on day 30. Appearance preference was higher for pak-choi Baikkimchi with 0% and 3% red pepper seed on day 10 and with the others on day 20. Texture preference decreased as the storage time. Overall preference of pak-choi Baikkimchi with 0%, 1% and 7% were higher on day 10, pak-choi Baikkimchi with 3% and 5% red pepper seed were higher on day 20. In conclusion, the quality properties and sensory characteristics of pak-choi Baikkimchi were optimal on day 20 of storage and 3% red pepper seed.

• Molecules and Cells
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• v.44 no.7
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• pp.493-499
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• 2021

Parkinson's disease (PD) is characterized by a progressive loss of dopamine-producing neurons in the midbrain, which results in decreased dopamine levels accompanied by movement symptoms. Oral administration of l-3,4-dihydroxyphenylalanine (L-dopa), the precursor of dopamine, provides initial symptomatic relief, but abnormal involuntary movements develop later. A deeper understanding of the regulatory mechanisms underlying dopamine homeostasis is thus critically needed for the development of a successful treatment. Here, we show that p21-activated kinase 4 (PAK4) controls dopamine levels. Constitutively active PAK4 (caPAK4) stimulated transcription of tyrosine hydroxylase (TH) via the cAMP response element-binding protein (CREB) transcription factor. Moreover, caPAK4 increased the catalytic activity of TH through its phosphorylation of S⁴⁰, which is essential for TH activation. Consistent with this result, in human midbrain tissues, we observed a strong correlation between phosphorylated PAK4^S474, which represents PAK4 activity, and phosphorylated TH^S40, which reflects their enzymatic activity. Our findings suggest that targeting the PAK4 signaling pathways to restore dopamine levels may provide a new therapeutic approach in PD.

• Journal of Integrative Natural Science
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• v.9 no.3
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• pp.161-165
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• 2016

The p21-activated kinase-1 (PAK1) has emerged as a potential target for anticancer therapy. It is overexpressed in ovarian, breast and bladder cancers. This suggests that PAK1 may contribute to tumorigenesis. 4-azaindole derivatives are reported as potent PAK1 inhibitors. The present work deals with the molecular docking studies of 4-azaindoles with PAK1. Probable binding mode of these inhibitors has been identified by molecular modeling. Docking results indicated that hydrogen bonding interactions with Glu345 and Leu347 are responsible for governing inhibitor potency of the compounds. Additionally, Val284, Val328, Met344 and Leu396 were found to be accountable for hydrophobic interactions inside the active site of PAK1.

• Proceedings of the Korea Institutes of Information Security and Cryptology Conference
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• 2003.07a
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• pp.126-132
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• 2003

본 논문에서는 PAK(Password-Authenticated Key Exchange)와 PAK-R 프로토콜 기반으로 세가지 형태의 MTI(Matsumoto, Takashima, Imai) 키 일치 프로토콜을 적용하여, 안전한 보안성 요구 조건을 만족하면서 다양한 시스템에 적용할 수 있는, 패스워드-인증 키 분배 프로토콜을 소개하고자 한다. PAK 패스워드-인증 키 프로토콜은 통신 주체의 짧은 길이의 패스워드를 이용하여 통신 주체의 식별 및 상호 인증 후, 크기가 긴 세션키를 분배하기 위한 프로토콜이다. 또한 PAK는 이미 안전한 보안성이 증명되었고,［8,9,10］이를 이용한 많은 패스워드 기반의 인증 키 분배 프로토콜이 소개되었다. 본 논문은 이미 안정성 검증이 된 키 분배 프로토콜을 이용하여 새로운 PAK 프로토콜을 제안하며, credential의 이용성을 보장하기 위한 다양한 응용에 적용될 수 있다.

• Research in Plant Disease
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• v.25 no.2
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• pp.98-101
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• 2019

Pak choi (or a Bok choy; Brassica rapa subsp. chinensis) is a popular brassicaceous vegetable worldwide. In January 2019, a downy mildew symptom on pak choi was found at a farm located in Yongin, Korea. Based on morphological characteristics and molecular phylogenetic inference, the pathogenic oomycete was identified as Hyaloperonospora brassicae. To our knowledge, this is the first report of downy mildew disease occurring on pak choi in Korea. Considering the increasing demand for this crop, this pathogen would be a potentially new threat to the cultivation of pak choi in Korea.

• The Korean Journal of Nuclear Medicine
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• v.33 no.4
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• pp.430-438
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• 1999

Purpose: We evaluated a rapid preparation procedures for the labeling and quality control of $^{99m}Tc$-ECD, $MAG_3$, and MIBI using microwave heating and Sep-Pak cartridges. Materials and Methods: $^{99m}Tc$ labeling of ECD, $MAG_3$, and MIBI kit preparation was performed according to the package inserts with microwave heating modification. Heating time was 10-15 sec, and heating was performed with 3 mm plastic bottle with screw cap to prevent radiation contamination. Labeling efficiency was obtained with $C_{18}$ or Alumina N Sep-Pak cartridges. Results: The radiochemical purity of $93{\sim}96%$ for $^{99m}Tc$-ECD and $95{\sim}99%$ for $^{99m}Tc$-MIBI was obtained using Alumina N Sep-Pak cartridge. The optimum irradiation time of microwave method for 3 ml $^{99m}Tc$-labeled radiopharmaceutical solution was 10 sec for $^{99m}Tc$-ECD and $^{99m}Tc$-MIBI, and 15 sec for $^{99m}Tc-MAG_3$. The results of quality control data with Sep-Pak cartridges were well correlated with TLC method. The total preparation time of these radiopharmcaeuticals was $5{\sim}6min$ including quality control procedure. Conclusion: This study demonstrates that radiopharmaceuticals preparation by microwave heating and quality control by Sep-Pak cartridges can be efficiently utilized as an alternative to the recommended method by manufacturer's manual.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.12 no.6
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• pp.113-124
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• 2002

Proposals for a password-based authenticated key exchange protocol that have been published so far almost concentrated on the provable security. But in a real environment such as mobile one, efficiency is a critical issue as security. In this paper we discuss the efficiency of PAK which is secure in the random oracle model ［l］. Among 4 hash functions in PAK the instantiation for $H_1$, which outputs a verifier of the password, has most important effect on the computational efficiency. We analyze two different methods for $H_1$ suggested in ［1］ and we show that $H_{lq}$ has merits in transforming to EC or XTR variants as well as in the efficiency. As an efficient variant. we propose PAK2-EC and PAK2-XTR which do not require any additional step converting a hash output into a point of elliptic curve or XTR subgroup when compared to the previous work on the PAK［2］. Finally we compare PAK2 with the password-based authenticated key exchange protocols such as SPEKE, SRP, and AMP.

• The monthly packaging world
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• s.111
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• pp.72-73
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• 2002

• KSBB Journal
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• v.9 no.4
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• pp.385-394
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• 1994

Large scale purification to get antifungal antibiotic KRF-001 of 90% purity, was investigated using preparative HPLC. Crude KRF-001 was purified by XAD-7 adsorption chromatography, acid precipitation and microfiltration. Microfiltration was the most effective isolation method of crude KRF-001. The purification methods using C18 chromatography was convenient compared with the conventional methods. Delta PAK C18 column and Bonda PAK C18 column were adapted large scale purification of KRF-001. Gradient system of prep HPLC using Delta PAK C18 column was more effective. With these conditions, final recovery of KRF-001 yielded 77%.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2008.04a
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• pp.1000-1004
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• 2008

As performance of medical air compressor improve, the problem of noise increased. Noise is very important to medical air compressor because most of this installed inside of building. The main goal of this paper is show TPA (Transfer Path Analysis) result for contribution analysis using PAK system. Generally, the conventional TPA method consists of two steps. First, transfer functions between output sound and sources are measured by excitation experiment. Second, transferred sound in each transfer path is generated by multiplying the transfer function and the sound source signal. Then, if the output sound synthesized from all transferred sounds doesn't give good agreement with the measured output sound (i.e., the accuracies of the transfer functions are low), setting a suitable countermeasure guideline becomes difficult. For obtaining highly accurate transfer functions, eliminating correlations among transfer functions and noise included in the measured data are necessary. In the new method with PAK system, the vibration acceleration and sound signals around the sound sources and the output sound were measured simultaneously to obtain the transfer functions when compressor was operating. By applying PAK system, a highly accurate and efficient transfer path analysis method was developed that does not require an excitation experiment.