• Analytical Science and Technology
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• v.22 no.1
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• pp.35-43
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• 2009

The goal of PAT (Process Analytical Technology) is to build quality into products through better understanding and control of manufacturing processes, rather than merely testing the quality of the end product. Pharmaceutical manufacturers are trying to develop and implement new technologies in pharmaceutical production and quality control for real-time measurements of critical product and process parameters. Characterization of manufacturing process through experimental design, for evaluation of the effect of product and process variables, represents an integral part of the PAT framework. However, the publications regarding real PAT application to pharmaceutical process are very limited and the technologies are confidential as well. In this review, the case studies related to PAT are shown with real applications from a pharmaceutical company. Additionally, various applications of PAT on the developing stage are introduced with high analytical technologies for the improvement of quality control on manufacturing process.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.60 no.6
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• pp.1209-1214
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• 2011

Photoacoustics has been broadly studied in biomedicine, for both human and small animal tissues. Photoacoustics uniquely combines the absorption contrast of light or radio frequency waves with ultrasound resolution. Moreover, it is non-ionizing and non-invasive, and is the fastest growing new biomedical method, with clinical applications on the way. This paper provides a brief recap of recent developments in photoacoustics in biomedicine, from basic principles to applications. The emphasized areas include the new imaging modalities as well as translational research topics. A primary PA application in biomedicine is photoacoustic tomography (PAT). The past decade has seen fast developments in both theoretical reconstruction algorithms and innovative imaging techniques, and PAT has been implemented in imaging different tissues, from centimeter-large breast tumors to several micrometer-large single red blood cels (RBC). PAT now provides structural, functional and molecular imaging. Overall, PA techniques for biomedicine are maturing. They have been widely used to study both animal and human tissues. Recently, more and more research focuses on clinical applications. Commercialized PA systems are expected to be available in the near future, and wide clinical PA applications are foreseen.

• Analytical Science and Technology
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• v.21 no.5
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• pp.345-363
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• 2008

Process analytics has been already widely utilized in a large-scale continuous production line such as petroleum industries for several decades. Although the process analytics has a long history, a concept of "Process Analytical Technology (PAT)" has been rapidly adopted as a new paradigm for the process monitoring in the production process of various industries. In this review, current status and recent developments of PAT in various research bodies have been introduced, including the introduction of various types of analytical instruments, chemometrics tools, and perspectives and future applications of PAT as well as the fundamentals on PAT such as terminology and its historical background.

• Korean Journal of Computational Design and Engineering
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• v.11 no.4
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• pp.303-314
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• 2006

The exchange of CAD (Computer Aided Design) models between different CAD systems and to downstream applications such as manufacturing has become very important to modem industry. One serious current issue is that the process cannot automatically import existing 3-D solid models in a variety of commercial CAD formats into the process without manually re-mastering the model in current standard including "SIEP AP(Application Protocol) 203 Edition 1" To fully integrate technical data from the design agency to the shop floor, design intent and validated 3D geometry of feature based parametric CAD model should be brought into the standardized processes. To overcome this limitation, AP203 Edition 2 (Ed.2) and its related STEP parts such as Part55, Part108, Part109, Part111 and Part112 are starting to be available to handle this problem. The features in Part111 are harmonized with the machining features available in AP224. This paper is focused on two mapping technologies: CAD to Part111 mapping and Pat111 to AP224 mapping including case studios and it will provide the guideline about what should be done next in the AP203 Ed.2 to AP224 mapping. The final goal of this project is to integrate technical data from CAD to AP224 based manufacturing information through AP203 Ed.2.