• Journal of Life Science
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• v.13 no.4
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• pp.463-472
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• 2003

Interactions between factor Va (HFVa) and membrane phosphatidylserine (PS) regulate the activity of the prothrombinase complex. I have previously shown that two solvent exposed hydrophobic residues located in the C2-domain, Trp2063 and Trp2064, are required for binding to immobilized PS and for expression of procoagulant activity on membranes containing 5% PS. In order to fully define the functional importance of these two residues I have expressed and isolated recombinant factor Va (rHFVa) W2063A/W2064A double mutant. In contrast to the native protein the two glycoforms resulting from alternative glycosylation of Asn2181 eluted as a single peak with rHFVa1 W2063A/W2064A eluting on the leading edge and rHFVa2 W2063A/W2064A eluting on the trailing edge. The double mutant rHFVa2 W2063A/W2064A expressed little or no procoagulant activity on membranes containing 1-10% mol % PS. In contrast, the procoagulant activity of this mutant was slightly greater than the native protein on membranes containing>18 mol % PS. The binding of rHFVa2 W2063A/W2064A to immobilized phospholipid vesicles was markedly reduced compared to the native protein in a surface plasmon resonance binding assay. I conclude that Trp2063 and Trp2064 are required for high affinity binding of factor Va to PS membranes and that this interaction is necessary for assembly of the prothrombinase complex on membranes containing physiological concentrations of PS.

• 한국정보디스플레이학회:학술대회논문집
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• 2009.10a
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• pp.156-158
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• 2009

New liquid crystal (LC) host mixtures and reactive mesogens (RMs) designed for the Polymer Sustainable Vertically Aligned (PS-VA) mode have been developed. The novel combination of LC host mixture with RMs enables to show superior LC display performance with high reliability and to contribute for the robust LC panel production process.

• Macromolecular Research
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• v.16 no.4
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• pp.329-336
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• 2008

Core/shell ($\pm$)PS/(-)silica nanocomposite particles were synthesized by dispersion polymerization using an amphoteric initiator, 2,2'-azobis [N-(2-carboxyethyl)-2,2-methylpropionamidine] ($HOOC(CH_2)_2HN$(HN=) $C(CH_3)_2CN$=NC $(CH_3)_2C$(=NH)NH $(CH_2)_2COOH$), VA-057. Negatively charged (-6.9 mV) silica was used as the stabilizer. The effects of silica addition time and silica and initiator concentrations were investigated in terms of polymerization kinetics, ultimate particle morphology, and size/size distribution. Uniform hybrid microspheres with a well-defined, core-shell structure were obtained at the following conditions: silica content = 10-15 wt% to styrene, VA-057 content=above 2 wt% to styrene and silica addition time=0 min after initiation. The delay in silica addition time retarded the polymerization kinetics and broadened the particle size distribution. The rate of polymerization was strongly affected by the silica content: it increased up to 15 wt% silica but then decreased with further increase in silica content. However, the particle size was only marginally influenced by the silica content. The zeta potential of the composite particles slightly decreased with increasing silica content. With increasing VA-057 concentration, the PS microspheres were entirely coated with silica sol above 1.0 wt% initiator.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2009.11a
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• pp.187-187
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• 2009

The PVA(patterned vertical alignment) mode has a excellent dark state at normal direction. but they has a disclination area at divided domain region at voltage on state. so this disclination make a slow response time and decrease transmittance. To overcome this problem, we research about polymer stabilized vertical alignment (PS-VA) method which was using the UV curable reactive mesogen. According to our research, UV exposure condition which was UV dosage condition effected to rising time and decay time and also threshold voltage.

• Current Optics and Photonics
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• v.1 no.2
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• pp.157-162
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• 2017

In large liquid crystal displays, the image quality in an oblique viewing direction is a crucial issue. From this perspective, 8-domain polymer-stabilized vertical alignment (PS-VA) mode has been developed to suppress the color shift in oblique viewing directions, compared to that in 4-domain PS-VA mode. To realize the 8-domain PS-VA, the four domains in a pixel are each divided into two regions, such that applying different electric potentials result in different tilt angles in these two regions, while keeping four azimuthal directions in each domain. However, applying different voltages in a pixel causes drawbacks, such as requiring additional processes to construct a capacitor and a transistor, which will further reduce the aperture ratio. Here we propose a different approach to form the 8-domain, by controlling surface polar anchoring energy and the width of patterned electrodes in two regions of a pixel. As a result, the gamma-distortion index (GDI), measured at an azimuthal angle of $0^{\circ}$, is reduced by about 23% and 8%, compared to that of a conventional 4-domain at polar angles of $30^{\circ}$ and $60^{\circ}$ respectively.

• Journal of the Optical Society of Korea
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• v.20 no.6
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• pp.794-798
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• 2016

A polymer-stabilized vertical alignment (PS-VA) mode with fishbone-shaped pixel electrode structure is mainly used in large-sized liquid crystal displays (LCDs) owing to its advantages such as wide viewing angle, good transmittance and fast response time. One drawback of this mode is a main bone electrode, which crosses in the center of a pixel. It causes the transmittance to decrease badly because LCs cannot be reoriented in this region, and thus, it is particularly unfavorable in an ultra-high-definition LCD. Here, we propose an innovative structure with the main bone electrode relocated to the edge area in a pixel, and investigate how this reverse directed fishbone-shaped pixel electrode structure affects electro-optic characteristics. The proposed structure shows enhanced electro-optic performance, such as the higher transmittance and the faster response time than the conventional VA mode with fishbone-shaped pixel electrode structure.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.4 no.5
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• pp.73-83
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• 1981

The purpose of value analysis is to assist each to approach nearer enough to this goal to provide substantial competitive and profit advantages. It provides planned and disciplined thought and act ion which hel ps identify unnecessary cost throughout the product or process cycle. Value analysis is a precise, disciplined, one-purpose thinking process. Its one purpose is to retain all the performance and aesthetic factors which now exist In the product, process or services, which the customer wants and is willing to pay for : and through disciplined thinking procedures, to put together Practical alternatives which will accomplish them at still lower cost. Value in a product or service is the reward for appropriate performance and appropriate cost Value analysis must therefore employ techniques which will sensitize any "lacking" area so that the need can be identified and satisfied. As the business begins to see the benefit of the activity, additional value analysts consultants may be added. This will provide more penetration in the three identified areas, of top managers group, individual value analysis consultants and senior member who organizes value analysis work, and besides, additional abilities will be secured.e secured.