• Title/Summary/Keyword: PaCO2

Search Result 362, Processing Time 0.032 seconds

PaCO2 at Early Stage is Associated with Adverse Cardiovascular Events in Acute Carbon Monoxide Poisoning (급성 일산화탄소 중독 환자에서 응급실 내원 초기 동맥혈 이산화탄소 분압의 임상적 의미)

  • Yang, Keun Mo;Chun, Byeong Jo;Moon, Jeong Mi;Cho, Young Soo
    • Journal of The Korean Society of Clinical Toxicology
    • /
    • v.17 no.2
    • /
    • pp.86-93
    • /
    • 2019
  • Purpose: The objective was to determine the association between PaCO2 and adverse cardiovascular events (ACVEs) in carbon monoxide (CO)-poisoned patients. Methods: This retrospective study included 194 self-breathing patients after CO poisoning with an indication for hyperbaric oxygen therapy and available arterial blood gas analysis at presentation and 6 hours later. The baseline characteristics and clinical course during hospitalization were collected and compared. The mean PaCO2 during the first 6 hours after presentation was calculated. Results: The incidence rates of moderate (30 mmHg< PaCO2 <35 mmHg) or severe (PaCO2 ≤30 mmHg) hypocapnia at presentation after acute CO poisoning were 40.7% and 26.8%, respectively. The mean PaCO2 during the first 6 hours was 33 (31-36.7) mmHg. The incidence of ACVEs during hospitalization was 50.5%. A significant linear trend in the incidence of ACVEs was observed across the total ranges of PaCO2 variables. In multivariate regression analysis, mean PaCO2 was independently associated with ACVEs (OR 0.798 (95% CI 0.641-0.997)). Conclusion: Mean PaCO2 during the first 6 hours was associated with increased ACVEs. Given the high incidence of ACVEs and PaCO2 derangement and the observed association between PaCO2 and ACVEs, this study suggests that 1) PaCO2 should be monitored at the acute stage to predict and/or prevent ACVEs; and 2) further study is needed to validate this result and investigate early manipulation of PaCO2 as treatment.

Changes in Physicochemical and Organoleptic Qualities of 'Niitaka' Pears during Controlled Atmosphere Storage (CA저장 중 신고 배의 이화학적 및 관능적 품질특성 변화)

  • Chung, Hun-Sik;Kim, Sung-Hwan;Chang, Eun-Ha;Youn, Kwang-Sup;Seong, Jong-Hwan;Choi, Jong-Uck
    • Korean Journal of Food Science and Technology
    • /
    • v.35 no.5
    • /
    • pp.865-870
    • /
    • 2003
  • The effects of storage atmosphere on the physicochemical and organoleptic properties of Asian pears (Pyrus pyrifolia Nakai cv. Niitaka) were investigated. The pears were stored at $0^{\circ}C$ for up to 8 months under CA conditions (3 kPa $O_2$+1 kPa $CO_2$, 1 kPa $O_2$+5 kPa $CO_2$, 1 kPa $O_2$+1 kPa $CO_2$) controlled by a static system or air (21 kPa $O_2$+0 kPa $CO_2$). CA conditions retarded the loss of weight, flesh firmness, organoleptic properties (appearance, aroma, sweetness, texture), and the development of injuries in the fruits during storage. Low $O_2$ plus high $CO_2$ conditions maintained the highest flesh firmness. In addition, low $O_2$ reduced injuries more than the other conditions. Skin color (lightness, chroma, hue), soluble solids, titratable acidity, pH and vitamin C were unaffected by storage atmosphere.

Pnatothenic Acid Satus in Pups and Dams Fed Pantothenic Acid Deficient Diet during Gestation (임신기간동안의 Pantothenic Acid 결핍식이가 어미쥐 및 새끼쥐의 Pantothenic Acid 대사에 미치는 영향)

  • 송요숙
    • Journal of Nutrition and Health
    • /
    • v.29 no.2
    • /
    • pp.206-212
    • /
    • 1996
  • This study was to see if pregnant rats fed a pantothenic acid(PA) deficient diet for whole 3 weeks gestation would produce pups comparable to the normal controls, at the cost of maternal tissue PA concentration ([PA]) or coenzyme A content ([Co A]). Compared to the controls, dams fed a PA deficient diet tended to decrease weight gain, and produced pups with lower body, liver and brain weight (p<0.05). Postpartum dam's blood [PA] decreased more in PA deficient group than control (p<0.05, PA deficient : 2.52$\pm$0.66 to 0.77$\pm$0.23uM, control : 2.58$\pm$0.52 to 1.45$\pm$0.68uM), although Hb concentration did not differ between two groups. Pup's blood [PA] at birth was lower in PA deficient group than control group(1.75$\pm$0.27uM vs. 3.90$\pm$0.76uM, respectively, p<0.05) and 2-3 times that of postpartum dams in both two groups. [Co A] and [PA] in pup's tissues were 23-68% of dams in both groups, in spite of the higher [PA] in pups. These data suggest that Co A metabolism differs between pups and dams ; the pups were more adversely affected than dams by the dietary PA deficiency of dams during gestation.

  • PDF

Structure direct agent-assisted hydrothermal synthesis and small gases adsorption behavior of pure RHO zeolite (구조유도물질 18-crown-6 ether를 이용한 순수한 RHO 제올라이트 수열합성과 작은 가스 흡착 거동)

  • Kim, Beom-Ju;Sharma, Pankaj;Han, Moon-Hee;Cho, Churl-Hee
    • Journal of Energy Engineering
    • /
    • v.23 no.4
    • /
    • pp.141-149
    • /
    • 2014
  • In the present study, pure RHO zeolite was hydrothermally synthesized by using 18-crown-6 ether as a structure directing agent(SDA), and the small gases adsorption was investigated. Synthesized RHO zeolite was a cube shape particle of which average edge length was around $1.2{\mu}m$ and composed of primary crystallites having a diameter of around 100 to 200 nm. RHO zeolite structure was stable under 3h calcination at $600^{\circ}C$. Water adsorption data announced that RHO zeolite has a specific surface area of 483.32 m2/g and its micropore diameter was about 4 A. Gas adsorption was studied in the pressure range of 50 to 500 kPa for $CO_2$, $N_2$, $O_2$ and $H_2$. It was evident that RHO zeolite showed a strong $CO_2$ adsorption behavior. Especially, RHO zeolite showed a transient $CO_2$ adsorption behavior. The 3h $CO_2$ up-take at 50 kPa and 500 kPa was 1.283 and 3.357 mmol/g, respectively. The $CO_2/H_2$ selectivity was around 16 at 500 kPa. Compared with gas adsorption data for some representative microporous adsorbents, it was certain that RHO zeolite is a beneficial adsorbent for $CO_2/H_2$ separation.

The Changes in Carbon Stocks and Emissions Assessment of Harvested Wood Products in Korea (우리나라의 수확된 목제품 탄소축적 변화량 및 배출량 평가)

  • Choi, Soo Im;Kang, Hag Mo
    • Journal of Korean Society of Forest Science
    • /
    • v.96 no.6
    • /
    • pp.644-651
    • /
    • 2007
  • This study compared and estimated the changes in carbon stocks and emissions of harvested wood products (HWP) by applying FAO statistics and domestic statistics for Korean HWP production, import, and export volume, which is almost always supposed to be included in the carbon emissions and removals inventory by country in negotiations since the 2nd commitment period (2013~2017) of the Kyoto Protocol, for assessing the changes in carbon stocks and emissions of HWP. As a result, when applying FAO statistics to the changes in carbon stocks of HWP as of 2005, stock-change approach (SCA) was estimated at 1.434 Tg C, atmospheric-flow approach (AFA) -1.330 Tg C, and production approach (PA) 0.597 Tg C. When applying Korean statistics, SCA was estimated at 1.246 Tg C, AFA -11.520 Tg C, and PA 0.444 Tg C. When applying FAO statistics to $CO_2$ emissions and removals from HWP, SCA showed a decrease of $-5,258Gg\;CO_2$ (removals), AFA showed an increase of $4,877Gg\;CO_2$ (emissions), and PA showed a decrease of $-2,189Gg\;CO_2$ (removals). When applying Korean statistics, SCA showed a decrease of $-4,569Gg\;CO_2$ (removals), AFA showed an increase of $5,573Gg\;CO_2$ (emissions), and PA showed a decrease of $-1,628Gg\;CO_2$, (removals). Therefore, the application of FAO statistics was shown to be more beneficial for the estimation of both the changes in carbon stocks and emissions of HWP by all methods other than that of Korean statistics.

Factors influencing arterial $CO_2$ tension in cats during high frequency oscillation ventilation (고빈도 진동 환기가 동맥혈의 호흡성 가스에 미치는 영향)

  • Do, Jun-Young;Lee, Jae-Yick;Lee, Kwan-Ho;Kim, Yeung-Jo;Chung, Jae-Chun;Lee, Hyun-Woo;Lee, Suck-Kang
    • Journal of Yeungnam Medical Science
    • /
    • v.6 no.2
    • /
    • pp.47-55
    • /
    • 1989
  • High frequency ventilation (HFV) is a new ventilatory technique that uses very small tidal volume(less than the anatomic dead space) and high frequency, and classified 4 distinct types according to frequency and mode of gas delivery. The mechanism of gas transport of high frequency oscillation ventilation(HFOV) is somewhat different to other types of HFV. To evaluate the determinants of $PaCO_2$ in HFOV, a study was done with a HFOV on 9 cats, and the results are : 1) $PaCO_2$ was not correlated with frequency at the constant stroke volume(6 voltage) and bias flow (6L/minutes). 2) $PaCO_2$ was correlated with stroke volume but not with bias flow under the constant frequency(15Hz/min) and bias flow(3 to 6L/min). From above results, the main determinant of $PaCO_2$ on artificial ventilation with HFOV was stroke volume, but further study between flow, the site of delivery to the airway and humidification of bias flow and $CO_2$ elimination is required in future research.

  • PDF

Evaluation of CO2 Emission to Changes of Soil Water Content, Soil Temperature and Mineral N with Different Soil Texture in Pepper Cultivation (고추재배에서 토성별 토양수분, 토양온도, 무기태질소 변화에 따른 CO2 배출량 평가)

  • Kim, Gun-Yeob;Song, Beom-Heon;Hong, Suk-Young;Ko, Byong-Gu;Roh, Kee-An;Shim, Kyo-Moon;Zhang, Yong-Seon
    • Korean Journal of Soil Science and Fertilizer
    • /
    • v.41 no.6
    • /
    • pp.393-398
    • /
    • 2008
  • Several researchers have proposed models or equations to predict soil $CO_2$ flux from more readily available biotic and abiotic measurement. Tree commonly used abiotic variables were N mineral and soil temperature and soil water content. This study was conducted to determine $CO_2$ emission to mineral N, soil water content and soil temperature with clay loam and sandy loam in pepper cultivation in 2004~2005. $CO_2$ flux in the upland with different levels of soil water potential was measured at least once in two weeks during the cropping period in the pepper cultivation plots. Soil water potential in the clay loam and sandy loam soils was established at -30kPa and -50kPa by measuring the soil gravimetric water content with two replications. $CO_2$ emission rate from the differently managed plots was highly correlation coefficient to between the mineral N ($R=0.830^{**}$, $0.876^{**}$) and soil temperature ($r^2=0.793^{**}$, $0.804^{**}$) in the clay loam and sandy loam, respectively. However, the relationships between $CO_2$ emission and soil water content were non-significant. $CO_2$ emissions at sandy loam soils was lower to 21~37% than at clay loam soils for both soil water conditions without differences in yield. At difference levels of soil water conditions, $CO_2$ emission at -50kPa decreased to 37.5% in comparison with that at -30kPa. From the path analysis as to contribution factors of GHGs, it appeared that contribution rate was in the order of soil temperature (54.9%), mineral N (32.7%), and soil moisture content (12.4%).

Fermented Soymilk Alleviates Lipid Accumulation by Inhibition of SREBP-1 and Activation of NRF-2 in the Hepatocellular Steatosis Model

  • Ahn, Sang Bong;Wu, Wen Hao;Lee, Jong Hun;Jun, Dae Won;Kim, Jihyun;Kim, Riji;Lee, Tae-bok;Jun, Jin Hyun
    • Journal of Microbiology and Biotechnology
    • /
    • v.28 no.2
    • /
    • pp.236-245
    • /
    • 2018
  • Ingredients of soy and fermented soy products have been widely utilized as food supplements for health-enhancing properties. The aim of this study was to evaluate the effects of fermented soymilk (FSM) and soymilk (SM) on free fatty acid-induced lipogenesis in the hepatocellular steatosis model. HepG2 cells were incubated with palmitic acid (PA) for 24 h to induce lipogenesis and accumulation of intracellular lipid contents. The PA-treated cells were co-incubated with FSM, SM, genistein, and estrogen, respectively. Lipid accumulation in the PA-treated HpG2 cells was significantly decreased by co-incubation with FSM. Treatment of HepG2 cells with PA combined with genistein or estrogen significantly increased the expression of SREBP-1. However, FSM co-incubation significantly attenuated SREBP-1 expression in the PA-treated HepG2 cells; in addition, expression of NRF-2 and phosphorylation of ERK were significantly increased in the PA and FSM co-incubated cells. PA-induced ROS production was significantly reduced by FSM and SM. Our results suggested that the bioactive components of FSM could protect hepatocytes against the lipid accumulation and ROS production induced by free fatty acids. These effects may be mediated by the inhibition of SREBP-1 and the activation of NRF-2 via the ERK pathway in HepG2 cells.

Association of Hypercapnia in the First Week of Life with Severe Intraventricular Hemorrhage in the Ventilated Preterm Infants (기계적 환기 요법을 시행 받은 미숙아에서 고탄산혈증과 뇌실내 출혈의 발생과의 관계)

  • Kim, Jeong-Eun;Namgung, Ran;Park, Min-Soo;Park, Kook-In;Lee, Chul;Kim, Myung-Jun
    • Neonatal Medicine
    • /
    • v.17 no.1
    • /
    • pp.34-43
    • /
    • 2010
  • Purpose : The aim of this study was to examine whether hypercapnia during the first seven days of life was associated with severe intraventricular hemorrhage (IVH) in preterm infants requiring mechanical ventilation. Methods : A matched pair analysis was performed for 19 preterm infants with severe IVH(grade$\geq$3) and 38 infants with no severe IVH (normal or grade 1), who required mechanical ventilation for more than seven days. The univariate and multivariate analysis of severe IVH with maximal and minimal $PaCO_2$, averag $PaCO_2$, SD of $PaCO_2$, and difference in the $PaCO_2$ were assessed. The major perinatal factors and maximal ventilator index (VI) were also compared. Results : Infants with severe IVH had a higher maximal $PaCO_2$ (86.1$\pm$18.4 mmHg vs. 60.1$\pm$ 11.6 mmHg, P <0.001) and mean $PaCO_2$ (47.5$\pm$5.6 mmHg vs. 41.2$\pm$6.3 mmHg, P=0.004) and a larger SD or difference in $PaCO_2$ (14.0$\pm$4.4 mmHg vs. 9.0$\pm$2.4 mmHg; 60.3$\pm$20.9 mmHg vs. 35.5$\pm$11.8 mmHg, P <0.001). However the minimal $PaCO_2$ values did not differ between the groups. Disseminated intravascular coagulation, pulmonary hemorrhage, and the air leak syndrome were more frequent in the IVH group than in the controls. The maximal VI on each day was higher in the IVH group. The multivariate logistic regression analysis after controlling for bleeding tendency showed that the air leak syndrome, maximal VI, and maximal $PaCO_2$ were independently associated with severe IVH [OR, 1.324 (95% CI, 1.011-1.733; P=0.041)]. Conclusion : Extreme hypercapnia was significantly associated with severe IVH in preterm infants, after adjustment for major perinatal risk factors. Frequent monitoring of the $PaCO_2$ may be important for early detection of inadvertent hypercapnia and prompt correction of high PaCOS levels.

The use of Thermodynamics and Phase Equilibria for Prediction of the Behavior of High Temperature Corrosion of Alloy 617 in Impure Helium Environment

  • Kim, Dong-Jin;Lee, Gyeong-Geun;Kim, Sung-Woo;Kim, Hong-Pyo
    • Corrosion Science and Technology
    • /
    • v.9 no.4
    • /
    • pp.164-170
    • /
    • 2010
  • Thermodynamic consideration was performed for Alloy 617 exposed to an impure helium ($H_2$ 20pa, $H_2O$ 0.5pa, $CH_4$ 2pa and CO 5pa) at $950^{\circ}C$. Oxidation power was decreased in the order Al > Ti > Si > Cr > Mn. Decarburization and carburization reactions were available leading to carbon activity decrease and increase, respectively, depending on carbon and Cr activities. The thermodynamic prediction was compared with the experimental results obtained in similar conditions (($H_2$ 20pa, $H_2O$ 0.05pa, $CH_4$ 5pa and CO 2pa) and $950^{\circ}C$) by others for Alloy 617. The driving force for oxidation of Al, Ti and Si is very large to be oxidized at a given impure helium and the environment is actually carburizing towards the structural alloy, which is consistent with this work.