• 제목, 요약, 키워드: Palate

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구개열의 유형에 따른 발음 비교 (Speech Evaluation Based on the Type of Cleft Palate)

  • 김석권;김민수;허정;권용석;이근철;정분선;이민혁
    • 대한두개안면성형외과학회지
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    • v.9 no.2
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    • pp.72-76
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    • 2008
  • Purpose: Authors evaluated results of palatoplasty by speech analysis in bilateral, unilateral complete, and unilateral incomplete and submucous cleft palate patients. Methods: The speech outcomes were studied in 15 bilateral, 28 unilateral complete, and 46 unilateral incomplete and submucous cleft palate patients who underwent push-back palatoplasties from January 1998 to July 2004. The patients were divided into 2 groups as 3 to 6, 7 to 10-year-old and compared with 20 normal children(control groups were divided into 10 children on each side). Nasal emission test, hypernasality test, and articulation test were done by speech evaluation table which was composed of 39 different words. Results: In all speech evaluation tests, the group of bilateral cleft palate patients got the worst score. And 7 to 10-year-old groups got better score when compared to the same type cleft palate. Conclusion: Bilateral cleft palate patients have many more speech problems than other patients. In cleft palate patients, the speech problem was improved with ages, postoperatively. And the speech therapy can improve the operative outcomes.

실험으로 유도된 구개열 마우스의 안면골 성장에 관한 연구 (A STUDY ON FACIAL BONE GROWTH OF PALATAL CLEFTS EXPERIMENTALLY INDUCED IN MICE)

  • 전윤식
    • 대한치과교정학회지
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    • v.18 no.2
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    • pp.329-342
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    • 1988
  • In methods of finding causes for cleft palate, many cases have been studied by investigators using teratogenic agents. Among them, a synthetic agent known as triamcinolone acetonide (TA) was widely used. When this drug was injected into mice during palatogenesis, it induced lowered body weight and a deformed mandible. But many cases have been studied on growth changes, only of the developmental stages of the palate. Therefore, the objective of this study was to evaluate craniofacial growth in experimentally induced cleft palate mice after finishing palatogenesis namely just before birth. Normal, alcohol treated, and TA treated DDY mice were obtained at 18-days of gestation and heads were prepared for serial sectioning in the sagittal plane. The midsagittal sections were photographically enlarged (${\times}40$) and measurements made to asses the amount of growth. The obtained results were as follows. 1. The incidence of cleft palate was 41.2% when TA was injected. 2. The body weight of the cleft palate group was lower than the control group. 3. In the cleft palate group, mandibular length (H-M) was lighter than the control group. 4. In the cleft palate group, degree of staining was not distinct compared to the control group by the double staining method. 5. In the cleft palate group, anteroposterior posture of the tongue tip to facial plane (C-M) was more posterior than the control group. 6. The cause of posterior posture of the tongue tip to facial plane (C-M) in the cleft palate group, was not short and retracted tongue but the mandibular length was increased. 7. The anteroposterior relationship of hyoid cartilage to cranial base was the same in all groups.

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BAPN으로 유도된 구개파열 백서의 osteonectin발현 양상에 대한 연구 (A study of osteonectin expression patterns in BAPN-induced cleft palate formed rats)

  • 태기출;김은철;이선경
    • 대한치과교정학회지
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    • v.30 no.4
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    • pp.433-440
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    • 2000
  • 이 연구는 정상구개백서와 비교하여 구개 파열 백서에서 osteonectin 발현 양상에 대한 관찰하기 위해 시도되었다. 임신 9일째 백서 4마리를 구입하여 1마리의 대조군과 3마리의 실험군으로 구분한후, beta-aminoproprionitrale를 임신 13일째 1g/kg체중 비율로 실험군에 투여하였다. 그 후 임신 20일째 백서를 모두 희생하여 대조군에서는 12마리, 실험군에서는 33마리의 백서 태자를 얻어 그 중 실험군에서 총 6마리의 구개파열 백서태자를 얻었다. 구개파열 백서태자 5마리를 각3마리씩 면역조직화학염색과 Western blot검사를 위해 나누고, 대조군의 구개와 구개파열군의 구개에서 osteonectin 발현양상은 다음과 같은 결과를 보였다. 1. 구개파열 백서의 간엽조직에서 osteonectin 발현 양상은 대조군에 비해 현저히 낮은 형태를 보였다. 2. 구개파열 백서의 골아세포와 골세포에서 osteonectin 발현 양상은 대조군에 비해 낮은 형태를 보였다. 3. 구개파열 백서의 비강 상피에서 osteonectin 발현 양상은 구개 상피의 발현양상과 차이가 없었다. 4. Western blot분석에서 구개 파열 백서의 osteonectin 밴드 굵기와 두께는 정상군에 비해 얇고 희미하였다.

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Retinoic Acid Induces Abnormal Palate During Embryogenesis in Rat

  • Shin, Jeong-Oh;Park, Hyoung-Woo;Bok, Jin-Woong;Kim, Myoung-Hee
    • 대한의생명과학회지
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    • v.16 no.1
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    • pp.1-9
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    • 2010
  • In order to understand the effects of all-trans-RA on palate development, RA was injected into the abdominal cavity of pregnant mice and then the embryos were taken in the following days and analyzed morphologically as well as molecular biologically. When RA was administered at the stage of E11 or E15, the overall craniofacial development was retarded. The length from jaw to eye was shortened, compared to that of normal group. When the E11 embryos were exposed to RA, cleft lip was also found along with the cleft palate. In vitro palate culture experiment also revealed that RA caused cleft palate. When RT-PCR was performed, early stage administration of RA at E11 inhibited the upregulation of Hoxa7 expression at E15 through E17. Whereas in control group, high level of Hoxa7 expression was detected in the palate of E15 to E17. In the case of Bax, the expression was decreased from E16, while remaining constant in control group. When TUNEL analysis was performed following the RA treatment at E15, TUNEL positive cells were detected in the mesenchymal cells as well as epithelial cells of palatal shelves of E16 and in E17 embryos. Whereas in normal control, TUNEL positive cells were observed mostly at the epithelium around the nasal cavity and oral cavity where rugae is made. These results altogether indicate that exposure to RA during palate development causes facial deformity including cleft palate and cleft lip by modulating the expression of homeotic genes such as Hoxa7 as well as an apoptosis-related gene, Bax, and thus malregulating the apoptosis.

Cleft Palate and Congenital Alveolar Synechiae Syndrome: A Case Report and Literature Review

  • Choi, Kang-Young;Chung, Ki-Ho;Yang, Jung-Dug;Chung, Ho-Yun;Cho, Byung-Chae
    • 대한두개안면성형외과학회지
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    • v.9 no.1
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    • pp.41-44
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    • 2008
  • Cleft palate and congenital alveolar synechia is a rare syndrome. Only eight cases have been previously reported. It consists of a spectrum of facial anomalies always including cleft palate and congenital alveolar synechiae without other abnormalities. This report described an unusual case of congenital alveolar synechial band spanning posterior alveolar of the two jaws with cleft palate. Previously reported cases showed bilaterally or anteriorly located fibrous band. In our department, a new born revealed unilateral posterior synechia. Under brief intravenous sedation, synechium was divided using bipolar diathermy in the nursery at 3 days of age because of poor feeding. This division allowed full jaw opening after brief passive exercise. The patient is growing and maturing as expected with no complications. This patient is supposed to be the first reported case of isolated unilateral alveolar synechium combined with cleft palate in the worldwide.

과대비성을 동반한 점막하구개열 환자에 대한 Double Opposing Z-plasty를 통한 수술적 치료 결과 (Outcomes for Patients with Submucous Cleft Palate Accompanying Hypernasality Treated with Double Opposing Z-plasty)

  • 김현준;김진영;배정호;김광문;최홍식
    • 대한후두음성언어의학회지
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    • v.11 no.1
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    • pp.81-86
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    • 2000
  • Submucous cleft palate is a relatively uncommon congenital anomaly accompanying velopharyngeal incompetence(VPI). Double opposing Z-plasty has many advantages including prolongation of soft palate, normal midfacial growth, midline scar. We analyzed postoperative results comparing with those of preoperative evaluation by several variables(nasometer, endoscopy, satisfactory scale) in 14 patients treated with double opposing Z-plasty due to submcous cleft palate. Nasalance score in Ah sound, Ma phrase, and Pa phrase decreased 20.23%, 3.25%, and 23.26% in the average, respectively. As a result, hypernasality improved significantly. Closure rate in velum evaluated by endoscopy was increased from 0.44 to 0.76. In objective satisfactory scale checked by each patient's guardian at the postoperative period, much improved in 3, improved in 6, minimally improved in 1, and no difference in 1 was reported. (n=11 patients) Double opposing B-plasty is a good surgical modality in patients accompanying VPI with submucous cleft palate or incomplete cleft palate and will be used more usefully and widely.

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선천성 구순, 구개열 환자에 대한 역학적 연구 (Epidemiologic Study on Patients With Congenital Cleft Lip and Palate)

  • 정성욱;손형민;장현석;권종진;임재석
    • 대한구순구개열학회지
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    • v.5 no.1
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    • pp.21-25
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    • 2002
  • Cleft lip and palate are most common congenital deformity to affect the orofacial region. Cleft lip and palate are caused by abnormal development of primary and secondary palate. It's causative mechanism is not completely understood, but genetic and environmental factors play an important role. Many epidemiologic surveys have been done extensively about incidence, racial influence, sex ratio, parent age, associated syndrome, and genetic factors. These researches are useful to dissolve many problems in prevention and treatment of cleft lip and palate. We performed epidemiologic survey of cleft lip and palate who visited the department of Oral & Maxillofacial surgery, Guro Hospital of Korea University from 1995 to 2001.

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구개열과 동반된 선천성 구개 기형종 1례 (A Case of Congenital Palatal Teratoma Associated with Cleft Palate)

  • 송현석;박동하;배남석;박명철
    • Archives of Plastic Surgery
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    • v.34 no.4
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    • pp.498-500
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    • 2007
  • Purpose: The oral teratoma is found approximately in live birth at the rate from 1 : 35,000 to 1 : 200,000. In a review of literature 16 cases of midline teratoma with cleft palate were reported. We report a case of congenital palatal teratoma with cleft palate in a 1-year-old girl. Methods: A 1-year-old girl was admitted our institution for the closure of cleft palate. On the intraoperative findings there was $4{\times}1{\times}0.5cm$ sized hairy soft mass at the midline and complete cleft palate. We did incisional biopsy intraoperatively and its pathology revealed heterotopic brain tissue. The excision of remaining mass and palatoplasty with Sommerlad's method were performed. The final pathology of the mass was mature cystic teratoma. Results: After the operation there were neither recurrence nor oronasal regurgitation. Conclusion: We report for one patient with congenital palatal teratoma associated with cleft palate and obtained an excellent result.

중국 덕주 지역의 구순구개열 의료 봉사 활동 보고 및 치험례 발표 (CASE PRESENTATIONS OF CHARITY OPERATIONS BY IL WOONG CLEFT LIP AND PALATE FOUNDATION IN DEOZHOU, CHINA)

  • 이원덕;이부규;최진영;김종렬;오용석;민병일;김명진
    • Maxillofacial Plastic and Reconstructive Surgery
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    • v.31 no.5
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    • pp.425-428
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    • 2009
  • Il Woong Cleft lip and palate foundation was founded in 1968 by Professor emeritus Byoung-Il Min. Since then the foundation has operated numerous cleft lip and palate patients not only in Korea but also in under-developed countries such as Vietnam, China, and Cambodia. In December 2005, the foundation was allowed as an incorporated association by Ministry of Foreign affairs and Trade, so that it could have official status. From March 6th 2009 to March 14th 2009, we conductp,d charity cleft lip and palate operations of 23 patients in areas of Deozhou, China. Hereby we present the results of operations.

Primary repair of untreated cleft palate in an elderly patient: a case report

  • Lee, Jun Sang;Lee, Jae-Yeol;Kim, Yong-Deok;Song, Jae-Min;Choi, Won Hyuk
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.47 no.1
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    • pp.47-50
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    • 2021
  • Untreated adult or elderly cleft lip and palate patients are rarely seen, but studies on delayed primary palatal closure have been performed in the less developed Asian and African countries, where access to medical care is difficult. A 64-year-old woman visited our clinic with untreated cleft palate with a 40×20-mm-wide defect in the medial palate. Two-flap palatoplasty under general anesthesia was performed to close the cleft palate. After 1 month, the result was favorable without any complications including oronasal fistula. Cleft palate primary repair in an elderly patient is rare and has some surgical problems that are associated with a wide range of defects, but good results can be obtained if surgery is performed well with appropriate considerations.