• Title/Summary/Keyword: Parameter

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Modeling Age-specific Cancer Incidences Using Logistic Growth Equations: Implications for Data Collection

  • Shen, Xing-Rong;Feng, Rui;Chai, Jing;Cheng, Jing;Wang, De-Bin
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.22
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    • pp.9731-9737
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    • 2014
  • Large scale secular registry or surveillance systems have been accumulating vast data that allow mathematical modeling of cancer incidence and mortality rates. Most contemporary models in this regard use time series and APC (age-period-cohort) methods and focus primarily on predicting or analyzing cancer epidemiology with little attention being paid to implications for designing cancer registry, surveillance or evaluation initiatives. This research models age-specific cancer incidence rates using logistic growth equations and explores their performance under different scenarios of data completeness in the hope of deriving clues for reshaping relevant data collection. The study used China Cancer Registry Report 2012 as the data source. It employed 3-parameter logistic growth equations and modeled the age-specific incidence rates of all and the top 10 cancers presented in the registry report. The study performed 3 types of modeling, namely full age-span by fitting, multiple 5-year-segment fitting and single-segment fitting. Measurement of model performance adopted adjusted goodness of fit that combines sum of squred residuals and relative errors. Both model simulation and performance evalation utilized self-developed algorithms programed using C# languade and MS Visual Studio 2008. For models built upon full age-span data, predicted age-specific cancer incidence rates fitted very well with observed values for most (except cervical and breast) cancers with estimated goodness of fit (Rs) being over 0.96. When a given cancer is concerned, the R valuae of the logistic growth model derived using observed data from urban residents was greater than or at least equal to that of the same model built on data from rural people. For models based on multiple-5-year-segment data, the Rs remained fairly high (over 0.89) until 3-fourths of the data segments were excluded. For models using a fixed length single-segment of observed data, the older the age covered by the corresponding data segment, the higher the resulting Rs. Logistic growth models describe age-specific incidence rates perfectly for most cancers and may be used to inform data collection for purposes of monitoring and analyzing cancer epidemic. Helped by appropriate logistic growth equations, the work vomume of contemporary data collection, e.g., cancer registry and surveilance systems, may be reduced substantially.

A Study on the Validity of the Prediction of Binaural Parameters by 5 Channel Microphone System (5채널 마이크로폰 시스템을 활용한 공간감 지표 예측의 타당성에 관한 연구)

  • Jang Jae-Hee;Oh Yang-Ki;Jeong Dae-Up;Jeong Hyok
    • The Journal of the Acoustical Society of Korea
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    • v.24 no.2
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    • pp.103-110
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    • 2005
  • Providing adequate amount of spatial impression for spaciousness) has been known to be one of the most important design considerations for the good acoustics of rooms for music. and the measurement, of room acoustics using parameters. such as LEF and IACC, forms an essential part of such evaluation. However. it is unavoidable to use different transducers (figure of eight microphones. head and torso) for the measurement of each parameter and it tends to make the measurement procedure complicated. The Present work tried to provide a simpler way to measure these binaural room acoustic parameters including monaural ones with a single measurement system using both spatial information collected through a 5-channel microphone and a trained neural network. A computer simulation program, CATT-Acoustic V7.2. which allowed us to obtain exactly the same spatial information as a 5-channel microphone was used. since it requires quite a large amount of data for practical training of a neural network. Since each reflection has different energy. delay and direction, energy should be integrated properly. the concept of ray tracing method was applied inversely in this work. Also applying weightings according to the delay times was considered in this work. Finally, predicted results were compared with the measured data md their correlations were analyzed and discussed.

Relationship between Eating Attitude in Female Adolescent and Psychological, Biological Factors ; Depression, Aggression, Impulsiveness and Blood Cholesterol Level (여고생 식이태도와 심리적 및 생리적 요인과의 상관관계 ; 우울감, 공격성, 충동성 및 혈중 콜레스테롤에 대하여)

  • Park, June-Sung;Lee, Joon-Seok;Lee, Jang-Han;Yang, Byung-Hwan;Cho, Yun-Gyoo
    • Korean Journal of Psychosomatic Medicine
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    • v.9 no.2
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    • pp.182-193
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    • 2001
  • The purpose of this study is to evaluate correlation of adolescent eating attitude and psychological factors which might influence the eating attitude such as depression, aggression and impulsiveness. The author also tried to identify relationship between adolescent eating attitude and biological factors such as serum cholesterol level and triglyceride level. Two hundred and forty one female high school students without physical disorder were selected as study subjects. For the study, Eating Attitude Test-26KA (EAT -26KA), Beck Depression Inventory (BDI) -Korean version, Barrat Impulsiveness scale (BIS) -Korean version, and Buss-DurKee Hostility Inventory (BDHI) -Korean version were used. Serum cholesterol level and triglyceride level were also investigated. For the purpose of identifying factors which could influence eating attitude of adolescence, stepwise multiple linear regression analysis was done. Total score of BDHI could be most significant factor to explain eating attitude, and BDI, serum cholesterol/triglyceride level be second, third position respectively. But, BIS was not significant predicting parameter. The contributing portion of these factors to explain eating behavior was 25.9%.

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Statistical Optimization for Biodegradation of 2,4-Dichlorophenoxyacetic Acid by Soil Isolated Bacterium (토양 분리 박테리아에 의한 2,4-Dichlorophenoxyacetic산의 분해 최적화)

  • Kim, Byunghoon;Myunghee Han;Sungyong Cho;Sungjin Ahn;Lim, Sung-Paal;Sunkyun Yoo
    • Microbiology and Biotechnology Letters
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    • v.31 no.1
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    • pp.83-89
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    • 2003
  • 2,4-Dichlorophenoxyacetic acid (2,4-D) as a widely used herbicide has caused serious environmental problems because of its difficult decomposition in nature. We isolated the strain capable of metabolizing 2,4-D as sole carbon and energy source by an enrichment culture technique from the 2,4-D contaminated soil collected at orchard in Gwangju, Korea. This strain was identified tentatively as Aeromonas sp. NOH2. With this strain, we established the response surface methodology (Box-Behnken Design) to optimize the principle parameters for maximizing biodegradation of 2,4-D such as culture pH, temperature, and nutrient concentration in liquid batch culture. The ranges of parameters were obtained from preliminary works done at our laboratory and chosen as 5.5, 6.5, and 7.5 for pH, 25, 30, and $35^{\circ}C$ for temperature, and 5, 20, and 35 g/1 nutrient concentration. Initial concentration of 2,4-D was 500 ppm and nutrient source was tryptic soy broth. The experimental data were significantly fitted to a second order polynomial equation using multiple regression. The most important parameter influencing 2,4-D degradation and biomass production was nutrient concentration. For 2,4-D degradation, the optimum values of pH and temperature, and nutrient concentration were obtained at pH (6.5), temperature (31.8 to $32.1^{\circ}C$), and nutrient concentration (29.6 to 30.1.0 g/1).

Application of Statistical Analysis for Optimization of Organic Wastes Acidogenesis (유기성 폐기물의 산발효 최적화를 위한 통계학적 분석 방안의 적용)

  • Jeong, Emma;Kim, Hyun-Woo;Nam, Joo-Youn;Oh, Sae-Eun;Hong, Seung-Mo;Shin, Hang-Sik
    • Journal of Korean Society of Environmental Engineers
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    • v.30 no.8
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    • pp.781-788
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    • 2008
  • This study shows how to find out optimum co-substrate conditions and continuous operating parameters for maximum acidification of three different organic wastes - livestock wastewater, sewage sludge and food waste. Design of experiments and statistical analysis were revealed as appropriate optimization schemes in this study. Analyses of data obtained from batch tests demonstrated the optimum substrate mixing ratio, which was determined by maximum total volatile fatty acids(TVFA) increase and soluble chemical oxygen demand(SCOD) increase simultaneously. Suggested optimum mixing ratio of livestock wastewater, sewage sludge and food waste was 0.4 : 1.0 : 1.1 based on COD, respectively. Response surface methodology(RSM) contributed to find out optimum operating parameter - hydraulic retention time(HRT) and substrate concentration - for the semi-continuous acidogenic fermentation of mixed organic wastes. The optimum condition for maximum TVFA increase was 2 days of HRT and 29,237 mg COD/L. Empirical equations obtained through regression analysis could predict that TVFA increase would be 73%. To confirm the validity of the statistical experimental strategies, a confirmation experiment was conducted under the obtained optimum conditions, and relative error between theoretical and experimental results was within 4%. This result reflects that using statistical and RSM technique can be effectively used for the optimization of real waste treatment processes.

Transbilayer Effects of n-Alkanols on the Fluidity of Model Membranes of Total Lipids Extracted from Synaptosomal Plasma Membrane Vesicles (n-Alkanols가 소의 대뇌피질 Synaptosomal Plasma Membrane Vesicles로부터 추출 제제한 총지질 인공세포막 이중층간에 형성된 비대칭적 유동성에 미치는 비대칭적 영향)

  • Yun, Il;Kang, Jung-Sook
    • The Korean Journal of Pharmacology
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    • v.28 no.2
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    • pp.191-199
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    • 1992
  • Selective quenching of 1,6-diphenyl-1,3,5-hexatriene (DPH) by trinitrophenyl groups was utilized to examine the transbilayer fluidity asymmetry of model membranes of total lipids (SPMVTL) extracted from synaptosomal plasma membrane vesicles (SPMV). The polarization (P), anisotropy (r), limiting anisotropy $(r_{\infty})$, and order parameter (S) of DPH in the inner monolayer were 0.031, 0.025, 0.033, and 0.070, respectively, greater than calculated for the outer monolayer of SPMVTL. Selective quenching of DPH by trinitrophenyl groups was also utilized to examine the effects of n-alkanols on the individual monolayer structure of SPMVTL. n-Alkanols fluidized the hydrocarbon region of bulk SPMVTL, and the potencies of n-alkanols up to 1-nonanol increased with carbon chain length. It appears that the potencies in bilayer fluidization increase by 1 order of magnitude as the carbon chain length increases by two carbon atoms. The cut-off phenomenon was reached at 1-decanol, where further increase in hydrocarbon length resulted in a decrease in pharmacological activity. The n-alkanols had greater fluidizing effects on the outer monolayer as compared to the inner monolayer of SPMVTL, even though these selective effects tended to become weaker as carbon chain length increased. Thus, it has been proven that n-alkanols exhibit selective rather than nonselective fluidizing effects within transbilayer domains of SPMVTL.

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A Study on Relation between Strategic Attributes of Technological Resources and Competitive Advantage: Empirical Analysis of VRIO Framework by Using Technology Evaluation Results of Technology Based SMEs (기술자원의 전략적 자원속성과 경쟁우위간의 관계에 관한 연구: 기술중소기업의 기술평가자료를 이용한 VRIO Framework의 실증분석)

  • Song, Juyoung Julian;Sung, Hyungsuk
    • Journal of Korea Technology Innovation Society
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    • v.18 no.3
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    • pp.416-443
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    • 2015
  • The resource-based view (RBV) explains that the competitive advantage is mainly based on the resources which have strategic characteristics. Therefore, finding, developing and maintaining strategically valuable resources has been one of main research topics and a starting point in the corporate strategy structure in RBV. In this regards, attempts to recognize strategically valuable resources have been one of crucial issues in RBV researches. Especially, Barney's VRIO has been widely used as a practical tool for finding strategically valuable resources. However, empirical studies on VRIO framework's effectiveness have not been sufficiently implemented, and there has been no proven relation among the components of the VRIO so far. This is mainly because the concepts or definitions on core components of the VRIO - Value, Rareness, Inimitability, and Organization - are too comprehensively explained and measurements of each component cannot be easily quantified. Considering these, this paper presents empirical results of the relation between VRIO components and competitive advantage, and tests effectiveness of VRIO Framework with utilizing sufficient technology evaluation cases and financial statements of 2,252 technology based SMEs in Korea. As a result, the components of the VRIO have a positive influence on competitive advantage. The attributes of strategic resources - Value, Rareness, and Inimitability - have a statistically meaningful positive effect on organization, while organization has a positive effect on the competitive advantage serving as a parameter between the attributes of strategic resources and competitive advantage.

Effect of irradiation and LDPE content on crystal formation of PP (PP의 결정형성에 대한 조사가교와 LDPE 함량의 영향)

  • Dahal, Prashanta;Kim, Youn Cheol
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.15 no.6
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    • pp.4039-4045
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    • 2014
  • The crystallization behavior of irradiated polypropylene (PP) and the blend is an important parameter for polymer processing. Blends of PP/low density polyethylene (LDPE) with different LDPE contents were prepared by melt mixing in a twin screw extruder. The effect of the LDPE content on the irradiation effectiveness of the PP/LDPE blend with trimethylolpropane-trimetacrylate (TMPTMA) as a crosslinking co-agent was investigated in conjunction with the LDPE loading in the blend. The non-isothermal crystallization and crystal structure were measured by DSC, X-ray diffraction (XRD), and polarized optical microscopy (POM). A decrease in the melting temperature of PP was observed due to irradiation, which may be due to the PP chain scissioning effect of irradiation. The Ozawa component n represents a rod shaped, disc shaped and sphere-shaped geometry of the crystal if the value corresponds to 2, 3 and 4, respectively. Based on Ozawa analysis, the values of n were 3.8 and 2.3 for the pure PP and PP blends with 30 wt% LDPE, respectively. The fact that the crystal geometry of PP changed from spherical to disc and rod shaped was confirmed by Ozawa analysis and POM. The ${\beta}$ form XRD peak of the PP/LDPE blend at $16.1^{\circ}$ disappeared after irradiation due to the crosslinking reaction.

Semantic Dependency Link Topic Model for Biomedical Acronym Disambiguation (의미적 의존 링크 토픽 모델을 이용한 생물학 약어 중의성 해소)

  • Kim, Seonho;Yoon, Juntae;Seo, Jungyun
    • Journal of KIISE
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    • v.41 no.9
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    • pp.652-665
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    • 2014
  • Many important terminologies in biomedical text are expressed as abbreviations or acronyms. We newly suggest a semantic link topic model based on the concepts of topic and dependency link to disambiguate biomedical abbreviations and cluster long form variants of abbreviations which refer to the same senses. This model is a generative model inspired by the latent Dirichlet allocation (LDA) topic model, in which each document is viewed as a mixture of topics, with each topic characterized by a distribution over words. Thus, words of a document are generated from a hidden topic structure of a document and the topic structure is inferred from observable word sequences of document collections. In this study, we allow two distinct word generation to incorporate semantic dependencies between words, particularly between expansions (long forms) of abbreviations and their sentential co-occurring words. Besides topic information, the semantic dependency between words is defined as a link and a new random parameter for the link presence is assigned to each word. As a result, the most probable expansions with respect to abbreviations of a given abstract are decided by word-topic distribution, document-topic distribution, and word-link distribution estimated from document collection though the semantic dependency link topic model. The abstracts retrieved from the MEDLINE Entrez interface by the query relating 22 abbreviations and their 186 expansions were used as a data set. The link topic model correctly predicted expansions of abbreviations with the accuracy of 98.30%.

Design and Implementation of VoIP Equipment including Telephone Function for Home Gateway Connection (전화기 기능을 포함한 홈 게이트웨이 접속용 VOIP 장비 설계 및 구현)

  • Lee Yong-Soo;Jung Kwang-Wook;Chung Joong-Soo
    • The Journal of the Korea Contents Association
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    • v.4 no.4
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    • pp.123-131
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    • 2004
  • Internet is absolutely contributed to information technology revolution nowadays. Internet services such as voice and data, etc. are provided home or small office via home gateway. The development of communication equipment via home gateway is implemented rapidly, and its product various. This paper presents the design and implementation of the VoIP equipment including the telephone function based on the embedded environment and being connected to the home gateway and the PC because of taking 2-ethernet LAN ports. As developing environment, the STLC1502 developed at ST Microelectronics as single chip solution, VxWorks as RTOS, and C language as coding mechanism are used. The verification of the developed systems for the voice test is carried out for the gatekeeper via Internet. The performance parameter is considered as the call processing capacity measuring the time of the call setup and clearing, and the data processing capacity for the file transfer. As a call setup and clearing is about 95ms, the call processing capacity is about 10 calls per second. The data processing capacity is 5.7Mbps in case of file transfer of server and client environment. Therefore the performance result is satisfied in the aspect of the call processing time and the data transfer time in Internet.

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