• Journal of the Korean Statistical Society
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• 제22권2호
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• pp.235-247
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• 1993

The predictive density function of a potential future observation and its first four moments are obtained in this paper to study the effects of a non-normal prior of the unknown mean of a normal population. The derived predictive density function is modified to study changes in utility curves, used to choose the optimum treatment from a given set of treatments, at a given level of stimulus due to slight deviations from normality of the prior distribution. Numerical illustrations are provided to exhibit some effectsl.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2000년도 춘계학술대회논문집B
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• pp.258-263
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• 2000

River water is higher in temperature than the surrounding environment during the winter. It is highly suitable a heat source for heat pump system. Despite its suitability, however, it is not widely used, due to its fouling and corrosive nature in heat exchanger tubes of evaporator. It is designed prior-treatment system which come into direct contact with the river water, such as auto-seamer, ozone generator for bactericidal test and auto-cleaning system. And it is analyzed treatment effects for its operation. It is designed two-stage compression heat pump system using R-134a with heating load 35.16kW, ad analyzed its performance. As a result it is obtained 3.08 COP when mid-point pressure is 1,200kPa, and bypass ratio of flowing refreigerant to high-stage compressor is 25.1%

• 한국초지조사료학회지
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• 제17권1호
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• pp.67-74
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• 1997

This experiment was conducted in 1992 and 1993 at the forage experimental field, College of Agriculture and Life Sciences, Seoul National University, Suweon to determine timing of rye(Secde cemde L.) harvest and residue chemical treatment prior to tillage in minimizing the adverse effects of the rye residue on growth and yield of succeeding corn(Zea muys L.). Eight treatments were established in 1993 which included four treatments such as no paraquat (1, l'diiethyl- 4, 4'-bipyridinium dichloride), paraquat treatment at 10, 23, and both 23 and 10 days prior to tillage when rye was harvested on April 14, and another four treatments such as no paraquat, paraquat treatment at 1, 5 and 10 days prior to tillage when rye was harvested on April 26. No paraquat treatment significantly resulted in reductions in corn plant height on June 3 and 10 when rye was harvested on April 14, but differences in the plant height and leaf number of corn among treatments were generally nonsignificant. Corn LA1 and silk emergence were not affected by paraquat treatment times regardless of rye harvested dates, but silk emergence was delayed by 1 to 2 days with no paraquat when rye harvested on April 14. Corn dry matter and TDN yields were significantly increased by paraquat treatment at 10 and 5 days prior to tillage treatment when rye was harvested on April 14 and 26, respectively, but other agronomic characteristics such as dry matter percentage, ear percent to total dry matter, and stover and ear yields of corn at harvest showed little or no response to paraquat treatment times.

• Annals of Laboratory Medicine
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• 제38권6호
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• pp.545-554
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• 2018

Background: The increasing morbidity and mortality rates associated with Acinetobacter baumannii are due to the emergence of drug resistance and the limited treatment options. We compared characteristics of colistin-resistant Acinetobacter baumannii (CR-AB) clinical isolates recovered from patients with and without prior colistin treatment. We assessed whether prior colistin treatment affects the resistance mechanism of CR-AB isolates, mortality rates, and clinical characteristics. Additionally, a proper method for identifying CR-AB was determined. Methods: We collected 36 non-duplicate CR-AB clinical isolates resistant to colistin. Antimicrobial susceptibility testing, Sanger sequencing analysis, molecular typing, lipid A structure analysis, and in vitro synergy testing were performed. Eleven colistin-susceptible AB isolates were used as controls. Results: Despite no differences in clinical characteristics between patients with and without prior colistin treatment, resistance-causing genetic mutations were more frequent in isolates from colistin-treated patients. Distinct mutations were overlooked via the Sanger sequencing method, perhaps because of a masking effect by the colistin-susceptible AB subpopulation of CR-AB isolates lacking genetic mutations. However, modified lipid A analysis revealed colistin resistance peaks, despite the population heterogeneity, and peak levels were significantly different between the groups. Conclusions: Although prior colistin use did not induce clinical or susceptibility differences, we demonstrated that identification of CR-AB by sequencing is insufficient. We propose that population heterogeneity has a masking effect, especially in colistin non-treated patients; therefore, accurate testing methods reflecting physiological alterations of the bacteria, such as phosphoethanolamine-modified lipid A identification by matrix-assisted laser desorption ionization-time of flight, should be employed.

• Journal of Korean Neurosurgical Society
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• 제59권6호
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• pp.637-642
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• 2016

Objective : Although many treatment modalities have been introduced for trigeminal neuralgia (TN), the long-term clinical results remain unsatisfactory. It has been particularly challenging to determine an appropriate treatment strategy for patients who have responded poorly to initial therapies. We analyzed the surgical outcomes in TN patients who failed prior treatments. Methods : We performed a retrospective analysis of 37 patients with recurrent or persistent TN symptoms who underwent surgery at our hospital between January 2010 and December 2014. Patients with follow-up data of at least one year were included. The prior treatment modalities of the 37 patients included microvascular decompression (MVD), gamma knife radiosurgery (GKRS), and percutaneous procedures such as radiofrequency rhizotomy (RFR), balloon compression, and glycerol rhizotomy (GR). The mean follow-up period was 69.9 months (range : 16-173). The mean interval between the prior treatment and second surgery was 26 months (range : 7-123). We evaluated the surgical outcomes using the Barrow Neurological Institute (BNI) pain intensity scale. Results : Among the 37 recurrent or persistent TN patients, 22 underwent MVD with partial sensory rhizotomy (PSR), 8 received MVD alone, and 7 had PSR alone. Monitoring of the surgical treatment outcomes via the BNI pain intensity scale revealed 8 (21.6%) patients with a score of I, 13 (35.1%) scoring II, 13 (35.1%) scoring III, and 3 (8.2%) scoring IV at the end of the follow-up period. Overall, 91.8% of patients had good surgical outcomes. With regard to postoperative complications, 1 patient had transient cerebrospinal fluid rhinorrhea (2.7%), another had a subdural hematoma (2.7%), and facial sensory changes were noted in 8 (21.1%) patients after surgery. Conclusion : Surgical interventions, such as MVD and PSR, are safe and very effective treatment modalities in TN patients who failed initial or prior treatments. We presume that the combination of MVD with PSR enabled us to obtain good short- and long-term surgical outcomes. Therefore, aggressive surgical treatment should be considered in patients with recurrent TN despite failure of various treatment modalities.

• 열처리공학회지
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• 제3권4호
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• pp.1-9
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• 1990

In this study, the ausformed martensite cooled to $-196^{\circ}C$ with various deformation degrees in Fe-30%Ni-0.24%C alloy was transformed to reversed austenite at $500^{\circ}C$ by cyclic reverse martensitic transformation. The effects of prior deformation and the number of cyclic reverse transformation on the microstructure and the mechanical properities of reversed anstensite were investigated. Experimental results showed that the strength of reversed austenite was higher than that of original austenite. This is due to higher dislocation density and grain refining. The reversed austenite formed from ausformed martensite was highly strengthened by prior deformation. This strengthening effect of reversed austenite is attributed to higher dislocation density than grain fefining. The yield strength of reversed austenite below 30% prior deformation, but above 30% prior deformation the strength of reversed austenite is lower than that of deformed austenite. This is due to partly disappearance of strain hardening effect at higher deformation degree by reverse transformation. The strength of reversed austenite is increased with the number of cyclic transformation. Especially, it is principally strengthened by the first cyclic transformation and shows higher increase in yield strength than that of ultimate tensile strength.

• 열처리공학회지
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• 제11권4호
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• pp.247-257
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• 1998

In order to evaluate the relation between prior structure and fatigue strength on a induction surface hardened medium carbon steel(SAE1050M) for automotive drive shafts, torsional fatigue test were conducted with various cases of different hardened depths and applied loads. Prior structures of the steel such as pearlite, fine pearlite and spheroidal pearlite were prepared by conventional nomalizing, tempering after quenching and spheroidized annealing, respectively. Maximum torsional fatigue strength can be obtained when the case depth is 18~25% diameter of the bar in each prior structure. The effect of case depth on the torsional fatigue strength was different depending on applied load to specimen, but the most good fatigue life was shown in the case of pearlitic structure when the case depth was 4.0~5.5mm(18~25% of bar diameter). Among three different prior structures, energy consumption, to obtain high strength or to get the same case depth, was the most saved in the case of pearlitic structure.

• Biomolecules & Therapeutics
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• 제3권4호
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• pp.279-287
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• 1995

This study examined the anti-cancer effects of diallyl sulfide(DAS) and/or diallyl disulfide(DDS), major components of garlic oil, with the DEN-PH model in rats, by the numbers and areas per cm$^2$ of induced glutathion S-transferase placental form(GST-P) positive foci and silver-stained nucleolar organizer regions(Ag-NORs) counts per nuclei in liver as indicator. Sprague-Dawley(SD) rats were given the diethylnitrosamine(DEN, 200 mg/kg, i.p.) as initiator and 2 weeks later, in experiment 1, rats were treated with DAS(200 mg/kg, i.g.) and/or DDS(50 mg/kg, i.g.) for 6 weeks, respectively and concomitantly and also were given the same dose of DAS and/or DDS prior to DEN treatment for 2 weeks, and in experiment II, rats were treated with potential cancer promoter, 2-acetylaminofluorene (2-AAF, 20 mg/kg, i.g.). The DAS and/or DDS were treated prior to 2-AAF for 8 weeks, respectively and concomitantly. Then the anti-promoting effects of DAS and/or DDS were assessed. All rats were subjected to the two-thirds partial hepatectomy(PH) at week 3 and sacrificed at week 8. In experiment I, DAS and/or DDS treatment only prior to DEN showed inhibition of the development of GST-P positive foci. In experiment II, DAS and/or DDS treatment prior to 2-AAF promotion showed obvious inhibition of the development of GST-P positive foci in numbers and areas and AgNORs counts. In conclusion, We found DAS and/or DDS had the preventive effects on the hepatocarcinogenesis in rats and the concomitant treatment had some additive effects compared with the each treatment and AgNORs counts correlated well with the preneoplastic hepatic lesion.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제33권2호
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• pp.143-151
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• 2007

One of the treatment methods for maxillary cancers or infections in maxilla is maxillectomy. Palatal defect can be resulted from this operation and it may cause functional problems with swallowing and speech, and psychological problems of patients. After maxillectomy, as rehabilitation, there can be two options. One is a prosthodontic treatment using obturator and the other is surgical reconstruction of defect with graft. As both methods have advantages and disadvantages, in determining treatment method after maxillectomy, various factors have to be considered. The purpose of this study is to compare the prosthodontic group to surgical group after maxillectomy with elapsed days prior to commencement of postoperative oral feeding, and to analyze the results of prosthodontic treatment and surgical treatment. During the period from March of 2000 to June of 2006, 74 patients were treatment by prosthodontic methods for maxillary defect. Among these patients, patients who had only velopharyngeal deficiency after surgery, whose data were incomplete, whose causes of palatal defect were not the treatment of diseases in maxilla, and who already had palatal defect due to previous surgery were excluded in this study. The patients who underwent maxillectomy for the treatment of diseases in the maxilla and were treated immediately after operation using surgical reconstruction or prosthodontic rehabilitation were included in this study. The records of 43 patients were reviewed to compare and to analyze the prosthodontic treatment and surgical reconstruction after maxillectomy. The median of days elapsed prior to commencement of postoperative oral feeding in the prosthodontic group was compared with data of surgical group. The data was analyzed using the Mann-Whitney test (${\alpha}$=.05). Days elapsed prior to postoperative oral feeding commencement in the prosthodontic group were less than those in the surgical group.

• Asian-Australasian Journal of Animal Sciences
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• 제16권8호
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• pp.1118-1125
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• 2003

Research was carried out to clarify whether a suppression of dry forage intake during the early stages of feeding in ruminants is caused by feeding induced hypovolemia which is produced by the accelerated secretion of parotid saliva. Goats with a parotid fistula were fed roughly crushed alfalfa hay cubes, commercial ground concentrate feed and $NaHCO_3$ twice daily (10:00-12:00, 16:00-18:00). The animals were free access to drinking water all day prior to, during and after experiments. The animals were intraruminally infused every day prior to the morning feeding period with parotid saliva collected from the parotid fistula over a 24 h period. The present experiment consisted of two treatments, non-infusion (RNI) and intraruminal infusion of parotid saliva (RSF). In the RSF treatment, 4-5 kg of parotid saliva (280-290 mOsm/l) collected over a 24 h period was intraruminally infused 1 h prior to the commencement of the morning feeding. During feeding, eating and parotid saliva secretion rates were measured. Blood samples were also periodically collected from the jugular vein. During and after 2 h feeding, water intakes were measured, respectively. These measurements were used to define thirst levels. It is thought that rumen fill in the RSF treatment was higher than the RNI treatment. Plasma osmolality in the RSF treatment increased in the first half of the 2 h feeding period due to the intraruminal infusion of parotid saliva. Therefore, parotid saliva secretion rates in the RSF treatment were lower than the RNI treatment for 30 min period from 30 to 60 min after the commencement of feeding. On the other hand, plasma total protein concentration and hematocrit in the RSF treatment decreased by 3.2 and 3.3% prior to the commencement of feeding due to the intraruminal infusion of parotid saliva. In the first half of the 2 h feeding period, plasma total protein concentration and hematocrit in the RSF treatment showed a tendency to decrease compared to the RNI treatment. Thirst level in the RSF treatment during feeding was approximately 31.3% less than the RNI treatment. Upon the completion of the 2 h feeding period, cumulative feed intake in the RSF treatment was significantly larger (19.7%) than the RNI treatment. The results suggest that a suppression of dry forage intake during the early stages of feeding in goats is partly caused by feeding induced hypovolemia, which is produced by the accelerated secretion of parotid saliva.