• Title/Summary/Keyword: Pulsed electromagnetic field

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IME EFFECT OF PULSED ELECTROMAGNETIC FIELD ON THE CULTURED CALVARIAL CELLS OF RAT (맥동 전자기장이 백서의 배양 두개관세포에 미치는 영향)

  • Choi, Byung-Taek;Yang, Won-Sik
    • The korean journal of orthodontics
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    • v.20 no.3 s.32
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    • pp.499-517
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    • 1990
  • Electrical stimulation among several factors that influence bone remodeling has been studied by many investigators with great enthusiasm in orthodontic field. The action mechanisms of Pulsed Electromagnetic Field (PEMF) are different from those of the conventional electrode application method in that PEMF induces endogenous current in the living tissues. PEMF is known to have the healing effect in nonunion of bone and osteoporosis. It is widely used in orthopaedic scopes and the possibility of using the method in clinical orthodontics Is also conceivable. But the exact mechanisms by which the PEMF exerts its effects are not clearly understood. Therefore, the author wanted to see the effect of PEMF on five groups of rat calvarial cells obtained by sequential enzyme digestion method, and observed the changes in enzyme activation, collagen synthesis and $^3H-thymidine$ incorporation. The results were as follows: 1. Under the effect of PEMF, there were no changes in the alkaline phosphatase activity in five groups of cell populations. 2. Both the PEMF group and the PTH with PEMF group shelved no changes in acid phosphatase activities and there were no differences between two experimental groups. 3. Under the effect of PEMF, there was significant increase of collagen synthesis in the group V cell population. 4. Under the effect of PEMF, there were significant increases of $^3H-thymidine$ incorporation in the group IV and V cell populations.

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Electromagnetic Launcher Sub-scaling Relationships and Small System Design for Research and Educational Purposes

  • Yun, Heedo
    • Journal of Magnetics
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    • v.5 no.2
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    • pp.65-71
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    • 2000
  • Although the electromagnetic launcher technology has been progressed significantly during the past two decades the number of firing test facilities are not many. This is prbably due to the large budget and man power required to build and maintain full scale electromagnetic launcher facilities. As the EM launcher technology's potential capabilities have been somewhat demonstrated with the full scale large systems the research is now headed more toward overcoming specific difficulties and answering questions experimentally with smaller, cost effective systems. The first half of this paper presents EM launcher's improved sub-scaling relationships based upon magnetic, thermal and momentum differential equations and EM launcher's basic equations. With the proposed scaling method the field variables can be matched or scaled linearly between the two geometrically scaled systems. The second half of the paper presents pulsed power system's circuit analysis and design technique, which is applied to the capacitor-powered small pulsed power system with crow-barring circuitry. The effect of the so-called speed volt is included. A sub-scaled small system's design is provided as an example.

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The Effect of a Pulsed Electromagnetic Field with Time on Pain in Muscle Crushed Rat Model

  • Kim, Min-Hee;Cheon, Song-Hee
    • Journal of Magnetics
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    • v.17 no.1
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    • pp.68-71
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    • 2012
  • Acute injuries to skeletal muscles can lead to significant pain and disability. Muscle pain results in muscle weakness and range of motion (ROM) decreases. Pulsed electromagnetic fields (PEMF) promote tissue repair, healing rates and reduce musculoskeletal pain. The results of many previous studies suggest that PEMF can contribute to chronic pain reduction, particularly in musculoskeletal injurys. However, we do not have enough information of its effects compared to a placebo. The principal objective of this study was to investigate differences in acute pain induced by the direct destruction of muscle tissue (extensor digitorum) with varying times of the application of PEMF, measured through the expression of c-fos on the spinal cord. Significant reduction of pain was found in groups exposed to PEMF and the group exposed to PEMF immediately after muscle injury showed the most significant differences. In conclusion, PEMF may be a useful strategy in reducing acute pain in muscle injury.

The Influences of Pulsed Electromagnetic Field Treatment Following Experimentally Induced Delayed-Onset Muscle Soreness in Biceps Brachii (펄스자기장이 위팔 두갈래근의 지연성 근육통에 미치는 영향)

  • Kang, Sun-Young;Park, Joo-Hee;Jeon, Hye-Seon;Lee, Hyun-Sook
    • Physical Therapy Korea
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    • v.20 no.2
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    • pp.11-19
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    • 2013
  • Delayed onset muscle soreness (DOMS) is a painful condition that arises from exercise-induced muscle damage after unaccustomed physical activities. Various therapeutic interventions have been applied to reduce the intensity and duration of DOMS-related symptoms. Recently, pulsed electromagnetic field (PEMF) intervention has been introduced as an alternative noninvasive treatment for DOMS. This randomized, double-blind, placebo-controlled experiment was conducted to examine the effects of PEMF therapy on DOMS in elbow flexors at 24, 48, and 72 hours after the experimental DOMS induction. Thirty healthy volunteers ($23{\pm}2.4$ yrs, $175{\pm}5.7$ cm, and $74{\pm}7.8$ kg) participated in this study. Each was randomly assigned to a PEMF or placebo group. On the first day, DOMS was induced in the elbow flexors by repeated isokinetic motions at low ($60^{\circ}/s$) and fast ($120^{\circ}/s$) speeds in all subjects. Thereafter, the PEMF group received 15-min daily treatment with a PEMF device. The placebo group received sham treatment of the same duration. Overall, PEMF application was more effective than the sham treatment in reducing the physiological symptoms associated with the DOMS including perceived soreness, median frequency, and electromechanical delay of the surface electromyography. In addition, median frequency and isokinetic peak torque of the PEMF group recovered to the pre-DOMS induction level earlier than the placebo group. In conclusion, this study suggests that PEMF can be applied as a new recovery strategy in reducing DOMS symptoms. Further experiments are required to examine the effect of the PEMF treatment on different types of exercise conditions and to determine the optimal treatment dosage and duration in a real clinical setting.

Effect of Pulsed Electromagnetic Field on MMP-9 and TIMP-1 Levels in Chondrosarcoma Cells Stimulated with IL-1β

  • Caliskan, Serife Gokce;Bilgin, Mehmet Dincer;Kozaci, Leyla Didem
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.7
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    • pp.2701-2705
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    • 2015
  • Chondrosarcoma, the second most common type of bone malignancy, is characterized by distant metastasis and local invasion. Previous studies have shown that treatment by pulsed electromagnetic field (PEMF) has beneficial effects on various cancer cells. In this study, we investigated the effects of PEMF applied for 3 and 7 days on the matrix metalloproteinase (MMP) levels in chondrosarcoma SW1353 cells stimulated with two different doses of $IL-1{\beta}$. SW1353 cells were treated with (0.5 and 5 ng/ml) $IL-1{\beta}$ and PEMF exposure was applied either 3 or 7 days. MMP-9 and TIMP-1 levels were measured in conditioned media by enzyme-linked immunosorbent assay. The results were relative to protein levels. Statistical analyses were performed using one-way analysis of variance (ANOVA). P<0.05 was considered significant. PEMF treatment significantly decreased MMP-9 protein levels in human chondrosarcoma cells stimulated with 0.5 ng/ml $IL-1{\beta}$ at day 7, whereas it did not show any effect on cells stimulated with 5 ng/ml $IL-1{\beta}$. There was no significant change in TIMP-1 protein levels either by $IL-1{\beta}$ stimulation or by PEMF treatment. The results of this study showed that PEMF treatment suppressed $IL-1{\beta}$-mediated upregulation of MMP-9 protein levels in a dual effect manner. This finding may offer new perspectives in the therapy of bone cancer.

Evaluation of Anti-Inflammatory Effect of Pulsed Electromagnetic Field on DNCB-Induced Atopic Dermatitis Using Principal Component Analysis (주성분 분석을 이용한 펄스형 전자기장 자극을 통해 DNCB로 유발된 아토피성 피부염의 개선 효과 분석)

  • Lee, Jiyoung;Kim, Jun-Yong;Lee, Yerin;Kim, Ko Eun;Lee, Yongheum;Yang, Sejung
    • Journal of Biomedical Engineering Research
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    • v.42 no.3
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    • pp.94-99
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    • 2021
  • Atopic dermatitis (AD), a chronic inflammatory skin disease, is characterized by itchy and age-dependent lesions. Previous studies have shown that pulsed electromagnetic field (PEMF) significantly improved chronic ulcers and ununited fractures, providing an evidence for the application of PEMF in resolving inflammation caused by AD. This study investigated the anti-inflammatory effect of PEMF on DNCB-induced AD in animal models. Five male hairless mice (6 weeks old) per group were assigned to a normal group, a sham group, and two PEMF groups (15Hz, 75Hz). Mice were treated with 2,4-Dinitrochlorobenzene (DNCB) to induce uniform AD among all groups excluding a normal group. To examine the inflammatory progress and the improvement of AD after the PEMF stimulation, images are taken with various cameras for non-invasive evaluation and the results are expressed using principal component analysis (PCA) for visualization. The results of this study demonstrated that PEMF effectively improved skin lesions without the use of drugs.

Pulsed electromagnetic field potentiates etoposide-induced MCF-7 cell death

  • Woo, Sung-Hun;Kim, Bohee;Kim, Sung Hoon;Jung, Byung Chul;Lee, Yongheum;Kim, Yoon Suk
    • BMB Reports
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    • v.55 no.3
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    • pp.148-153
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    • 2022
  • Etoposide is a chemotherapeutic medication used to treat various types of cancer, including breast cancer. It is established that pulsed electromagnetic field (PEMF) therapy can enhance the effects of anti-cancer chemotherapeutic agents. In this study, we investigated whether PEMFs influence the anti-cancer effects of etoposide in MCF-7 cells and determined the signal pathways affected by PEMFs. We observed that co-treatment with etoposide and PEMFs led to a decrease in viable cells compared with cells solely treated with etoposide. PEMFs elevated the etoposide-induced PARP cleavage and caspase-7/9 activation and enhanced the etoposide-induced down-regulation of survivin and up-regulation of Bax. PEMF also increased the etoposide-induced activation of DNA damage-related molecules. In addition, the reactive oxygen species (ROS) level was slightly elevated during etoposide treatment and significantly increased during co-treatment with etoposide and PEMF. Moreover, treatment with ROS scavenger restored the PEMF-induced decrease in cell viability in etoposide-treated MCF-7 cells. These results combined indicate that PEMFs enhance etoposide-induced cell death by increasing ROS induction-DNA damage-caspase-dependent apoptosis.

Design and Evaluation of Pulsed Electromagnetic Field Stimulation Parameter Variable System for Cell and Animal Models (세포 및 동물모델용 펄스형 전자기장 자극 파라미터 가변장치 설계 및 평가)

  • Lee, Jawoo;Park, Changsoon;Kim, Junyoung;Lee, Yongheum
    • Journal of Biomedical Engineering Research
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    • v.43 no.1
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    • pp.11-18
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    • 2022
  • An electromagnetic generator with variable stimulation parameters is required to conduct basic research on magnetic flux density and frequency for pulsed electromagnetic fields (PEMFs). In this study, we design an electromagnetic generator that can conduct basic research by providing parameters optimized for cell and animal experimental conditions through adjustable stimulation parameters. The magnetic core was selected as a solenoid capable of uniform and stable electromagnetic stimulation. The solenoid was designed in consideration of the experimental mouse and cell culture dish insertion. A voltage and current adjustable power supply for variable magnetic flux density was designed. The system was designed to be adjustable in frequency and pulse width and to enable 3-channel output. The reliability of the system and solenoid was evaluated through magnetic flux density, frequency, and pulse width measurements. The measured magnetic flux density was expressed as an image and qualitatively observed. Based on the acquired image, the stimulation area according to the magnetic flux density decrease rate was extracted. The PEMF frequency and pulse width error rates were presented as mean ± SD, and were confirmed to be 0.0928 ± 0.0934% and 0.529 ± 0.527%, respectively. The magnetic flux density decreased as the distance from the center of the solenoid increased, and decreased sharply from 60 mm or more. The length of the magnetic stimulation area according to the degree of magnetic flux density decrease was obtained through the magnetic flux density image. A PEMF generator and stimulation parameter control system suitable for cell and animal models were designed, and system reliability was evaluated.

Pulsed Ferrite Magnetic Field Generator for Through-the-earth Communication Systems for Disaster Situation in Mines

  • Bae, Seok;Hong, Yang-Ki;Lee, Jaejin;Park, Jihoon;Jalli, Jeevan;Abo, Gavin S.;Kwon, Hyuck M.;Jayasooriya, Chandana K.K.
    • Journal of Magnetics
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    • v.18 no.1
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    • pp.43-49
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    • 2013
  • A pulsed ferrite magnetic field generator (FMFG) was designed for the use in the 1000 m long through-the-earth (TTE) communication system for mining disaster situations. To miniaturize the TTE system, a ferrite core having 10,000 of permeability was used for the FMFG. Attenuation of the magnetic field intensity from the FMFG (200-turn and 0.18 m diameter) was calculated to be 89.95 dB at 1000 m depth soil having 0.1 S/m of conductivity. This attenuation was lower than 151.13 dB attenuation of 1 kHz electromagnetic wave at the same conditions. Therefore, the magnetic-field was found to be desirable as a signal carrier source for TTE communications as compared to the electromagnetic wave. The designed FMFG generates the magnetic field intensity of $1{\times}10^{-10}$ Tesla at 1000 m depth. This magnetic field is detectable by compact magnetic sensors such as flux gate or magnetic tunneling junction sensor. Therefore, the miniature FMFG TTE communication system can replace the conventional electromagnetic wave carrier type TTE system and allow reliable signal transmission between rescuer and trapped miners.

Effect of Pulsed Electromagnetic Field Treatment on Alleviation of Lumbar Myalgia; A Single Center, Randomized, Double-blind, Sham-controlled Pilot Trial Study

  • Park, Won-Hyung;Sun, Seung-Ho;Lee, Sun-Gu;Kang, Byoung-Kab;Lee, Jong-Soo;Hwang, Do-Guwn;Cha, Yun-Yeop
    • Journal of Magnetics
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    • v.19 no.2
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    • pp.161-169
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    • 2014
  • The aim of this study is to investigate the efficacy of pulsed electromagnetic field (PEMF) on the alleviation of lumbar myalgia. This is a randomized, real-sham, double blind pilot study. 38 patients were divided into the PEMF group and the Sham group, each of which was composed of 19 patients (1 patient dropped out in the Sham group) of randomized allocation. The PEMF group was treated by using the PEMF device and the Sham group by using a sham device on the lumbar muscle and acupuncture points, three times a week for a total of two weeks. Evaluations of Visual Analogue Scale for bothersomeness (VASB), Visual Analogue Scale for pain intensity (VASP), Oswestry Disability Index (ODI), 36-Item Short Form Health Survey Instrument (SF-36), EuroQol-5Dimension (EQ-5D), Beck's Depression Inventory (BDI) and Roland-Morris Disability Questionnaire (RMDQ), etc. before and 1 week after treatment were carried out. The primary outcome measure was the VASB, measured 1 week after the end of the pulsed electromagnetic therapy. VASB scores for the PEMF group changed by $-2.06{\pm}2.12$ from the baseline, and that for the Sham group changed by $-0.52{\pm}0.82$ (p < 0.05). VASP scores for the PEMF group were reduced by $-2.10{\pm}2.12$ from the base line, and that for the Sham group was reduced by $-0.53{\pm}1.50$ (p < 0.05). PEMF group showed significant improvements in all VASB, VASP, ODI, SF-36, EQ-5D, BDI and RMDQ scores, while the Sham group showed significant improvements in all scores, except the VASP score. However, the VASB, VASP and RMDQ scores of the PEMF group were much lower than those of the Sham group. The two groups showed no significant difference in ODI, SF-36, EQ-5D and BDI. This study demonstrates the effectiveness of PEMF treatment for alleviating lumbar myalgia.