• Natural Product Sciences
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• v.27 no.1
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• pp.54-59
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• 2021

Bergenia ciliata (Family: Saxifragaceae) is a folklore remedy for the treatment of various ailments in Asian countries. Bergenin (1) has been isolated as an active constituent in many studies, however, the amount of bergenin has not been determined in all parts of the plant. A simple RP-HPLC method was developed to determine the amount of bergenin in methanol extracts of leaves, rhizomes and roots of the plant. Separation was achieved on an Agilent Eclipse XDB-C18 column maintained at 25 ℃ using isocratic solvent system (water: methanol: acetic acid; 62.5:37:0.5 v/v/v) adjusted at pH 2 0 at a flow rate of 1.0 mL/min. and detected at 275 nm. Correlation coefficient (0.9952) showed linearity of concentration (5-200 ㎍/mL) and response. The values of LOD (0.00947 ㎍/mL) and LOQ (0.02869 ㎍/mL) indicated that method was sensitive. The recovery of bergenin was 99.99-100% indicating accuracy of method. The methanol extract of rhizomes contained higher amount of bergenin (19.4%) than roots (9.2%) and leaves (6.9%). It is concluded that methanol extract of rhizomes is a better source of bergenin than other parts of the plant. The findings are useful for standardization of bergenin containing extracts and herbal preparations.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.12
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• pp.5107-5110
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• 2015

The State of Punjab has been in focus because of aperceived increasing rate of cancer. Both print and electronic media have created an impression that Punjab, especially the cotton belt of Malwa Region, has become a high incidence cancer region. Actually the increased number of cancer patients might be at least partly because of increasing population and heightened health awareness and reporting. The purpose of this study is to find out the pattern of cancer amongst patients registered in Mukh Mantri Punjab Cancer Rahat Kosh Scheme (MMPCRKS), under cancer registry at Rajindra Hospital Patiala from the various districts of Punjab. The study covers 500 cancer patients registered under MMPCRKS at Rajindra Hospital Patiala, for free cancer treatment. Information regarding age, gender, religion, method of diagnosis and affected sites was obtained. Results were analyzed statistically. Of the 500 patients, 65% were females and 35% were males. The most affected female age groups were 50-54 and 60-64; while males in the age groups of 65-69 and 60-64 had the highest risk. The leading cancers in females were breast followed by cervix and ovary where as in males they were were colon followed by esophagus and tongue. The commonest histological type was adenocarcinoma followed by squamous cell carcinoma. The increasing trend of cancer in Punjab is alarming. Since this study is a preliminary investigation, it could provide a leading role in prevention, treatment and future planning regarding cancer in Punjab.

• The Journal of Asian Finance, Economics and Business
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• v.8 no.9
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• pp.67-77
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• 2021

The importance of Entrepreneurship has been widely acknowledged by researchers and practitioners worldwide, however, the idea of Social Entrepreneurship is still considered to be an emerging area. Entrepreneurship is vital not only because of its economic impacts but also because it helps to address issues of poverty and welfare, where it can act as a catalyst for change. The importance of social entrepreneurship is that it serves to turn a profit and find success while helping others throughout the world. They know the power of social enterprise and are eager to serve the societal and economic benefits. This study aims to identify the level of orientation of youth towards social entrepreneurship in Pakistan. The study identifies the role of various factors that affect Social Entrepreneurial Orientation and is conducted following a quantitative research strategy and survey research design where data is collected from 302 individuals. Structural Equation Modelling was used to analyze the data and to test the hypotheses. The main finding of this research is that there is an increasing trend in the orientation towards social entrepreneurship. The exogenous variables namely Perceived Educational Support, Perceived Structural Support, and Perceived Relational Support were found to have positive and significant effects on the endogenous construct of Social Entrepreneurial Orientation.

• Asian Journal for Public Opinion Research
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• v.9 no.1
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• pp.48-82
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• 2021

This research article attempts to understand the current situation of fake news on social media in India. The study focused on four characteristics of fake news based on four research questions: subject matter, presentation elements of fake news, debunking tool(s) or technique(s) used, and the social media site on which the fake news story was shared. A systematic sampling method was used to select a sample of 90 debunked fake news stories from two Indian fact-checking websites, Alt News and Factly, from December 2019 to February 2020. A content analysis of the four characteristics of fake news stories was carefully analyzed, classified, coded, and presented. The results show that most of the fake news stories were related to politics in India. The majority of the fake news was shared via a video with text in which narrative was changed to mislead users. For the largest number of debunked fake news stories, information from official or primary sources, such as reports, data, statements, announcements, or updates were used to debunk false claims.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.7
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• pp.3349-3355
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• 2012

Background and objectives: Chromosomal abnormalities play an important role in genesis of acute lymphoblastic leukemia (ALL) and have prognostic implications. Five major risk stratifying fusion genes in ALL are BCR-ABL, MLL-AF4, ETV6-RUNX11, E2A-PBX1 and SIL-TAL1. This work aimed to detect common chromosomal translocations and associated fusion oncogenes in adult ALL patients and study their relationship with clinical features and treatment outcome. Methods: We studied fusion oncogenes in 104 adult ALL patients using RT-PCR and interphase-FISH at diagnosis and their association with clinical characteristics and treatment outcome. Results: Five most common fusion genes i.e. BCR-ABL (t 9; 22), TCF3-PBX1 (t 1; 19), ETV6-RUNX1 (t 12; 21), MLL-AF4 (t 4; 11) and SIL-TAL1 (Del 1p32) were found in 82/104 (79%) patients. TCF3-PBX1 fusion gene was associated with lymphadenopathy, SIL-TAL1 positive patients had frequent organomegaly and usually presented with a platelets count of less than $50{\times}10^9/l$. Survival of patients with fusion gene ETV6-RUNX1 was better when compared to patients harboring other genes. MLL-AF4 and BCR-ABL positivity characterized a subset of adult ALL patients with aggressive clinical behaviour and a poor outcome. Conclusions: This is the first study from Pakistan which investigated the frequency of5 fusion oncogenes in adult ALL patients, and their association with clinical features, treatment response and outcome. Frequencies of some of the oncogenes were different from those reported elsewhere and they appear to be associated with distinct clinical characteristics and treatment outcome. This information will help in the prognostic stratification and risk adapted management of adult ALL patients.

• Honam Mathematical Journal
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• v.43 no.1
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• pp.152-166
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• 2021

In this paper, we study the geometry of semi-slant lightlike submanifolds of an indefinite Kenmotsu manifold. The integrability conditions of distributions D1 ⊕ {V}, D2 ⊕ {V} and RadTM on semi-slant lightlike submanifolds of an indefinite Kenmotsu manifold are defined. Furthermore, we derive necessary and sufficient conditions for the above distributions to have totally geodesic foliations.

• Honam Mathematical Journal
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• v.46 no.1
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• pp.47-59
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• 2024

The purpose of the Nash embedding theorem was to take extrinsic help for studying the intrinsic Riemannian geometry. To realize this aim in actual practice there is a need for optimal relationships between the known intrinsic invariants and the main extrinsic invariants for Riemannian submanifolds. This paper aims to provide an optimal relationship for CR-warped product submanifolds of locally conformal Kähler manifolds.

• Clinical and Experimental Reproductive Medicine
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• v.44 no.4
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• pp.159-170
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• 2017

The development of biomarkers of reproductive medicine is still in its infancy because many black boxes are still present in reproductive medicine. Novel approaches to human infertility diagnostics and treatment must be developed because reproductive medicine has lagged behind in the implementation of biomarkers in clinical medicine. Despite the dearth of the available literature, the current rapid pace of publications suggests that this gap will soon be filled therefore; this review is a $pr\acute{e}cis$ of the research that has been done so far and will provide a basis for the development of biomarkers in reproductive medicine.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.12
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• pp.4877-4883
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• 2014

Cervical cancer is one of the leading causes of morbidity and mortality amongst the gynecological cancers worldwide, especially in developing countries. There are few to no initial symptoms and signs. This study was conducted to assess the awareness level of young Pakistani women about cervical cancer and to educate them about this deadly disease. A detailed questionnaire regarding demographic data and information about cervical cancer was distributed in different cities of Punjab. A total of 873 women took part in this survey and 70.1 percent were totally unaware of this cancer. Only 8.5% of the whole surveyed population knew accurately about cancer of cervix, 7% of the surveyed respondents correctly specified the human papilloma virus as the causative agent. Only 5.2% respondents were able to identify the Pap smear test as a diagnostic measure. Out of all the surveyed population only 4.3% of individuals were found to be vaccinated against this disease and the majority was found from the medical profession. Medical professionals, students, working women, housewives and uneducated individuals took active part in this survey. This study demonstrates a low level of awareness among Pakistani women and a need for an active campaign by media and government to increase understanding as well as introducing measures for improved prevention and treatment of cervical cancer.

• Archives of Pharmacal Research
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• v.17 no.2
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• pp.131-133
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• 1994

New istain-3-isonicotinylhydrazones, isationazine and its Mannich bases and spiro (indoline-3,2'-thiadiazoline)-2-one have been synthesized. These compounds have been screenced for their antibacterial activity against the Gram-positive and Gram-negative bacteria.