• Natural Product Sciences
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• v.13 no.4
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• pp.347-354
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• 2007

In this study, we investigated the potential of Resina Pini (RP) for anti-inflammatory and analgesic agents to treat inflammatory diseases such as gingivitis and periodontitis. Crude RP (RP1), recrystallized RP (RP2), and Ramus Mori Albae-treated RP (RP3), plus their respective water extracts (RP1-WE, RP2-WE and RP3-WE) were prepared for in vitro and in vivo tests. We couldn't find any signs of heavy metals pollution in all the RP samples. RP2-WE exhibited the highest viability of human gingival fibroblasts (HGF) and the strongest scavenging activity on superoxide anion. RP1, RP2 and RP3, RP2 showed potent scavenging activity on DPPH free radical. RP2-WE displayed a stronger inhibition on hyaluronidase (HAase) activity and RP3 also displayed potent HAase inhibition. RP2-WE, RP3-WE, RP3 and RP2 were reduced admirably the production of $PGE_2$ in HGF. In addition, RP2-WE and RP3-WE exhibited potent inhibitory activities on arachidonic acid-induced ear edema in mouse. Moreover, RP-2 prevented completely acetic acid-induced writhing by 100.0% and RP1, RP3, RP1-WE and RP2-WE also exhibited excellent protective activities against writhing. While aminopyrine, the positive control, showed 76.9% analgesic effect at the same dose. Taken together, these results suggest that recrystallized aqueous extract of Resina Pini could be a promising drug for the treatment of periodontal diseases.

• Korean Journal of Microbiology
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• v.26 no.3
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• pp.173-180
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• 1988

Chromosomal gene transferable hybrid plasmids, RP4::Mu cts and RP4::mini-Mu, were transferred by conjugation from E. coli to Pseudomonas strains. In order to use for recipient cells of RP4::Mu cts and RP4:: mini-Mu, plasmid-free Pseudomonas strains were characterized for their antobiotic resistance, aromatic hydrocarbon utility and degradation patterns of chlorinated herbicide. Transfer frequencies of RP4::mini-Mu exhibited about $10^{-2}$ to $10^{-4}$, while those of RP4::Mu cts exhibited very low value of $10^{-7}$ in recipients tested except Pseudomonas aeruginosa KU557. Existance of hybrid plasmids in Pseudomonas transconjugants were identified by their antibiotic resistance and agarose gel electrophoresis. In case of RP4::Mu cts transconjugants it was also confirmed by demonstrating that they were capable of releasing phage and forming plaques at $43^{\circ}C$. Plaque forming unit of the transconjugants was about $10^{5}$. It was shown by the stability test that RP4::Mu cts and RP4::mini-Mu in Pseudomonas were relatively stable.

• CDE review
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• v.2 no.2
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• pp.12-16
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• 1996

Rapid Prototyping(RP)이란 짧은 시간 내에 CAD 그래픽 데이터로부터 3차원 형상의 시제품을 만들어 내는 기술을 일컬으며, 1986년 3D Systems라는 회사에 의하여 상용화된 SLA(Stereolithography Apparatus)방식을 선두로 하여 지난 10년간 급속히 발전을 해왔다. 원하는 형상의 부품을 만들 때 기존의 machining은 원자재에서 재료를 깎아내면서 만드는 반면에, RP는 재료를 한 층씩 차례로 쌓아서 부품을 만드는 가산적인 공정 특징을 가지고 있다. 액체, 고체, 심지어 기체 상태의 재료까지 다양한 재료를 사용하고 있으며 또한 여러가지 적층방법으로 부품을 제작하고 있다. 성공적인 RP기술의 창출에는 RP기계제작에 직접 관계되는 기술뿐만 아니라, 재료 기술, RP제작에 적합한 CAD데이터 생성기술, 후처리 및 가공기술 등이 모두 관건이 된다. 여기서는 RP기술의 주요 파트 제작방법과 RP에 쓰이는 재료, RP의 용도 및 그 한계성 등에 대하여 생각하여 보았다. RP기술은 3차원 CAD 모델이 없으면 실현이 불가능하다. 3차원(3D)화는 제품을 설계하고 만드는 대부분의 회사가 경쟁력을 갖기 위하여 싫든 좋든 이루어야 하는 목표 중의 하나라고 할 수 있는데, RP기술 도입은 이러한 3차원화를 단축시키는 촉매제의 역할을 할 수 있다고 생각한다. RP기술이 부분적으로 정확도의 문제와 제작 가능한 재료의 종류 및 성능에 제한이 있지만, 현재로서도 여러 응용분야에 성공적으로 이용되고 있으며 향후에는 더욱 그 응용 범위를 넓혀갈 것으로 전망된다.

• The KIPS Transactions:PartC
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• v.8C no.1
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• pp.60-67
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• 2001

Multicast Protocol for multimedia service on the Internet can be classified into two types, e.g., source based tree and shared tree according to difference of tree construction method. Shared tree based multicast is known to show outstanding results in the aspect of scalability than source based tree. Generally, There have been lots of researches on the method to satisfy QoS constraints through proper Rendezvous Point (RP) in the shared tree. In addition, as the multicast group members join and leave dynamically in the service time, RP of the shared tree should b be reselected for guranteeing Qos to new member, But, RP reselection method has not been considered generally as the solution to satisfy QoS C constraints. In this paper, new initial RP selection and RP reselection method are proposed, which utilize RTCP (Real Time Control Protocol) report packet fields. Proposed initial RP selection and RP reselection method use RTCP protocol which underlying multimedia application service So, the proposed method does not need any special process for collecting network information to calculate RP. New initial RP selection method s shows better performance than random and topology based one by 40-50% in simulation. Also, RP reselection method improves delay p performance by 50% after initial RP selection according to the member’s dynamicity.

• Korean Journal of Veterinary Research
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• v.53 no.3
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• pp.143-147
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• 2013

Ginsenoside Rp1 is one of ginseng saponins with chemotherapeutic activity. In this study, we investigated the effects of Rp1 on spleen cells. Spleen is a major immune organ consisted of crucial immune cells, such as T lymphocytes, B lymphocytes, natural killer cells, and some antigen-presenting cells. Although the anti-tumor potential of Rp1 was studied, the effects of Rp1 on immune cells have not investigated yet. A viability assay using 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT), flow cytometric analysis, Western blot analysis were used to detect cellular changes on Rp1-treated spleen cells. MTT assay showed that Rp1 decreased the viability of spleen cells. To further investigate the effects of Rp1 on activated spleen cells, we treated lipopolysaccharide (LPS) as a representative inflammatory agent and Rp1 on spleen cells in a combination. The surface expression levels of activation markers for lymphocytes, CD25 and CD69 were measured. Apoptotic analysis revealed the cytotoxic effects of Rp1 on both na$\ddot{i}$ve and activated cells, and the expression pattern of some apoptosis-related proteins was correlated to apoptotic events of cells. Taken together, ginsenoside Rp1 increases the cellular death of spleen cells and also inhibits the LPS-induced activation of spleen cells.

• Journal of the Korean Society for Precision Engineering
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• v.20 no.2
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• pp.120-128
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• 2003

When considering the use of rapid prototyping (RP), there are many issues a designer has to address for handling an STL model, the de facto standard fur RP. Today designers can skip all these issues by visiting web-based service bureaus that readily supply needed information for the RP services. Since orders are taken for RP parts through the web page of service providers designers are now asked to upload their STL files to the company server either by direct upload, ftp file transfer, or as an e-mail attachment. If the service bureau, however, fixes or edits an STL filceto optimize the RP process but neglects to tell its customer about the rework in detail, it may cause problems down the line in processing of the original CAD data for other applications. In this paper, we propose a framework for a collaborative virtual environment between CAD designers and RP processes on the internet which directly provides designers with an advanced preprocessor functionality, design visualization, as well as model display, repair, and slicing over the network. This can help smooth data transfer from CAD to RP process with minimum inconsistency in CAD.

• Natural Product Sciences
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• v.11 no.1
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• pp.27-32
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• 2005

The purpose of this study is to evaluate the inhibitory effects of Resina Pini against Streptococcus mutans (S. mutans) that is one of the major causes of dental caries and oral diseases. Topically applied Resina Pini (RP) would be incorporated in saliva and thus the factor associated with water solubility should be considered. In this paper, therefore, effects of various treatment for RP and activities of water extracts from unprocessed and processed RP were compared. The crude RP (RP1) and the recrystallized RP (RP2) in ethanol solution showed strong antimicrobial activities (d.>15mm) against S. mutans. All RP samples exhibited considerable inhibitory effect against glucosyltransferase produced by S. mutans $(IC_{50}=91.2\;to\;276.2\;{\mu}g/ml)$. The very considerable increase in cellular permeability of S. mutans was observed with RP1, RP2 and their water extracts. These results suggest that RP1 and RP2 may be a potential source for pharmaceutical products used for prevention and/or treatment of dental caries and periodontal disease.

• Journal of Animal Science and Technology
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• v.48 no.5
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• pp.663-670
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• 2006

The present study was performed to investigate the effect of plant type recombinant porcine somatotropin (pST) adminstration on growth performance and blood profile of finishing pigs. Forty-eight Landrace barrows weighing 78 kg were employed for six week growth trial. Twelve barrows were allocated into various rpST types ; the control (CONT), the 4:1 type rpST (TRT 1), the 1:1 type rpST (TRT 2); and the 4:1 type rpST group(TRT 3) respectively. CONT group were not planted rpST. TRT 1 group was treated with rpST once a week for 6 weeks. Each dose contained the rpST equivalent to 100mg from initial to two weeks and 125mg from three weeks to finial week. TRT 2 and TRT 3 groups were planted rpST four times contained the rpST equivalent to 100mg during trial period from initial to two weeks, and 125 mg from three weeks, to four weeks, respectively. All pigs were fed a commercial feed containing 0.9% lysine ad lib. Daily gain increased by 19.4% in TRT 1(p<0.05) compared to the CONT. rpST improved feed/gain by 13.4～28.9% in all treatment groups(p<0.05). Back fat thickness of the all rpST treated groups were 23.3～29.2% thinner than that of the CONT. These results indicated that the rpST stimulated growth performance in finishing pigs and plant type rpST could be used as a growth stimulant for finishing pigs.

• Biomolecules & Therapeutics
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• v.16 no.4
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• pp.370-376
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• 2008

Ginsenoside Rp1 (G-Rp1) is a ginseng saponin derivative with chemopreventive and anti-cancer activities. In this study, we examined the regulatory activity of G-Rp1 on the functional activation of macrophages. G-Rp1 remarkably inhibited TNF-$\alpha$ production, LPS-induced cell cytotoxicity, NO production, ROS generation, and phagocytic uptake from lipopolysacchride (LPS)-activated RAW264.7 cells. According to structural feature study using several G-Rp1 analogs, two carbohydrates (glucose-glucose) at R1 position were observedto be highly effective, compared to other structural derivatives. Although the inhibitory activities of G-Rp1 on macrophage functions were not remarkable, several points that G-Rp1 was known to be safe, and that this compound was orally effective, suggest that G-Rp1 may be beneficial in treating macrophage-mediated immunological diseases.

• Journal of Korean Clinical Nursing Research
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• v.26 no.3
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• pp.305-313
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• 2020

Purpose: The purpose of this study was to identify factors influencing the Radiation Protection(RP) behaviors of endoscopy nurses during endoscopic interventional radiology. Methods: A total of 188 endoscopy nurses working at 30 tertiary or general hospitals participated in this questionnaire-based study. The questionnaire included items on general and job related characteristics, RP knowledge, RP attitude, RP behavior, self-efficacy, and safety climate. Data were collected through online surveys from March 22 to April 10, 2019. Results: Multivariate analysis revealed that RP attitude (β=.65, p<.001), safety climate (β=.12, p=.035), self-efficacy (β=.14, p=.009), and existence of RP protocols (β=.11, p=.038) were significant predictors of better RP behavior. Conclusion: The findings showed that the RP behavior of endoscopy nurses was at high levels and the continuing education for endoscopy nurses and development of a radiation safety management education program were important to improve RP behavior.