• Biomolecules & Therapeutics
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• 제24권1호
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• pp.85-93
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• 2016

We already reported that genetically engineered resveratrol-enriched rice (RR) showed to down-regulate skin melanogenesis. To be developed to increase the bioactivity of RR using calli from plants, RR was adopted for mass production using plant tissue culture technologies. In addition, high-pressure homogenization (HPH) was used to increase the biocompatibility and penetration of the calli from RR into the skin. We aimed to develop anti-melanogenic agents incorporating calli of RR (cRR) and nanoparticles by high-pressure homogenization, examining the synergistic effects on the inhibition of UVB-induced hyperpigmentation. Depigmentation was observed following topical application of micro-cRR, nano-calli of normal rice (cNR), and nano-cRR to ultraviolet B (UVB)-stimulated hyperpigmented guinea pig dorsal skin. Colorimetric analysis, tyrosinase immunostaining, and Fontana-Masson staining for UVB-promoted melanin were performed. Nano-cRR inhibited changes in the melanin color index caused by UVB-promoted hyperpigmentation, and demonstrated stronger anti-melanogenic potential than micro-cRR. In epidermal skin, nano-cRR repressed UVB-promoted melanin granules, thereby suppressing hyperpigmentation. The UVB-enhanced, highly expressed tyrosinase in the basal layer of the epidermis was inhibited by nano-cRR more prominently than by micro-cRR and nano-cNR. The anti-melanogenic potency of nano-cRR also depended on pH and particle size. Nano-cRR shows promising potential to regulate skin pigmentation following UVB exposure.

• 대한한방종양학회지
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• 제2권1호
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• pp.75-90
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• 1996

This experiment was designed to study the antitumor effects and Activity of Natural Killer Cell of semen Tiglii plus Rhizoma Rhei. The cytotoxic and antitumor effects were evaluated on human cell lines(A549, Caki-1, LL2, Sarcoma 180, NIH/3T3) after exposure to prebrewed Semen Tiglii plus Rhizoma Rhei water extract 0.1, 0.2, 0.4, 0.8, 1.6mg/ml using in MTT assay, LDH, colony forming efficency and SRB assay which were regarded as a valuable method for cytotoxic and antitumor effects of unknown compound on tumor cell lines. The results obtained in this studies were as follows. 1. From the result of MTT assay, the cytotoxicity of ST(生巴豆霜), ST+RR(生巴豆霜加大黃) were concentration-dependently increased in both group of the ST and ST+RR, the cytotoxicity of ST+RR(生巴豆霜加大黃) was similar to that of ST(生巴豆霜). 2. From the result of LDH, the cytotoxicity of ST, ST +RR were concentrati -on-dependently increased in both group of the ST and ST+RR, the cytotoxicity of ST+RR was similar to that of ST. 3. The antitumor effect on A549 tumor cell from the result of colony forming efficiency showed the inhibitory effect on the growth in both group of the ST and ST+RR, the inhibitory effect on growth was low slightly in the ST+RR. 4. From the result of SRB assay, the antitumor effect on caki-1 tumor cell of ST, ST+RR showed the inhibitory effect on the growth in both group of the ST and ST+RR, the antitumor effect of ST+RR was similar to that of ST. 5. Median survival time and increased life span were increased slightly in both group of the ST and ST+RR. 6. The inhibitory effect on the growth of Sarcoma 180 and Lewis lung carcinoma tumor cell were increased slightly in both group of the ST and ST+RR. 7. The activity of NK cell was increased in the ST+RR.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제23권1호
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• pp.35-48
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• 2020

Purpose: Gastrointestinal symptoms are often related to antibiotic treatment. Their incidence, risk and protective conditions in children are not well defined and represent the aims of this study. Methods: We prospectively enrolled inpatient children submitted to antibiotic treatment. Indication, type, dose and duration of treatment, probiotic supplementation and gastrointestinal symptoms were recorded at recruitment, after two and four weeks. Antibiotic-associated diarrhea (AAD) was defined as the presence of at least 3 loose/liquid stools within 14 days from antibiotic onset. Results: AAD occurred in 59/289 (20.4%) of patients, with increased risk in children younger than 3 years (relative risk [RR]=4.25), in lower respiratory (RR=2.11) and urinary infections (RR=3.67), intravenous administration (RR=1.81) and previous AAD episodes (RR=1.87). Abdominal pain occurred in 27/289 (9.3%), particularly in children >6 years (RR=4.15), with previous abdominal pain (RR=7.2) or constipation (RR=4.06). Constipation was recorded in 23/289 (8.0%), with increased risk in children having surgery (RR=2.56) or previous constipation (RR=7.38). Probiotic supplementation significantly reduced AAD (RR=0.30) and abdominal pain (RR=0.36). Lactobacillus rhamnosus GG (LGG) and L. reuteri significantly reduced AAD (RR=0.37 and 0.35) and abdominal pain (RR=0.37 and 0.24). Conclusion: AAD occurred in 20.4% of children, with increased risk at younger age, lower respiratory and urinary tract infections, intravenous treatment and previous AAD. LGG and L. reuteri reduced both AAD and associated abdominal pain.

• 한국정보통신학회논문지
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• 제15권12호
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• pp.2655-2663
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• 2011

지금까지 심방세동을 검출하는 방법은 P파의 형태, 시간 주파수 영역 분석법이 주를 이루었다. 하지만 P파는 잡음의 영향을 많이 받는 환경에서는 검출의 정확도가 떨어지며, 시간 주파수 영역 분석법은 RR 간격에 따라 변화하는 불규칙적 리듬에 관한 정보를 정확하게 얻지 못하는 단점이 있다. 본 연구에서는, P파의 형태는 고려하지 않고, 불규칙 RR 간격 리듬의 비선형적 특성 분석을 통한 심방세동 검출 알고리즘을 제안한다. 이를 위해 불규칙 RR 간격 리듬을 다양성, 무작위성, 복잡성으로 각각 정의하고 제곱평균제곱근(RMSSD), 전환점비(TPR), 표본 엔트로비(SpEn)의 3가지 비선형적 특성 분석을 통하여 심방세동을 분류하였다. 제안된 알고리즘의 검출 성능을 평가하기 위해 3가지 통계치의 최적값을 설정하고 MIT-BIH 심방세동 데이터베이스와 부정맥 데이터베이스를 이용하여 실험하였다. 성능 평가 결과, MIT-BIH 심방세동 데이터베이스에 대해서는 민감도(sensitivity:94.5%), 특이도(specificity:96.2%)를 각각 나타내었으며, 부정맥 데이터베이스에 대해서는 민감도(89.8%), 특이도(89.62%)를 각각 나타내었다.

• 정보보호학회지
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• 제16권1호
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• pp.99-111
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• 2006

바인딩 갱신 프로토콜은 이동노드가 흠 링크가 아닌 외부 링크로 이동했을 경우 기존 통신노드와 지속적인 연결을 유지하고 경로를 최적화하기 위한 목적으로 설계된 프로토콜이다. IETF의 모바일 IPv6 표준문서에는 RR(Return Routability) 기법을 이용해서 바인딩 갱신을 수행하도록 권장하고 있다 하지만 RR 기법이 모바일 IPv6 보안 요구사항들을 전적으로 보장하지 않는다. 이 문제점을 해결하기 위해 IETF에서는 RR 기법에 IPsec을 이용하여 바인딩 갱신을 수행할 것을 권장하고 있다. 그러나 단기간의 연결 세션을 갖거나 저전력의 모바일 장치에 IPsec을 사용하는 것은 효율성이 떨어질 수 있다. 이 논문에서는 표준으로 제안된 RR 기법을 비롯하여. RR의 문제점을 해결하고자 제안된 여러 프로토콜을 살펴보고. 각 프로토콜의 안전성과 효율성을 분석한다.

• Nuclear Engineering and Technology
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• 제55권10호
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• pp.3700-3708
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• 2023

The stochastic origin ensembles method with resolution recovery (SOE-RR) has been proposed to reconstruct proton-induced prompt gammas (PGs), and the reconstructed PG image was used for range verification. However, due to low detection efficiency, the number of valid events is low. Such a low-count condition can degrade the accuracy of the SOE-RR method for proton range verification. In this study, we proposed two strategies to improve the reconstruction of the SOE-RR algorithm for low-count PG imaging. We also studied the number of iterations and repetitions required to achieve reliable range verification. We simulated a proton beam (10⁸ protons) irradiated on a water phantom and used a two-layer Compton camera to detect 4.44-MeV PGs. Our simulated results show that combining the SOE-RR algorithm with restricted volume (SOE-RR-RV) can reduce the error of the estimation of the Bragg peak position from 5.0 mm to 2.5 mm. We also found that the SOE-RR-RV algorithm initialized using a back-projection image could improve the convergence rate while maintaining accurate range verification. Finally, we observed that the improved SOE-RR algorithm set for 60,000 iterations and 25 repetitions could provide reliable PG images. Based on the proposed reconstruction strategies, the SOE-RR algorithm has the potential to achieve a positioning error of 2.5 mm for low-count PG imaging.

• 한국식품영양과학회지
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• 제33권7호
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• pp.1133-1138
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• 2004

본 연구는 streptozotocin(STZ)을 투여하여 고혈당이 유발된 생쥐(UM군)에 생지황(Rhemanniae Radix) 전탕액의 투여(5.0 mL/kg/day, RR군)효과를 밝히기 위하여 수행하였다. STZ로 유발된 생쥐에 생지황 전탕액을 6주 동안 구강 투여한 후 혈당과 당내성 검사 및 췌장섬의 면역조직화학 검사를 하였다. 혈당수준은 RH군이 HM군에 비하여 2, 3, 5, 6주에서 유의성 있게 낮았으며, 당내성 검사 또한 RR군이 HM군에 비하여 우수한 결과를 보여 주었다. 6주 후 insulin-양성 5-세포들과 insulin-like growth factor-II 양성 물질들은 HM군에 비하여 RR군에서는 보다 높게 나타났다. HM군에서는 apoptosis 면역반응성 과립들이 췌장섬 전반에 걸쳐 관찰되었으나, RR군에서는 일부 세포들의 핵에서 면역반응성을 보여주었다. HM군에서는 대부분 췌장섬들이 파괴되어 소수 관찰되었으나 RR군은 다수 관찰되었다. 이와 같은 결과로 보아 생지황 전탕액은 STZ로 유발된 손상으로부터 췌장섬을 회복시키는 효과가 있는 것으로 사료된다.

• 한국엔터테인먼트산업학회논문지
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• 제14권4호
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• pp.355-363
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• 2020

이 연구는 만성요통환자의 호흡패턴이상과 통증관의 상관관계를 알아보기 위해 실시하였다. 104명의 만성요통환자의 날숨끝 이산화탄소농도(EtCO₂)와 호흡률을 카프노그래프를 통해 측정하였고, 호흡유지시간과 Nijmegen Questionnaire, 가슴우리 움직임거리, 시각적사상척도를 추가로 평가하였다. Pearson's 검사로 상관관계를 분석하였으며, 결과는 EtCO₂와 BHT, 가슴우리 움직임거리에서 통계적으로 유의한 상관관계를 보였으며(r=.302, r=.281)(p<.01), RR과 VAS에서 낮은 음의 상관관계(r=-.253,-.200)(p <.05)를 보였다. RR과 NQ에서도 유의한 상관관계를 보였으며(r=.237)(p<.05). 가슴우리 움직임거리와 VAS사이에서는 낮은 음의 상관관계를 보였다(r=-.370)(p<.01). 가슴 호흡과 가로막호흡 사이의 EtCO₂, RR, BHT, 가슴우리 움직임거리, 그리고 VAS에서 통계적으로 유의한 차이가 있었으며(p<.05), NQ에서는 유의한 차이가 없었다(p>.05). 만성요통환자의 EtCO₂, BHT, 가슴우리움직임거리, RR, 그리고 VAS 사이에는 상관관계가 있었다. 또한, RR과 NQ, 흉부 소풍과 VAS 사이에는 상관관계를 보였다. 결과적으로 호흡패턴이상과 통증 사이에는 밀접한 관계가 있었으며, 가슴호흡과 가로막호흡의 비교에서 EtCO₂, RR, BHT, 가슴우리 움직임거리 및 VAS에서 유의한 차이가 있었다. 이것은 만성요통환자의 재활 및 통증 관리에서 호흡패턴중재가 기초자료로 사용될 수 있을 것으로 사료된다.

• 한방안이비인후피부과학회지
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• 제21권3호
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• pp.104-110
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• 2008

Objectives : This experiment study was performed to investigate the anti-inflammation and anti-oxidant effects of Indigo Naturalis(IN) and Rehmanniae Radix(RR) which were herbs for clearing heat. Methods : Anti-inflammation and anti-oxidation effects of IN and RR that were measured by the inhibitory ability of Nitric oxide(NO) production and the scavenging for 1,1-diphenyl-2-picrylhydrazyl(DPPH) radical. Results : 1. IN and RR groups were not showed cell toxicity. 2. In the inhibitory ability of NO production, IN groups were better than RR groups, but there were no statistical significances among the groups. 3. In the scavenging for DPPH radical, IN groups were better than RR groups, but there were no statistical significances among the groups. Conclusions : These results showed that the IN group was better than the RR group in treating skin eruptions, especially those such as erythema, purple spot, papule, pustules which appear in acute inflammation.

• Journal of the Korean Statistical Society
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• 제34권4호
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• pp.297-309
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• 2005

We consider 'efficiency versus privacy-protection' problem concerned with several well-known randomized response (RR) devices to estimate pro­portion of people bearing a stigmatizing characteristic in a community. The literature of RR on respondent's privacy protection discusses only about response specific jeopardy measures. We propose a measure of jeopardy that is independent of the RR offered by the interviewee and recommend it for using as a technical characteristic of the RR device. For ensuring better cooperation from the interviewees this new measure that depends only on the design parameters of the RR devices may be disclosed to the respondents before producing the RR by implementing the randomization device.