• Journal of Korean Neurosurgical Society
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• v.29 no.1
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• pp.72-77
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• 2000

The authors describe the experience with the interactive image-guided Zeiss SMN system, which has been applied to 20 patients with various intracranial lesions during one year. Preoperative radiologic evaluation was CT scan in 6 cases, MRI in 14 cases. In all except one case, average fiducial registration errors were less than 2mm. There was no statistical difference in registration error between CT and MR image. This system considered to be relatively stable with respect to soft and hardware. Also it was useful for the designing of the scalp incision and bone flap and assessing the extent of resection in tumors, especially in gliomas. Moreover, it was helpful to evaluate complex surgical anatomy in skull base surgery.

• The Journal of Korean Physical Therapy
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• v.13 no.2
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• pp.433-444
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• 2001

This review highlights the ontogenesis and the differentiation of motor neuron in spinal cord, and introduce the survival motor neuron(SMN) which is associated with growth and survival of motor neurons. The differentiation of floor plate cells and motor neurons in the vertebrate neural tube appears to be induced by signals from the notochord. This signal is Sonic hedgehog(Shh). The early development of motor neurons involves the inductive action of Shh. The SMN gene is essential for embryonic viability. SMN mRNA is also expressed in virtually all cell types in spinal cord, including large motor neurons. The SMN protein is involved in RNA processing and during early embryonic development is necessary fer cell survival. Two SMN genes are present in 5q 13 in humans: the telomeric gene(SMNt), which is the SMA-determining gene, and the centromeric analog gene(SMNc). The majority of transcripts from the SMNt gene are full length but, major transcripts of the SMNc gene have a high degrees of alternative splicing and tend to have little or no exon 7. The SMN is involved in the RNA processing(the biogenesis of snRNPs and pre-mRNA splicing), the anti-apoptotic effects, and regulating gene expression.

• Applied Chemistry for Engineering
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• v.32 no.5
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• pp.556-561
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• 2021

Recently, iron oxide nanoparticles have been used as the subject of many studies on drug delivery system (DDS) due to their excellent magnetic properties and biocompatibility in response to external magnetic fields. In this study, hyaluronic acid-superparamagnetic microneedles (HA-SMNs) and carboxy methyl cellulose-superparamagnetic microneedles (CMC-SMNs) containing superparamagnetic iron oxide nanoparticles (SIONs) were prepared with HA and CMC as a matrix materials of MNs (microneedles). Various properties of SMNs were then investigated with scanning electron microscopy (SEM), superconducting quantum interference device-vibrating sample magnetometer (SQUD-VSM), frequency mixing magnetic detection (FMMD), and polymer/bio membrane. The SQUID-VSM measurements showed superparamagnetism of HA-SMNs and CMC-SMNs containing SIONs. The FMMD results demonstrated that the signal intensity changed significantly as the concentration of SIONs increased. In addition, SMNs exhibited the average skin permeability intensities on the bio membrane for HA-SMNs and CMC-SMNs were 92.5 and 98.5%, respectively. These results suggested that SMNs could be utilized as deliver materials for a TDDS and MR molecular imaging.

• Journal of Genetic Medicine
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• v.1 no.1
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• pp.33-37
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• 1997

Spinal muscular atrophy (SMA) is the second most common fatal disease of childhood with autosomal dominant mode of inheritance, and in its less severe form the third most common neuromuscular disease of childhood after Duchenne muscular dystrophy. The genetic defect was found to be on the long arm of chromosome 5 (5q11.2-q13.3) where many genes and microsatellite markers were missing. One of the most important genes is the Survival Motor Neuron (SMN) gene which is homozygously missing in 90% of SMA patients. Another important gene, the Neuronal Apoptosis Inhibitory Protein (NAIP) gene was found to be defective in 67% of SMA type I patients. Studies so far suggest SMA occurs when the genes on the long arm of chromosome 5 are mutated or deleted. Recently our hospital encountered 2 SMA patients of type I and II respectively. These patients both had homozygously defective SMN genes but intact NAIP genes. We are reporting these cases with bibliographic review and discussion. Korean SMA patients presumably have defects in SMN genes similar to those found in European patients, although the significance of NAIP genes remains to be established. SMN gene defects can be easily diagnosed using PCR and restriction enzymes, and this method could be applied towards convenient prenatal diagnosis and towards screening for family members at risk.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.58 no.5
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• pp.1025-1034
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• 2009

In steel making production line, steel slabs are given a unique identification number. This identification number, Slab management number(SMN), gives information about the use of the slab. Identification of SMN has been done by humans for several years, but this is expensive and not accurate and it has been a heavy burden on the workers. Consequently, to improve efficiency, automatic recognition system is desirable. Generally, a recognition system consists of text localization, text extraction, character segmentation, and character recognition. For exact SMN identification, all the stage of the recognition system must be successful. In particular, the text localization is great important stage and difficult to process. However, because of many text-like patterns in a complex background and high fuzziness between the slab and background, directly extracting text region is difficult to process. If the slab region including SMN can be detected precisely, text localization algorithm will be able to be developed on the more simple method and the processing time of the overall recognition system will be reduced. This paper describes about the slab region localization using SIFT(Scale Invariant Feature Transform) features in the image. First, SIFT algorithm is applied the captured background and slab image, then features of two images are matched by Nearest Neighbor(NN) algorithm. However, correct matching rate can be low when two images are matched. Thus, to remove incorrect match between the features of two images, geometric locations of the matched two feature points are used. Finally, search rectangle method is performed in correct matching features, and then the top boundary and side boundaries of the slab region are determined. For this processes, we can reduce search region for extraction of SMN from the slab image. Most cases, to extract text region, search region is heuristically fixed [1][2]. However, the proposed algorithm is more analytic than other algorithms, because the search region is not fixed and the slab region is searched in the whole image. Experimental results show that the proposed algorithm has a good performance.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.48 no.5
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• pp.381-387
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• 2003

Winter hairy vetch (HV) can be used as green manure with conventional tillage system (CT), in which chemical N fertilizer required for cultivation of sub-sequent com could be fully saved, or as cover crop with no-tillage system (NT) in which soil could be protected from erosion, control of weed, and the reduction of N fertilizer application. This experiment was carried out to compare the enrichment of soil mineral nitrogen (SMN) at corn root zone, and the changes of com growth and N uptake according to HV amounts (winter fallow, above-ground HV removed, intact HV, and HV added from aboveground HV removed) under two tillage systems in the upland field of National Crop Experiment Station, Suwon, Korea in 1996. HV cultivation during winter decreased SMN a little at com planting. HV incorporation with CT increased SMN rapidly during early growth stage according to rapid decomposition of Hv. SMN by HV cover with NT was increased slowly and its increase was higher in the surface soil (soil layer 0-7.5cm) compared to deep soil layer 7.5-22cm. Com growth and N status at corn silking stage, com yield and N uptake at harvest were increased in proportion to aboveground HV amounts regardless of tillage system. Average hairy vetch nitrogen (HV-N) uptake efficiency by com was 10% higher with CT than with NT in which average HV-N uptake efficiency was 43 %. Corn yields were not different between two tillage systems, but corn N uptake was increased by 33 kgN/ha more with CT than with NT due to the increase of corn N concentration. The increase of SMN and com N uptake from HV cover with NT could not be disregarded though those with CT were higher than with NT

• Journal of Microbiology and Biotechnology
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• v.13 no.4
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• pp.487-494
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• 2003

2,3-Dihydroxybiphenyl 1,2-dioxygenase (23DBDO), an enzyme of the biphenyl biodegradation pathway encoded by the bphC gene of Comnmonas sp. SMN4, was expressed and purified using column chromatographies. SDS-PAGE of purified 23DBDO showed a single band with a molecular mass of 32 kDa, which was consistent with the data from the gel filtration chromatography (GFC). The purified enzyme exhibited a maximum 23DBDO activity at pH 9.0 and was stable at pH 8.0. The enzyme showed maximum activity at $40^{\circ}C$ and maintained activity at $30^{\circ}C$ for 24 h. Kinetic parameters represented by Michaelis-Menten constants such as $K_m\;and\;V_{max}$ values for various substrates were determined by Lineweaver-Burk plots: The purified enzyme 23DBDO from Comamonas sp. SMN4 had the highest catalytic activity for 2,3-dihydroxybiphenyl and 3-methylcatechol, and had very poor activity with catechol and 4-methylcatechol.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.13 no.6
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• pp.478-484
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• 2000

The structural changes and the microwave dielectric properties of $Ba_{1-x}$/A$_{x}$/(Mg$_{1}$3//Nb$_{2}$3/)O$_3$(A=Sr, Ca=x0, 0.2, 0.4, 0.6, 0.8, 1.0) were investigated. The densities of samples are gradually decreased with increasing x(BMN=6.1, SMN=5.22 and CMN=4.26 g/m$^3$)The crystal structure of BMN was untilting of oxygen octahedral. The structural changes of BSMN showed the antiphase tilting at x>0.4, and those of BCMN showed the antiphase tilting at 0.20.8. The variation of dielectric constant with Sr was small(BMN=32, SMN=30) However the variation with Ca was large the highest value was 42 at Ca=0.2(CMN=25) The maximum quality factor was 68,000 GHz at Sr=0.2 and the minimum quality factor was 3,000 GHz at Ca=0.2 (BMN=35,000, SMN=20,000 and CMN=23,000 GHz) The temperature coefficients of resonant frequency of BSMN were about 2 times larger than those of BCMN in all composition.ion.

• Investigative Magnetic Resonance Imaging
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• v.21 no.4
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• pp.223-232
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• 2017

Purpose: To report the use of multiband accelerated echo-planar imaging (EPI) for resting-state functional MRI (rs-fMRI) to achieve rapid high temporal resolution at 3T compared to conventional EPI. Materials and Methods: rs-fMRI data were acquired from 20 healthy right-handed volunteers by using three methods: conventional single-band gradient-echo EPI acquisition (Data 1), multiband gradient-echo EPI acquisition with 240 volumes (Data 2) and 480 volumes (Data 3). Temporal signal-to-noise ratio (tSNR) maps were obtained by dividing the mean of the time course of each voxel by its temporal standard deviation. The resting-state sensorimotor network (SMN) and default mode network (DMN) were estimated using independent component analysis (ICA) and a seed-based method. One-way analysis of variance (ANOVA) was performed between the tSNR map, SMN, and DMN from the three data sets for between-group analysis. P < 0.05 with a family-wise error (FWE) correction for multiple comparisons was considered statistically significant. Results: One-way ANOVA and post-hoc two-sample t-tests showed that the tSNR was higher in Data 1 than Data 2 and 3 in white matter structures such as the striatum and medial and superior longitudinal fasciculus. One-way ANOVA revealed no differences in SMN or DMN across the three data sets. Conclusion: Within the adapted metrics estimated under specific imaging conditions employed in this study, multiband accelerated EPI, which substantially reduced scan times, provides the same quality image of functional connectivity as rs-fMRI by using conventional EPI at 3T. Under employed imaging conditions, this technique shows strong potential for clinical acceptance and translation of rs-fMRI protocols with potential advantages in spatial and/or temporal resolution. However, further study is warranted to evaluate whether the current findings can be generalized in diverse settings.

• Journal of the Korean Ceramic Society
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• v.36 no.7
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• pp.762-766
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• 1999

The crystal structure of A2+(Mg1/3Nb2/3)O3,(A2+=Sr2+ and Ca2+)ceramics was studied usig X-ray diffraction (XRD) and high resolution transmission electrion microscopy(HRTEM). Ba(Mg1/3Nb2/3)O3 (SMN) has the 1:2 ordered monoclinic structure which has the anti-phase tilt of octahedra. The type of tilting in SMN was considered to be a$^{\circ}$a$^{\circ}$c- or a­a­c$^{\circ}$ Ca(Mg1/3Nb2/3)O3 (CMN) also has the 1:2 ordered monoclinic structure which was distorted by the anti-phase tilt or in-phsae tilt of octahedra. A unit cell containing both the in-phase tilt axis and anti-phase tilt axis was not observed in the CMN. Therefore CMN has the mixed phase consisting of the 1:2 ordered monoclinic phase with anti-phase tilt of octahedra and the one with in -phase tilt of ocatahedra,. The anti-parallel shift of cation was also observed in the CMN.