• Title/Summary/Keyword: SMR

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Complete Nucleotide Sequence of Small Multidrug Resistance Plasmid pKH4 (Small Multidrug Resistance(smr) 플라스미드 pKH4의 염기서열 결정)

  • 고창학;문경호
    • YAKHAK HOEJI
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    • v.43 no.6
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    • pp.789-792
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    • 1999
  • The complete nucleotide sequence of pKH4, a small multidrug resistance (smr) plasmid isolated from multidrug resistant Staphylococcus aureus SA5, was determined. Sequence analysis has revealed that pKH4 has two open reading frames for Rep and Smr proteins. The comparison of the amino acid sequence of Smr protein of pKH4 with those of other Smr proteins of various Staphylococcus showed that Smr protein of pKH4 is a new member of the SMR family.

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Comparison of Meta-analysis Results with and Without Adjustment for Healthy Worker Effect on the Association Between Occupational Exposure to Trichloroethylene and Cancer Risk (건강근로자효과 보정 전후의 메타 분석 결과 비교 -직업적 트리클로로에틸렌 노출과 암의 연관성-)

  • Park, Tae Won;Hwang, Sung Ho;Lee, Kyoung-Mu
    • Journal of Environmental Health Sciences
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    • v.40 no.5
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    • pp.385-396
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    • 2014
  • Objectives: By conducting a meta-analysis of cohort studies reporting standardized mortality ratios (SMRs) for workers exposed to trichloroethylene, we attempted to adjust for healthy hired effect by applying the same methods as described in a recent report from the Agricultural Health Study. Methods: Among all cohort studies that evaluated the association between all cancer, non-Hodgkin's lymphoma (NHL), kidney cancer, liver cancer and occupational exposure to trichloroethylene, a total of 10 studies reporting SMR values were selected. A random-effects model was used to estimate the summary SMRs or rSMRs and 95% confidence intervals. Relative SMR ($rSMR=SMR_x/SMR_{not\;x}$) was calculated comparing observed and expected counts for all cancer, NHL, kidney cancer, and liver cancer with an independent referent set of values consisting of the observed and expected counts for other causes. Results: The SMR values for all causes ranged from 0.68 to 1.03, suggesting moderate to weak healthy worker effect for the selected studies. When the healthy worker hire effect was taken into account, the summarized risk became statistically significant; the summary SMR of all cancer was 0.95 (0.91-1.00) and the summary rSMR of all cancer was 1.10 (1.04-1.15). The summary SMR of NHL was 1.04 (0.93-1.14) and the summary rSMR of NHL was 1.23 (1.04-1.46). The summary SMR of kidney cancer was 1.08 (0.88-1.33) and the summary rSMR of kidney cancer was 1.23 (1.02-1.49). The summary SMR of liver cancer was 0.88 (0.78-0.99), and the summary rSMR of liver cancer was 0.95 (0.84-1.07). Conclusion: The rSMR method is useful to determine summary risk adjusted for healthy worker effect through meta-analysis.

Analysis of the Economy of Scale for Domestic Steam Methane Reforming Hydrogen Refueling Stations Utilizing the Scale Factor (Scale Factor를 이용한 국내 천연가스 개질식 수소충전소의 규모의 경제 분석)

  • GIM, BONGJIN;YOON, WANG LAI;SEO, DONG JOO
    • Transactions of the Korean hydrogen and new energy society
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    • v.30 no.3
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    • pp.251-259
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    • 2019
  • The aim of this study is to evaluate the economic feasibility of domestic on-site steam methane reforming (SMR) hydrogen refueling stations. We evaluated the levelized cost of hydrogen (LCOH) for the SMR hydrogen refueling stations, which have production capacities of 100 kg/day (SMR 100), 200 kg/day (SMR 200), and 500 kg/day (SMR 500) utilizing the scale factor. The main results indicated that the LCOH of SMR 100, SMR 200, and SMR 500 were 14,367 won/kg, 11,122 won/kg, and 8,157 won/kg, if the utilizations of hydrogen stations were 70%. These results imply that the production capacity of the domestic SMR hydrogen station should be greater than 500 kg/day to compete with other hydrogen stations when we consider the current sale price of hydrogen at the hydrogen stations.

Improvement of Resonant Characteristics due to the Thermal Annealing Effect in Multi-layer Thin-film SMR Devices (Thermal Annealing 효과에 의한 다층 박막 FBAR 소자의 공진 특성 개선)

  • ;;Mai Linh
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2003.10a
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    • pp.633-636
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    • 2003
  • In this work, We, for the first time, present the effects of the thermal annealing of the W/SiO$_2$ multi-layer quarter wavelength reflectors on the resonant properties of the ZnO-based SMR devices. In order to improve the resonant properties of the SMR devices, we annealed thermally the reflectors formed on a silicon substrate using a RF magnetron sputtering technique. As a result, the resonant properties of the SMR devices were observed to strongly depend on the annealing conditions applied to the reflectors. The SMR devices with the reflectors annealed at 40$0^{\circ}C$/30min showed excellent resonance properties as compared to those with the reflectors non-annealed (as-deposited). The newly proposed simple thermal annealing process will be very useful to more effectively improve the resonant properties of the future SMR devices with W/SiO$_2$ multi-layer quarter wavelength reflectors.

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신업보건역학연구사례 - SMR, PMR, Healthy Worker Effect

  • Lee, Won-Cheol;Park, Jeong-Il;Maeng, Gwang-Ho
    • 월간산업보건
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    • s.67
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    • pp.30-35
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    • 1993
  • 지난 호에 게재하였던 Formaldehyde와 nasal cancer의 관련성에 관한 글에서 볼수 있었던 바와 같이 SMR과 PMR은 산업보건역학연구에서 가장 흔히 접하게 되는 지수들이다. SMR을 설명하다 보면 heal worker effect를 설명하지 않을수 없게 된다. 이 글에서는 SMR, PMR, 그리고 healthy worker effect에 대한 설명을 하고자 하였다

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Effects of Salvia Miltriorrhiza Radix on Neuronal Apoptosis following Intracerebral Hemorrhage of Rats (단삼(丹蔘)이 뇌조직출혈 흰쥐의 신경세포 자연사에 미치는 영향)

  • Lee, Hung-Gi;Kim, Youn-Sub
    • The Korea Journal of Herbology
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    • v.27 no.3
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    • pp.89-94
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    • 2012
  • Objects : The purpose of this study was to observe the effect of Salviae Miltriorrhiza Radix(SMR) water-extract on intracerebral hemorrhage(ICH) and neuronal apoptosis in the injured areas. Method : ICH was induced by the stereotaxic intrastriatal injection of bacterial collagenase type IV in Sprague-Dawley rats. The rats were givened oral SMR treatment once a day for three days after the ICH treatment. TUNEL positive cells in the affected regions were performed by TUNEL assay, Bax and Bcl-2 positive cells by immunohistochemistry and the Bax expression by western blotting method. Results : The results are as follow; 1. SMR significantly reduced the number of TUNEL positive cells in the peri-hematoma reigions of ICH-induced rats. 2. SMR significantly reduced the number of Bax positive cells in the peri-hematoma regions of ICH-induced rats. 3. SMR did not affect the number of Bcl-2 positive cells in the peri-hematoma regions of ICH-induced rats. 4. SMR significantly reduced the Bax expressions compared with ICH group in hemorrhagic hemisphere of ICH-induced rats. Conclusion : These results suggest that SMR is effective in reducing neuronal apoptosis.

Hamstring Foam Roller release and Sole Self Myofascial Release for Improving Hamstring Muscles Flexibility in Participants with Hamstring Shortness

  • Kim, Geun-Woo;Lee, Ji-Hyun
    • Journal of the Korean Society of Physical Medicine
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    • v.15 no.4
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    • pp.1-9
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    • 2020
  • PURPOSE: The current generation has shortened hamstrings due to a sedentary lifestyle, resulting in reduced flexibility of the hamstring and dysfunction. This study was undertaken to compare effects of three different release exercises on hamstring flexibility, in participants with short hamstrings. METHODS: Totally, 20 subjects having short hamstrings were involved in this study. The inclusion criterion for study participation was active knee extension test (AKET) less than 60°. All participants were subjected to 3 methods: hamstring foam roller release (HFRR), sitting self myofascial release (sitting SMR), and standing self myofascial release (Standing SMR). All participants randomly performed all three methods to avoid bias caused by learning or fatigue. Passive knee extension test (PKET), AKET, finger to floor distance test (FTFT), and pelvic tilting angle test (PTAT) were measured pre- and post-exercises. RESULTS: The PKET, AKET and FTFT were significantly increased after HFRR, sitting SMR, and standing SMR exercise (p < .05). However, PTAT was not significantly increased after the three exercises (p > .05). Furthermore, no significant differences were observed between PKET, AKET, FTFT and PTAT subsequent to HFRR, sitting SMR, and standing SMR (p > .05). CONCLUSION: Our results indicate that HFRR, sitting SMR and standing SMR were immediately effective in improving hamstring flexibility in participants with short hamstrings.

Effects of Salviae miltiorrhizae Radix (SMR) on Serum Lipid Level in Hyperlipidemic Rats (단삼(丹蔘)이 고지혈증 흰쥐의 혈중 지질 변화에 미치는 영향)

  • Kim, Hyeong-Cheol;Kim, Hyung-Woo;Kim, Yong-Seong;Lee, Jang-Sik;Kwon, Jeong-Nam;Kim, Young-Gyun;Cho, Su-In
    • The Korea Journal of Herbology
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    • v.22 no.4
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    • pp.239-245
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    • 2007
  • Objective : Salviae miltiorrhizae Radix (SMR) has widely used to treat patients with cardiovascular diseases such as coronary arteriosclerosis, angina pectoris and hyperlipidemia. This study was designed to investigate the effects of SMR on changes in serum cholesterol and protective effects on liver tissue damage in Hyperlipidemic rats. Methods : The present author investigated changes in serum glucose, cholesterols, AST/ALT and histopathological changes of liver tissue by oral administration of SMR in Rats. Results : In this study, body weights of hyperlipidemic rats induced high fat diet did not changed, and treatment with SMR did not affect body weights in hyperlipidemic rats. For experimental period, Food and Water uptake in SMR administered group were the same as those in hyperlipidemic control group. In this experiment, treatment with SMR decreased total cholesterol and AST in serum which elevated by high fat diet respectively. In addition, SMR administration protected liver tissue from damage induced by induction of hyperlipidemia. Conclusions: These results suggest that SMR is useful to treat patients with disease related to cardiovascular diseases including hyperlipidemia, because SMR can decrease cholesterol and AST in serum and also have non-specific protective effect on tissues including liver.

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Potential Explosion Risk Comparison between SMR and DMR Liquefaction Processes at Conceptual Design Stage of FLNG (FLNG개념설계 단계에서 SMR 및 DMR 액화공정의 잠재적 폭발위험도 비교)

  • You, Wonwo;Chae, Minho;Park, Jaeuk;Lim, Youngsub
    • Journal of Ocean Engineering and Technology
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    • v.32 no.2
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    • pp.95-105
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    • 2018
  • An FLNG (floating liquefied natural gas) or LNG FPSO (floating production, storage and offloading) unit is a notable offshore unit with the increasing demand for LNG. The liquefaction process on an FLNG unit is the most important process because it determines the economic feasibility, but would be a hazard source because of the large quantity of hydrocarbons. While a high efficiency process such as C3MR has been preferred for onshore liquefaction processes, a relatively simple process such as the SMR (single mixed refrigerant) or DMR (dual mixed refrigerant) liquefaction process has been selected for offshore units because they require a more compact size, lighter weight, and higher safety due to their space limitation for facilities and long distance from shore. It is known that an SMR has the advantages of a simple configuration, small footprint, and lower risk. However, with an increased production rate, the inherent safety of SMR needs to be evaluated because of its small train capacity. In this study, the potential explosion risks of the SMR and DMR liquefaction processes were evaluated at the conceptual design stage. The results showed that an SMR has a lower overpressure than a DMR at the same frequency, only with a small production capacity of 0.9 MTPA. With increased capacity, the overpressure of the SMR was higher than that of the DMR. The increased number of trains increased the frequency in spite of the small amount of equipment per train. This showed that the inherent risk of an SMR is not always lower than that of a DMR, and an additional risk management strategy is recommended when an SMR is selected as the concept for an FLNG liquefaction process compared to the DMR liquefaction process.