• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.260.2-260.2
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• 2002

SPH-2 is a herbal medicine composing oriental prescription. We have studied the antidiabetic effect and mechanism of SPH-2 in insulin-resistant diabetic db/db mice. Mice were grouped and treated for 3 weeks as follows: control group was administrated with tap water orally: treated group was administrated with SPH-2 orally at dose of 500 mg/kg. SPH-2 lowered plasma glucose level by 43% as compared to the diabetic control. Total cholesterol. triglyceride and free fatty acid were all reduced in SPH-2 treated group. (omitted)

• 한국해안·해양공학회논문집
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• 제26권1호
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• pp.9-15
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• 2014

암석과 같은 입자들로 구성된 구조체의 거동을 일반적인 요소망을 이용한 유한요소해석으로 구현하기 어렵다. 이는 입자로 구성된 구조체의 거동 해석시 입자간의 상호작용을 무시할 수 없기 때문이다. 본 연구에서는 입자로 구성된 구조체(rock-berm)의 분할에 Smooth Particle Hydrodynamics (SPH) 기법을 이용하여 충돌해석을 수행하고 이를 기존의 Lagrange 기법을 사용한 해석결과와 비교하여 SPH 기법의 적용 가능성을 알아보았다. 결과적으로 SPH 기법이 입자로 구성된 구조체의 충돌해석에 사실적인 모사가 가능한 것으로 파악되었다.

• 한국터널지하공간학회 논문집
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• 제15권3호
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• pp.345-356
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• 2013

본 연구에서는 SPH(Smoothed Particle Hydrodynamics) 코드를 사용하여 TBM에 장착되는 디스크커터에 의한 암석의 절삭과정을 모사하였다. 이를 위하여 본 연구에서는 3차원 FEM 해석 상용프로그램인 AUTODYN3D를 사용하였으며 이를 통해 국내 황등화강암을 대상으로 총 25개의 절삭조건에 대한 수치적인 절삭시험을 수행하였다. 암석과 디스크커터를 각각 라그란지안 솔버와 SPH 솔버를 사용하여 3차원 형상으로 모델링 하고 두 개의 디스크커터가 순차적으로 암석을 절삭하도록 모델링 하였다. 수치해석과 LCM시험에서 측정한 디스크커터의 작용력은 오차 10%이내의 값을 보여 대체로 일치하는 것으로 나타났고 균열의 전파양상과 암석의 파쇄양상 또한 유사한 것으로 나타났다. 또한 절삭된 최적 커터간격을 측정한 결과 LCM시험 결과와 일치하였다. 이를 통해 SPH코드를 사용한 수치해석기법의 적용성을 확인할 수 있었으나 해석시간을 단축하기 위한 Lagrange-SPH코드의 커플링에 관한 후속연구가 필요할 것으로 판단되었다.

• BMB Reports
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• 제41권2호
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• pp.119-125
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• 2008

Our previous work confirmed that Sph2/LA1029 was a sphigomyelinase-like hemolyisn of Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai. Characteristics of both hemolytic and cytotoxic activities of Sph2 were reported in this paper. Sph2 was a heat-labile neutral hemolysin and had similar hemolytic behavior as the typical sphingomyelinase C of Staphylococcus aureus upon sheep erythrocytes. The cytotoxic activity of Sph2 was shown in mammalian cells such as BALB/C mouse lymphocytes and macrophages, as well as human L-02 liver cells. Transmission electron microscopic observation showed that the Sph2 treated BALB/C mouse lymphocytes were swollen and ruptured with membrane breakage. They also demonstrated condensed chromatin as a high-density area. Cytoskeleton changes were observed via fluorescence confocal microscope in Sph2 treated BALB/C mouse lymphocytes and macrophages, where both cytokine IL-$1{\beta}$ and IL-6 were induced. In addition, typical apoptotic morphological features were observed in Sph2 treated L-02 cells via transmission electron microscope and the percentage of apoptotic cells did increase after the Sph2 treatment detected by flow cytometry. Therefore, Sph2 was likely an apoptosis-inducing factor of human L-02 liver cells.

• 한국군사과학기술학회지
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• 제6권4호
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• pp.89-99
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• 2003

Smoothed particle hydrodynamics, SPH, is a gridless Lagrangian technique which is a useful alternative numerical analysis method to simulate high velocity deformation problems as well as astrophysical and cosmological problems. The SPH method brings about some difficulties such as tensile Instability and stress oscillation. A new SPH method, so called normalized algorithm, was introduced to overcome these difficulties. In this paper we aimed to estimate this method and have developed an one-dimensional normalized SPH program. The high velocity impact model of an aluminum bar has been analysed by using the developed program and a commercial hydrocode, LS-DYNA. The obtained numerical results showed good agreement with the results of the same model in reference. The program also showed more stable results than those of LS-DYNA in stress oscillation. We hopefully expect that the developed one-dimensional normalized SPH program can be used to solve hydrodynamic problems especially for explosive detonation analysis.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.263.2-264
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• 2002

SPH-l is a herbal medicine composing oriental prescription. We have studied the antidiabetic effect and mechanism of SPH-l in insulin-resistant diabetic db/db mice. Mice were grouped and treated for 3 weeks as follows: control group was administrated with tap water orally: treated group was administrated with SPH-l orally at dose of 500 mg/kg. SPH-l lowered plasma glucose level by 67% as compared to the diabetic control (omitted)

• 한국치위생학회지
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• 제8권2호
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• pp.53-66
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• 2008

There was to purpose of this study improves analyzing cause that prosthesis brings bite engaging that is inaccurate in patient's mouth, when supposed that all conducts that do in operatory and dental laboratory are perfect. Impression did check bite by alginate impression material and polymerization style silicon impression material that use usually in presence at a sickbed Irreversibility, hydrocolloid, alginate impression material washed in flowing water and poured anhydrite after wait about 8 minutes so that region that charge interest after impression check bite may become undoing. And hydrophile property addition polymerization style impression material poured anhydrite after blow 30 considering impression material dwell time and H2 gas occurrence time (5~15 minute) after have washed in flowing water. I got each 7 models, result that manufactures total 28 and measures by third dimension measuring instrument (Meteo, Korea) following sequence curing in tray holder and floor 1, By Alginate impression when is hardened in tray holder and when is hardened in the floor after do check bite, SPH 4, SPH5 all as there is synonymy appeared(P<0.05). By in case do not use average 0.1741 in case use tray holder in 0.0447 SPH5s in case do not use average 0.2838 pastas in case use tray holder in SPH4 0.0309, When did not use both SPH4 and SPH5 tray holder, when used tray holder, 1 appeared more greatly. 2. By amity sex addition polymerization style silicon impression when is hardened in tray holder after do check bite and when is hardened in the floor SPH 4, a11 of the SPH5s very big synonymy be(P>0.05). And in case use tray holder in 0.000657 pasta SPH5s in case do not use average 0.000129 pastas in case use tray holder in SPH4 average 0.000114 pastas, by in case do not use 0.000757, I appeared more greatly when used tray when did not use both SPH4 and SPH5 tray holder, but 1 appeared is not level to keep in mind(Table 8~9). 3 SPH4 was looked very big mindfulness in model that manufacture doing impression check bite by Alginate and model that do impression check bite by amity sex accessory penalty silicon without using tray holder(P< 0.001). I use tray holder and SPH4 did not appear synonymy in model that manufacture doing impression check bite by Alginate and model that do impression check bite by amity sex accessory penalty silicon(P>0.05). Study finding of above when see synthesis Alginate certainly tray holder use must and I could know that hardening method does not exert big influence on volume stability if remove impression sieve of excess because amity sex accessory penalty silicon passes over tray, Also, Alginate impression material previewed can get heading a conspiracy style that volume stability of accessory penalty silicon impression material degree is if use tray holder.

• BMB Reports
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• 제40권5호
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• pp.708-714
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• 2007

The two-component signal transduction, which typically consists of a histidine kinase and a response regulator, is used by bacterial cells to sense changes in their environment. Previously, the SphS-SphR histidine kinase and response regulator pair of phosphate sensing signal transduction has been identified in Synechocystis sp. PCC 6803. In addition, some response regulators in bacteria have been shown to be cross regulated by low molecular weight phosphorylated compounds in the absence of the cognate histidine kinase. The ability of an endogenous acetyl phosphate to phosphorylate the response regulator, SphR in the absence of the cognate histidine kinase, SphS was therefore tested in Synechocystis sp. PCC 6803. The mutant lacking functional SphS and acetate kinase showed no detectable alkaline phosphatase activity under phosphate-limiting growth conditions. The results suggested that the endogenous acetyl phosphate accumulated inside the mutants could not activate the SphR via phosphorylation. On the other hand, exogenous acetyl phosphate could allow the mutant lacking functional acetate kinase and phosphotransacetylase to grow under phosphate-limiting conditions suggesting the role of acetyl phosphate as an energy source. Reverse transcription PCR demonstrated that the transcripts of acetate kinase and phospho-transacetylase genes in Synechocystis sp. PCC 6803 is up-regulated in response to phosphate limitation suggesting the importance of these two enzymes for energy metabolism in Synechocystis cells

• 대한토목학회논문집
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• 제31권2A호
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• pp.71-77
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• 2011

본 논문은 고체의 동적 탄소성해석을 수행하기 위해 인장불안정이 제거된 SPH기법을 사용하였다. 인장불안정은 SPH 입자들이 인장력에 의해 서로 떨어져나가는 해석적 오류현상이며, 재료적 특성에 따라 해석결과에 큰 영향을 미치게 된다. 이와 같은 인장불안정을 제어하기 위한 방법으로 본 연구에서는 가상응력의 개념을 적용하였다. 본 연구에서 제시한 SPH에 의해 해석예제를 수행하여 해석법의 효율성을 검증하였으며, 해석예제로 원형 링의 충돌문제와, 절단, 균열과 같은 재료적 파괴문제를 수행하였다.

• 한국항공우주학회지
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• 제43권1호
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• pp.8-22
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• 2015

지금까지 인젝터의 수치적 시뮬레이션은 대부분 Eulerian 기법의 바탕위에서 이루어져 왔다. 그러나 액체제트의 미립화현상과 복잡한 공기와의 경계면 변화를 나타내는데 있어 기존의 기법들이 갖는 선천적인 단점이 존재하며 따라서 본 연구에서는 새로운 Smoothed Particle Hydrodynamics(SPH)라는 입자 기법을 도입하였다. 수치적 시뮬레이션을 위해 먼저 해석을 위한 SPH 코드를 개발하였으며 본 논문에서는 인젝터 문제를 정확하게 나타내는데 있어 필수적인 알고리즘중 하나인 다상유동모사에 대한 검증문제가 제시 되어 있다. 마지막으로 다양한 인젝터 종류 중 하나인 액체-액체 동축형 스월 인젝터에 대한 시뮬레이션이 수행되었으며 실제실험과의 비교를 진행하였다.