• Journal of Acupuncture Research
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• 제40권2호
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• pp.97-110
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• 2023

This review aimed to examine and analyze trends of clinical research using case studies on facial spasms in Korean medicine. Seven web databases were searched for case studies on facial spasms using Korean and English search terms. Case studies were selected using the exclusion and inclusion criteria. Overall, 13 case studies were selected, analyzed, and classified according to the publication year and journal, study participants, cause, treatment methods, pattern identification, evaluation methods, improvement, and side effects. Case studies reporting on various treatment methods in Korean medicine, including acupuncture and pharmacopuncture for facial spasms, have been published since 2000. In addition, studies on new treatment methods in Korean medicine for facial spasm have been published. Combination therapy is the most common method used in Korean medicine-based case studies; therefore, future studies on single treatment are necessary. Most of the case studies on Korean medicine reported improved symptoms and patient satisfaction with the Korean medicine treatment method. No side effects were reported, except for facial swelling and bruising, indicating that Korean medicine treatment methods for facial spasm were safe and effective. Therefore, the Korean medicine treatment methods for facial spasm can be actively used in clinical practice and future research.

• Journal of the Korean Data and Information Science Society
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• 제15권4호
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• pp.945-955
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• 2004

'Complete-case analysis' is easy to carry out and it may be fine with small amount of missing data. However, this method is not recommended in general because the estimates are usually biased and not efficient. There are numerous alternatives to complete-case analysis. One alternative is the single imputation. Some of the most common single imputation methods are reviewed and the performances are compared by simulation studies.

• Journal of the Korean Data and Information Science Society
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• 제25권5호
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• pp.1127-1135
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• 2014

Genome-wide association studies (GWAS) are designed to discover genetic variants such as single nucleotide polymorphisms (SNPs) that are associated with human complex traits. Although there is an increasing interest in the application of GWAS methodologies to population-based cohorts, many published GWAS have adopted a case-control design, which raise an issue related to a sampling bias of both case and control samples. Because of unequal selection probabilities between cases and controls, the samples are not representative of the population that they are purported to represent. Therefore, non-random sampling in case-control study can potentially lead to inconsistent and biased estimates of SNP-trait associations. In this paper, we proposed inverse-probability of sampling weights based on disease prevalence to eliminate a case-control sampling bias in estimation and testing for association between SNPs and quantitative traits. We apply the proposed method to a data from the Korea Association Resource project and show that the standard estimators applied to the weighted data yield unbiased estimates.

• 대한예방한의학회지
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• 제25권3호
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• pp.39-55
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• 2021

Objective : To investigate specific prescriptions, herbal medicines and treatment strategy, this study systematically reviewed case studies on traditional Chinese medicine (TCM) treatment for childhood cancer. Method : Literature searches were performed on database of China National Knowledge Infrastructure (CNKI). Studies published before December 2020 were categorized and analyzed according to the treatment strategy and we also investigated Chinese herbs used in the prescriptions. Results : Twenty-five studies including 17 case series and 8 single case reports were included in our review. Of the total 439 patients, 379 (85.7%) had leukemia and other myeloplastic disease. Conventional western medicine (CWM) treatment was also used with TCM based on the syndrome identification. Most studies reported favorable effect of combination treatment with CWM and TCM. Among 266 herbs in the studies, reinforcing herbs were more frequently used than anti-cancer herbs. Conclusion : Traditional herbal treatment for childhood cancer should be performed considering the syndrome identification as well as stage of CWM. Reinforcing herbs should be more focused because of the fragility and growth of the childhood.

• 대한예방한의학회지
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• 제27권2호
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• pp.85-107
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• 2023

Objective : To investigate the usage of Korean herbal medicine (KHM) for climacteric symptoms, this study reviewed clinical studies conducted in Korea. Method : Literature search was performed on three Korean database; OASIS, RISS and NDSL. Studies published before July 2023 were categorized and analyzed according to the study type and herbal prescriptions. Results : Fifty-eight studies including 7 controlled trial, 27 case series and 24 single case reports were included in our review and the total number of case patients was 420. 52 prescriptions based on syndrome identifications and 11 prescriptions of Sasang constitutions were used and the most frequently used prescriptions were Soyosan(逍遙散) and Guibitang(歸脾湯). Thirty-two prescriptions were also mentioned in previous delphi research or clinical practice guideline, and the rest were not. Thirty-five studies used acupuncture combined with KHM and 10 studies used pharmacopuncture and 5 studies used herbal hipbath. Conclusion : To increase the therapeutic effect of KHM and establish KHM as an alternative to hormone treatment, various prescriptions should be used according to syndrome identifications in the clinical field. High-quality RCTs on frequently used prescriptions and the development of various type of KHM are also necessary.

• 가족자원경영과 정책
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• 제9권4호
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• pp.95-112
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• 2005

The purpose of this study is to identify the characteristics and the limits of, as well as, Propose an improvement of, the government based policies that support poor single families. For this purpose, this study has analyzed the government based supporting policies for poor single families into four different aspects; income support, dwelling support, medical support, and child-caring support. Also, in order to analyze the situation of the poor single family as well as the limits of the government based supporting policies, an in-depth interview has been conducted with 8 personnel (including 7 single parents and 1 social worker). In the final analysis, a total of 5 case studies have been used to identify the characteristics of the government based supporting policies for various poor single families. As a result, it turned out that the economic situation of the poor single families were extremely unfavorable, and the quality of life was extremely low in the aspects of dwelling, nutrition, health child nurturing and education. Therefore, we are proposing the following supporting policies for the improvement of these families' living conditions: increasing income levels, providing job opportunities, securing dwelling places, providing medical support, and implementing child care benefit policies. Furthermore, we are proposing an expansion of the human services provided by the healthy family support center to these poor single families.

• Genomics & Informatics
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• 제10권2호
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• pp.117-122
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• 2012

A sample size with sufficient statistical power is critical to the success of genetic association studies to detect causal genes of human complex diseases. Genome-wide association studies require much larger sample sizes to achieve an adequate statistical power. We estimated the statistical power with increasing numbers of markers analyzed and compared the sample sizes that were required in case-control studies and case-parent studies. We computed the effective sample size and statistical power using Genetic Power Calculator. An analysis using a larger number of markers requires a larger sample size. Testing a single-nucleotide polymorphism (SNP) marker requires 248 cases, while testing 500,000 SNPs and 1 million markers requires 1,206 cases and 1,255 cases, respectively, under the assumption of an odds ratio of 2, 5% disease prevalence, 5% minor allele frequency, complete linkage disequilibrium (LD), 1:1 case/control ratio, and a 5% error rate in an allelic test. Under a dominant model, a smaller sample size is required to achieve 80% power than other genetic models. We found that a much lower sample size was required with a strong effect size, common SNP, and increased LD. In addition, studying a common disease in a case-control study of a 1:4 case-control ratio is one way to achieve higher statistical power. We also found that case-parent studies require more samples than case-control studies. Although we have not covered all plausible cases in study design, the estimates of sample size and statistical power computed under various assumptions in this study may be useful to determine the sample size in designing a population-based genetic association study.

• 대한교통학회지
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• 제14권1호
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• pp.69-80
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• 1996

In most cities, travel demand is distributed along long corridors and its destinations tend to concentrate in a central business district. For this kind of many-to-one or one-to-many travel demand pattern, a zonal operation of buses can be an efficient bus operation technique in which a long bus-demand corridor is divided into service zones and each service zone is provided with its own bus route connecting the service zone and single destination separately. This paper develops models of the total transportation costs for a single-zone operation and 2-zonal operation of buses for a long demand corridor with single destination in terms of various cost parameters, demand density, bus operation speeds, and location of the boundary between two service zones. In this study the total transportation cost is assumed to consist of the bus operation cost, passenger waiting cost and passenger travel time cost. It was proved that a zonal operation of buses can be more efficient than a single-zone operation for certain circumstances of the system and an boundary condition between two operation techniques was obtained. Also, several case studies were performed for various values of the cost parameters.

• 대한약침학회지
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• 제11권4호
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• pp.65-77
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• 2008

Objective The purpose of this study was to analyze the directions of Korean Medicine treatment of diabetes mellitus. Methods We reviewed the 52 studies about diabetes mellitus which had been published from 2000 to 2007. We selected those studies from the search engine of the web site of five journals. Those were the Journal of Korean Oriental Medical Society, Korean Journal of Oriental Physiology & Pathology, the Journal of Korean Acupuncture & Moxibustion Society, Korean Journal of Oriental Internal Medicine and the Journal of Korean Pharmacopuncture Institute. Results 1. The types of diabetes mellitus model in studies were the model used Alloxan(2cases), the model used Streptozotocin(41cases), NOD mice(1case), ob/ob mice(1case), db/db mice(5cases) and rats fed highfat diet(2cases). 2. The types of method in studies were pharmacopuncture(8cases), herbal medcine(47case) and both pharmacopuncture and herbal medcine(3cases). the types of materials in studies were single herb(24cases), multiple herbs(32cases) and both single and multiple herbs(4cases). 3. The types of evaluation criteria in studies were glucose, pancreas, liver, kidney, serum lipid, oxidative stress, nervous system, vascular system and immunity. Conclusions There have been reported many studies of diabetes mellitus in Korean Medicine. It requires to study further types of diabetes mellitus, kinds of herbs and complications of diabetes mellitus for Korean Medicine treatment of diabetes mellitus was covered the ground.

• Steel and Composite Structures
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• 제5권5호
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• pp.345-358
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• 2005

The response of single story buildings and other case studies are investigated to observe trends in response and to develop a better understanding of the impact of some design parameters on the seismic response of CBF. While it is recognized that many parameters have an influence on the behavior of braced frames, the focus of this study is mostly on quantifying energy dissipation in compression and its effectiveness on seismic performance. Based on dynamic analyses of single story braced frame and case studies, it is found that a bracing member designed with bigger R and larger KL/r results in lower normalized cumulative energy, i.e., cumulative compressive energy normalized by the corresponding tensile energy (${\sum}E_C/E_T$), in both cases.