• Journal of Pharmacopuncture
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• v.11 no.2
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• pp.75-79
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• 2008

Objectives This study was done to investigate the safety of Soyeom pharmacopuncture solution manufactured with freezing dryness method to use eye drop. Methods The eye irritation test of this material was performed according to the Regulation of Korea Food & Drug Administration(2005. 10. 21, KFDA 2005-60). After Soyeom pharmacopuncture solution was medicated in the left eye of the rabbits, the auther observed eye irritation of the cornea, iris, conjunctiva at 1, 2, 3, 4 & 7day. Results 1. After Soyeom pharmacopuncture solution was medicated in the left eye of the rabbits, there wasn't physical problem at 9 rabbits. 2. After Soyeom pharmacopuncture solution was medicated in the left eye of the rabbits, there wasn't eye irritation of the cornea, iris, conjunctiva at 1, 2, 3, 4 & 7day. Conclusions I suggested that Soyeom pharmacopuncture solution didn't induced eye irritation in rabbits.

• Journal of Pharmacopuncture
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• v.12 no.1
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• pp.21-33
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• 2009

Objective : This experimental study was performed to investigate the safety of Soyeom Pharmacopunture solution manufactured by extraction of alcohol and water. To identify the use of it as eyedrops, the eye irritation test of rabbits and antibacterial test of Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, Aspergillus niger, Fusarium oxysporum, and Candida albicans was performed. Methods : 1. The eye irritation test of this material was performed according to the Regulation of Korea Food & Drug Administration(2005. 10. 21, KFDA 2005-60). After Soyeom pharmacopuncture solution was administered in the left eye of the rabbits, eye irritation of the cornea, iris and conjunctiva was observed at 1, 2, 3, 4 & 7day. 2. After administering Soyeom Pharmacopuncture solution on bacterial species (Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, Aspergillus niger, Fusarium oxysporum, Candida albicans) which cause Keratitis, MIC(Minimum Inhibition Concentration) and the size of inhibition zone were measured. Anti-bacterial potency was also measured using the size of inhibition zone. Results : 1. After Soyeom pharmacopuncture solution was administered in the left eye of the rabbits, it was found that none of nine rabbits have abnormal signs and weight changes. 2. After Soyeom pharmacopuncture solution was medicated in the left eye of the rabbits, no eye irritation of the cornea, iris and conjunctiva was observed at 1, 2, 3, 4 & 7day. 3. There was no response to MIC on bacterial species (Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, Aspergillus niger, Fusarium oxysporum, Candida albicans) after Soyeom pharmacopuncture solution was medicated. Conclusions : The present study suggests that Soyeom pharmacopuncture solution is a non-toxic and non-irritant medicine, which does not cause eye irritation in rabbits, but dosen't have anti-bacterial effects on bacterial species which cause Keratitis. These study result recommends that more research on other herbal medicines of eye drop for Keratitis are required.

• Journal of Korean Medicine Rehabilitation
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• v.27 no.3
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• pp.95-105
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• 2017

Objectives To evaluate the evidence supporting the effectiveness of Soyeom pharmacopuncture therapy for Pain. Methods We conducted search across 6 electronic databases (Pubmed, CAJ, Oasis, RISS, DBPIA and KoreanTK) and 2 journals to find clinical trials that used Soyeom pharmacopuncture therapy as treatment for pain. The methodological quality of Randomized controlled clinical trials (RCTs) was assessed using the Cochrane Risk of Bias (RoB) tool, while NRCTs (Non-Randomized controlled clinical trials) were assessed using the Risk of Bias Assessment tool for Non-randomized Study (RoBANS) tool. Results Among 75 articles that were searched, 5 RCTs and 2 NRCTs were finally selected. Among 7 selected studies, all studies showed that Soyeom pharmacopuncture therapy has significant effect on Pain. Conclusions Our systematic review found encouraging but limited evidence of Soyeom pharmacopuncture therapy for Pain. We recommend clinical trials which compare the effectiveness of Soyeom pharmacopuncture therapy with other pharmacopuncture therapies to clarify the effectiveness of Soyeom pharmacopuncture therapy from other pharmacopuncture therapies.

• Journal of Korean Medicine Rehabilitation
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• v.32 no.3
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• pp.109-117
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• 2022

Objectives To compare the therapeutic effect of ultrasound guided soyeom pharmacopuncture therapy and unguided soyeom pharmacopuncture therapy on cervical facet joint of patient who have cervical pain caused by traffic accidents. Methods The study was planned as a retrospective study that analyzes the patient's medical records. We analyzed medical records of 20 patients with acute cervical pain caused by traffic accidents from April 1, 2022 to May 31, 2022. 10 patients (Group A) were treated ultrasound guided soyeom pharmacopuncture therapy on cervical facet joint, 10 patients (Group B) were treated unguided soyeom pharmacopuncture therapy on cervical facet joint. We used visual analogue scale (VAS) and neck disability index (NDI) to evaluate improvements in cervical functions and pain, five point Likert scale to estimate patient's satisfaction. We used the IBM SPSS Statistics version 25 program (IBM Co., Armonk, NY, USA) for statistical analysis. Results Group A showed a significant decrease in the VAS on the 5^th day of the soyeom pharmacopuncture therapy (p=0.001). However, there was no statistically significant difference of VAS between two groups (p=0.142). Group A showed significant decrease in the NDI on the 5^th day of the therapy (p=0.002). Also, there was statistically significant difference on NDI between two groups (p=0.018). Difference of five point Likert scale between two groups was not statistically significant (p=0.407). Conclusions In patients of acute cervical pain caused by traffic accidents, ultrasound guided soyeom pharmacopuncture therapy on cervical facet joint showed significant efficacy on reduction of neck disability compared with unguided therapy.

• Journal of Pharmacopuncture
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• v.25 no.4
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• pp.396-403
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• 2022

Objectives: Gout is an inflammatory arthritis of the joints and soft tissues occurring due to deposition of monosodium urate (MSU) crystals, which are caused by persistent hyperuricemia. Soyeom pharmacopuncture is one treatment method that has been traditionally used for pain management in Oriental medicine. However, studies on its effect in reducing gout pain have been insufficient. Therefore, we selected Soyeom pharmacopuncture among natural products used in Korea as the new target of our study. Methods: The effects of Soyeom pharmacopuncture were examined in mouse models of acute gout induced by injection of MSU crystals into footpads. IL-1β, IL-6, and TNF-α production were examined by immunoblotting and enzyme-linked immunosorbent assay as hallmarks of NLRP3 inflammasome and cytokine activation. Results: Soyeom pharmacopuncture reduced foot edema in gout-induced mice, as well as IL-1β, nitrite, IL-6, and TNF-α production. Moreover, Soyeom pharmacopuncture also reduced MSU-induced gout inflammatory gene expressions, specifically those in the NF-kB pathway. Conclusion: Pharmacopuncture may serve as a new solution for other inflammatory diseases as well. Through active follow-up studies, we could thoroughly understand the clinical value of Soyeom pharmacopuncture.

• Journal of Acupuncture Research
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• v.26 no.6
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• pp.41-49
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• 2009

Objectives : This study was designed to evaluate the effect of Soyeom Pharmacopuncture on postauricular pain accompanied acute peripheral facial paralysis. Methods : We observed thirty peripheral facial palsy inpatients with postauricular pain at Cheonan oriental hospital of Daejeon university from Jan. 1st, 2009 to July 31th, 2009. These inpatients were divided into two groups; Group A was treated using general treatment and Group B was treated using general treatment and Soyeom Pharmacopuncture on the posterior ear area. Results : 1. Postauricular pain was significantly decreased in Group B. 2. Duration of postauricular pain was significantly reduced in Group B. 3. Improvement of facial paralysis was not significantly different between Group A and Group B. Conclusions : Soyeom Pharmacopuncture has significant effects on a postauricular pain accompanied with peripheral facial paralysis.

• Journal of Pharmacopuncture
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• v.13 no.2
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• pp.121-129
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• 2010

Objectives : The main purpose of this research is to evaluate the effect of treatment with Soyeom Pharmacupuncture at G20(Punji) for ten patients with hemifacial spasm. Methods : We have treated them with acupuncture treatment and Soyeom Pharmacupuncture at G20(Pungji), and evaluated the effect by Scott's scale. Results: After treatment, the grades of spasm intensity classified by Scott's description were improved in 9 cases. Conclusion : This data suggested that Soyeom Pharmacupuncture at G20(Pungji) for hemifacial spasm was effective and will be attempted to the patients wi1h it.

• The Journal of Internal Korean Medicine
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• v.31 no.2
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• pp.388-394
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• 2010

Objectives : This study reports two cases of grade four pressure ulcer patients mainly treated by pharmacopuncture Soyeom and Taklisodok-eum. Methods : Two patients with grade four pressure ulcers at the oriental medicine hospital of Woosuk University were treated by pharmacopuncture Soyeom and herbal medicine Taklisodok-eum. Soyeom was treated once a day and Taklisodok-eum was given three times a day. We then observed the patients' appearances of pressure ulcer and changes of blood test results. Results and Conclusions : After ten days or three months each, wound sizes were reduced, tissue regeneration was accelerated and blood tests were improved. In conclusion, it is our belief that pharmacopuncture and herb medicine are effective to treat grade four pressure ulcers, and future studies will be required to ascertain this method on grade four pressure ulcers.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.32 no.2
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• pp.107-119
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• 2019

Objectives : The purpose of this study is to report the effectiveness of Cheongshimyeonja-eum gagambang and Soyeom pharmacopuncture for nummular eczema patients. Methods : This study was conducted with three patients treated with nummular eczema at Cheonan Oriental Medical hospital of Daejeon university. All three patients were treated with Cheongshimyeonja-eum gagambang and Soyeom pharmacopuncture. For the evaluation of the results, we used Visual Analogue Scale(VAS) as an assessment methods and took photographs of the lesions for comparison. Results : After the medication, eczema lesions of the three patients were remarkably improved. The lesions were examined by the photographs and the VAS of pruritus and relating symptoms, Conclusions : This study suggests that Cheongshimyeonja-eum gagambang and Soyeom pharmacopuncture could show effectiveness on nummular eczema.

• Journal of Pharmacopuncture
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• v.21 no.1
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• pp.14-17
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• 2018

Objective: It has been attempted to find out that Homine Placents and Soyeom mixed Pharmacopuncture (HSP) procedure is effective for the removal of melanocytic nevus of considerable size which cannot be applied to general acupuncture. Methods: Hominis placenta (0.5ml) and Soyeom (0.5ml) mixed pharmacopuncture (1.0ml) was subcutaneously injected in several places of melanocytic nevus. The treatment was performed about 20 times, once a week. Layer analysis of pigmentation was carried out using ECOSKIN. Results: One year after the HSP procedure, the pigmentation of the melanocytic nevus was slightly reduced and completely removed after 2 years of procedure. Conclusion: The HSP could be effective for removing hyperpigmentation in the melanocytic nevus.