• Journal of Ginseng Research
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• v.16 no.1
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• pp.18-23
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• 1992

Central dopaminergic activity of standardized ginseng extract G115 was investigated in comparison with those induced by haloperidol in rats. The effects of G115 on the locomotor activity and, stereotyped behavior induced by apomorphine, which interacts directly with dopamine receptor were observed. Apomorphine(2 mg/kg) significantly decreased locomotor activity, whereas it showed a markdly increased incidence of stereotyped behavior. Standardized ginseng extract G115(100 mg/kg) and haloperidol(1 mg/kg) showed a significant decrease in locomotor activity but not induced stereotyped hehavior. Locomotor activity induced by apomorphine was markdly decreased by haloperidol(1 mg/kg), but that was significantly increased by standardized ginseng extract G115(50 mg/kg). Stereotyped behavior induced by apomorphine was completely supressed haloperidol(1 mg/kg), but was not changed by standardized ginseng extract G115. These results suggest that standardized ginseng extract G115 plays an important role in central dopaminergic activity, and haloperidol and standardized ginseng extract G115 seem to have a different action in behavior.

• Journal of Ginseng Research
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• v.16 no.3
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• pp.183-189
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• 1992

Effect of the standardized ginseng extract(G115) on the central monoaminergic systems were investigated in comparison with that of halcperidol in rats. Immediately after sacrificed by decapitation, the strlata and frontal cortex were removerl. Concentations of the monoamines dopamine and serctorLin and their metabolites were deterinintd by HPLC-EC. G115 increased the concentration of 5-HIAA and DOPAC/UA ratio in striatum. However, dopaminrrgic neuronal activities were not affected by G115 that decreased the concentratio,Is of 5-HT and 5-HIAA in frontal cortex. G115 in combination with apomorphine significantly irlcreased the concentration of DA and S-HT but decreased the DO PAC/DA ratio and 5-HIAA/5-HT ratio only in frontal cortex. These results suggest that G115 like HPD inhibits the activity of nigrostriatal dopamine neuron in striatum. However, unlike HPD it activates central monoaminergic neuron activity in frontal cortex.

• Journal of Ginseng Research
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• v.44 no.2
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• pp.179-193
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• 2020

Ginseng products on the market show high variability in their composition and overall quality. This becomes a challenge for both consumers and health-care professionals who are in search of high-quality, reliable ginseng products that have a proven safety and efficacy profile. The botanical extract standardization is of crucial importance in this context as it determines the reproducibility of the quality of the product that is essential for the evaluation of effectiveness and safety. This review focuses on the well-characterized and standardized ginseng extract, G115, which represents an excellent example of an herbal drug preparation with constant safety and efficacy within the herbal medicinal products. Over the many decades, extensive preclinical and clinical research has been conducted to evaluate the efficacy and safety of G115. In vitro and in vivo studies of G115 have shown pharmacological effects on physical performance, cognitive function, metabolism, and the immune system. Furthermore, a significant number of G115 clinical studies, most of them double-blind placebo-controlled, have reinforced the findings of preclinical evidence and proved the efficacy of this extract on blood glucose and lipid regulation, chronic obstructive pulmonary disease, energy, physical performance, and immune and cognitive functions. Clinical trials and 50 years of presence on the market are proof of a good safety profile of G115.

• Proceedings of the Ginseng society Conference
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• 1984.09a
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• pp.119-126
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• 1984

Several publications in scientific journals affirming that ginseng could be toxic and have harmful effects on the organism, gave us reason to undertake extensive investigations as to the toxicity of the standardized ginseng extract G115, Acute and chronic toxicity, teratogenicity, carcinogenicity, its action on the cardiovascular and the hormonal system have been studied. The data obtained, which represent five years of research, are confirmed by clinical results: The standardized ginseng extract G115 is absolutely safe, no toxic actions or side effects were observed.

• Proceedings of the Ginseng society Conference
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• 1978.09a
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• pp.85-92
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• 1978

The aim of the double blind test was to assess the prophylactic and therapeutic efficacy of the preparation GINSANA, containing the standardized ginseng extract PHARMATON G115,. The determination was carried out with special emphasis on the following features : general physical condition, physical performance, mental performance, enjoyment of life/mood, concentration and memory, as well as sleeping habits. Sixty test persons took part in the study, men and women between the ages of 22 and 80. The 90-day test was carried out in the form of a double blind experiment. Experimental measurements were made and the persons were also questioned. The reaction time, the optical merging threshold, the coordination of both hands and the recovery quotients, as well as the recovery rates were analyzed. The results for the serum group were clearly better than those for the placebo group, particularly for the characteristics: general physical condition, physical performance and sleeping habits. The results of the test methods used, especially with regard to the reaction time, the coordination of both hands, the recovery quotient and the recovery period, permit the following conclusion to be drawn: when administered for several weeks, GINSANA has a positive action, in the sense of an activation of the entire personality by the ginseng glycosides contained in the standardized Extracts G115.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2018.10a
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• pp.21-21
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• 2018

Natural product substances have historically served as the most significant also be prepared by source of new leads for pharmaceutical development. They can chemical synthesis(both semisynthesis and total synthesis) and have played a important role in the field of organic chemistry by providing synthetic targets. Rcently, they have also been extended for commercial purpose to refer to medicinal products, health functional foods, dietary supplements and cosmetics from natural sources. A large number of currently prescribed drugs have been either directly derived from or inspired by natural products. However, with the advent of robotics, bioinformatics, high throughput screening(HTS), molecular biology-biotechnology, combinatorial chemistry, in silico(molecular modeling) and other methodologies, the pharmaceutical industry has largely moved away from plant derived natural products as a source for leads and prospective drug candidates. The strategy for natural prduct industry is now changing from drug approaches to health foods by identifying effective natural products as preparations. In Korea, a lot of development of natural product based drugs have been done, but very few on health functional foods. The concept of natural product based health foods is not active components as lead compounds but standardized extracts or preparation mixed with other medicinal plants. The representative material has been recently known to be a standardized ginseng extract "Ginsana G 115" developed by Swiss Pharmaton company. The purpose of this presentation is to underline how natural products research continues to make significant contributions in the domain of discovery and development of new health functional foods. It is proposed to present the development of high value added health food or health functional foods through scientific investigation on efficacy and standardization of new materials form natural products.