• BMB Reports
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• v.31 no.2
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• pp.201-208
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• 1998

Amino acid analogs, like other inducers of stress response, induce the synthesis of stress proteins in mammalian cells. In this study, Drosophila Kc cells, in which translation is tightly controlled during stress response, was treated with proline analogs, L-azetidine-2-carboxylic acid (AzC) and 3,4-dehydro-L-proline (dh-P). Kc cells exposed to AzC or dh-P induced the synthesis of several proteins which had the same molecular weights as known heat shock proteins. However, in Kc cells, normal protein synthesis still continued in the presence of amino acids analogs unlike in heat-shocked cells. For the induction of stress response, the incorporation of dh-P into the protein was not essential, but the incorporation of AzC was. The stress protein synthesis was regulated mainly at the transcriptional level by AzC, whereas it was regulated by dh-P at the transcription level and possibly posttranscription level. During recovery, the stress protein synthesis stopped sooner in analog-treated cells than in heat-shocked cells even though the accumulated amount of Hsp70 was much less in proline analogstreated cells. It could be concluded that the proline analogs, AzC and dh-P, induced stress response through a different mechanism from heat shock.

• Journal of the Korea Safety Management & Science
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• v.24 no.4
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• pp.15-23
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• 2022

This study investigated the effects of job stress, job attitude, and social support on the relationship between client violence and social worker job response. The multi-mediating effect of job stress, job attitude, and social support between client violence and social worker job response was empirically analyzed. 257 social workers in social welfare facilities were analyzed using SPSS. The following conclusions were drawn. First, there was a significant correlation between client violence, job stress, job attitude, social support, and job response variables. Client violence was affecting variables related to social worker job response. Second, job stress, job attitude, and social support had multiple mediating effects. The parallel mediation effect and the serial mediation effect were verified. Third, job attitude was found to be a variable of multiple mediating effects. Fourth, job stress and social support were found to be double mediating effect variables. In response, programs and manuals suitable for the type of social welfare facilities and the policy basis for preparing countermeasures for social workers were limited, and follow-up studies on various variables were suggested.

• Journal of Korean Biological Nursing Science
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• v.21 no.3
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• pp.178-187
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• 2019

Purpose: The purpose of this study was to investigate how college students' perceived stress, cognitive stress, and somatization affect their heart rate variability (HRV). Methods: This study is a cross-sectional survey research on 191 university students, registered at the G University. The perceived stress scale (PSS) and cognitive stress response scale, were used to assess level of stress. The somatization symptom scale of the Symptom Check List 90 (SCL-90), was used to assess level of somatization caused by stress. To assess heart rate variability (HRV), we conducted a five-minute test using a pulse wave analyzer, to analyze short-term HRV. Results: The SCL-90 somatization score had relatively high positive correlation (p< .001) with cognitive stress, but low positive correlation (p< .001) with perceived stress. Cognitive stress response had low negative correlation (p< .001) with 1nSDNN and 1nRMSSD among HRV parameters. Perceived stress was not correlated with HRV. Multiple regression analysis showed that variables of perceived stress, cognitive stress, and somatization symptoms, could not explain HRV. By contrast, one of the HRV indicators, 1nSDNN, was affected by age, gender, and aggressive-hostile thought, the latter being a subscale of the cognitive stress response scale. Conclusion: This study suggests that stress evaluation for people in early adulthood will be more effective, if the evaluation examines cognitive stress and heart rate variability.

• Geomechanics and Engineering
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• v.25 no.4
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• pp.341-345
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• 2021

1D sand compression response to ko-loading experiences volume contraction from low to high effective stress regimes. Previous study suggested compressibility model with physically correct asymptotic void ratios at low and high stress levels and examined only for both remolded clays and natural clays. This study extends the validity of Enhanced Terzaghi model for different sand types complied from 1D compression data. The model involved with four parameters can adequately fit 1D sand compression data for a wide stress range. The low stress obtained from fitting parameters helps to identify the initial fabric conditions. In addition, strong correlation between compressibility and the void ratio at low stress facilitates determination of self-consistent fitting parameters. The computed tangent constrained modulus can capture monotonic stiffening effect induced by an increase in effective stress. The magnitude of tangent stiffness during large strain test should not be associated with small strain stiffness values. The use of a single continuous function to capture 1D stress-strain sand response to ko-loading can improve numerical efficiency and systematically quantify the yield stress instead of ad hoc methods.

• Korean Journal of Occupational Health Nursing
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• v.8 no.1
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• pp.56-67
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• 1999

This study was designed to identify the relationships of role-conflict and role-overload, coping strategies, and stress response of clerical workers. The subjects were 115 clerical workers from two company. The instruments were the role-conflict and role-overload scale developed by Lee(1989), coping scale developed by Latack(1986), and the stress response scale developed by Chang(1993). Analysis of data was done by descriptive statistics, Cronbach's $\alpha$, Pearson correlation coefficietnt, ANOVA. The results of this study were summarized as follows ; 1. The average score for the level of stress response was $83.6({\pm}9.1)$. The high risk stress group was 86.1% of the clerical workers, the latent stress group members was 13.9%, and healthy group was 0%. The overall stress level was very high. 2. Considering the coping strategies by sociodemographic factors, the use of control coping strategies showed significant differences by work-time. The use of symptom management coping strategies showed significant differences by sex, age, married status, year of career, pay, and type of work. The organizational coping strategies showed significant differences by year of education and type of work. 3. The clerical workers who had worked below 44 hours per week complained significantly lower stress response(F=4.942, p<.05). 4. Above 65% of all respondents answered that they needed all of organizational level coping strategies. 5. The role-confilct positively related to escape and organizational level coping strategies(r=.562, r=.495, p<.05). The role-overload didn't related to individual level coping strategies, but positively related to organizational level coping strategies(r=.320, p<.05). 6. The control coping strategies and the escape coping strategies positively related to symptom management, organizational level coping strategies(r=.409, r=.324, r=.316, r=.339, p<.05). 7. The relationship between role-related stress and stress response revealed positive correlation(r=.482, r=.431, p<.05), and the relationship between stress response and control, symptom management coping strategies revealed negative cor-relation(r=-.3204, r=-.3146, p<.05). In conclusion, this study revealed that relationship of role related stress, coping strategies, stress response was statistically significant. The result of this study support that coping strategies vary across situation of stress. Based on survey results, future studies should consider coping strategies in specific stress situation and concept of symptom management coping strategy. Also organizational or training interventions could be developed and initiate to help to increase the use of adaptive coping strategies in light of individual and situational differences.

• Journal of the Ergonomics Society of Korea
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• v.21 no.2
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• pp.59-70
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• 2002

This paper is about the evaluation of stress response and recovery using biosignals and fuzzy theory. We caused mental stress by means of a coin-stacking task. During the experiment, 4 kinds of biosignals, including frontalis EMG, ECG, peripheral skin temperature and skin conductance level, were acquired. Then, the degree of stress was assessed by synthetically those signals using fuzzy inference. From the fuzzy inference result, the parameters (amount of physiological change / amount of imposed stress) and (time to 25% recovery), which represent response and recovery respectively, were derived. We made a two-dimensional point graph using the response parameter as an abscissa and the recovery parameter as an ordinate for each subject.

• Laboraroty Animal Research
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• v.34 no.4
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• pp.203-210
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• 2018

Stress severely disturbs physiological and mental homeostasis which includes adult neurogenesis in hippocampus. Neurogenesis in hippocampus is a key feature to adapt to environmental changes and highly regulated by multiple cellular signaling pathways. The primary cilium is a cellular organelle, which acts as a signaling center during development and neurogenesis in adult mice. However, it is not clear how the primary cilia are involved in the process of restraint (RST) stress response. Using a mouse model, we examined the role of primary cilia in repeated and acute RST stress response. Interestingly, RST stress increased the number of ciliated cells in the adult hippocampal dentate gyrus (DG). In our RST model, cell proliferation in the DG also increased in a time-dependent manner. Moreover, the analysis of ciliated cells in the hippocampal DG with cell type markers indicated that cells that were ciliated in response to acute RST stress are neurons. Taken together, these findings suggest that RST stress response is closely associated with an increase in the number of ciliated neurons and leads to an increase in cell proliferation.

• Clinical and Experimental Reproductive Medicine
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• v.42 no.1
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• pp.1-7
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• 2015

Stress coping mechanisms are critical to minimize or overcome damage caused by ever changing environmental conditions. They are designed to promote cell survival. The unfolded protein response (UPR) pathway is mobilized in response to the accumulation of unfolded proteins, ultimately in order to regain endoplasmic reticulum (ER) homeostasis. Various elements of coping responses to ER stress including Perk, Ask1, Bip, Chop, Gadd34, Ire1, Atf4, Atf6, and Xbp1 have been identified and were found to be inducible in oocytes and preimplantation embryos, suggesting that, as a normal part of the cellular adaptive mechanism, these coping responses, including the UPR, play a pivotal role in the development of preimplantation embryos. As such, the UPR-associated molecules and pathways may become useful markers for the potential diagnosis of stress conditions for preimplantation embryos. After implantation, ER stress-induced coping responses become physiologically important for a normal decidual response, placentation, and early organogenesis. Attenuation of ER stress coping responses by tauroursodeoxycholate and salubrinal was effective for prevention of cell death of cultured embryos. Further elucidation of new and relevant ER stress coping responses in periimplantation embryos might contribute to a comprehensive understanding of the regulation of normal development of embryonic development and potentiation of embryonic development in vitro.

• Journal of Society of Preventive Korean Medicine
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• v.12 no.3
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• pp.175-183
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• 2008

This study was founded to identify the differences of the stress responses according to Sasang Constitutions(the Taeyangin, Taeumin, Soyangin and Soumin) of female college students. The subject were 226 the regular female students who majored in nursing in Kyungbuk, Kimcheon. Tools used in this study were the Questionnare for the Sasang Constitution Discrimination and the Scale for the Stress Response which were revised in some parts. The values of Cronbach's alpha for the Questionnare for the Sasang Constitution Discrimination and the Scale for the Stress Response were $0.45{\sim}0.73$ and $0.66{\sim}0.85$ respectively. The collected data was anaylyzed with the SPSS 10.0 windows statistical program. The results of this study were as follows; 1. The constitutions were shown in the order of Taeumin(45%), Soyangin(28%), Soumin(18%) and Taeyangin(9%). 2. There were significant difference in the stress response for Depression(p<.05), Anxiety(p<.05), Emotional irritability(p<.01) and the Total stress response(p<.05) according to the Sasang Constitutions (the Taeyangin, Taeumin, Soyangin and Soumin). In conclusion, it is needed to find out an effective ways of treating stress individually to apply Sasang Constitutions to a new esthetic treatment.

• Journal of Korean Academy of Nursing
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• v.42 no.2
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• pp.161-170
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• 2012

Purpose: Purpose of this study was to examine the effects of the Mindfulness Meditation program on perceived stress, ways of coping, salivary cortisol level, and psychological stress response in patients with breast cancer. Methods: This was a quasiexperimental study with a non-equivalent control group pre-post test design. Participants in this study were 50 patients who had completed breast cancer treatment (experimental group, 25, control group, 25). The experimental group received the Mindfulness Meditation program for 3 hours/session/ week for 8 weeks. Data were analyzed using $X^2$-test and t-test for subject homogeneity verification, and ANCOVA to examine the hypotheses. Results: The experimental group had significantly lower scores for perceived stress, emotional focused coping, salivary cortisol level, and psychological stress response compared to the control group. However, no significant differences were found between two groups for the scores on problem focused stress coping. Conclusion: According to the results, the Mindfulness Meditation program was useful for decreasing perceived stress, emotional focused coping, salivary cortisol level, and psychological stress response. Therefore, this program is an effective nursing intervention to decrease stress in patients with breast cancer.