• Nuclear Engineering and Technology
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• v.41 no.5
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• pp.677-690
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• 2009

A previous study demonstrated that the two-row fuel assembly has much more favorable neutron-physical and thermal-hydraulic behavior than the conventional one-row fuel assemblies. Based on the newly developed two-row fuel assembly, an SCWR core is proposed and analyzed. The performance of the proposed core is investigated with 3-D coupled neutron-physical and thermal-hydraulic calculations. During the coupling procedure, the thermal-hydraulic behavior is analyzed using a sub-channel analysis code and the neutron-physical performance is computed with a 3-D diffusion code. This paper presents the main results achieved thus far related to the distribution of some neutronic and thermal-hydraulic parameters. It shows that with adjustment of the coolant and moderator mass flow in different assemblies, promising neutron-physical and thermal-hydraulic behavior of the SCWR core is achieved. A sensitivity study of the heat transfer correlation is also performed. Since the pin power in fuel assemblies can be non-uniform, a sub-channel analysis is necessary in order to investigate the detailed distribution of thermal-hydraulic parameters in the hottest fuel assembly. The sub-channel analysis is performed based on the bundle averaged parameters obtained with the core analysis. With the sub-channel analysis approach, more precise evaluation of the hot channel factor and maximum cladding surface temperature can be achieved. The difference in the results obtained with both the sub-channel analysis and the fuel assembly homogenized method confirms the importance of the sub-channel analysis.

• Nuclear Engineering and Technology
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• v.54 no.5
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• pp.1874-1889
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• 2022

In this study, we evaluate the thermal-hydraulic performance and economics of Printed Circuit Heat Exchanger (PCHE) according to the channel types and associated shape variables for the design of recuperators with Sodium-cooled Fast Reactors (SFRs). To perform the evaluations with variables such as the Reynolds number, channel types, tube diameter, and shape variables, a code for the heat exchanger is developed and verified through a comparison with experimental results. Based on the code, the volume and pressure drop are calculated, and an economic assessment is conducted. The zigzag type, which has bending angle of 80° and a tube diameter of 1.9 mm, is the most economical channel type in a SFR using CO₂ as the working fluid. For a SFR using N₂, we recommend the airfoil type with vertical and horizontal numbers of 1.6 and 1.1, respectively. The airfoil type is superior when the mass flow rate is large because the operating cost changes significantly. When the mass flow rate is small, volume is a more important design parameter, therefore, the zigzag type is suitable. In addition, we conduct a sensitivity analysis based on the production cost of the PCHE to identify changes in optimal channel types.

• BMB Reports
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• v.54 no.6
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• pp.311-316
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• 2021

Ethanol often causes critical health problems by altering the neuronal activities of the central and peripheral nerve systems. One of the cellular targets of ethanol is the plasma membrane proteins including ion channels and receptors. Recently, we reported that ethanol elevates membrane excitability in sympathetic neurons by inhibiting Kv7.2/7.3 channels in a cell type-specific manner. Even though our studies revealed that the inhibitory effects of ethanol on the Kv7.2/7.3 channel was diminished by the increase of plasma membrane phosphatidylinositol 4,5-bisphosphate (PI(4,5)P₂), the molecular mechanism of ethanol on Kv7.2/7.3 channel inhibition remains unclear. By investigating the kinetics of Kv7.2/7.3 current in high K⁺ solution, we found that ethanol inhibited Kv7.2/7.3 channels through a mechanism distinct from that of tetraethylammonium (TEA) which enters into the pore and blocks the gate of the channels. Using a non-stationary noise analysis (NSNA), we demonstrated that the inhibitory effect of ethanol is the result of reduction of open probability (P_O) of the Kv7.2/7.3 channel, but not of a single channel current (i) or channel number (N). Finally, ethanol selectively facilitated the kinetics of Kv7.2 current suppression by voltage-sensing phosphatase (VSP)-induced PI(4,5)P₂ depletion, while it slowed down Kv7.2 current recovery from the VSP-induced inhibition. Together our results suggest that ethanol regulates neuronal activity through the reduction of open probability and PI(4,5)P₂ sensitivity of Kv7.2/7.3 channels.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.31 no.2A
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• pp.110-118
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• 2006

In part-I of the paper, two sub-channel structures, either contiguous or distributed, were considered. Modeling the SNR distribution over a sub-channel as Ricean in general, the statistical chracteristics were investigated. In this part of the paper, we develop a generalized two step channel/resource allocation algorithm, which incorporates the two statistical measurements, and analyze the spectral efficiency of OFDMA in terms of average frequency utilization for the two sub-channel structures. In OFDMA with distributed structure, the key design parameter would be the sub-channel bandwidth. To give an insight into the impact on this parameter, we show in the numerical results the frequency utilization as a function of sub-channel bandwidth normalized to coherence bandwidth. As confirmed by numerical results, for contiguous sub-channel structure, we obtain the nominal multiuser diversity gain when the sub-channel bandwidth is smaller than the coherence bandwidth and lose the gain as it is getting larger.

• Nuclear Engineering and Technology
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• v.54 no.11
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• pp.4338-4347
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• 2022

The CUPID code was developed and is continuously updated in KAERI. Verification and validation (V&V) is mainly done for light water reactors (LWRs). This paper describes a benchmarking of the detailed mesh level compared with sub-channel level for application to pressurized heavy water reactors (PHWRs), even though component scale comparison for the PHWR moderator system was done once before. We completed a sub-channel level comparison between the CUPID code and the ASSERT code and a CUPID code analysis. Because the ASSERT code has already been validated with numerous experiments, benchmarking with the ASSERT code will offer us more trust on the CUPID code. The target channel has high power and thus high pressure deformation. The high power channel tends to have a high possibility of critical heat flux (CHF), because a high void fraction and quality in channel exit region appear. In this research, after determining the reference grid and T/H model, we compared the sub-channel level results of the CUPID code with those of the ASSERT code.

• Proceedings of the IEEK Conference
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• 2003.11c
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• pp.216-219
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• 2003

In this paper, we present performance analysis of an IEEE P802.15.3a high rate wireless personal area network transceiver. This physical layer standard uses QOSK as its sub-channel modulation scheme and orthogonal frequency domain modulation (OFDM) for sub-bands. OFDM is used for each sub-band so that multi-path effects are absorbed by equalizer and guard, and fading can be approximately modeled as additive white Gaussian noise. In multi-band ultra-wideband system, DAC quantization error is important noise source since high resolution conversion cannot be used due to high power consumption. Simulation result shows that, to get 640-Mbps throughput, at least 5-bits precision is necessary to maintain bit-error rate under 10$\^$-2/, which can be lowered, with channel coding, to 10$\^$-6/ that is the bit-error rate required by IEEE 802.15 upper protocol layer, in 4-meter LOS fading channel.

• Journal of Biomedical Engineering Research
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• v.43 no.5
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• pp.331-340
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• 2022

Early afterdepolarization (EAD), a significant cause of fatal ventricular arrhythmias including Torsade de Pointes (TdP) in long QT syndromes, is a depolarizing afterpotential at the plateau or repolarization phase in action potential (AP) profile early before completing one pace. AP duration prolongation is related to EAD but is not necessarily accounted for EAD. Several computational studies suggested EAD can form from an abnormality in the late plateau and/or repolarization phase of AP shape. In this sense, we hypothesized the slope during repolarization has the characteristics to predict TdP risk, mainly focusing on the maximum slope during repolarization (dVm/dt_{max_repol}). This study aimed to predict the sensitivity of dVm/dt_{max_repol} to ion channel conductances as a TdP risk metric through a population simulation considering multiple effects of simultaneous reduction in six ion channel conductances of g_NaL, g_Kr, g_Ks, g_to, g_K1, and g_CaL. Additionally, we verified the availability of dVm/dt_{max_repol} for TdP risk prediction through the correlation analysis with qNet, the representative TdP metric. We performed the population simulations based on the methodology of Gemmel et al. using the human ventricular myocyte model of Dutta et al. Among the sixion channel conductances, dVm/dt_{max_repol} and qNet responded most sensitively to the change in g_Kr, followed by g_NaL. Furthermore, dVm/dt_{max_repol} showed a statistically significant high negative correlation with qNet. The dVm/dt_{max_repol} values were significantly different according to three TdP risk levels of high, intermediate, and low by qNet (p<0.001). In conclusion, we suggested dVm/dt_{max_repol} as a new biomarker metric for TdP risk assessment.

• Journal of IKEEE
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• v.28 no.1
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• pp.110-115
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• 2024

This paper analyzed the V_th (Threshold Voltage) variations in 3D NAND Flash memory with tapered O/N/O (Oxide/Nitride/Oxide) structure and O/N/F (Oxide/Nitride/Ferroelectric) structure, where the blocking oxide is replaced by ferroelectric material. With a tapering angle of 0°, the O/N/F structure exhibits lower resistance compared to the O/N/O structure, resulting in reduced V_th variations in both the upper and lower regions of the WL (Word Line). Tapered 3D NAND Flash memory shows a decrease in channel area and an increase in channel resistance as it moves from the upper to the lower WL. Consequently, as the tapering angle increases, the V_th decreases in the upper WL and increases in the lower WL. The tapered O/N/F structure, influenced by V_fe proportional to the channel radius, leads to a greater reduction in V_th in the upper WL compared to the O/N/O structure. Additionally, the lower WL in the O/N/F structure experiences a greater increase in V_th compared to the O/N/O structure, resulting in larger V_th variations with increasing tapering angles.

• The Korean Journal of Physiology and Pharmacology
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• v.24 no.4
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• pp.363-372
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• 2020

Gardenia jasminoides (GJ) is a widely used herbal medicine with anti-inflammatory properties, but its effects on the ORAI1 channel, which is important in generating intracellular calcium signaling for T cell activation, remain unknown. In this study, we investigated whether 70% ethanolic GJ extract (GJ_EtOH) and its subsequent fractions inhibit ORAI1 and determined which constituents contributed to this effect. Whole-cell patch clamp analysis revealed that GJ_EtOH (64.7% ± 3.83% inhibition at 0.1 mg/ml) and all its fractions showed inhibitory effects on the ORAI1 channel. Among the GJ fractions, the hexane fraction (GJ_HEX, 66.8% ± 9.95% at 0.1 mg/ml) had the most potent inhibitory effects in hORAI1-hSTIM1 co-transfected HEK293T cells. Chemical constituent analysis revealed that the strong ORAI1 inhibitory effect of GJ_HEX was due to linoleic acid, and in other fractions, we found that genipin inhibited ORAI1. Genipin significantly inhibited I_ORAI1 and interleukin-2 production in CD3/CD28-stimulated Jurkat T lymphocytes by 35.9% ± 3.02% and 54.7% ± 1.32% at 30 μM, respectively. Furthermore, the same genipin concentration inhibited the proliferation of human primary CD4⁺ T lymphocytes stimulated with CD3/CD28 antibodies by 54.9% ± 8.22%, as evaluated by carboxyfluorescein succinimidyl ester assay. Our findings suggest that genipin may be one of the active components of GJ responsible for T cell suppression, which is partially mediated by activation of the ORAI1 channel. This study helps us understand the mechanisms of GJ in the treatment of inflammatory diseases.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.25 no.9
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• pp.1227-1236
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• 2001

A systematic analysis is made of suboptimal control for drag reduction. The influence of the amplitude of actuation (A) and the time scale of actuation ($\Delta$t(sub)a(sup)+) is evaluated. Two wall sensing variables are employed (∂w/∂y│(sub)w and ∂p/∂z│(sub)w) with two wall actuations (${\Phi}$$_2$and ${\Phi}$$_3$). To test the suboptimal control, direct numerical simulations of turbulent channel flow at Re(sub)$\tau$=100 are performed in a spectral domain. It is found that the effect of A and $\Delta$t(sub)a(sup)+∼1. The near-wall behaviors of flow structure are analyzed to characterize the drag reduction. The size effect of the sensor/actuator is examined.