• Title/Summary/Keyword: TN

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Usefulness of Cardiac Troponin I as a Prognostic Marker in Noncardiac Critically Ill Patients (비순환기계 중환자의 예후인자로서 Cardiac Troponin I의 유용성)

  • Kim, Hwi Jong;Ham, Hyoun Seok;Cho, Yu Ji;Kim, Ho Cheol;Lee, Jong Deok;Hwang, Young Sil
    • Tuberculosis and Respiratory Diseases
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    • v.59 no.1
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    • pp.53-61
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    • 2005
  • Background : Cardiac troponin I (cTnI) is a specific marker of myocardial injury. It is known that a higher level of cTnI is associated with a poor clinical outcome in patients with acute coronary syndrome. An elevation in cTnI is also observed in various noncardiac critical illnesses. This study evaluated whether cTnI is useful for predicting the prognosis in noncardiac critically ill patients. Methods : From June 2003 to July 2004 at Gyeongsang National University Hospital, we enrolled 215 patients (male:142, female:73, mean age:$63{\pm}15$ years ) who were admitted for critical illness other than acute coronary syndrome at the medical intensive care unit(ICU). The severity score of critical illness (SAPS II and SOFA) was determined and serum cTnI level was measured within 24 hours after admission to the ICU. The mortality rate was compared between the cTnI-positive (${\geq}0.1{\mu}g/L$) and cTnI-negative ($cTnI<0.1{\mu}g/L$) patients at the $10^{th}$ and $30^{th}$ day after admission to the ICU. The mean cTnI value was compared between the survivors and non-survivors at the $10^{th}$ and $30^{th}$ day after admission to the ICU in the cTnI-positive patients. The correlation between cTnI and the severity of the critical illness score (SAPS II and SOFA) was also analyzed in cTnI-positive patients. Results : 1) The number of cTnI-negative and positive patients were 95(44%) and 120(56%), respectively. 2) The mortality rate at the $10^{th}$ and $30^{th}$ day after admission to the ICU was significantly higher in the cTnI-positive patients (29%, 41%) than in the cTnI-negative patients (12%, 21%)(p<0.01). 3) In the cTnI-positive patients, the mean value of the cTnI at the $10^{th}$ and $30^{th}$ day after admission to the ICU was significantly higher in the non-survivors ($4.5{\pm}9.2{\mu}g/L$, $3.5{\pm}7.9{\mu}g/L$) than in the survivors($1.8{\pm}3.6{\mu}g/L$, $2.0{\pm}3.9{\mu}g/L$) (p < 0.05). 4) In the cTnI-positive patients, the cTnI level was significantly correlated with the SAPS II score (r=0.24, p<0.001) and SOFA score (r=0.30, p<0.001). Conclusion : The cTnI may be a useful prognostic marker in noncardiac critically ill patients.

Production and characterization of anti-thyrog1obulin monoclonal antibodies (Thyroglobulin에 대한 단일클론항체의 제작 및 특성)

  • 남경수;손윤희;백태선;김철호;임종국;황철원
    • Journal of Life Science
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    • v.12 no.4
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    • pp.460-463
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    • 2002
  • Twelve clones of monoclonal antibodies (mAbs) against thyroglobulin were produced and characterized. Among them, three mAbs (TN-1, TN-2 and TN-3) showed high binding affinity to thyroglobulin. from ELISA inhibition assay, TN-2 showed considerable reactivity with soluble thyroglobulin. TN-2 also reacted with phosphatidylserine which has a negative charge in aqueous condition. These results suggest that TN-2 has characteristics of autoantibody concerned with thyroiditis.

Study for Thermal Stability of Liquid Crystal Device (액정 소자의 열적 안전성에 관한 연구)

  • 이상극;황정연;서대식;이준웅
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.17 no.4
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    • pp.439-442
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    • 2004
  • In this study, we investigated about electrooptics characteristic of three kinds of TN cell on the polyimide surface. Monodomain alignments of thermal stressed TN cell over temperature of liquid crystal isotropic phase were almost the same as that of no thermal stressed TN cells. However, the thermal stressed TN cells have many defects. Also, threshold voltage and response time of thermal stressed TN cells show the same performances as no thermal stressed TN cells. There were little changes of value in these TN cells. However, transmittances of TN cells on the polyimide surface decrease with increasing thermal stress time. Finally, the residual DC voltage of the thermal stressed TN cell on the polyimide surface shows decrease of characteristics as increasing thermal stress time. Therefore, the thermal stability of TN cell was decreased by high thermal stress for the long times.

Electro-optical performance of TN-LCD wish oblique UV light irradiation on polyimide surface (경사진 자외선 조사를 이용한 TN-LCD의 전기광학 특성)

  • 서대식;박두석;한정민;황율연;박태규
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 1998.06a
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    • pp.113-116
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    • 1998
  • In this paper, we studied the electro-optical(EO) performance of photo-aligned twisted nematic(TN)-liquid crystal display(LCD) with oblique non-polarized ultraviolet(UV) light irradiation on polyimide(Pl) surface. We observed that the voltage-transmittance and response time characteristics of photo-aligned TN-LCD is almost same compared to conventional TN-LCD. Also, we observed that the voltage-holding-ratio(VHR) of photo-aligned TN-LCD is almost same compared to conventional TN-LCD.

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Study on of polarity effect on alignment film in transcription-aligned TN-LCD (전사배향 TN-LCD 에서의 배향막의 극성효과에 관한 연구)

  • Kim, Jin-Ho;Seo, Dae-Shik
    • Proceedings of the KIEE Conference
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    • 1999.07d
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    • pp.1812-1814
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    • 1999
  • The effects of polarity of the polymer on transcription-aligned twisted nematic (TN)-liquid crystal display (LCD) on various the polyimide (PI) surfaces were investigated. The monodomain alignment of nematic (N)LC is obtained in cells fabricated by transcription alignment method on PI surface with medium polarity. The LC alignment using transcription alignment method is attributed to polarity of the polymer. The threshold voltage of transcription-aligned TN-LCD decreases with increasing the polarity of the polymer on three kinds of the PI surfaces. The threshold voltage of transcription-aligned TN-LCD on PI surface with high polarity is almost the same compared to rubbing-aligned TN-LCD. The response time of transcription-aligned TN-LCD decreases with the increasing the polarity of the polymer on all PI surfaces. The decay time of transcription-aligned TN-LCD is slow compared with the rubbing-aligned TN-LCD.

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Integration and Expression of BaciZlus thun'ngiensis Crystal Protein Gene in Chromosomal DNA of Pseudomonas Strains Using Transposon Tn5 (Transposon Tn5에 의한 Bacillus thuringiensis 독소단백질 유전자의 Pseudomonas 내로의 도입 및 발현)

  • 신병식;구본탁;박승환;김정일
    • Microbiology and Biotechnology Letters
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    • v.19 no.1
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    • pp.25-30
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    • 1991
  • The crystal protein gene (cp) of Bacillus tizuringienszs subsp. liuvstaki (B.t.k.) HI173 was subcloned into HanzHI site of central region (Tn5-cp) or BglII site of IS50L region (IS50L-cp) in Tn5, and transposed into the chromosomal DNA of five strains of root-colonizing Pseudomonas. The expression of cp gene in Acwiomoncrs transconjugants was demonstrated by immunoblot analysis and bioassay against larvae of the Hyphantria cunea.

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The Application Method of a Protection Conductor for the Prevention of Electric Shock in England (감전사고 예방을 위한 영국의 보호도체 적용 방법)

  • Jung, Jin-Soo;Jung, Jong-Wook;Han, Woon-Ki;Lee, Jun
    • Proceedings of the KIEE Conference
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    • 2008.07a
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    • pp.2216-2217
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    • 2008
  • This paper write about earth system for the prevention electric shock and a protection of equipment in england. The IEC60364 and BSI(British Standards Institution) define earthing method(IT, TT, TN-C, TN-S, TN-C-S)-BSI is british standards and in case of england almost use the TN system. TN system can classify TN-S & TN-C-S(PME). The findings on survey in england are used the TN-S system and TN-C-S system about 70% and residue 30% are used TT system and IT system from the exiting state of things.

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Study on Thermal Stability of Liquid Crystal Display for Projection TV Application (프로젝션 TV 적용을 위한 액정 디스플레이의 열적 안정성에 관한 연구)

  • Kang, Hee-Jin;Hwang, Jeoung-Yeon;Oh, Yong-Cheul;Seo, Dae-Shik
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.19 no.11
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    • pp.1033-1036
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    • 2006
  • We have investigated electro-optical characteristics in three kinds of twisted nematic (TN) cells on the polyimide surface. The threshold voltage and the response time of thermal stressed TN cells were same that of no thermal stressed TN cells. There were little change of value in these TN cells. On the other hand, transmittance of no thermal stressed TN cells were better than that of thermal stressed TN cells. Transmittances of TN cells on the polyimide surface decreased by increasing thermal stress time. Moreover, the residual DC of the thermal stressed TN cells increased as increasing thermal stress temperature and time. Therefore, thermal stability of TN cells were decreased gradually by giving high thermal stress for a long time.

Adipogenic function of tetranectin mediated by enhancing mitotic clonal expansion via ERK signaling

  • Go, Seulgi;Park, Jihyun;Rahman, Safikur;Jin, Juno;Choi, Inho;Kim, Jihoe
    • BMB Reports
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    • v.54 no.7
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    • pp.374-379
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    • 2021
  • Tetranectin (TN), an adipogenic serum protein, enhances adipocyte differentiation, however, its functional mechanism has yet to be elucidated. In the present study, we investigated the adipogenic function of TN by using medium containing TN-depleted fetal bovine serum (TN-del-FBS) and recombinant mouse TN (mTN). The adipocyte differentiation of 3T3-L1 cells was significantly enhanced by mTN supplementation essentially at differentiation induction, which indicated a potential role of the protein in the early differentiation phase. The adipogenic effect of mTN was more significant with insulin in the differentiation induction cocktail, implicating their close functional relationship. mTN enhanced not only the proliferation of growing cells, but also mitotic clonal expansion (MCE) that is a prerequisite for adipocyte differentiation in the early phase. Consistently, mTN increased the phosphorylation of ERK in the early phase of adipocyte differentiation. Results of this study demonstrate that the adipogenic function of mTN is mediated by enhancing MCE via ERK signaling.

GROWTH AND PUBERTY TRAITS OF THAI NATIVE (TN) AND TN × ANGLO-NUBIAN DOES

  • Pralomkam, W.;Saithanoo, S.;Ngampongsai, W.;Suwanrut, C.;Milton, J.T.B.
    • Asian-Australasian Journal of Animal Sciences
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    • v.9 no.5
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    • pp.591-595
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    • 1996
  • This paper presents results from a study of the age and weight at puberty of Thai does. A randomized block $3{\times}3$ factorial design was used. Factors were genotype (Thai Native; TN, 75% TN $\times$ 25% Anglo-Nubian; AN and 50 TN $\times$ 50% AN does), year of kidding (1989, 1990 and 1991) and birth type (single or twin) as a block. It was shown that there were no significant (p > 0.05) difference in age at puberty among genotypes ($167.6{\pm}6.0$, $157.6{\pm}7.0$ and 160.0 = 4.7 days for TN, 75% TN $\times$ 25% AN and 50% TN $\times$ 50% AN does, respectively) and between birth types. However, does kidded in 1991 had significantly (p < 0.01) longer age at puberty ($194.0{\pm}7.4$ days) than did does kidded in 1989 ($143.0{\pm}4.5$ days) or in 1990 ($148.1{\pm}5.7$ days). There was an interaction effect between genotype and year. Fifty % TN $\times$ 50% AN does had significantly (p < 0.05) higher weights at pubery ($17.2{\pm}0.4kg$) than those of TN($14.3{\pm}0.5kg$ and 75% TN $\times$ 25% AN ($14.4{\pm}0.6kg$) does. There was no significant difference in weights at puberty between TN and 75% TN $\times$ 25% AN does. There was no effect of birth type on weight at puberty. There was an interaction effect between genotype and year of kidding on age and weight at puberty and on growth rate from birth to weaning.