• Title/Summary/Keyword: Therapeutic Park

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Regulation of p53 Expression in an Acidic Environment after Radiation

  • Park, E-K;Chung, H-S;Rhee, Y-H;Ha, S-W;Song, C-W;Park, H-J
    • Proceedings of the Korean Biophysical Society Conference
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    • 2001.06a
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    • pp.59-59
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    • 2001
  • The purpose of this study was to investigate the molecular mechanism by which environmental pH alters the radiation-induced expression of p53, the key regulator of cellular responses to radiation. We have already reported that an acidic environment markedly prolongs the radiation-induced expression of p53 and also prolongs the radiation-induced G2/M arrest.(omitted)

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Antibody Engineering for the Development of Therapeutic Antibodies

  • Kim, Sang Jick;Park, Youngwoo;Hong, Hyo Jeong
    • Molecules and Cells
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    • v.20 no.1
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    • pp.17-29
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    • 2005
  • Therapeutic antibodies represent one of the fastest growing areas of the pharmaceutical industry. There are currently 19 monoclonal antibodies in the market that have been approved by the FDA and over 150 in clinical developments. Driven by innovation and technological developments, therapeutic antibodies are the second largest biopharmaceutical product category after vaccines. Antibodies have been engineered by a variety of methods to suit a particular therapeutic use. This review describes the structural and functional characteristics of antibody and the antibody engineering for the generation and optimization of therapeutic antibodies.

An Experimental Dosimetry of Irregularly-Shaped-Field Using Therapeutic Planning Computer (치료계획용 콤퓨터를 이용한 부정형 조사면의 선량분포에 관한 실험)

  • Park, Joo-Sun;Lee, Gui-Won;Han, Yong-Moon;Kwon, Hyoung-Cheol;Yoon, Sei-Chul
    • The Journal of Korean Society for Radiation Therapy
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    • v.2 no.1
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    • pp.87-92
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    • 1987
  • The authors have intended to measure intrinsic dose distribution by Farmer dosimeter in irregularly shaped fields such as L, M, T,-shape model in order to determine dose inhomogeneity in those models. We made 2 off-axis points in each model and measured the depth dose at 1.5,5, and 9cm below surface. The results showed $1-3\%$ dose discrepancy between 2 points. We also measured the depth dose by geometric approximation and computer calculation in those models, and came to the conclusion that computer calculation using Clarkson's principle is simpler and the measurements are to the ideal data obtained by the experiment in those three models of irregularly shaped fields than those of geometric approximation method.

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Effects of Therapeutic Ball Exercise and Hippotherapy for Balance Ability in Elderly

  • Kang, Kwon Young;Kim, Ji Sung;Choi, Yoo Rim;Lee, Joon Hee;Wang, Joong San;Park, Si Eun;Kim, Hong Rae;Shin, Hee Joon
    • Journal of International Academy of Physical Therapy Research
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    • v.3 no.2
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    • pp.435-439
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    • 2012
  • This study was conducted to evaluate the effect of the exercise on elderly balance ability by using hippotherapy and therapeutic ball exercise. 10 patients were assigned to the hippotherapy group and they got with 30 minutes of hippotherapy. Another 10 elderly were assigned to the therapeutic ball group and they got with 30 minutes of therapeutic ball exercise. All procedures were repeated 5 times a week for the total of four weeks. To investigate the participants balancing abilities, the Time" Up & Go"(TUG) and One Leg Stand Test(OLST) were evaluated. The results of study were significant differences between pre-test and post-test of TUG and OLST(p<.05), and there were no significant differences between hippotherapy and therapeutic ball exercise(p>.05). The conclusion showed that both the hippotherapy and the therapeutic ball exercises were effective on elderly balancing ability. Consequently, it would be better to practice therapeutic ball than hippotherapy for elderly exercise because the more economical and there is less restriction of space than the hippotherapy.