• Title/Summary/Keyword: Transport phenomena

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Pharmacokinetic Modeling and Simulation of the Carrier-Mediated Hepatic Transport of Organic Anions (음이온계 약물의 간수송과정에 있어서 담체매개 수송의 약물동력학적 모델링 및 시뮬레이션)

  • 이준섭;강민희;김묘경;이명구;정석재;심창구;정연복
    • YAKHAK HOEJI
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    • v.47 no.2
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    • pp.110-119
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    • 2003
  • The purpose of the present study was to kinetically investigate the carrier-mediated uptake in the hepatic transport of organic anions, and to simulate the ″in vivo counter-transport″ phenomena, using kinetic model which was developed in this study. The condition that the mobility of carrier-ligand complex is greater than that of free carrier is not essential for the occurrence of ″counter-transport″ phenomenon. To examine the inhibitory effects on the initial uptake of a ligand by the liver, it is necessary to judge whether the true counter-transport mechanism (trans-stimulation) is working or not. The initial plasma disappearance curves of a organic anion were then kinetically analyzed based on a flow model, in which the ligand is eliminated only from the peripheral compartment (liver compartment). Moreover, ″in vive counter-transport″ phenomena were simulated based on the perfusion model which incorporated the carrier-mediated transport and the saturable intracellular binding. The ″in vivo counter-transport″ phenomena in the hepatic transport of a organic anion were well demonstrated by incorporating the carrier-mediated process. However, the ″in vivo counter-transport″ phenomena may be also explained by the enhancement of back diffusion due to the displacement of intracellular binding. In conclusion, one should be more cautious in interpreting data obtained from so-called ″in vivo counter-transport″ experiments.

Pharmacokinetic Modelling and Simulation of the Counter-transport in the Hepatic Transport of Organic Anions (음이온계 약물의 간수송과정에 있어서 대향수송의 약물동력학적 모델링 및 시뮬레이션)

  • Song, Suk-Gil;Lee, Jun-Seup;Chung, Youn-Bok
    • YAKHAK HOEJI
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    • v.49 no.4
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    • pp.275-283
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    • 2005
  • The purpose of the present study was to kinetically investigate the carrier-mediated uptake in the hepatic transport of organic anions, and to simulate the 'in vivo counter-transport' phenomena, using kinetic model which was developed in this study. The condition that the mobility of carrier-ligand complex is greater than that of free carrier is not essential for the occurrence of 'counter-transport' phenomenon. To examine the inhibitory effects on the initial uptake of organic anions by the liver, it is necessary to judge whether the true counter-transport mechanism (trans-stimulation) is working or not. Effects of bromophenol blue (BPB) or bromosulfophthalein (BSP) on the plasma disappearance curves of a 1-anilino-8-naphthalene sulfonate (ANS) were then kinetically analyzed based on a flow model, in which the ligand is eliminated only from the peripheral compartment (liver compartment). Moreover, 'in vivo counter-transport' phenomena were simulated based on the perfusion model which incorporated the carrier-mediated transport and the saturable intracellular binding. The 'in vivo counter-transport' phenomena in the hepatic transport of a organic anions were well demonstrated by incorporating the carrier-mediated process. However, the 'in vivo counter-transport' phenomena may be also explained by the enhancement of back diffusion due to the displacement of intracellular binding. In conclusion, one should be more cautious in interpreting data obtained from so-called 'in vivo counter-transport' experiments.

Computational Analysis of Transport Phenomena in a Planar-Type Solid Oxide Fuel Cell with a Simplified Treatment of the Electrochemical Heat Generation (전기화학 반응에 의한 생성 열의 단순화된 처리 기법을 이용한 평판형 고체산화물 연료전지 내부의 이동현상에 대한 전산 해석)

  • Cha, Hoon;Sohn, Jeong-Lak;Ro, Sung-Tack
    • Journal of the Korean Ceramic Society
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    • v.42 no.12 s.283
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    • pp.846-853
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    • 2005
  • For the performance prediction of a planar-type solid oxide fuel cell, the computational analysis of transport phenomena with a simplified treatment of heat generation by the electrochemical reaction is conducted. From the result of the computational analysis, it is shown that the electrochemical reaction is closely related to the transport phenomena inside a solid oxide fuel cell. Transport phenomena including heat and mass transfer influences on the distribution of local current density and, as a result, on the performance characteristics of the fuel cell. Computational analysis is also extended to the parametric study to investigate the performance behavior of the fuel cell with different amount of supplied fuel flow rates. It is also demonstrated that the mathematical formulation and computational procedures proposed in this study can be applied to prove the importance of the specific TPB area in the manufacturing process of electrodes in solid oxide fuel cells.

Characteristics of East Asia Synoptic Meteorological Conditions in Association with Haze phenomena (연무와 연관된 동아시아의 종관기상 특성)

  • Jo, Hyun-Young;Kim, Cheol-Hee
    • Atmosphere
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    • v.20 no.2
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    • pp.161-172
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    • 2010
  • In an effort to investigate the characteristics of synoptic meteorological conditions in association with long-range transport of haze phenomena occurred over Korea, we statistically classified characteristics of haze events into two types of haze: stagnant case and long-range transport case, based on the synoptic meteorological parameters, and analyze comparatively the characteristics of synoptic meteorological conditions for each case. The results showed that the occurrence frequency of stagnant case accounts for 64.5%, showing superiority of stagnant haze cases over the long-range transport case which occupies only 35.5% among total 67 cases for the period from 2000 to 2007. This result indicates that haze phenomena occurred over Korea has influenced by not only the emission in Korea by itself but long range transport effects originating from China inland. The synoptic condition on 850hPa level showed that, when stagnant case occurred, Korean peninsula was located under the effects of negative vorticity with the significantly weak wind speed and stable atmospheric condition. In contrast, long-range transport case shows positive vorticity and relatively strong wind speed over 850hPa level, especially with the location of high pressure system over the area of southwestern China. This location of high pressure system implies to induce the westerlies or northwesteries consistently due to its pressure gradient by itself. Also other comparative studies haze days (vs.) Asian dust days are carried out, and we found out that the patterns of long-range transport of haze phenomena in Korea shows similar to Asian dust case but the static stability condition indicates more stabilized atmospheric condition than dust phenomena.

Experimental Observations of Boiling and Flow Evolution in a Coiled Tube

  • Ye, P.;Peng, X.F.;Wu, H.L.;Meng, M.;Gong, Y. Eric
    • International Journal of Air-Conditioning and Refrigeration
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    • v.16 no.1
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    • pp.22-29
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    • 2008
  • A sequence of visually experimental observations was conducted to investigate the flow boiling and two-phase flow in a coiled tube. Different boiling modes and bubble dynamical evolutions were identified for better recognizing the phenomena and understanding the two-phase flow evolution and heat transfer mechanisms. The dissolved gases and remained vapor would serve as foreign nucleation sites, and together with the effect of buoyancy, centrifugal force and liquid flow, these also induce very different flow boiling nucleation, boiling modes, bubble dynamical behavior, and further the boiling heat transfer performance. Bubbly flow, plug flow, slug flow, stratified/wavy flow and annular flow were observed during the boiling process in the coiled tube. Particularly the effects of flow reconstructing and thermal non-equilibrium release in the bends were noted and discussed with the physical understanding. Coupled with the effects of the buoyancy, centrifugal force and inertia or momentum ratio of the two fluids, the flow reconstructing and thermal non-equilibrium release effects have critical importance for flow pattern in the bends and flow evolution in next straight sections.

Transprt Phenomena in Bulk Crystal Growth Processes

  • Lan, C.W.
    • Proceedings of the Korea Association of Crystal Growth Conference
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    • 1998.06a
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    • pp.29-33
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    • 1998
  • Transport phenomena paly an inmportant role in bulk crystal growth processes. During crystal growth, the control of the growth front and the dopant concentration is crucial to crystal quality. The growth feasibility in thus determined by the heat transfer controlling the interface convexity and by the mass transfer controlling the constitutional supercooling. Through numerical modeling, a thorough understanding of the growth processes is possible, which in turn is a key to process improvenment. In this paper, we will summarize some work dine in my laboratory, both numerical and experimental, to illustrate the importance of understanding the transport phenomena during crystal growth processes.

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Simulation of Submicron MOSFET Using Hydrodynamic Model (Hydrodynamic model을 이용한 Submicron MOSFET의 Simulation)

  • 김충원;한백형;김경석
    • Journal of the Korean Institute of Telematics and Electronics A
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    • v.30A no.11
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    • pp.122-131
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    • 1993
  • In this paper, we have developed a submicron Si MOSFET simulator, which is physically based on the hydrodynamic energy transport mode. The simulator was used to investigate the nonstationary transport effects and the transient phenomena in submicron Si MOSFET's. It is found that the velocity overshoot and the carrier heating are dominant transport mechanism near the drain end of the channel and the transient phenomena is more retained in a long channel MOSFET.

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Control of axial segregation by the modification of crucible geometry

  • Lee, Kyoung-Hee
    • Journal of the Korean Crystal Growth and Crystal Technology
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    • v.18 no.5
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    • pp.191-194
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    • 2008
  • We will focus on the horizontal Bridgman growth system to analyze the transport phenomena numerically, because the simple furnace system and the confined growth environment allow for the precise understanding of the transport phenomena in solidification process. In conventional melt growth process, the dopant concentration tends to vary significantly along the crystal. In this work, we propose the modification of crucible geometry for improving the productivity of silicon single-crystal growth by controlling axial specific resistivity distribution. Numerical analysis has been performed to study the transport phenomena of dopant impurities in conventional and proposed Bridgman silicon growth using the finite element method and implicit Euler time integration. It has been demonstrated using mathematical models and by numerical analysis that proposed method is useful for obtaining crystals with superior uniformity along the growth direction at a lower cost than can be obtained by the conventional melt growth process.

Charge Transport Phenomena of Polyaniline-DBSA/Polystyrene Blends (폴리 아닐 린-DBSA/폴리스타이렌 블렌드의 전하 이동 현상)

  • 김원중;김태영;고정우;김윤상;박창모;서광석
    • The Transactions of the Korean Institute of Electrical Engineers C
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    • v.53 no.6
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    • pp.305-311
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    • 2004
  • Charge transport phenomena of polyaniline-DBSA/High Impact Polystyrene (PAM-DBSA/HIPS) blends have been studied through an examination of electrical conduction. HIPS used host polymer in the blends and PANI-DBSA obey a space charge limited conduction mechanism and a ohmic conduction mechanism respectively. However, PANI-DBSA/HIPS blends do not obey any classical conduction mechanism. Analysis of conduction mechanism revealed that the charging current of PANI-DBSA/HIPS blends increased with the increase of PANI-DBSA content. This result migrlt be explained by the reduction in the distance between PANI-DBSA particles enabling the charge carriers to migrate from a chain to a neighboring chain via hopping or micro tunneling. It was also found that the charging current of PANI-DBSA/HIPS blends decreased as the temperature was elevated, which is of typical phenomena in metals. It is speculated that the charge transport in PANI-DBSA particle was somewhat constrained due to strong phonon scattering.

Fundamentals of Stress-Induced Diffusion: Theoretical Approach to Hydrogen Transport through Self-Stressed Electrode

  • Lee, Sung-Jai;Pyun, Su-Il
    • Journal of the Korean Electrochemical Society
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    • v.8 no.1
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    • pp.47-54
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    • 2005
  • This article covers the fundamentals of stress-induced diffusion, focusing on the theoretical model for hydrogen transport through self-stressed electrode. First, the relationship between hydrogen diffusion and macroscopic deformation of the electrode specimen was briefly introduced, and then it was classified into the diffusion-elastic and elasto-diffusive phenomena. Next, the transport equation for the flux of hydrogen caused simultaneously by both the concentration gradient and the stress gradient was theoretically derived. Finally, stress-induced diffusion was discussed on the basis of the numerical solutions to the derived transport equation under the permeable and impermeable boundary conditions.