• 제목/요약/키워드: Treating of wound

검색결과 76건 처리시간 0.032초

Successful Tractotomy Technique for a Penetrating Lung Injury in a Patient with One Lung

  • Kang, Dong Hoon;Park, Hyun Oh;Moon, Sung Ho;Jang, In Seok;Byun, Jung Hoon;Kim, Sung Hwan
    • Journal of Chest Surgery
    • /
    • 제50권5호
    • /
    • pp.399-402
    • /
    • 2017
  • We report the case of a patient with penetrating chest trauma (right chest) who had undergone a left pneumonectomy due to pulmonary tuberculosis 24 years ago. We performed an emergent thoracotomy, finding an opening of the penetrating wound in a lower-lobe basal segment of the right lung. A stapled tractotomy was performed along the tract. Bleeding control and air-leakage control was done easily and rapidly. The patient was discharged without any complications on the seventh day of admission. Tractotomy can be a good option for treating penetrating lung injuries in patients with limited lung function who need emergent surgery.

성대구증에서 KTP Laser를 사용한 수술적 치료 1례 (Surgical Treatment of Sulcus Vocalis Using KTP Laser)

  • 정찬민;김지형;임재열;최홍식
    • 대한후두음성언어의학회지
    • /
    • 제28권2호
    • /
    • pp.131-134
    • /
    • 2017
  • Sulcus vocalis remains a surgical challenge despite many recent advances in laryngomicrosurgeries. We previously reported that 585-nm Pulsed dye laser (PDL) exerts favorable outcome in treatment of sulcus vocalis due to its therapeutic effects of collagen rearrangement and improved wound remodeling. In spite of the usefulness of PDL glottoplasty for treating sulcus vocalis, the device is no more available in the country. It prompted us to focus another angiolytic laser ; 532-nm KTP laser which has similar mechanisms of action and has been used for treatment of other laryngeal lesions elsewhere. Herein, we present a case of sulcus vocalis successfully treated with KTP laser. A patient underwent laryngomicrosurgery with angiolytic KTP laser (KTP glottoplasty) by the same surgical procedure with PDL glottoplasty. After the surgery, the patient presented improved voice outcome in time without complications.

  • PDF

심장 자상 후에 발생된 삼첨판막 폐쇄부전의 삼첨판막 성형술 - 1예 보고 - (Tricuspid Valve Repair for Tricuspid Valve Insufficiency Following a Cardiac Stab Injury - One case report -)

  • 김동현;이승진;이철세;이길노;이석열
    • Journal of Chest Surgery
    • /
    • 제40권5호
    • /
    • pp.376-379
    • /
    • 2007
  • 51세 환자가 3개월 전에 심장 자상으로 본원에 입원하여 심장봉합수술을 받았다. 이후 별다른 소견 없이 지내다가 약 2개월 전부터 발생된 호흡곤란을 주소로 내원하였다. 심장초음파상 심한 삼첨판막 페쇄부전이 관찰되었으며 삼첨판막의 건삭치환술과 판윤 성형술을 실시하였다. 이에 저자들은 심장 자상 후에 발생된 삼첨판막 폐쇄부전을 판막성형술로 치료하였기에 증례보고를 하는 바이다.

관상동맥질환의 방사성동위원소 치료 (Brachytherapy in Coronary Artery Disease)

  • 송호천
    • Nuclear Medicine and Molecular Imaging
    • /
    • 제40권2호
    • /
    • pp.113-119
    • /
    • 2006
  • Coronary artery disease is a loading cause of morbidity and mortality across the world. Percutaneous coronary intervention has become the major technique of revascularization. However, restenosis remains a major limitation of this procedure. Recently the need for repeat intervention due to restenosis, the most vexing long-term failure of percutaneous coronary intervention, has been significantly reduced owing to the introduction of two major advances, intracoronary brachytherapy and the drug-eluting stents. Intracoronary brachytherapy has been employed in recent years to prevent restenosis lesions with effective results, principally in in-stent restenosis. Restenosis is generally considered as au excessive form of normal wound healing divided up in precesses: elastic recoil, neointimal hyperplasia, and negative vascular remodeling. Restenosis has previously been regarded as a proliferative process in which neointimal thickening, mediated by a cascade of inflammatory mediators and other factors, is the key factor. Ionizing radiation has been shown to decrease the proliferative response to injury in animal models of restenosis. Subsequently, several randomized, double blind trials have demonstrated that intracoronary brachytherapy can reduce the rates of both angiographic restenosis and clinical event rates in patients undergoing percutaneous coronary intervention for in stent restenosis. Some problems, such as late thrombosis and edge restenosis, have been identified as limiting factors of this technique. Brachytherapy is a promising method of preventing and treating coronary artery restenosis.

CIPA(Congenital Insensitivity to Pain with Anhidrosis)를 가진 환아에서 욕창의 치험례 (A Case of Pressure Sore in Congenital Insensitivity to Pain with Anhidrosis)

  • 황재하;박선형;유성인;노복균;김의식;김광석;이삼용
    • Archives of Plastic Surgery
    • /
    • 제33권5호
    • /
    • pp.669-671
    • /
    • 2006
  • Purpose: Congenital insensitivity to pain with anhidrosis(CIPA) is a rare form of autosomal recessive peripheral sensory neuropathy. Patients with CIPA show loss of pain sensation, which leads to corneal ulcers and opacities, self-mutilation of the tongue and fingertips, as well as fractures with subsequent joint deformities and chronic osteomyelitis. The purpose of this report is to highlight the fact that pressure sores also are a potential complication of CIPA. Methods: This case report describes a patient presenting with pressure sores resulting from CIPA. A 5-year-old boy was referred to our department for the treatment of a $5{\times}5cm$ sacral pressure sore as a result of a hip spica cast applied for the treatment of a left hip joint dislocation. He had a history suggesting CIPA such as multiple bony fractures, mental retardation, recurrent hyperpyrexia, anhidrosis, and clubbing fingers due to oral mutilation. A microscopic examination of the sural nerve showed mainly large myelinated fibers, a few small myelinated fibers and an almost complete loss of unmyelinated fibers. After wound preparation for two weeks, the exposed bone was covered with two local advancement flaps. Results: Two weeks later, complete wound healing was achieved. A 16-month follow-up showed no recurrence. However, the patient presented with a new pressure sore on the left knee due to orthosis for the treatment of the left hip joint dislocation. Conclusion: The early diagnosis of CIPA and special care of pressure sores are important for preventing and treating pressure sores resulting from CIPA.

쇄골 간부 골절에 대한 경피적 골수강내 금속핀 고정 수술법과 결과 보고 (Surgical Techniques for Percutaneous Intramedullary Fixation with Steinmann Pins for Clavicle Shaft Fractures)

  • 하성식;심재천;성민철;전종현;서이락
    • 대한정형외과학회지
    • /
    • 제52권1호
    • /
    • pp.7-14
    • /
    • 2017
  • 목적: 쇄골 간부 골절에서 경피적 골수강내 금속핀 고정술을 시행 후 결과를 보고하고자 한다. 대상 및 방법: 쇄골 간부 골절로 내원한 환자 중 2004년 1월부터 2014년 6월까지 경피적 골수강내 금속핀 고정술을 시행한 135예를 대상으로 하였다. 평균 추시 기간은 15개월(12-24개월)이었다. 기능적 평가로 Disabilities of the Arm, Shoulder and Hand(DASH) score와 Constant score, 임상적 평가로 쇄골의 단축, 수술 반흔의 길이, 수술 시간 및 Kang's criteria에 등에 의하여 분석하였다. 결과: 방사선적 골유합 기간은 평균 11.6주(8-16주), DASH score는 평균 11.8점, Constant score는 평균 91.2점이었다. 임상적 결과로 쇄골의 단축은 평균 20 mm 이하였으며, 수술 반흔의 길이는 평균 1.2 cm (0.7-1.5 cm), 수술 시간은 평균 18분(10-35분)이었으며 Kang's criteria를 기준으로 한 임상적 치료 결과는 우수 이상이 총 131예(97.0%)로 만족할 만한 치료 결과를 보였다. 합병증으로는 3예의 핀 전이, 그 중 2예에서 불유합이 관찰되었다. 결론: 쇄골 간부 골절에서 시도한 경피적 골수강내 금속핀 고정술은 유용한 수술법이라 생각된다.

단일 술자에 의해 시행된 배꼽상부 피부절개 및 복강경 유문근 절개술의 임상적 결과 비교 (Comparison of Pyloromyotomy with Supraumbilical Incision and Laparoscopic Pyloromyotomy for Hypertrophic Pyloric Stenosis Performed by a Single Surgeon)

  • 이종우;김대연;김성철;남궁정만;황지희
    • Advances in pediatric surgery
    • /
    • 제20권2호
    • /
    • pp.43-47
    • /
    • 2014
  • Purpose: Hypertrophic pyloric stenosis (HPS) is known to be one of the most common cause of surgery for infants and pyloromyotomy was considered to the standard treatment. There has been an ongoing debate about whether laparoscopic pyloromyotomy (LP) or open pyloromyotomy (OP) is the best option for treating HPS. The aim of this study is to evaluate safety and effectiveness of LP by comparing the clinical results of both surgical strategies performed by single surgeon. Methods: Between January 2000 and December 2013, 60 patients who underwent pyloromyotomy at Asan Medical Center performed by a surgeon were followed: open-supraumbilical incision (n=36) and LP (n=24). The parameters included sex, age and body weight at operation. Clinical outcomes included operation time, time to full feeding, postoperative hospital stay, and postoperative complications. Results: There were no significant differences in characteristics, postoperative hospital stay between the two groups. Time to full feeding was shorter in LP (OP 24.5 hours vs. LP 19.8 hours; p=0.063). In contrast, the mean operation time was longer in LP (OP 37.5 minutes vs. LP 43.5 minutes; p=0.072). Complications such as perforation of mucosal layer (OP 1 vs. LP 0) and wound problems (OP 2 vs. LP 0) were found to be not worse in laparoscopic group as compared with open group. Conclusion: There has no difference both laparoscopic and open-supraumbilical incision in terms of postoperative hospital stay, time to full feeds and frequency of complications.

Single Stage Circumferential Cervical Surgery (Selective Anterior Cervical Corpectomy with Fusion and Laminoplasty) for Multilevel Ossification of the Posterior Longitudinal Ligament with Spinal Cord Ischemia on MRI

  • Son, Seong;Lee, Sang-Gu;Yoo, Chan-Jong;Park, Chan-Woo;Kim, Woo-Kyung
    • Journal of Korean Neurosurgical Society
    • /
    • 제48권4호
    • /
    • pp.335-341
    • /
    • 2010
  • Objective : Anterior cervical corpectomy with fusion (ACF) or laminoplasty may be associated with substantial number of complications for treating multilevel cervical ossification of the posterior longitudinal ligament (OPLL) with significant cord compression. For more safe decompression and stabilization in multilevel cervical OPLL with prominent cord compression, we propose circumferential cervical surgery (selective ACF and laminoplasty) based on our favorable experience. Methods : Twelve patients with cervical myelopathy underwent circumferential cervical surgery and all patients showed multilevel OPLL with Signal change of the spinal cord on magnetic resonance imaging (MRI). A retrospective review of clinical, radiological. and surgical data was conducted. Results : There were 9 men and 3 women with mean age of 56.7 years and a mean follow up period of 15.6 months. The average corpectomy level was 1.16 and laminoplasty level was 4.58. The average Japanese Orthopedic Association score for recovery was 5.1 points and good clinical results were obtained in 11 patients (92%) (p < 0.05). The average space available for the cord improved from 58.2% to 87.9% and the average Cobb's angle changed from 7.63 to 12.27 at 6 months after operation without failure of fusion (p < 0.05). Average operation time was 8.36 hours, with an estimated blood loss of 760 mL and duration of bed rest of 2.0 days. There were no incidences of significant surgical complications, including wound infection. Conclusion : Although the current study examined a small sample with relatively short-term follow-up periods, our study results demonstrate that circumferential cervical surgery is considered favorable for safety and effectiveness in multilevel OPLL with prominent cord compression.

Bee venom inhibits the proliferation and migration of cervical-cancer cells in an HPV E6/E7-dependent manner

  • Kim, Da-Hyun;Lee, Hyun-Woo;Park, Hyun-Woo;Lee, Han-Woong;Chun, Kyung-Hee
    • BMB Reports
    • /
    • 제53권8호
    • /
    • pp.419-424
    • /
    • 2020
  • Bee venom (BV), secreted from the venom gland of the honey bee, contains several biological active compounds. BV has been widely used as a traditional medicine for treating human disease, including cancer. In this study, we have shown the molecular mechanism underlying the therapeutic effect of BV on cancer. Treatment with BV reduced the proliferation of cervical-cancer cells in a dose- and time-dependent manner. Interestingly, the killing effect of BV was specific to HPV-positive cervical-cancer cell lines, such as Caski and HeLa cells, and not to HPV-negative cervical-cancer cells (C33A). BV reduced the expression of HPV E6 and E7 at RNA and protein levels, leading to an increase in the expression of p53 and Rb in Caski and HeLa cells. Further, BV decreased the levels of cell-cycle proteins, such as cyclin A and B, and increased the levels of cell-cycle inhibitors, such as p21 and p27. BV significantly induced apoptosis and inhibited wound healing and migration of cervical-cancer cells. It also upregulated the expression of pro-apoptotic BAX and downregulated the expression of anti-apoptotic Bcl-2 and Bcl-XL. Cleavage of caspase-3, caspase-9, and PARP were also induced by BV treatment, whereas the phosphorylation of mitogenic signaling-related proteins, such as AKT, JNK, p38, and ERK, were downregulated. Our results indicate that BV has a therapeutic selectivity for HPV-positive malignant cells, so further clinical studies are needed to assess its clinical application.

Cisplatin Combined with Metformin Inhibits Migration and Invasion of Human Nasopharyngeal Carcinoma Cells by Regulating E-cadherin and MMP-9

  • Sun, Xiao-Jin;Zhang, Pei;Li, Hai-Hui;Jiang, Zhi-Wen;Jiang, Chen-Chen;Liu, Hao
    • Asian Pacific Journal of Cancer Prevention
    • /
    • 제15권9호
    • /
    • pp.4019-4023
    • /
    • 2014
  • Metformin has been shown to be useful in reducing insulin resistance by restoring sensitivity. Recent evidence suggests that metformin might also possess anti-tumour activity. This study aimed to investigate the effects of cisplatin combined with metformin on the proliferation, invasion and migration of HNE1/DDP human nasopharyngeal carcinoma (NPC) cells, and to provide a new target for treating metastasis. The MTT assay was used to assess viability of HNE1/DDP cells after exposure to different concentrations of 2, 5-diaminopyrimidine-4, 6-diol (DDP; 2, 4, 8, 16, and $32{\mu}mol{\cdot}L^{-1}$), metformin (5, 10, 15, 20, and $25{\mu}mol{\cdot}L^{-1}$), and $4{\mu}mol{\cdot}L^{-1}$ of DDP combined with metformin. Wound healing and transwell migration assays were performed to assess cell migration and invasion, and expression of E-cadherin and MMP-9 was detected using Western blotting. MTT assay results showed that DDP could inhibit the proliferation of HNE1/DDP cells in a time- and concentration-dependent manner, with an IC50 of $32.0{\mu}mol{\cdot}L^{-1}$ at 24 h (P < 0.05), whereas low concentrations of DDP had almost no inhibitory effects on cell invasion and migration. DDP combined with metformin significantly inhibited cell invasion and migration. In addition, genes related to migration and invasion, such as those of E-cadherin and MMP-9, showed differential expression in the NPC cell line HNE1/DDP. In the present study, with an increasing concentration of metformin, the expression of MMP-9 was downregulated whereas that of E-cadherin was significantly upregulated. Taken together, our results show that cisplatin combined with metformin has effects on proliferation, invasion, and migration of human NPC cells.