• Title, Summary, Keyword: UK

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A Collaborative Study to Establish a Korea National Biological Standard for Antithrombin Concentrate

  • Kang, Hye-Na;Lee, Sung-Han;Kim, Soon-Nam;Hong, Choong-Man;Lee, Ki-Hong;Oh, Ho-Jung;Yoo, Si-Hyung;Shin, In-Soo;Choi, Seung-Eun;Lee, Seok-Ho;Gray, Elaine;Okada, Yoshiaki;Hong, Seung-Hwa
    • Proceedings of the PSK Conference
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    • pp.272.1-272
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    • 2002
  • We have carried out collaborative study to evaluate a preparation of antithrombin concentrate whether or not it was suitable to serve as the candidate for a Korea National Biological Standard. Six laboratories. including three manufacturers and three National Control Laboratories. participated in this study. The potency of this candidate preparation was determined using the heparin cofactor chromogenic method. (omitted)

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RUNX1 Dosage in Development and Cancer

  • Lie-a-ling, Michael;Mevel, Renaud;Patel, Rahima;Blyth, Karen;Baena, Esther;Kouskoff, Valerie;Lacaud, Georges
    • Molecules and Cells
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    • v.43 no.2
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    • pp.126-138
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    • 2020
  • The transcription factor RUNX1 first came to prominence due to its involvement in the t(8;21) translocation in acute myeloid leukemia (AML). Since this discovery, RUNX1 has been shown to play important roles not only in leukemia but also in the ontogeny of the normal hematopoietic system. Although it is currently still challenging to fully assess the different parameters regulating RUNX1 dosage, it has become clear that the dose of RUNX1 can greatly affect both leukemia and normal hematopoietic development. It is also becoming evident that varying levels of RUNX1 expression can be used as markers of tumor progression not only in the hematopoietic system, but also in non-hematopoietic cancers. Here, we provide an overview of the current knowledge of the effects of RUNX1 dosage in normal development of both hematopoietic and epithelial tissues and their associated cancers.

Survey of Status for Ageing Population, Charge Organizations and Polices in UK

  • Kee, Dohyung
    • Journal of the Ergonomics Society of Korea
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    • v.33 no.5
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    • pp.387-394
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    • 2014
  • Objective: The purpose of this study is to survey trend and the real state of ageing population in UK, and its charge organizations, relevant policies and studies. Background: As in other countries, UK population is ageing and people aged 65 or over account for about 17% of population in UK. Considering this ageing population, there are varying basic studies and policies for older people in UK. Method: First, the author consulted ageing and its policies in UK with some faculties in an UK university. Next, based on the results of consultation, wide literature survey was conducted, which includes papers in relevant academic journals, publications and website surfing. Results: A number of basic studies for surveying status and characteristics of older people as well as simple population trend for them have been conducted in UK. Healthcare services are free for all UK residents, and varying social care services including equipment, home and residential cares, financial support, etc., are provided by local governments. Cost of social cares is means-tested and is not free for everyone. There are a number of governmental or non-profit organizations dedicated to help older people access social care services or to financially fund research projects older people. Conclusion: There are more basic studies, and healthcare and social care services for older people in UK, compared to Korea. Application: It would be useful as basic data for establishing effective polices for old people in Korea.

The development of Britain after the European era (后脱欧时代英国的发展走向)

  • Chuan, Zhou
    • Industry Promotion Research
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    • v.2 no.1
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    • pp.113-115
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    • 2017
  • A brief analysis of the impact of the UK off Europe paper on both the positive and negative aspects. For example, in the UK after the EU referendum, out of the shackles of the UK's European Union in the short term, away from the impact of refugees. On the contrary, however, it can have a tremendous impact on the UK's foreign trade and financial industry, while the UK's International will be influenced by the West.

Effects of UK 14,304, An ${\alpha}_2$-Adrenergic Agonist, on Renal Function in Dog (${\alpha}_2$-아드레날린 효능약인 UK 14,304의 신장기능에 미치는 영향)

  • Ko, Suk-Tai;Kim, Hai-Suk;Choi, Hong-Seok
    • YAKHAK HOEJI
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    • v.41 no.4
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    • pp.498-511
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    • 1997
  • The effects of UK 14,304, an ${\alpha}_2$-adrenergic agonist, on renal function were investigated in dogs. UK 14,304, when given intravenousely($15.0{\mu}g/kg,\;50{\mu}g/kg$), produced the increase of urine flow accompanied with the marked augmentation of free water clearance ($C_{H_2O}$) and reabsorption rates of sodium in renal tubules ($R_{Na}$), and the remarkable decrease of osmolar clearance ($C_{osm}$) and the amounts of sodium excreted in urine ($E_{Na}$). UK 14,304 given into a renal artery($1.5{\mu}g/kg,\;5.0{\mu}g/kg$) elicited the increase of urine flow with the augmentation of $C_{H_2O}$ in both kidney. UK 14,304, when administered into carotid artery($3.0{\mu}g/kg,\;10.0{\mu}g/kg$). exhibited the same aspect as shown in intravenous UK 14.304 at smaller dose than the intravenous dose. Diuretic action of intravenous UK 14,304 were produced together with increase of $C_{H_2O}$ in situation of water diuresis too, changes of renal function in this state were the increase of $C_{osm},\;E_{Na},\;and\;E_K$ (excreted amounts of potassium in urine), and the decrease of $R_{Na}\;and\;R_K$, these were different appearances from situation of saline diuresis. Diuretic action of intravenous UK 14,304 were blocked completely by post or pretreatment of yohim-bine, ${\alpha}_2$-adrenergic blocking agents, and inhibited by pretreatment of vasopressin, antidiuretic hormone. Above results suggest that UK 14,304 produces the diuretic action by the inhibition of vasopressin secretion and suppression of electrolytes reabsorption of electrolytes in renal tubules mediated with central ${\alpha}_2$-adrenoceptor in dog.

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Fusion Protein Cleavage by Urokinase Covalentley Immobilized to Activated Sepharose Gels (활성화된 Sepharose Gels에 공유결합으로 고정화된 Urokinase를 이용한 융합단백질 절단반응)

  • 서창우;강관엽;이효실;안상점;이은규
    • KSBB Journal
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    • v.15 no.1
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    • pp.42-48
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    • 2000
  • Urokinase (UK), a thrombolytic enzyme used to clear catheters obstructed by blood clots, can be also used industrially in the recombinant protein purification system to cleave a fusion protein linked with a certain fragment of GST. We have immobilized UK by covalent attachment to activated Sepharose 6B-Cl gels and evaluated its performance to cleave a fusion protein of hGH and GST. The Sepharose gels were activated by etherification with glycidol (2,3-epoxypropanol) and further oxidized with periodate resulting in glyceryl-Sepharose gels. After the activation treatment, surface density of the aldehyde groups was 7-30 $\mu$mol-aldehde/mL-gel. Immobilization yield was higher than 99% at high pH (10.5), and the immobilized UK maintained ca. 80% specific activity of the soluble UK. In a column reaction the cleavage yield heavily depended on the feed rate, and it was nearly 86% of that from soluble UK. And the immobilized UK was successfully regenerated by unfolding and refolding with 6M GuHCl. After cleavaging reaction, the monomeric hGH was purified by using expanded bed adsorption chromatography.

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The Knowledge Transfer of Tesco UK into Korea, in Terms of Retailer Brand Development and Handling Processes

  • Cho, Young-Sang
    • Journal of Distribution Science
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    • v.9 no.2
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    • pp.13-24
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    • 2011
  • With the increasing market share of retailer brands, many authors have paid considerable attention to retailer brands. Before market liberalisation in 1996 in Korea, retailer brand market was led by the supermarket retailing format, although the first retailer brand product was developed by the department store format. In parallel with the entry of foreign multiple retailers, the retailer brand market has experienced rapid growth. Particularly, the expansion of Tesco UK with well-established retailing know-how into Korea has encouraged Tesco Korea to actively get involved in retailer brand program. As a result, Tesco Korea has led retailer brand market in the Korean marketplace. The research starts with the question of why Tesco Korea has achieved such a higher retailer brand share. Accordingly, this study is to explore how Tesco UK has transferred its own retailing knowledge into Tesco Korea, in terms of retailer brand program development. In order to explore why the retailer brand share of Tesco Korea is higher than that of its counterparts, the author adopted in-depth interview with prepared-questions and store observation as a research methodology. To examine working process as well as information flows within Tesco Korea and from UK to Korea, in-depth interview method is one of the most suitable research methodologies, because of the difficulty of quantifying information or data related to work flows. In addition, to increase the validity of information, the researcher had interviews with Tesco Korea supplier and store personnel. Based on these research techniques, this research explored how Tesco UK has influenced or advised Tesco Korea, particularly, from the point of view of knowledge transfer. Since the entry of Tesco UK into Korea as a joint-venture, the retailer brand market share of Tesco Korea has continuously increased. It would be expected that Tesco UK has helped Tesco Korea to settle down in the Korean market. During interviews with Tesco and a Tesco supplier, the researcher found that Tesco Korea has obviously taken an advantage of retailing know-how created by Tesco UK. Furthermore, the retailer brand development and handling process of Tesco Korea has been operated with the help of Tesco UK. This might mean that Tesco UK has directly or indirectly an impact on the improvement of Korean retailer brand development skills. As a mechanism to transfer retailing knowledge developed in the home market into the host market, one of the international retailers, Tesco UK has adopted many different ways such as annual meeting, trading meeting to import or export own retailer brand products, offering of operation manual developed by Tesco UK and buyer cooperation between Tesco UK and Korea, in order to share information. Through these communication techniques, the knowledge of Tesco UK has been transferred to Tesco Korea. This research accordingly suggests that retailer brand market share is apparently related to how sophisticated or advanced the knowledge of the retailer brand development and handling process of retailers are. It is also demonstrated by this research that advanced development and handling skills make a considerable contribution to increasing retailer brand share in markets with a lower share or no presence of retailer brands.

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