• Biomolecules & Therapeutics
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• v.25 no.1
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• pp.69-79
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• 2017

Viruses continue to evolve a new strategy to take advantage of every aspect of host cells in order to maximize their survival. Due to their central roles in transducing a variety of transmembrane signals, GPCRs seem to be a prime target for viruses to pirate for their own use. Incorporation of GPCR functionality into the genome of herpesviruses has been demonstrated to be essential for pathogenesis of many herpesviruses-induced diseases. Here, we introduce US28 of human cytomegalovirus (HCMV) as the best-studied example of virally-encoded GPCRs to manipulate host GPCR signaling. In this review, we wish to summarize a number of US28-related topics including its regulation of host signaling pathways, its constitutive internalization, its structural and functional analysis, its roles in HCMV biology and pathogenesis, its proliferative activities and role in oncogenesis, and pharmacological modulation of its biological activities. This review will aid in our understanding of how pathogenic viruses usurp the host GPCR signaling for successful viral infection. This kind of knowledge will enable us to build a better strategy to control viral infection by normalizing the virally-dysregulated host GPCR signaling.

• Korean Journal of Organic Agriculture
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• v.28 no.1
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• pp.31-57
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• 2020

Korea-US FTA amendment became effective January 1, 2019 through several trade negotiations between the two countries. These amendments did not include changes in the agricultural sector. However, given the policy direction of the Trump administration, it is difficult to be certain that the existing Korea-US FTA on the agricultural sector will remain unchanged. This study examines the potential impact of changes in the US beef import tariff rates under the Korea-US FTA, which is progressively eliminated until 2026 using a dynamic partial equilibrium model. The modelling system is simulated with 100% decreases of tariff rates over 2020~2026 period and then compared to the baseline which is developed based on the current Korea-US FTA tariff rates. According to the scenario analyses results, 100% decreases of US beef tariff rate lowered Korean beef cattle production value up to 4.23%. Looking at this change in terms of absolute value rather than percentage, the total production value over 2020~2026 is expected to decrease by 815 billion won compared to Baseline. This reduction in production value in dynamic analysis is 67 billion won higher than the comparative static analysis.

• Journal of IKEEE
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• v.23 no.2
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• pp.552-556
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• 2019

This paper present a capless low drop out regulator (LDO) that improves the load transient response characteristics by using a current regulator. A voltage regulator circuit is placed between the error amplifier and the pass transistor inside the LDO regulator to improve the current characteristics of the voltage line, The proposed fast transient LDO structure was designed by a 0.18 um process with cadence's virtuoso simulation. according to test results, the proposed circuit has a improved transient characteristics compare with conventional LDO. the simulation results show that the transient of rising increases from 1.954 us to 1.378 us and the transient of falling decreases from 19.48 us to 13.33 us compared with conventional capless LDO. this Result has improved response rate of about 29%, 28%.

• Herbal Formula Science
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• v.28 no.1
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• pp.41-51
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• 2020

Objectives : US extract is a mixture of each extract of Ulmi cortex and Smilacis rhizoma. In this study, we investigated the antioxidant, anti-inflammatory, antibacterial, and ovoprotective effects of US extract in in vitro model to identify potential candidates for improving female reproductive function. Methods : The antioxidant activity of US extract was measured using 1,1-diphenyl- 2-picrylhydrazyl free radical and superoxide anion radical scavenging assays. The anti-inflammatory effect of US extract on lipopolysaccharide (LPS)-stimulated RAW 264.7 cells were determined with a nitric oxide (NO) assay, enzyme linked immunosorbent assays, and western blots analysis. The antibacterial activity of US extract against vaginitis infection microorganisms were determined with disc diffusion and minimum inhibitory concentration assays. The ovoprotective effect of US extract on 4-vinylcyclohexene diepoxide (VCD)-induced ovotoxicity in CHO-K1 cells were evaluated with a cell viability assay. Result : US extract showed good antioxidant capacity and inhibited LPS-induced NO production as well as iNOS and COX-2 expression and secretion of pro-inflammatory cytokine IL-6 without affecting the cell viability. It showed significant clear zones for Staphylococcus aureus and Candida albicans but did not indicate the clear zones for Escherichia coli and Enterococcus faecium. VCD-induced ovotoxicity in CHO-K1 cells was significantly reduced by US extract pre-treatment. Conclusions : These results demonstrate that US extract has antioxidant activity, anti-inflammatory effects on the LPS-stimulated macrophages, antibacterial activity against vaginitis infection microorganisms, and protective effects on the ovarian cells against VCD-induced ovotoxicity. These findings suggest that the US extract can be used as new prescriptions, supplements, functional foods, and cosmetics for improving female reproductive function.

• Korean Journal of Mathematics
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• v.28 no.1
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• pp.89-104
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• 2020

In this paper, we connect (α, β) union soft sets and their ideal related properties with KU-algebras. In particular, we will study (α, β)-union soft sets, (α, β)-union soft ideals, (α, β)-union soft commutative ideals and ideal relations in KU-algebras. Finally, a characterization of ideals in KU-algebras in terms of (α, β)-union soft sets have been provided.

• Journal of Fisheries and Marine Sciences Education
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• v.28 no.2
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• pp.489-501
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• 2016

The purpose of this research is to analyze the narratives of elementary school history textbooks of Korea and US. The research problems are as follows. Firstly, what are the form and content of narratives of Korea's elementary school history textbook of Korea and US. Secondly, what are the characteristics of narratives of American elementary school history textbook of Korea and US. The content analysis method was utilized for analyzing narratives of textbooks. Research results are summarized as follows. Firstly, the features of Korea's elementary school history textbook are described. Secondly, the features of American elementary school history textbook are described. Thirdly, the common features and differences between both countries' textbook narratives are analyzed. Lastly, the implications for diversifying the narratives of Korea's elementary school history textbook are recommended.

• Research in Community and Public Health Nursing
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• v.28 no.2
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• pp.173-181
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• 2017

Purpose: Early sexual intercourse is associated with poor health outcomes in adolescents. It is known that sexual intercourse coincides with other health risk behaviors such as smoking, drinking, and using drugs. The purpose of this study is to identify the relationships between sexual intercourse and health risk behaviors among Korean and US adolescents using nationally representative data. Methods: Data were collected from the 2011 Korea Youth Risk Behavior Web-based Survey (29,676 students) and 2011 Youth Risk Behavior Surveillance System (10,135 high school students). Logistic regression analysis was performed. Results: In Korea, students who had sexual intercourse accounted for 7.0% in total. Among these, 9.7% were male and 4.2% were female students. In the US, a total of 51.3% students had sexual intercourse, and the proportion of the US male (49.3%) and female (53.4%) students who had sexual intercourse was similar. Korean and US students who experienced sexual intercourse were more likely to smoke, drink alcohol, and use drugs. Conclusion: Since the results of this study show the relationships between sexual intercourse and health risk behaviors, it is necessary to develop comprehensive sex education programs with effective strategies to reduce health risk behaviors in adolescents.

• ETRI Journal
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• v.28 no.4
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• pp.541-544
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• 2006

From its foundation until 2004, ETRI has registered over 1,000 US patents. This letter analyzes the characteristics of these patents and addresses the explanatory factors affecting their citation counts. For explanatory variables, research team related variables, invention specific variables, and geographical domain related variables are suggested. Zero-altered count data models are used to test the impact of independent variables. A key finding is that technological cumulativeness, the scale of invention, outputs in the electronic field, and the degree of dependence on the US technology domain positively affect the citation counts of ETRI-invented US patents. The magnitude of international presence appears to negatively affect the citation counts of ETRI-invented US patents.

• International journal of thyroidology
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• v.10 no.1
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• pp.14-23
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• 2017

Background and Objectives: To evaluate and compare the diagnostic performances of grayscale ultrasound (US) and quantitative parameters obtained from texture analysis of grayscale US and elastography images in evaluating patients with diffuse thyroid disease (DTD). Materials and Methods: From September to December 2012, 113 patients (mean age, $43.4{\pm}10.7years$) who had undergone preoperative staging US and elastography were included in this study. Assessment of the thyroid parenchyma for the diagnosis of DTD was made if US features suggestive of DTD were present. Nine histogram parameters were obtained from the grayscale US and elastography images, from which 'grayscale index' and 'elastography index' were calculated. Diagnostic performances of grayscale US, texture analysis using grayscale US and elastography were calculated and compared. Results: Of the 113 patients, 85 (75.2%) patients were negative for DTD and 28 (24.8%) were positive for DTD on pathology. The presence of US features suggestive of DTD showed significantly higher rates of DTD on pathology, 60.7% to 8.2% (p<0.001). Specificity, accuracy, and positive predictive value was highest in US features, 91.8%, 84.1%, and 87.6%, respectively (all ps<0.05). Grayscale index showed higher sensitivity and negative predictive value (NPV) than US features. All diagnostic performances were higher for grayscale index than the elastography index. Area under the curve of US features was the highest, 0.762, but without significant differences to grayscale index or mean of elastography (all ps>0.05). Conclusion: Diagnostic performances were the highest for grayscale US features in diagnosis of DTD. Grayscale index may be used as a complementary tool to US features for improving sensitivity and NPV.

• Journal of Korean Society on Water Environment
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• v.28 no.1
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• pp.57-62
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• 2012

In this study, the inactivation efficiency of Mycobacterium marinum was evaluated in buffered water (pH 7) using a low pressure ultraviolet (LP-UV) lamp, ultrasonic (US), and UV/US sequential processes. In the UV alone process, 3 log inactivation of the M. marinum was achieved with a UV dose of $120mJ/cm^2$. However, a tailing phase was later observed because M. marinum has a high tendency for cell aggregation. Even though the M. marinum was not inactivated in the US alone process, the hydrophobicity decreased and turbidity increased due to the crumbling of the cell aggregation. Among the candidate processes which were UV alone, US-UV sequential process and UV-US-UV sequential process, the US-UV sequential process showed the highest synergistic effects for M. marinum inactivation. Consequently, US is a very useful process as a UV irradiation pre-treatment to inactivate M. marinum in water.