• 한국응용과학기술학회지
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• 제7권1호
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• pp.107-114
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• 1990

Optical resolution of aminoalcohols had been achived efficiently by use of (R)-2,2'-dihydroxy-l,1'-binaphtholphosphoric acid as the resolving agent in various organic solvents. Racemic aminoalcohols were resolved very easily and high enantiomer yield (about 70% e,e) in THF. On the other hand, absolute configuration of resolved aminoalcohol was (R)-configuration but one of the Valinnol and Phhenylglycinol was anti-type because of sterichindrance.Optical resolution of aminoalcohols had been achived efficiently by use of (R)-2,2'-dihydroxy-1,1'-binaphtholphosphoric acid as the resolving agent in various organic solvents. Racemic aminoalcohols were resolved very easily and high enantiomer yield (about 70% e,e) in THF. On the other hand, absolute configuration of resolved aminoalcohol was (R)-configuration but one of the Valinnol and Phhenylglycinol was anti-type because of sterichindrance.

• Archives of Pharmacal Research
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• 제27권2호
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• pp.136-142
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• 2004

In this study, a highly diastereoselective synthesis of anti-1 ,2-aminoalcohol was explored starting from L-amino acids as chiral sources. The higher yield and diastereoselectivity was shown when the aza-Claisen rearranqement was performed with allylic trichloroacetimidate 6a in the presence of palldium(II) catalyst.

• Bulletin of the Korean Chemical Society
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• 제24권7호
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• pp.921-924
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• 2003

Homochiral (-)-pipecolaldehyde 6 from D-glucono- δ-lactone underwent a highly diastereoselective addition upon treatment with vinylmagnesium bromide. Treatment with vinylmagnesium bromide produced antiaminoalcohol 7a which was easily converted into the synthesis of 1,6-diepicastanospermine 2.