• Convergence Security Journal
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• v.2 no.2
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• pp.39-47
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• 2002

To recently with the love-letter and Back Orifice the same Worm-virus, with the Trojan and the Linux-virus back against the new species virus which inside and outside of the country to increase tendency the malignant new species virus which is the possibility of decreasing the damage which is enormous in the object appears and to follow a same network coat large scale PC is being quicker, it disposes spontaneously to respect, applied an artificial intelligence technique the research against the next generation malignant computer virus of new form is demanded. Will reach and to respect it analyzes the digital immunity system of the automatic detection which is quick against the next generation malignant virus which had become unconfirmed and the foreign countries which has an removal function.

• Journal of Engineering Education Research
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• v.23 no.2
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• pp.14-23
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• 2020

Based on the constructivist learning environments model and the learner-centered psychological principles, STEAM education program with the theme of eliminating smog was developed. Through the program, senior elementary school students will learn and apply the convergence knowledge of science, technology, engineering, arts and mathematics such as the human body's respiratory system (S), immune system (S), big data (M, T), computer programming(M), and aduino sensor utilization (E) directly to solve the problem. After expert validity testing, we found that developed program meet the standards of STEAM education program development and can develop creative thinking skills to find and solve problems in students' daily lives. In addition, this study is meaningful in providing a reference example for the development of STEAM education programs that enhance convergence knowledge in the future.

• Journal of fish pathology
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• v.14 no.2
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• pp.97-102
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• 2001

Olive flounder, Paralichthys olivaceus known as an one of the major aquacultured species in Korea were exposed to cadmium(Cd) with different protocols and analyzed the effects of exposure on the immune response. Antibody levels in sera of the group exposed to Cd(20ppb) by immersion method from 2 weeks before immuniztion with formalinised Edwardsiella tarda(E. tarda) KFE entigen to the end of experiment reached to peak level faster than that of the non-exposed group. After this peaking time the levels decreased much at a faster rate compared to the non-exposed group. This tendency was also appeared in the numbers of specific antibody secreting cells(SASC) analyzed with the enzyme-linked immunospot (ELISPOT)-assay technique in the splenocytes of the experimental groups exposed to Cd with different ways. Interestingly, the group exposed to Cd for 2 weeks before immunization also showed increased numbers of SASC unlikely the antibody production and suggested a more critical influence of cadmium exposure in early stage of immune reaction. Artificial infection with live E. tarda KFE induces 100% mortality in the flounder exposed to cadmium throughout the experimental period from two weeks before the immunization. It may imply that some other factors related to specific immunity are involving in the defence system of flounder exposed to Cd. Taked together. Cd exposure may induce temporaily stimulatory or indhibitory effects on the immune reaction, but suppress the physiological systems for the resistant against the infective agents with other toxic effects.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 2003.05a
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• pp.173-176
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• 2003

지문은 종생불변성, 만인부동성, 그리고 사용상의 편리함 때문에 신원인증을 위한 생체인식에 많이 사용되고 있다. 최근에는 기하학구조에 기반한 특이점 매칭방식이 제안되어 인식성능이 매우 높고 잡음에 강한 특성이 있으나 매칭 회수가 많아 인식속도가 느린 단점이 있다. 따라서 기존의 방식은 소수의 지문에 대한 1:다 매칭이나 1:1매칭에 주로 사용된다. 본 논문에서는 기존의 문제점들을 개선하기 위하여 생체 면역계의 자기-비자기 인식 능력에 주목하였다. 생체 면역계는 자기-비자기의 구별 능력을 바탕으로 바이러스나병원균 등의 낮선 외부침입자로부터 자신을 보호하고 침입자를 식별, 제거하는 시스템이다. 본 논문에서는 생체 면역계를 이루는 면역세포 중의 하나인 세포독성 T세포의 생성과정에서 자기, 비자기를 구별하기 위한 MHC 인식부를 형성하는 과정에 착안한 빠르고 신뢰성 있는 지문 인식 알고리즘을 제안한다. 제안한 방식은 지문에 존재하는 특이점(minutiae)인식을 통해 1단계로 global 패턴을 생성하고 2단계로 기하학적인 구조를 만들며, 인식시 global 패턴을 인식한 MHC 인식부에 대해서만 2차 local 매칭을 수행함으로써 매칭 속도가 매우 빠르며 지문의 비틀림이나 회전 등에 대하여 강인하게 인식된다.

• Journal of the Korean Institute of Intelligent Systems
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• v.14 no.4
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• pp.451-456
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• 2004

Signature based intrusion detection system (IDS), having stored rules for detecting intrusions at the library, judges whether new inputs are intrusion or not by matching them with the new inputs. However their policy has two restrictions generally. First, when they couldn't make rules against new intrusions, false negative (FN) errors may are taken place. Second, when they made a lot of rules for maintaining diversification, the amount of resources grows larger proportional to their amount. In this paper, we propose the learning algorithm which can evolve the competent of anomaly detectors having the ability to detect anomalous attacks by genetic algorithm. The anomaly detectors are the population be composed of by following the negative selection procedure of the biological immune system. To show the effectiveness of proposed system, we apply the learning algorithm to the artificial network environment, which is a computer security system.

• Journal of the Korean Institute of Intelligent Systems
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• v.14 no.1
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• pp.75-81
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• 2004

Signature based intrusion detection system (IDS), having stored rules for detecting intrusions at the library, judges whether new inputs are intrusion or not by matching them with the new inputs. However their policy has two restrictions generally. First, when they couldn`t make rules against new intrusions, false negative (FN) errors may are taken place. Second, when they made a lot of rules for maintaining diversification, the amount of resources grows larger proportional to their amount. In this paper, we propose the learning algorithm which can evolve the competent of anomaly detectors having the ability to detect anomalous attacks by genetic algorithm. The anomaly detectors are the population be composed of by following the negative selection procedure of the biological immune system. To show the effectiveness of proposed system, we apply the learning algorithm to the artificial network environment, which is a computer security system.

• KSBB Journal
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• v.23 no.2
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• pp.109-117
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• 2008

Phellinus linteus (Sang Hwang mushroom; P. linteusis) has been widely used for a traditional medicine in Japan, Korea and China. In traditional oriental applications, P. linteus and their extracts have been exclusively used to treat various diseases like insomnia, neurasthenia, gastric ulcers, arthritis, nephritis, stress, asthma, bronchitis, neuromuscular disorders, hypertension and also as an immune system stimulator in cancer therapy. In a number of articles, it is indicated how tremendous their therapeutic values are. According to these studies, P. linteus and their extracts show immunomodulatory activities like enhancing immune system function including anti-tumor activity and inhibiting the growth of existing tumors. P. linteus and their extracts have been being studied for use as immunotherapy agents and biological response modifiers (BRMs) for the possible treatment of cancer without side effects. Recently, the cultured mycelium product of P. linteus has been developed and approved as a medicine in Korea. This review shows not only the current status of methods of developmental technology like artificial culture and various biological applications of P. linteus but also recent market trends of functional foods made from P. linteus.

• Korean Journal of Microbiology
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• v.49 no.2
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• pp.172-178
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• 2013

The strains were added to the feed in the concentration of $10^3$, $10^5$, and $10^7$ CFU/kg and 2% of fishes were given the feed twice a day (8 AM and 5 PM) for 12 weeks. In result of the nonspecific immune response study to examine Respiratory burst activity, Lysozyme activity and Phagocytosis activity every two weeks until the end of the study, all test samples showed greater activities than control samples and improved immune activity with Bacillus sp. IS-2. The mortality test performed by artificial infection using Streptococcus iniae, a pathogenic bacterium, after the completion of this study also showed over 55% greater survival rate in all test samples. In result of performing PCR using the universal primer to verify that the probiotic stays in the intestines of the fishes, all test samples showed PCR product of 1,465 bp. Based on the above findings, it was concluded that Bacillus sp. IS-2 in the feed improved farmed flatfish's immune system and resistance against diseases as the probiotics. Also, the physiological indicators discovered by this study would be useful for identifying the mechanisms of probiotics.

• Journal of the Korean Dietetic Association
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• v.3 no.2
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• pp.169-181
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• 1997

In this study, I made researches of 510 mothers who breed their infants in total (256 boys & 254 girls), among which 410 in urban area and 100 in the rural area, as an object of the investigation so as to make an intensive examination and analysis of the actual state of feeding nutritive method, grasp several related factors, and finally suggest the elementary data for both campaign encouraging breast feeding and the infant feeding education. 1. Mothers showed the meaningful local differences as in an education and income level at 1% and as in a delivery type at 5%. 2. To have decided the feeding conditions according to the residences by the Kaup index distribution (P<0.05) resulted in a meaningful difference according to regions and also made us be more thoughtful of the overnutrition in the urban area than in the rural area, and it didn't showed a meaningful difference the nutritive state according to the infant feeding method thought desirable (P<0.01). 3. The feeding methods consist of breast feeding at 21.8%, artificial feeding at 48.8%, and the mixed one at 29.4%. As for the feeding method thought desirable, breast feeding was 52%. Even though they were thinking that breast feeding is better, the breast feeding case didn't go beyond 32.5% only and as for the actual feeding methods it showed a meaningful difference according to the feeding method thought desirable (P<0.01). 4. Regarding the reasons why they chose breast milk, it was 64%, the most because mother's milk contains the immune system, 63.1% for the baby's health, 52.3% because of its most because breast milk is of little quantity, 37.8% because of the mother's occupation, 14.1% because they have fed the baby artificially from the beginning and so on. Considering the reasons why they chose the mixed feeding, it was 70.7%, the most because the amount of breast milk a little, 27.3%, the next one, because of the mother's occupation and so on. 5. The respondents who answered that how to increase the number of breast feeding population depends on the reinforcement of breast feeding education for the women were 190 (37.3%), the most among all 150 persons and those who had the opinion that they should spread and actualize the temporary childcare rest (from office) system for the women who have jobs were the secondly most, 107 (21%).

• Journal of Life Science
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• v.27 no.10
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• pp.1097-1103
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• 2017

For the artificial induction of the sexual maturation of Anguilla japonica, salmon pituitary extract (SPE) is continuously injected into females, and the eggs obtained from artificial sexual maturation are artificially fertilized with sperms and hatched. However, repeated injection of SPE in the abdominal cavity causes tremendous stress in females, which may prevent their complete sexual maturation and reduce the immune system function, ultimately resulting in death. In addition, the poor quality of the ovulated eggs can reduce the hatching and survival rate of larvae. In the present study, sexual maturation of females was induced by inserting an osmotic (OS) pump containing hormone analogs known to effectively induce sexual maturation into the abdominal cavity of female eels, and the effect of the OS pump on the induced sexual maturation was investigated. Our study results showed that the gonadosomatic index (GSI) was significantly higher in the fish subjected to SPE injection than those subjected to human chorionic gonadotropin (hCG), gonadotropin-releasing hormone analog (GnRHa), and methyl testosterone (MT) injections, either separately or in combination. In addition, a histological analysis showed that the oocytes in the SPE OS pump groups were more mature (entered the nuclear shift stage) than those in the other groups. These results suggest that an osmotic pump containing hormone analogs can be used to induce sexual maturation in female A. japonica artificially.