• Annals of Clinical Neurophysiology
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• v.9 no.2
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• pp.102-104
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• 2007

Spinocerebellar ataxia type 2 (SCA2) is characterized by progressive cerebellar ataxia and slow saccades. A 40-year-old woman presented with progressive gait disturbance and ataxia over 15 years. Neurologic examination revealed scanning speech, ataxia, and hyporeflexia. Brain CT showed diffuse atrophy of the cerebellum. Electronystagmography demonstrated slowed saccades with normal accuracy and delayed latency. The diagnosis of SCA2 was confirmed by the genetic test. Documentation of slow saccades may help differentiation among SCA subgroups.

• The Journal of Internal Korean Medicine
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• v.37 no.2
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• pp.322-329
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• 2016

Objective: This study reports on one clinical case of type 3 spinocerebellar ataxia (SCA) to examine the effectiveness of herbal medicine and traditional Korean treatments.Methods: A patient with type 3 spinocerebellar ataxia was treated using traditional Korean medicine options such as acupuncture and Hyangsayukgunja-tang. The effects on type 3 spinocerebellar ataxia were measured using the numeric rating scale (NRS) and ambulatory status.Results: Improvements in NRS and ambulatory status were observed after treatment.Conclusion: According to this study, traditional Korean medicine may be effective in the treatment of type 3 spinocerebellar ataxia.

• Korean Journal of Acupuncture
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• v.19 no.2
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• pp.79-85
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• 2002

Objective : In 1983 Autosomal dominent spinocerebellar ataxia(ADCA) has been classified to four types by a useful clinical features according to Harding. Since 1993 ADCA referred to as SCA by molecular genetic characteristics. We focused on the improvement of clinical symptoms in SCA patient through oriental medical treatment. Methods ＆ Results : The assessment included neurophysiological examination and clinical symptoms. For example slow saccade, gaze limitation, upward and lateral, nystagmus, truncal and gait ataxia. The patient(M/30) was clinically charaterized by ocular abnormalities, trunkal and gait ataxia and the MRI showed atrophy of cerebellar vermis. The patient was taken both common acupuncture and Dong-Si venepuncture on Hwasan with herbal medicine. Before the treatment Rt. ocular movement were slowed and a significant eye fixation was observed always in abduction and intermittently presented trunkal and gait ataxia. During the treatment trunkal and gait ataxia has not been presented and ocular obnomalities changed to normal state. This case suggests the possibility of oriental medical treatment on SCA but further observation is needed on this patient.

• The Journal of Internal Korean Medicine
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• v.38 no.5
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• pp.744-752
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• 2017

Objectives: In this report, we describe two patients with central dizziness and cerebellar ataxia who were treated with traditional Korean medicine. Methods: We applied traditional Korean medicine treatments of herbal medication (Banhabaekchulcheonma-tang and Bojungikki-tang), acupuncture, and moxibustion. Results: After 31 days of treatment, we observed improvement in the central dizziness on a numeric rating scale and in the cerebellar ataxia based on the patient's ambulation state. Conclusions: Traditional Korean medicine may be effective in the treatment of central dizziness and cerebellar ataxia.

• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.5
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• pp.1183-1187
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• 2009

We presented an ataxia patient who was difficult to diagnose and treated her by oriental medical treatment. We applied various methods of oriental medicine including herb medicine, acupunture, moxibustion and so on. After that, we checked the extent of dysarthria, pruritus, finger to nose and rapid alternative movement and measured the progress of general condition with Modified Barthel Index(MBI). After the oriental medical treatment was applied to her, ataxia, dysarthria, pruritus, finger to nose and rapid alternative movement were improved. The score of MBI was improved from 45 to 71, too. Even though there is no exact pattern identification about ataxia in oriental medicine, the oriental medicine can have an effect on the ataxia patient. In addition, more clinical study and observation should be needed.

• Journal of Sasang Constitutional Medicine
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• v.26 no.2
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• pp.194-204
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• 2014

Objectives The aim of this study was to examine significant improvement of gait ataxia, vertigo and tremor after treatment with Sipyimigwanjung-tang, Hyangsayangwi-tang in a Soeumin Greater Yin Symptomatology patient Diagnosed as Cerebellar ataxia. Methods The patient was diagnosed with Soeumin Greater Yin Symptomatology and treated with Soeumin's constitutional medications and acupuncture. The primary outcome measures for this study were the Unified Multiple System Atrophy Rating Scale(UMSARS) and Cerebellar function test to assess the overall function of patient. Secondary outcome assessment included Global Assessment Scale(GAS), change of patient's sleep, stool and digestion. Results The symptoms of gait ataxia, vertigo and tremor decreased from GAS 100 to GAS 0~40 after treatment, and the UMSARS score decreased in Part I, II. Conclusions This case showed that Sasang Constitutional medicine treatment can be effective treatment method for cerebellar ataxia. We consider that consistent treatment can contribute to improve the patient's quality of life.

• The Journal of the Society of Stroke on Korean Medicine
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• v.15 no.1
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• pp.39-49
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• 2014

This report is about a case of an ataxia patient with sensory loss diagnosed with thalamic Infarction. The patient had symtoms of gait disturbances and dysmetria. We used Korean medicine treatment modalities including acupunture, electroacupuncture, moxibustion and herb medicines. The improvement of ataxia was evaluated by International Cooperative Ataxia Rating Scale and Balance master^Ⓡ system. After treatment, decreased scores of International Cooperative Ataxia Rating Scale and change of the trace of Balance master^Ⓡ system showed that symtoms of ataxia were improved. Sensory deficits and other conditions were also getting better. This report suggests that Korean medicine could have a therapeutic effect for Thalamic ataxia.

• The Journal of Internal Korean Medicine
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• v.35 no.3
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• pp.373-382
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• 2014

Objectives: This study is a report of the clinical application of traditional Korean medicine on ataxia with cerebellar atrophy. Methods: The ataxia in this case occurred 5 years ago. The symptoms had been getting worse until the patient came to hospital. The MRI of this patient showed atrophy of the cerebellum. We measured the state of this case with the Korean version of the Berg Balance Scale (K-BBS), before and after treatment and Numeric Rating Scale-11 (NRS-11) of the symptoms, every week. We treated the case with traditional Korean medicine such as acupuncture and Gamiyukmijihwang-tang. Results: After treatment, the score of K-BBS increased, while the score of NRS-11 decreased. Conclusions: According to this study, traditional Korean medicine is effective for controlling ataxia caused by cerebellar atrophy.

• Journal of Genetic Medicine
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• v.14 no.2
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• pp.71-74
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• 2017

Mutations in the DNA methyltransferase 1 gene (DNMT1) were reported to cause two phenotypes: OMIM 604121 and OMIM 614116. The first phenotype includes autosomal dominant cerebellar ataxia, deafness, and narcolepsy, which were reported to be caused by mutations in exon 21. The second phenotype includes hereditary sensory and autonomic neuropathy type 1E, which was suggested to be caused by mutations in exon 20 and 21. In this article, we report a novel heterozygous missense variant c.898A>C, p.(Lys300Gln) in exon 12 of DNMT1 in a young woman who presented with pure cerebellar ataxia. This report indicates that a mutation in exon 12 may lead to pure cerebellar ataxia. Another possibility is that the patient is currently in an early stage of the disease, and as the disease progresses, she will have more manifestations. To confirm or exclude this possibility, a subsequent follow-up study reporting the disease progression in this patient may be needed. Further reports of cases with the same mutation are needed to confirm the phenotype of this mutation.

• The Journal of Internal Korean Medicine
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• v.37 no.5
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• pp.806-814
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• 2016

Objective: To describe the effect of Korean medicine on gait disturbance in a patient with multiple system atrophy and cerebellar ataxia. Methods: We observed a 75-year-old female patient who had multiple system atrophy and cerebellar ataxia. The patient was treated with Korean medicine, including acupuncture, moxibustion, and herbal medicine (Yukmijihwang-tang-gamibang and Boyanghwano-tang-gamibang) for 38 days. We evaluated the patient with the Korean version of the Berg Balance Scale (K-BBS), the Unified Multiple System Atrophy Rating Scale (UMSARS), and the Numeric Rating Scale-11 (NRS-11). Results: After treatment, the patient’s symptoms were improved. The K-BBS score increased from 9 to 19, while the UMSARS score decreased from 16 to 12 in Part I, from 15 to 7 in part Ⅱ, and from 4 to 3 in part Ⅳ. The NRS-11 score of gait disturbance decreased from 10 to 5. Conclusions: Korean medicine may be an effective treatment for gait disturbance in multiple system atrophy with cerebellar ataxia.