• Journal of the Institute of Convergence Signal Processing
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• v.22 no.2
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• pp.51-56
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• 2021

The brachial systolic blood pressure and pulse pressure are the predictors of cardiovascular disease in individuals over 50 years of age. As the stiffness increases, the reflex amplitude and pressure in the late systole increase, resulting in an increase in left ventricular load and myocardial oxygen demand. Therefore, it is necessary to study how stiffness affects blood pressure. In this study, the blood pressure pulse waves were measured before and after taking the drug, and the blood pressure pulse wave was measured before and after myocardial heart transplantation in patients with heart failure. The correlation between R, L, and C components of the Windkessel model was estimated by increasing blood pressure. As a result of modeling the parameters of the Windkessel model using the curve fitting method, the increase in blood pressure and decrease in systolic rise time were due to the increase in the L component in the RLC Windkessel model. Among the various mechanical characteristics of blood vessels, the most important parameter affecting high BP waveform is the inertance.

• The Journal of the Korea institute of electronic communication sciences
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• v.18 no.6
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• pp.1353-1362
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• 2023

Various methods are being attempted to resolve the inconvenience of blood glucose meters used to check blood sugar levels. In this paper, we attempted to estimate blood sugar levels non-invasively using machine learning technology from spectral data acquired using a near-infrared sensor. The non-invasive blood glucose meter used in the study has a total of six near-infrared ray emitters, including visible rays, and a light receiver that receives them. It is a device created to collect spectral data on specific parts of the human body, such as the fingers. To verify whether there was a significant difference depending on blood sugar level, we attempted to estimate blood sugar level through machine learning algorithms. As a result of applying five machine learning algorithm techniques to the collected data and adjusting various hyper parameters, it was confirmed that the support vector regression algorithm showed the best performance.

• Environmental Analysis Health and Toxicology
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• v.18 no.1
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• pp.33-44
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• 2003

The possibility that liver and kidney function is adversely affected by current levels of environmental exposure to cadmium (Cd) as investigated in adult men and women in the general population in Seoul. From February to August in 2001, blood and morning spot urine samples were collected from 136 not occupationally exposed group (age range 20∼75 years) at 4 survey sites throughout seoul. Liver and kidney function parameters in serum and urine were examined by conventional methods. The questionnaire included factors, i.e. sex, age, smoking, alcohol, diet habit etc. The geometric mean values for Cd in blood (Cd-B) were 1.43 $\mu\textrm{g}$/1, It seemed prudent to conclude that liver and kidney function as not disturbed by the current environmental exposure to Cd in study.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.34 no.2
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• pp.131-134
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• 2008

Purpose: The objective of this study was to evaluate the clinical parameters in terms of the midazolam sedation in patients undergoing dental practice. Patients and Methods: Total 28 patients were included in this study. They received the dental practice in the daycare center and sedation was done with midazolam. The recorded variables were blood pressure, pulse rate, $SpO_2$, and patient's response. The differences between observations were analyzed with paired samples t-test. Results: The blood pressure was significantly decreased after the administration of midazolam and the systolic pressure was significantly increased at the start of operation (P<0.05). The pulse rate was significantly increased after lidocaine injection (P<0.001). The amnesic effect was shown 21 cases out of 28 cases (75%). Conclusions: The effect of midazolam on pulse rate was not significant. However, midazolam could decrease the blood pressure significantly. Therefore, the sedation with midazolam could be successfully used in the dental practice, particularly for the patients having the hypertension.

• YAKHAK HOEJI
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• v.34 no.1
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• pp.40-46
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• 1990

Pharmacokinetic studies on praziquantel in rabbits were performed in this paper. The pharmacologically active parent drug was separated from the pharmacologically inactive metabolites by HPLC method. The pharmacokinetic parameters of parent drug were obtained. In vitro partition to blood cells of praziquantel was measured. The mean value (n = 3) of partition to blood cells was 44% at concentrations between $1\;{\mu}g/ml$ and $40\;{\mu}g/ml$. Therefore, the relatively high partition to blood cells should be considered in further pharmacokinetic studies on praziquantel.

• Korean Journal of Clinical Pharmacy
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• v.10 no.1
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• pp.19-24
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• 2000

The effect of cimetidine on the pbarmacokinetic parameters of cyclosporine (intravenous administration) were determined in 6 healthy volunteers (22-48 years old, 48-62 kg) by cross-over design. Cyclosporine and cyclosporine metabolites in whole blood were analysed by fluororescence polarization immunoassay (TDx-FLX). The blood concentrations of cyclosporine After pretreatment with cimetidine (200 mg bid, for 3days) were increased significantly at 8-12 hrs compared to the control (p<0.05). The ratios of blood concentrations of cyclosporine metabolites (M1, M17) to parent drug were decreased significantly at 8-12 hrs (p<0.05). Total body clearance (CL) was also decreased significantly (p<0.05), and area under the curve $(AUC,\%)$ was increased but not significant.

• The Transactions of the Korean Institute of Electrical Engineers
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• v.34 no.7
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• pp.257-266
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• 1985

A new method for the artificial beta cell which can be used to control the hyperglycemia in diabetic patients was represented. The relationship between the insulin infusion rate and the blood glucose concentration was described by the second order ARMA model, and the time varying parameters were identified by exponentially weighted least squares estimator. The design of controller was based on the pole assignment self tuning altorithm with discrete blood sampling and the constraints of input and output responsse rate were considered. The results of animal experiments show that this method may be a fruitful approach for regulating the blood glucose level. We expect that this device can be used as both therapeutic and research tools providing that its stability and reliability are improved a little more.

• Proceedings of the Korean Society of Toxicology Conference
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• 2003.10b
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• pp.148-148
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• 2003

The cynomolgus monkey(Macaca fascicularis) is used widely in efficacy and safety assessment of new drugs. The ranges of physiological variables are important end points in the toxicological study. Both the basic physiological variables such as body weight, body temperature, blood pressure, urine pH and blood variables such as biochemical and hematological variables were determined in nineteen male and sixteen female monkey prior to treatment.(omitted)

• Advances in nano research
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• v.13 no.3
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• pp.217-231
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• 2022

This study investigates the geometrical impact on the nanomedicine drug delivery via nanodevices. A nanomotor made of the nanotube carrying the drug as the motor blade is considered in the blood flow. Physical activities change the blood flow, and sports training enhances the blood flow and plays a significant role in the stability of drug delivery devices. This paper studies the impact of geometrical parameters on the nanomotors carrying the nanomedicine. The effect of physical exercise on the dynamic response regarding the stability of drug delivery devices is discussed in detail.

• Advances in nano research
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• v.14 no.3
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• pp.247-259
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• 2023

Muscle strength and hypertrophy are equivalent when low-intensity resistance exercise is paired with blood flow restriction. This paper deals with the impact of physical exercise in the form of body activities on drug delivery using nanodevices. The body's actions impact the blood flow since the nano drug delivery devices are released into the bloodstream, and physical exercise and all the activities that change the blood flow influence the stability of these nanodevices. The nanodevice for the drug delivery purpose is modeled via nonuniform tube structures based on the high-order beam theory along with the nonlocal strain gradient theory. The nanodevice is made by a central nanomotor as well as two nanoblade in the form of truncated conical nanotubes carrying the nanomedicine. The mathematical simulation of rotating nanodevices is numerically solved, and the effect of various parameters on the stability of nanodevices has been studied in detail after the validation study.