• 대한약침학회지
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• 제16권1호
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• pp.12-20
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• 2013

Objective: Standard cancer therapy prolongs survival, but can be detrimental to the quality of life, compromise the immune system, and leave residual disease that can cause recurrence years or decades in the future. Tumor dormancy therapy is a novel therapeutic approach that may improve these shortcomings, promote quality of life, and prolong survival. The aim of this study was to analyze studies on dormancy therapy, especially studies using traditional Oriental herbal medicine, so as to evaluate the efficacy of dormancy therapy with traditional oriental herbal medicine. Methods: We conducted a systematic literature review using Scientific and Technical Information Integration Services (NDSL), PubMed, and RISS. We searched for clinical reports, papers, and books related to tumor metastasis, recurrence, immunotherapy, tumor dormancy, and traditional oriental herbal medicine with anticancer effects. Seventy-nine (79) experimental and clinical articles in both Korean and English were reviewed. This study was conducted from March 1, 2012 to May 31, 2012. Results: This approach, Tumor dormancy therapy, rather than seeking to remove the tumor, includes combination of low-dose chemotherapy, immunotherapy, immunosurveillance, and other methods to stabilize tumor growth and to enhance the host is immunity against disseminated tumor cells and thus to manage cancer as a chronic disease while maintaining quality of life. In particular, integrative use of Oriental herbal medicine has been shown to induce or maintain tumor dormancy, increase the effectiveness of conventional chemotherapy, improve quality of life, and prolong survival. Conclusion: Tumor dormancy therapy is a promising novel therapeutic approach that may be especially effective with Oriental herbal medicine. Further research is needed to determine its potential mechanisms and therapeutic applications.

• BMB Reports
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• 제56권9호
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• pp.482-487
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• 2023

Hematopoiesis is regulated by crosstalk between long-term repopulating hematopoietic stem cells (LT-HSCs) and supporting niche cells in the bone marrow (BM). Here, we describe the role of KAI1, which is mainly expressed on LT-HSCs and rarely on other hematopoietic stem-progenitor cells (HSPCs), in niche-mediated LT-HSC maintenance. KAI1 activates TGF-β1/Smad3 signal in LT-HSCs, leading to the induction of CDK inhibitors and inhibition of the cell cycle. The KAI1-binding partner DARC is expressed on macrophages and stabilizes KAI1 on LT-HSCs, promoting their quiescence. Conversely, when DARC+ BM macrophages were absent, the level of surface KAI1 on LT-HSCs decreases, leading to cell-cycle entry, proliferation, and differentiation. Thus, KAI1 acts as a functional surface marker of LT-HSCs that regulates dormancy through interaction with DARC-expressing macrophages in the BM stem cell niche. Recently, we showed very special and rare macrophages expressing α-SMA+ COX2+ & DARC+ induce not only dormancy of LT-HSC through interaction of KAI1-DARC but also protect HSCs by down-regulating ROS through COX2 signaling. In the near future, the strategy to combine KAI1-positive LT-HSCs and α-SMA/Cox2/DARC triple-positive macrophages will improve the efficacy of stem cell transplantation after the ablative chemo-therapy for hematological disorders including leukemia.

• 대한암한의학회지
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• 제15권1호
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• pp.89-103
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• 2010

Background: The greatest threats to the lives of cancer patients consist of both complications due to metastasis and the recurrence of original cancer. However, the existing forms of chemotherapy do not prevent these adverse events adequately because they suppress the patients' immune systems. A new methodology is required. Aim: To provide further validation for cancer immunotherapy (involving the use of traditional oriental herbal medicine). Method: Related articles, in both Korean and English were reviewed. Results: Cancer immunotherapy involving the use of traditional oriental herbal medicine can create inhospitable conditions for cancer cells and strengthen patients' immunological functioning. These effects are a demonstration of the principles of "strengthening healthy qi (扶正)" and "eliminating pathogens (祛邪)". As a result, immunotherapy protects against metastasis and original cancer recurrence by preventing the growth of cancer cells. This is very similar to the concept of a cancer dormancy therapy. Conclusion: It is strongly urged by the authors that more advanced studies be carried out on this promising therapy in the future in order to improve patients' quality of life and increase their survival time.

• 대한한방내과학회지
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• 제40권1호
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• pp.70-88
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• 2019

Objective: This study investigated the trends in pancreatic cancer research on Korean medicine in order to establish a direction for further study. Methods: Pancreatic cancer research on Korean medicine was reviewed using databases such as OASIS, KoreanTK, KISS, RISS, KISTI, and NDSL. The search terms were "pancreatic cancer" "Korean medicine," and "herbal medicine." There was no restriction on publication dates, and the reviewed studies were analyzed according to the type of research. Results: Nineteen studies were reviewed. The numbers and types of research were as follows: 9 clinical studies including case reports, 2 review studies, and 8 in vitro studies; there was no in vivo study. Among the clinical research were 3 descriptive studies and 6 case reports. The baseline characteristics and quality of life of pancreatic cancer patients were analyzed in the descriptive studies. In the case reports, interventions such as herbal medicine, pharmacopuncture, and acupuncture were used. Research articles on the review of pancreatic cancer were titled "Preliminary Study for Development of Korean Medicine Clinical Practice Guideline for Pancreatic Cancer" and "Systemic Review on the Tumor Dormancy Therapy." Cell lines such as PANC-1, MIA PaCa-2, and AsPC-1 were used for in vitro studies. These studies have reported decreased cell viability, induced apoptosis, and changes in cancer-related gene expression. Conclusion: Through this review, we found that using Korean medicine for treating pancreatic cancer is applicable. However, due to overall limited the number of study, the benefit of Korean medicine for pancreatic cancer may be substantiated to a limited degree. Better methodological quality and large controlled trials are expected to further quantify the therapeutic effect of Korean medicine.

• 원예과학기술지
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• 제33권5호
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• pp.796-804
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• 2015

본 연구는 아스파라거스 4 품종의 생장 특성, 휴면타파, 수량 및 생리활성 함량(플라보노이드와 페놀화합물 함량, 아질산염 소거 및 폐암세포 생존율)를 조사하였다. 국내 아스파라거스 재배 시 생리활성 고효능 품종 선택 가능성을 검토하기 위해 실험을 수행하였다. 'Jersey Giant', 'Jersey Supreme' 그리고 'NJ953' 품종들은 'UC157' 품종보다 눈의 개수, 뿌리의 생체중과 건물중 등이 높았지만 뿌리의 개수에 차이가 없었다. 'Jersey Supreme' 품종의 휴면타파 기간은 다른 품종들보다 길었다. 'Jersey Giant'와 'NJ953'품종들은 다른 품종들보다 순의 개수, 직경 및 생산량이 높았다. 총 플라보노이드 함량은 품종 간에 차이가 없었지만 에탄올 추출에서 열수 추출보다 총 플라보노이드 함량이 높았다. 총 페놀화합물은 열수 추출과 에탄올 추출 모두 'NJ953' 품종은 가장 낮은 반면에 에탄올 추출에서 'UC157'에서 가장 많은 $39.23mg{\cdot}L^{-1}$을 나타냈다. 'Jersey Giant', 'Jersey Supreme' 그리고 'NJ953'의 아질산염 소거 효과는 70% 이상 효과를 나타냈다. 에탄올 추출 시 추출물의 농도와 관계없이 'Jersey Giant', 'Jersey Supreme' 그리고 'UC157' 품종들은 'NJ953' 품종보다 폐암세포 생존율 낮은 결과를 나타냈다. 또한 폐암세포 생존율은 에탄올 추출보다 열수 추출에서 낮아 아스파라거스 식용도 폐암 예방 효과에 도움이 될 것으로 기대된다. 본 연구결과를 통해 규명된 아스파라거스의 생육 특성과 생리 활성 효과는 생리활성 고효능 품종 선택 및 이용에 도움이 될 것으로 기대된다.

• 한국작물학회지
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• 제39권2호
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• pp.146-157
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• 1994

본 연구는 항암식물로 효능이 인정되는 와송에 대한 기초적인 연구로 와송의 해부형태적 관찰, 대량증식을 위한 발아실험, 자생지의 토양분석 및 토양적응실험을 실시하였다. 와송의 잎은 끝에 가시가 있는 건생형이며, 엽세포엽록체는 유관속주위에 집중분포하고, 크고 엽록체를 갖지 않는 저수조직을 갖고 있으며 기공이 양면에 있는 양면기공엽이다. 줄기는 외사포위형유관속이며 중심주는 원기둥상이고 원생중심주이다. 뿌리는 다원형이며, 원생목부가 후생목부주위에 환상으로 배열되어 있고 외원형이다. 꽃의 구조는 꽃잎이 5개, 수술은 10개, 자방은 5개이며, 자방상위이고, 2심피 중축태좌이다. 와송종자 발아적온는 명상태 $25^{\circ}C$에서 22.5%로 가장 좋았고, 휴면타파는 5$^{\circ}C$에서 6~8일, $GA_3$ 100 ppm처리에서 가장 효과가 좋았다. 와송 자생지 토양분석결과 적정수준의 밭토양보다 유기물, 유효인산 석회 등은 높았고, 보비력, 치환성가리는 차이가 없었으며, 고토는 낮았다. 토양적응실험에서 돌가루 조합과 기와가루 조합에서 돌가루와 기와가루가 많이 첨가될수록 생육상태가 불량하였고, 배수가 양호한 처리구에서는 생육상태가 양호하였다.

• Tuberculosis and Respiratory Diseases
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• 제84권1호
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• pp.1-12
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• 2021

Mycobacterium tuberculosis has infected more than two billion individuals worldwide, of whom 5%-10% have clinically active disease and 90%-95% remain in the latent stage with a reservoir of viable bacteria in the macrophages for extended periods of time. The tubercle bacilli at this stage are usually called dormant, non-viable, and/or non-culturable microorganisms. The patients with latent bacilli will not have clinical pictures and are not infectious. The infections in about 2%-23% of the patients with latent status become reactivated for various reasons such as cancer, human immunodeficiency virus infection, diabetes, and/or aging. Many studies have examined the mechanisms involved in the latent state of Mycobacterium and showed that latency modified the expression of many genes. Therefore, several mechanisms will change in this bacterium. Hence, this study aimed to briefly examine the genes involved in the latent state as well as the changes that are caused by Mycobacterium tuberculosis. The study also evaluated the relationship between the functions of these genes.

• Asian Pacific Journal of Cancer Prevention
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• 제15권22호
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• pp.9631-9634
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• 2014

Background: : In 2012, the breast cancer estimate worldwide stood at 1.67 million new cases, these accounting for 25% of all types of cancer diagnosed in women. For 2014, 57,120 new cases are expected, with a risk estimated at 56.1 cases for every 100,000 women. The objective of this study was to analyze the satisfaction regarding the use of external breast prostheses by women undergoing mastectomy. Materials and Methods: This cross-sectional study was conducted with 76 women who used an external breast prosthesis (EBP), registered in the services of the Cuiaba Center for Comprehensive Rehabilitation, Mato Grosso, Brazil, from 2009 to 2012. Data were collected from the records of women who had requested the opening of a process of external breast prosthesis concession. Results: Satisfaction with the EBP was identified in 56.6% of the women. Those satisfied with the EBP reported that its weight was not annoying (p<0.01). Although the women felt body sensations of stitches, pains, pulling, dormancy and phantom limb, they are satisfied with the EBP. The variable related to the displacement of the breast prosthesis during activity of everyday life has demonstrated that even though the women have reported the possibility of displacements, they are satisfied with the EBP. The satisfaction with the use of external breast prosthesis did not affect the sexuality of the women with mastectomy. Conclusions: Learning the specificities of the EBP, taking into consideration the satisfaction of its use, allows the rehabilitation team, by listening to their clientele more attentively, following up this woman throughout her life journey, supporting and guiding the best way of use, with an eye to her personal, emotional and social life, as well as to her self-esteem.