• Title/Summary/Keyword: chemical substance

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Basic Concepts of Western Medicine Toxicology and $LD_{50}$ in Herbal Drugs (서양의학 독성학의 기본적 개념 및 한약의 $LD_{50}$)

  • Park Yeon-Chul;Lee Sun-Dong;Park Kyoung-Sik
    • Journal of Society of Preventive Korean Medicine
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    • v.3 no.2
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    • pp.91-100
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    • 1999
  • Today, toxicology is used for many purpose, in many fields. Classification of special toxic effect is related next 4 important principles. 1. The chemical substance must move to target organ or tissue that can induce Biological effect. For this movement, we have to understand the physical-chemical characteristic of substance, and the rout of absorption, metabolism, diffusion and excretion of toxic substance. 2. Every biological effect that induced by chemical substance is not harmful. For example, some specific chemical substance is not harmful in liver enzyme system. 3. The strength of biological effect induced by chemical substance is deep related with dose. Nearly all substance is not effective below the specific dose, and it may toxic to death over the specific dose. It is the 'Dose - response relationship' But carcinogen may toxic whether it is law dose or not. 4. The information that was obtained by experimental animal test, could have to adapt in human biology. Because biological effect of chemical substance could be different in every biological species. In past, drugs was obtained by animal or plants. But in the future, it could be obtained by biochemistry, and genome project. Therefore, in Oriental medicine, research and approach is needed at this time, and have to develop new method of experience in toxic method.

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Case Analysis of the Harmful Chemical Substances' Spill (유해화학물질 유출의 사례 분석)

  • You, Jisun;Chung, Yeong-Jin
    • Fire Science and Engineering
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    • v.28 no.6
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    • pp.90-98
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    • 2014
  • Lately accidents of harmful chemical substance in korea were repeatedly replaying. We studied problems and preparation plan in 2008 years~2014 years through analysis cases of harmful chemical substance. Leakage of chemical substance's accident situation shows that leakage in the workplace is the most 10 cases, accounting for 58.6% is the largest proportion in 2009. Leakage according to explosion accounting for 50% (5 cases) in 2004, 25% (4 cases) in 2007 and 33.3% (4 cases) in 2011 has very irregular change. Therefore, A major cause of accidents is lack of safety management. Harmful chemical substance showed various aspects, high residual substance and non-visible characteristic so response and recovery was easy. And the second damage to move a distance causes environment pollution. So a mutual-assistance system and integrated system of related organization have to build and expert of chemical incident response and therapist of chemical substance response have to establish to do efficient and rapid response.

The effects of work environment monitoring organization's analysts' equipment and chemical substance incident response to the safety management awareness

  • Park, Hyun-A;Choi, Seo-Yeon;Rie, Dong-Ho
    • Journal of the Korea Society of Computer and Information
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    • v.22 no.5
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    • pp.97-103
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    • 2017
  • In this paper, we propose a method to investigate the safety consciousness of a analyst incident response. This study conducted a statistical survey on 154 analysts who hired as expert in environment monitoring organizations in South Korea. The results of the analyses showed that respondents had good awareness on the equipment incident response and complied with laboratory safety regulations very well. Secondly, respondents were aware of the importance in the order of equipment incident response, an analytical laboratory incident response, and the cause of a chemical substance associated incident in an analytical laboratory in regarding the regulation compliance for creating a safe laboratory environment and the securement of laboratory safety. Therefore, (it was identified that) it would be necessary to create a safe environment and integrate a safety management system.

A study on the supply status of chemical substance information including MSDS and a way of improving Database management in Korea (국내 MSDS 등 화학물질정보의 제공실태와 DB관리 개선방안 연구)

  • Lee, Kwon Seob;Yoon, Seok Joon;Choi, Jae Wook;Kim, Hyun Ock;Lee, Jong Han;Yang, Jeong Sun
    • Journal of Korean Society of Occupational and Environmental Hygiene
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    • v.17 no.1
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    • pp.63-70
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    • 2007
  • This study investigated the current management staus of chemical substance information on Material Safety Data Sheets(MSDS) and Chemical Information Cards(CIC) provided by Korea Occupational Safety & Health Agency(KOSHA) and also researched the kind and the characteristics of chemical substance information provided in other organizations. MSDS DB in Korean provided on KOSHANET(which is Kosha website) is 50,802 in total, among whom are single chemical substances with 31,870 kinds(18,932%) and are mixed chemical substances with 31,870 kinds(62.7%). The number of visiting MSDS DB on KOSHANET for the search of chemicals was 2,049,806. The number has increased each year. The CIC provided for workplaces is all 542 kinds : 14 harmful substances subject to permission, 168 harmful substances subject to management, 360 KOEL(Korean Occupational Exposure Limits) establishment substances. MSDS internationally provided by organizations producing MSDS DB was written with 16 sections, which is suitable for the writing basis of American Standards Institute(ANSI) and International Organization for Standardization(ISO) and provided chemical substance information on more than 100,000 kinds in most organizations.

Worker Symptom-based Chemical Substance Estimation System Design Using Knowledge Base (지식베이스를 이용한 작업자 증상 기반 화학물질 추정 시스템 설계)

  • Ju, Yongtaek;Lee, Donghoon;Shin, Eunji;Yoo, Sangwoo;Shin, Dongil
    • Journal of the Korean Institute of Gas
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    • v.25 no.3
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    • pp.9-15
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    • 2021
  • In this paper, a study on the construction of a knowledge base based on natural language processing and the design of a chemical substance estimation system for the development of a knowledge service for a real-time sensor information fusion detection system and symptoms of contact with chemical substances in industrial sites. The information on 499 chemical substances contact symptoms from the Wireless Information System for Emergency Responders(WISER) program provided by the National Institutes of Health(NIH) in the United States was used as a reference. AllegroGraph 7.0.1 was used, input triples are Cas No., Synonyms, Symptom, SMILES, InChl, and Formula. As a result of establishing the knowledge base, it was confirmed that 39 symptoms based on ammonia (CAS No: 7664-41-7) were the same as those of the WISER program. Through this, a method of establishing was proposed knowledge base for the symptom extraction process of the chemical substance estimation system.

The Safety Design of Corrosive Chemical Handling Process based on Reliability Database (신뢰도 데이터베이스 기반 부식성 화학물질 취급공정의 안전설계)

  • Chu, Chang Yeop;Baek, Jong Bae
    • Journal of the Korean Society of Safety
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    • v.33 no.5
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    • pp.141-149
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    • 2018
  • In a PCB factory, there is a corrosive chemical substance supply system that can causes major leakage accidents. These accidents can give rise to shut down the factory and do residents damage that cause enormous loss of properties. To mitigate these risks, it is necessary to provide a chemical disaster prevention system. Moreover, after considering the situation and environment of the production site, it is of great importance to build an optimal chemical accident prevention system by reflecting risk reduction measures from the point of process design and by assessing quantitative risk based on reliability data. However, because there was no established database of the reliability about facilities and equipment that can be used in the domestic, the business site and consulting organization had being used the reliability data such as USA CCPS(Center for Chemical Process Safety). In these days, Korean institutes are studying on reliability data utilization method of quantitative risk assessment for preventing chemical accidents and domestic utilization algorithms and storage bed of reliability data. This study presents samples of reliability database about the chemical substance supply system that constructed from the history data such as failure, maintenance for 10 years at a PCB factory. Also, this work proposes the safety design criteria for supply facilities of corrosive chemical substance by assessing quantitative risk on the basis of the reliability data.

Statistical Analysis of Chemical Substance Transporting Accidents (화학물질 운송 화학사고의 통계 특성 분석에 관한 연구)

  • Lee, Tae-Hyung;Lee, Sang-Jae;Shin, Chang-Hyun
    • Fire Science and Engineering
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    • v.30 no.6
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    • pp.23-30
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    • 2016
  • This study analyzed the characteristics of chemical accidents, including the accidents occurring each year according to status, type of accident, accident cause for chemical substance transporting accidents. The major aim of this study was to provide information on the chemical accidents that occurred involving chemical substance transporting accidents from 2013 to July - 2016. The total incidence of chemical transporting accidents was 77 cases; 74 cases occurred by the spill & leakage type. The main cause of the accidents analyzed was traffic accidents (41 cases). Forty-six accidents were related to hazardous chemical substances. Among the 46 hazardous chemical substances involved in transporting chemical accidents, 46% of the accident substances were hydrogen chloride. For the prevention and response to accidents occurring during the transportation of chemicals, it is necessary to complement the precautions for chemical accidents caused by transportation accidents and chemical spills and leaks of chemicals. In addition, when the chemical transport of an accident occurs, it is necessary to apply a chemical transport safety system for chemical transfer.

A Study on the Characteristics of Chemicals in Major Industrial Complexes (주요 산업단지의 화학물질 배출량 특성에 관한 연구)

  • Kim, Hyunji;Im, JiYoung;Yun, Jeonghyeon;Lee, JiHo;Jeon, JunHo;Lee, ChungSoo
    • Journal of Environmental Health Sciences
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    • v.44 no.6
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    • pp.515-523
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    • 2018
  • Objectives: Based on the results of a chemical substance emissions survey, we investigated characteristics of chemical emissions in industrial complexes and used them as basic data for chemical management. Methods: The emissions and characteristics of chemicals by major industrial complexes from 2011 to 2015 were analyzed using the Pollutant Release and Transfer Register homepage. To understand the status of chemical accidents for major chemicals emitted from the industrial complexes, the Chemistry Safety Clearing-house system of the National Institute of Chemical Safety was used. Results: Emissions from the top five industrial complexes accounted for about 30% of total chemical emissions. The chemical emission was the highest in the order of Ulsan Mipo Industrial Complex and Okpo Industrial Complex. The main chemicals emitted were xylene, ethylbenzene, ethyl acetate, toluene, dichloromethane, and others. Carcinogen emissions differed by industrial complex, but ethylbenzene and dichloromethane were the major chemicals for this type of emissions. Conclusion: Recently, the use and emission of chemicals have been continuously increasing. A chemical management plan should be prepared considering the characteristics of industrial complexes and chemical substance emissions.

Factors Affecting the Recognition and Practice of Hazardous Chemical Substance & the Management of Material Safety Data Sheet (MSDS) among Workers in Dental Clinics (구강보건의료기관 종사들의 유해화학물질 인식, 실천 및 물질안전보건자료 (MSDS) 관리에 영향을 미치는 요인)

  • Jung, Hye-Young;Mun, Won-Suk;Kim, Ji-Young
    • Journal of The Korean Society of Integrative Medicine
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    • v.9 no.3
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    • pp.79-86
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    • 2021
  • Purpose : This study was conducted to provide fundamental data to prepare for countermeasure to protect health of workers in the dental clinics from hazardous chemical substance, and to assess effecting factors on management of Material Safety Date Sheet(MSDS) and handling of hazardous chemical substance among workers in dental clinics. Methods : This study was carried out a survey with structured self-administered questionnaire which was consisted of 7 questions about the management of MSDS, 9 questions about recognition and practice of hazardous chemical substances in dental clinics, and 7 questions about general characteristics. Total subjects of this study were 204 adult who workers in dental clinics located in Busan and Gyeng-nam province area. The collected data were analysed using the SPSS statistical package program (ver. 23.0). Results : The factor that positively affected factor on recognition and practice of hazardous chemical substances in dental clinics has experience that has been institutional health-care accreditation. The factor that positively affected the management of MSDS has experience that has been institutional health-care accreditation. Conclusion : It is necessary to prepare countermeasures such as campaign and education on cognition of general chemical substances, and also the author concern that it should be perform the education on handling of hazardous chemical substances in dental clinics for more effecting management of MSDS. In order to improve the management of MSDS and improve the awareness and safety of chemicals, it is necessary to encourage the implementation of the institutional health-care accreditation system or prepare guidelines for the management of MSDS.