• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.22 no.1
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• pp.76-88
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• 2009

Back ground and Objective : There is a need for objectification and scientific verification of Pattern identification in Oriental medicine. The purpose of this study was to investigate the skin characteristics of Qi deficiency and Blood deficiency animal models. Material and Methods : Sprague-Dawley rats were divided into three groups: normal group, Qi deficiency group and Blood deficiency group. The Qi deficiency animal model was induced through restriction of food (75g/kg/day) for 20 days. Blood deficiency animal model was induced by bleeding from tail vein(0.3 ml/time) 8 times. The normal animal model was kept without any intervention. The general condition was observed by measuring body weight, body temperature, blood pressure, pulse rate, and hematological and biochemical parameters. The skin characteristics were observed by measuring the erythema index(EI), melanin index(Ml), transepidermal water loss(TEWL) and dermal microcirculation. Results : 1. In the Qi deficiency group, body weight was lower than the other groups. In the Qi deficiency group, blood pressure was lower than in the Normal group. There was no difference in body temperature and pulse rate between the three groups. 2. In the Qi deficiency group, blood sugar was lower than in the Blood deficiency group. There was no difference in triacylglycerol between the three groups. In the Qi deficiency group, the WBC count was lower than in the Blood deficiency group. RBC count was highest in the Qi deficiency group, Normal group and Blood deficiency group respectively. In the Qi deficiency group, Hb and Hct were higher than the other groups. 3. EI and MI were decreased in the Qi deficiency group, and EI showed a significant decrease. 4. EI and MI were increased in the Blood deficiency group, and MI showed a significant increase. 5. TEWL was significantly increased in the Qi deficiency group, while it was decreased in the Blood deficiency group, TEWL was highest in the Qi deficiency group, Normal group and Blood deficiency group respectively and all three groups showed significant difference. 6. In the Qi deficiency group, dermal microcirculation was lower than the other groups. Conclusion : The above results show that the erythema index decreases in the Qi deficiency model, and the melanin index increases in the Blood deficiency model. The Qi deficiency animal model shows an increase in transepidermal water loss, while the Blood deficiency animal model shows a decrease. Further studies should develop new models of Pattern Identification that are more specific.

• Journal of Physiology & Pathology in Korean Medicine
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• v.32 no.5
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• pp.299-304
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• 2018

The aim of this study to distinguish Yin-Deficiency and Blood-Deficiency in Donguibogam To Investigate the Donguibogam Hu-Ro Sector "Yin-Deficiency Medication" and other parts and associating Herb(Bencao) In Donguibogam Hu-Ro Sector "Yin-Deficiency Medication", Yin-Deficiency is divided Blood-Deficiency and Em Hu Hwa Dong. But Si Wu Tang treating Blood-Deficiency be used at Em Hu Hwa Dong and Da Bu Yin Wan treating Em Hu Hwa Dong be used at Blood-Deficiency. But in the use of each Herb(Bencao), Yin-Deficiency Medicine and Blood-Deficiency Medicine are distinguised. One can understand that Donguibogam's use of prescription might not distinguish Yin-Deficiency and Blood-Deficiency, But each Herb(Bencao) distinguish those conceptions. Because each view is both meaningful, choosing of view in accordance with the purpose of treatment is necessary for successful clinical trial.

• Journal of Physiology & Pathology in Korean Medicine
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• v.27 no.4
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• pp.343-349
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• 2013

This article is a study on to which categories of modern diseases blood deficiency pattern types are assigned by reference to modern clinical papers. Clinical papers were searched in China National Knowledge Infrastructure(CNKI) from 1994 to 2013. Results are as follows. First, diverse diseases classified in qi-blood depletion pattern and pattern of blood deficiency and wind-dryness are reported and pattern types designated by the name of viscera are the minority. Second, among pattern types in Korean Standard Classification of Diseases(KCD), diseases classified in heart blood deficiency pattern, liver blood deficiency pattern and heart-liver blood deficiency pattern are a few. Third, the level of designation by the combined patterns such as qi deficiency, fluid deficiency, yin deficiency, kidney deficiency, essence deficiency, wind-cold, cold-dampness, dampness-heat, liver hyperactivity, liver depression and static blood is more specific than KCD, which makes pattern types more useful to clinical application. The detailed relation between modern diseases and pattern types can be an another topic.

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.2
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• pp.177-186
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• 2010

This study is about researching DongEuiBoGam by analysing with pattern identification of modern Traditional Korean medical patholgy as more logical, systematic and standardized theory. Disease pattern mechanisms of essence, spirit, qi and blood in NaeGyungPyeb of DongEuiBoGam are these. In Essence, this explain mechanism of disease patterns those are seminal emission, dream emission, spermatorrhea, white ooze. These disease pattern's mechanisms are kidney yang deficiency, kidney yin deficiency, heart yang deficiency, heart yin deficiency, heart qi deficiency, spleen qi deficiency and so on. On viewpoints of viscera and bowels they are related with heart, kidney, spleen. And most of them are deficiency from deficiency-excess Pattern Identification. Classifying disease pattern of qi is about upward, downward movement and more concentrated deficiency than excess pattern. Fright palpitations can be classified heart deficiency with timidity, heart blood and qi deficiency, heart qi deficiency, heart blood deficiency, heart qi movement stagnation, water qi intimidating the heart, phlegm-fire harassing the heart, phlegm clouding the pericardium, and so on. Palpitations can be classified heart blood deficiency, heart yin deficiency, heart deficiency with timidity, heart spleen blood deficiency, spleen qi deficiency, phlegm-fire harassing the heart, intense heart fire, and so on. Forgetfulness can be classified heart spleen blood deficiency, heart spleen qi deficiency, kidney essence deficiency, heart qi deficiency, non-interaction between the heart and kidney, etc. for deficiency pattern, phlegm clouding the pericardium for excess pattern. In Blood just say inside bleeding pattern's category, there are nose bleeding, flopping syncope, qi counterflow, blood vomiting, hemoptysis, spitting of blood, bloody stool, hematuria, and so on. Like these, this study identify pattern of disease in DongEuiBoGam by mechanism of disease theory.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.22 no.2
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• pp.74-81
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• 2009

Background and Objective : There are a lot of theories that explained the aging process, and the oxidative stress is one of the important theory that explained the aging process. The aim of this study was to investigate active oxygen and antioxidant capacity of Qi deficiency and Blood deficiency animal models. Material and Methods : Sprague-Dawley rats were divided into three groups: normal group, Qi deficiency group and Blood deficiency group. The Qi deficiency animal model was induced through restriction of food (12g/kg/day) for 20 days. Blood deficiency animal model was induced by bleeding from tail vein(0.4ml/time) 8 times. The normal animal model was kept without any intervention. The oxidative stress was observed by measuring the active oxygen and antioxidant capacity. Results and Conclusion : 1. Active oxygen was significantly increased in the Qi deficiency group and Blood deficiency group. (P=0.061) 2. Antioxidant capacity was increased in the Qi deficiency group and Blood deficiency group. But there is no significant difference. (P=0.113)

• Journal of Physiology & Pathology in Korean Medicine
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• v.28 no.3
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• pp.346-354
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• 2014

The study was performed to determine the reliability and validity of the 'Qi Blood Yin Yang Deficiency Questionnaire (Qi Blood Yin Yang DQ)' for the 100 subjects with chronic fatigue. After 100 subjects respond to the 'Qi Blood Yin Yang DQ', Korean medical doctor classified the subjects into 4 groups such as Qi deficiency group, Blood deficiency group, Yin deficiency group and Yang deficiency group. 100 subjects were retested in the same way after 3 weeks. The reliability and the validity of the questionnaire were inspected. Internal consistency of the 'Qi Blood Yin Yang DQ' was excellent (Cronbach alpha 0.916). Test-retest reliability was good (intra-class correlation coefficient 0.699). Construct validity analyzed by exploratory factor analysis produced 4 factors, which were selected from eigenvalues that are greater than 1.0. The 'Qi Blood Yin Yang DQ' consisted of 4 factors. The factor 1, 2, 3 and 4 showed 'Qi deficiency', 'Yin deficiency', 'Yang deficiency' and 'Blood deficiency' respectively. The 'Qi Blood Yin Yang DQ' restructured in this study may provide a fundamental questionnaire and a further study is required for a more advanced, standardized and statistically proven questionnaire.

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.5
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• pp.727-736
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• 2010

This study is about researching mechanistic pattern identification of disease for DongEuiBoGam NaeGyungPyen by analysing with pattern identification of modern Traditional Korean medical patholgy as more logical, systematic and standardized theory. Disease pattern mechanisms of uterine, urine and excrements parts of DongEuiBoGam NaeGyun gPyen in NaeGyungPyen of DongEuiBoGam are these. Menstrual irregularities in DongEuiBoGam can be classified flui d-humor depletion, blood deficiency, qi deficiency, qi stagnation, qi stagnation complicated by heat, blood stasis, blood deficiency complicated by heat, syndrome of heat entering blood chamber, syndrome of cold entering blood chamber. The disease pattern of abdominal pain after menstruation in DongEuiBoGam is blood deficiency complicated by heat, and a dysmenorrhea represents blood stasis with heat, fluid-humor deficiency. Advanced menstruation represent dual heat of the qi and blood, delayed menstruation is blood deficiency. The disease pattern of inhibited urination in DongEuiBoGam can be classified deficiency heat pattern of kidney yin deficiency(yin deficiency with effulgent fire), kidney qi deficiency, yin deficiency with yang hyperactivity, fluid-humor depletion, spleen-stomach dual deficiency, and excess he at pattern of bladder excess heat. The disease pattern of urinary incontinence in DongEuiBoGam can be classified deficiency pattern of kidney-bladder qi deficiency, consumptive disease, lung qi deficiency, kidney yin deficiency(yin deficiency with effulgent fire), kidney yang deficiency and excess pattern of lower energizer blood amassment, bladder excess heat. And most of them are deficiency from deficiency-excess Pattern Identification. The disease pattern of diarrhea in DongEuiBoGam can be classified deficiency pattern of qi deficiency, qi fall, spleen yang deficiency, kidney yang deficiency and so on and excess pattern of wind-cold-summerheat-dampness-fire, phlegm-fluid retention, dietary irregularities, qi movement stagnation. And most of them are deficiency from deficiency-excess Pattern Identification. Like these, this study identify pattern of disease in DongEuiBoGam by mechanism of disease theory.

• The Journal of Korean Obstetrics and Gynecology
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• v.15 no.4
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• pp.111-127
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• 2002

Purpose : This study investigated reliability of Oriental OB&GY questionnaires, valued the items and correlated relation of differentiation of syndromes of Oriental OB&GY questionnaires which is used by Dong-Eui OB&GY. Method : We analysised the result of 721 outpatients's questionnaires from March. 1. 1998 to March. 30. 2002 Results : 1. The reliability of Oriental OB&GY questionnaires above 95% is deficiency of Ki, deficiency of blood, dry of blood, deficiency of Um, stagnation of Ki, insuficiency of the kidneys, liver, heart, above 90% under 95% is deficiency of Yang, heat of constitution, heat of disease, dampness, stagnated blood, above 85% under 90% is phlegm, spleen above 80% under 85% is cold syndrom. 2. The order of frequency diagnosed by Oriental OB&GY questionnaires is dampness(78.7%), heart(66.8%), stagnation of Ki(63.8%), deficiency of blood(53.5%), deficiency of Ki(53.1%), phlegm(53.7%), insuficiency of the kidneys(50.1%), dry of blood(45.1%), spleen(41.4%), liver(36.2%), stagnated blood(36.2%), deficiency of Yang(35.6%), cold syndrom(29.8%), deficiency of Um(24.1%), heat of disease(22.5%), heat of constitution(20.1%). 3. The average of item of differentiation of syndromes above 90 is dampness, above 80 under 90 is deficiency of Ki, deficiency of blood, dry of blood, deficiency of Yang, cold syndrom, heat of constitution, stagnation of Ki, phlegm, stagnated blood, insuficiency of the kidneys, liver, heart, spleen, above 70 under 80 is deficiency of Um, heat of disease. 4. Deficiency of Ki is connected with question compounded of stagnation of Ki, deficiency of Yang is connected cold syndrom, cold syndrom is connected deficiency of Yang, stagnation of Ki is connected deficiency of Ki. 5. The differentiation of syndromes accompanied with others which is related to compounded question is deficiency of Ki, deficiency of blood, cold syndrom, stagnation of Ki, dampness, phlegm, stagnated blood, insuficiency of the kidneys, liver, heart, spleen, which isn't related to compounded question is dry of blood, deficiency of Um, deficiency of Yang, heat of disease.

• Journal of Haehwa Medicine
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• v.19 no.2
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• pp.35-42
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• 2011

The purpose of this study is to evaluate the difference about pathogenesis of skin type. the theory that explains each individual react to certain stress is generally accepted in traditional oriental medicine. The aim of this experiment is to find out relationship between the effect of facial condition and the vital conditions of traditional Oriental medicine. We recognized that pattern identification of fluid-humor could be divided into 4 different groups. The reason is that the fluid-humor could be interpreted as Qi & Blood, furthermore Qi & Blood were categorized into deficiency and excess groups. Korean female volunteers in good health participated in this experiment. Three doctors of Oriental medicine classified them into 4 groups based on qi-blood and deficiency-excess concept(qi-deficiency; qi-excess:qi-stagnation; blood-deficiency; blood-excess:static-blood). Volunteers were assessed with non-invasive skin measuring devices. And we analyzed the correlation of skin physiological parameters with vital conditions; moisture, sebum and elasticity. Measurement moisture and sebum of facial skin tended to deacease only in static blood group.

• Clinical and Experimental Pediatrics
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• v.57 no.8
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• pp.345-350
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• 2014

Iron deficiency affects approximately one-third of the world's population, occurring most frequently in children aged 6 months to 3 years. Mechanisms of iron absorption are similar to those of other divalent metals, particularly manganese, lead, and cadmium, and a diet deficient in iron can lead to excess absorption of manganese, lead, and cadmium. Iron deficiency may lead to cognitive impairments resulting from the deficiency itself or from increased metal concentrations caused by the deficiency. Iron deficiency combined with increased manganese or lead concentrations may further affect neurodevelopment. We recently showed that blood manganese and lead concentrations are elevated among iron-deficient infants. Increased blood manganese and lead levels are likely associated with prolonged breast-feeding, which is also a risk factor for iron deficiency. Thus, babies who are breast-fed for prolonged periods should be given plain, iron-fortified cereals or other good sources of dietary iron.