• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.26 no.3
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• pp.20-35
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• 2013

Objectives : The purpose of this study is to provide grounds for the development of preparation of Korean medicine through investigating the usage of smoking preparation, fumigant and buccal preparations in "Dongeuibogam". Methods : We have researched the usage of related preparations as following procedure : 1. Choosing a related words such as combustion(燒, 燎, 燃) smoking(烟), fumigation(熏, 熏烟, 熏洗), inhalation(聞, 嗅, 齅), holding in mouth(含, 噙). 2. Searching sentences : We have searched sentences containing the related words in "Dongeuibogam", analyzed the selected sentences and made tables of the usage including indication, formula, material. Conclusions : 1. Smoking preparations and Fumigant can be classified into two different groups : 1) internal usage for the treatment of internal diseases such as dizziness, congestion, stroke, cough. 2) external usage for the treatment of wounds, sores, genital diseases, anal disease and for the prevention of diseases. 2. Buccal preparation is mainly used for the treatment of mouth, tongue, throat and lung diseases. 3. These preparations have been used not only for external diseases but internal diseases. 4. Each preparation has chief herbs for its peculiar properties of treatment.

• The Korea Journal of Herbology
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• v.33 no.2
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• pp.69-77
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• 2018

Objectives : Daesiho-tang (DSHT) has been widely used in the treatment of cerebral infarct in traditional medicine. However, there was not report on the anti-obesity-related diseases efficacy of DSHT. In this study, we investigated the effects for the new formulation of DSHT, on the adipocyte differentiation cycle in 3T3-L1 cells. Methods : 3T3-L1 cells were treated with DSHT (50, 100, $200{\mu}g/m{\ell}$) during differentiation for 6 days. Also, the inhibitory effect of DSHT against 3T3-L1 adipogenesis was evaluated in various stage of adipogenesis such as early (0-2day), intermediate (2-4day), and terminal stage (4-6day). The accumulation of lipid droplets was determined by Oil Red O staining. and, the expressions of genes related to adipogenesis were measured by RT-PCR and Western blot analyses. Results : DSHT showed inhibitory activity on adipocyte differentiation at 3T3-L1 preadipocytes without affect cell toxicity as assessed by measuring fat accumulation and adipogenesis. In addition, DSHT significantly reduced the expression levels of several adipocyte marker genes including proliferator activated $receptor-{\gamma}$ ($PPAR-{\gamma}$) and CCAAT/ enhancer-binding $protein-{\alpha}$ ($C/EBP-{\alpha}$). Also, the anti-adipogenic effect of DSHT was strongly limited in the intermediate (2-4 day), terminal stage (4-6 day) of 3T3-L1 adipogenesis. In addition, the DSHT treatment down- regulated mRNA expression levels of $PPAR-{\gamma}$,, $C/EBP-{\alpha}$ in mature 3T3-L1 adipocytes. Conclusions : These results suggest that, the ability of DSHT has inhibited overall adipogenesis and lipid accumulation in the 3T3-L1 cells. The new formulation of DSHT may be a promising medicine for the treatment of obesity and related metabolic disorders.

• The Korea Journal of Herbology
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• v.31 no.6
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• pp.1-9
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• 2016

Objectives : Gamisoyosan (GMS) is a useful prescription for treating insomnia, dysmenorrhea and infertility induced by a stress. Also, GMS has been used traditionally to improve systemic circulation and biological energy production. The purpose of this study was to assess the anti-oxidant activity and anti-inflammatory effects of Gamisoyosan Formulation (Soft extract, GMS-SE). Methods : The biological activities such as anti-oxidant and anti-inflammatory effects were measured through cell line-based in vitro assay. We investigated the anti-oxidant properties of GMS-SE on the 1,1-diphenyl-2-picryhydrazyl (DPPH) radical, contents of total flavonoid and polyphenol. GMS-SE compared to butyl hydroxy anizole (BHA). Furthermore, based on this result the anti-inflammatory effects of GMS-SE have verified by mechanism from LPS- treated Raw264.7 macrophages. Results : The anti-oxidant activities of GMS-SE increased markedly, in a dose-dependent manner. The GMS-SE showed significant scavenging activity (GMS-SE $500{\mu}g/m{\ell}$ : $32.77{\pm}1.65%$, GMS-SE $1000{\mu}g/m{\ell}$ : $45.06{\pm}1.04%$ and BHA $100{\mu}g/m{\ell}$ : $39.25{\pm}2.41%$ for DPPH assay). and, The total phenolic compound and flavonoids contents of GMS-SE were $73.93{\pm}6.87{\mu}g/mg$ and $698.75{\pm}6.78{\mu}g/mg$. GMS-SE which is LPS has diminished in the LPS-induced release of inflammatory mediators (NO, iNOS, COX2 and PGE2) and pro-inflammatory cytokines (TNF-${\alpha}$, IL-6 and IL-$1{\beta}$) from the RAW264.7 macrophages. Moreover, GMS-SE inhibited the activation of phosphorylation of p38 and ERK MAPKs by induced LPS. Conclusion : The present results indicate that GMS-SE has an anti-oxidant and anti-inflammatory properties, therefore may be beneficial in diseases which related to oxidative stress-mediated inflammatory disorders.

• 한국디지털정책학회:학술대회논문집
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• 2005.11a
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• pp.613-628
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• 2005

The purpose of this study was to design and implementation of project learning site by using XML. The development of the Internet site for project learning was planned as per preparation, development and test/application stages. At the stage of preparation, literature and cases were reviewed to find the elements of design principles needed for development of a project learning program and those required in the actual development. At the stage of development, the elements of the design principles and those for the actual development, both explored from the stage of preparation were used to develop a draft Internet site for project learning. The elements used for the development of the Internet site for project learning were motivation, specification of learning goals, reminiscence of preceding knowledge, positive participation in teaching activities, learning-guide feedback, evaluation, reinforcement and correction. It is changing web based format. XML advent because of HTML limitations of web based internet and expand it's field. XML is able to gather data on HTML of text based format, thus it is possible to control it's inside. It is expected that many teachers apply this model to their classes and show realistic results.

• Journal of the Korean Home Economics Association
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• v.38 no.5
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• pp.1-14
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• 2000

The purpose of this study is to develop and evaluate a remarriage preparation program. Based on the system theory, strong family perspective, care & justice perspectives, and empirical research in this field,4 session remarriage preparation program is developed. Target population of this program is persons who remarry and persons who marry with remarried partner This program is evaluated in terms of the level of remarriage preparation and level of changing attitude after education in terms of self-esteem, cognition & knowledge of parent behavior in the remarried family, object evaluation of their future remarriage life. Future research, theoretical and practical implications are added.

• Korean Journal of Human Ecology
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• v.4 no.2
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• pp.29-47
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• 2001

The purpose of this study is to provide marital information that premarital preparation education program is to actively help families happiness, to be reinforced by the developmental service and the protective service. The premarital education program to help unmarried or premarital couples to begin initial adaptation for successful marriage. This program is to enrich the marital relationship provided with the wholesome, potent marital system as center of a family. and further to development preserve. enhance a healthy, genial family relationship. Particularly the elevated marital relationship. The data were collected for 122 collage students. The data were analyzed by statistical methods such as frequency percentage. This program is for college students as curriculum. So it was consisted of fourteen-sessions. The sessions included as follows: Intimacy & Love. Mate Selection. Understanding Together, Communication, Family Stress & Coping, Understanding Marriage & Family Dynamics. Gender Role & Power Intimacy. Sexuality & Relationship. Financial Management, Marriage Preparation. Evaluation.

• Journal of Families and Better Life
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• v.22 no.1
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• pp.91-101
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• 2004

This study is a part of three year project of “A Study on the Development, Evaluation ＆ Outreach of Marriage Preparation Program”. The purpose of this study is to analyse the unmarried and married couples' attitude about marriage and family, marriage preparation status, their needs of marriage preparation program and ingredients of marital happiness to developing base line data of the marriage preparation program. The result showed that communication ＆ conflict resolution, financial management, relationship characteristics are the major contents area to be considered to develop marriage preparation program. Critics and recommendation for need assessment and educational methods were added.

• Journal of Pharmacopuncture
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• v.12 no.1
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• pp.77-89
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• 2009

Objectives : Mistletoe extracts have been in use for around 85 years, predominantly in the area of cancer therapy. Today mistletoe preparations are among the most prescribed drugs in cancer medicine, thus constituting a standard biological therapy in the area of oncology. The purpose of this study is to analyze the practical implications of mistletoe cancer therapy, their clinical status, their preparation techniques and companies. Contents : Mistletoe therapy for cancer has been developed within the context of anthroposophical medicine. One major effect of mistletoe extract is that it stimulates the immune system and cancer defences. In Germany, a total of eight different mistletoe preparations are available, five developed by Anthroposophic Medicine and three evolved from research in phytotherapy. Therapy always consists of an introductory phase in order to test the patient's tolerance, find the right dosage and choose the most suitable preparation. This paper covers the background of mistletoe medical plant materials, mistletoe therapy for cancer, the anthroposophical medicine and clinical research, the practical regulation of treatment, preparation of mistletoe drugs. Result & suggestion : Mistletoe extracts are a complementary teratment of cancer, widely used in intergrative cancer care. The study of the integration of korean mistletoe extracts to oriental cancer medicine, its development and feasibility in Korea are urgently needed. The products, substances, compositions of european mistletoe drugs are very similar to those of oriental medicine theory. Applying the mistletoe cancer therapy and its preparation techniques to oriental medicine, the herbal acupuncture preparation should be modernized and korean mistletoe products are to be developed. To this end, government and herbal acupuncture society need to interact each other for the development of oriental mistletoe cancer medicine.

• Journal of the Korean School Mathematics Society
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• v.12 no.2
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• pp.195-227
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• 2009

The study was designed to describe the pre service teachers' development of their TPCK throughout the teacher preparation program that integrated technology throughout the program and how they succeeded in teaching with technology in the actual classroom during student teaching. Multiple data sources were used to obtain information toward answering the research questions. Overall, the emphasis of the teacher preparation program in this study in helping preservice teachers to acquire TPCK transformed the preservice teachers' understanding described by the four components of TPCK. However, the diversity of beliefs, teaching, and technology background affected their understanding and development of TPCK throughout the program.

• The Korea Journal of Herbology
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• v.33 no.2
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• pp.9-18
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• 2018

Objectives : Hwangryunhaedok-tang (HRHDT) is one of the well-known prescription herbal drugs of Korean herbal medicine, which has been widely used for the treatment of various bacterial and inflammatory diseases. This study was conducted in order to develop the tablet formulations of HRHDT and compare its efficacy with the other commercial formulations. Methods : Corresponding herbal medicines comprising of HRHDT were extracted with water for 3 hr at $95{\sim}100^{\circ}C$ and then vacuum dried. Subsequently, some pharmaceutical excipients such as microcrystalline cellulose, croscarmellose sodium, magnesium stearate, etc were used to prepare the HRHDT tablets. The contents with characterizing components of HRHDT tablet was compared with the HRHDT decoction. The contents of characterizing components were analyzed with HPLC. Furthermore, we investigated the anti-inflammatory and anti-oxidative abilities of two different commercial HRHDT granules (HJP-1 and HJP-2) and were compared with that of the formulated HRHDT tablets. The anti-oxidant properties of HRHDR were studied using the 1,1-diphenyl-2-picryhydrazyl (DPPH) radical, contents of total flavonoid and polyphenol. In addition, based on this result the anti-inflammatory effects have verified by mechanism from LPS- treated Raw264.7 macrophages. Results : The results demonstrated that HRHDT tablets showed more anti-inflammatory and anti-oxidative effects than HJP-1, HJP-2. Moreover, it showed more superior effects in terms of dose, usability and stability than the granules. Conclusion : Hence, we concluded that in order to improve the quality and efficacy of the Korean herbal medicine, it is necessary to develop appropriate methods and establish standardized techniques for the development of good formulations.