• 대한수학회보
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• 제58권3호
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• pp.767-779
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• 2021

Schatten-Herz class Toeplitz operators on weighted Bergman spaces induced by doubling weights are investigated in this paper.

• 대한수학회보
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• 제60권5호
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• pp.1201-1219
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• 2023

We characterize the boundedness and compactness of differences of weighted composition operators acting from weighted Bergman spaces A^p_ω to Lebesgue spaces L^q(dµ) for all 0 < p, q < ∞, where ω is a radial weight on the unit disk admitting a two-sided doubling condition.

• Asian-Australasian Journal of Animal Sciences
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• 제20권2호
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• pp.263-272
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• 2007

This experiment was conducted to examine the effects of cage type (CT) and cage density (CD) on physiological variables in growing rats. Sprague Dawley rats (n=108) weighing an average of 46 g were housed in metallic cage with woodchip bedding (MCWB), metallic cage with wire mesh (MCWM), and plastic shoebox with woodchip bedding (PCWB) separately by sex at normal ($160-cm^2/rat$, ND) and high ($80-cm^2/rat$, HD) CD from 3 to 10 wks of age. All cages were in dimension of $24{\times}40{\times}20$ cm ($W{\times}D{\times}H$). At the end of the experiment, blood samples were collected and 6 rats from each cage were sacrificed. No death was observed among rats at ND, whereas mortality rate at HD was 22.3% for males and 13.9% for females. Heart weight was affected by CT. Doubling CD caused 23, 11.8, 17.9, 8.6, 6.9, and 16.4% decreases in BW and weights of heart, liver, kidney, testis, and ovary, respectively. Except for adrenal gland, other organs for males were heavier than for females. Liver weight of males and females responded differently to CT and CD. Comparing with females, males had 7.3 and 5.2% heavier and 9.9% lighter liver weights in MCWB, MCWM, and PCWB, respectively. As CD doubled, liver weight for males and females decreased by 22.4 and 13.1%, respectively. Mean adrenal gland weight increased by 8.4% and decreased by 9.7% for males and females, respectively, with doubling CD. CT affected glucose, TG, Ca, and ALP levels. However, CD did not alter blood chemistry. Rats housed in metallic cages had greater neutrophil count and neutrophil:lymphocyte ratio than rats housed in plastic cages. Doubling CD caused a 24.2% increase in lymphocyte count. There were CT by CD, CT by sex, and CD by sex interaction effects on lymphocyte count. Doubling CD caused 0.1% decrease and 49.8 and 26.7% increases in lymphocyte count for rats housed in MCWB, MCWM, and PCWB, respectively. Comparing with females, lymphocyte count for males housed in MCWB, MCWM, and PCWB had 8.9 and 12.9% greater and 30.3% less lymphocyte counts, respectively. Lymphocyte count decreased by 4.12% for males, whereas it increased by 61.0% for females as CD doubled. Doubling CD resulted in 2.5 and 2.3% increases in erythrocyte count and hematocrit value. These data suggest that animals perform better in metallic cages than in plastic cages and that cage density had pronounceable effects on physiological parameters in a cage type and sex dependent-manner.

• Journal of Nutrition and Health
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• 제24권5호
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• pp.431-441
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• 1991

To investigate the influence of age and dietary fat level on the immune function and the growing potential of the fibroblast cells, male rats of 2 month, 6 month and 30 month of age were fed either 6% or 30% fat diet for 16 weeks. The weight of thymus decreased linearly with increasing age. And this age-dependent degeneration of thymus was delayed in rats fed low fat diets. The blastogenesis of spleen lymphocytes to PHA, ConA, and PWM was decreased with increasing age, however, no effect of dietary fat level was observed. The age-related decline in ratios of PHA/ConA response may suggest that T suppressor cell activity increases with age. In cell culture system, lung fibroblast cells from 30M rats showed lower plating efficiency. longer doubling time. and shorter cumulative doubling potential than those from 2M or 6M animals. Also. the morphology of fibroblasts from 30M rats was tended to be rouned rather than flattened and more variable in size and being generally larger. wherease those from 2M and 6M rats were uniform in size and adhered tightly to the culture vessel in ordered arrays. Therefore fibroblast cell culture system tried in this study reflects the changes of cellular aging.

• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.7575-7582
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• 2015

Cyclin E, a key coordinator of the G1 to S transition in the cell cycle, may be deregulated in several malignancies, including breast cancer. The most significant aberration in cyclin E is its elastase mediated proteolytic cleavage into tumor specific low molecular weight isoforms (LMW-Es). LMW-Es are biochemically hyperactive and biologically drive tumorigenesis in transgenic mouse models. Additionally, expression of LMW-Es has been correlated with poor survival in breast cancer cases. Here we determine whether expression of LMW-Es in a breast cancer cell line that is naturally devoid of these deregulated forms would alter their progression through each phase of the cell cycle. The results revealed that LMW-Es expression resulted in an increased doubling time, concomitant with a predominant increase in the population in the S phase of the cell cycle. Moreover, downregulation of p53 in LMW-Es cells resulted in additional shortening of the doubling time and enrichment of cells in the S and G2/M phases of the cell cycle. Furthermore, expression of LMW-Es sensitized cells to ${\beta}$-estradiol (E2) mediated growth and changed expression patterns of estrogen receptor and Bcl-2. Intriguingly, expression of LMW-Es could surpass anti-apoptotic effects raised by p53 upregulation. Taken together these studies suggest that overexpression of LMW-Es in collaboration with p53 loss results in altered g rowth properties of MCF-7 cells, enhancing the oncogenic activity of these ER positive breast cancer cells.

• Radiation Oncology Journal
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• 제9권1호
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• pp.1-6
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• 1991

2-ODG가 쥐의 섬유육종(FSall)에 미치는 영향에 대한 연구로 에너지 신진대사는 체내에서의 $^{31}P$-자기공명 분광기를 이용하여 관찰하였고 세포 증식 능력은 유세포 분석기를 사용하여 연구하였다. 성장속도는 10개의 세포를 $C_3Hf/Sed$ 쥐의 발등에 이식한 후 3차원적으로 측정하여 관찰하였다. 2-DDG를 투여한 경우에는 이식후 12일에 복강내로 주사하였다. 이식후 12일의 종양의 평균 크기는 $250mm^3$이었다. Fsall종양의 성장속도는 semilog graph의 기울기와 종양의 doubling time으로 측정하였다. 2-DDG를 투여한 후 성장속도가 감속되었다. 5~12일 사이의 성장속도의 기울기가 0.828, 종양의 Idubling time이 0.84일이고 대조군에서는 13~28일 사이의 기울기가 0.218, doubling time이 3.2일인 반면 2-DOG 투여군에서는 성장속도의 기울기가 0.135이고 doubling time이 5.1일이었다. $^{31}P$-자기공명 분광기를 이용하여 2-DDG의 영향을 분석해 본 결과 2-DDG 투여후 종양증식 속도의 감속과 더불어 phosphornonester (PME)와 inorganic phosphate (Pi)의증가속도가 감소하였다. 이것은 2-DDG투여후 세포의 괴사가 감소하였다는 의미가 있다. 유세포 분석기를 이용하여 종양의 증식 능력을 분석한 결과는 2-DDG 투여후 5-phase와 G2+M phase의 DNA분포가 크게 증가하였다. 이것은 2-DDG투여후 세포가 좀더 방사선에 민감한 cycle로 진행함을 의미하는 것으로 해석할 수 있다. 이에 저자들은 2-DDG가 Fsall 종양세포에 미치는 흥미있는 결과를 토대로 방사선 치료에 미치는 영향과실제 이용 가능성에 대하여 더 연구하고자 한다.

• 한국자원식물학회지
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• 제29권3호
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• pp.347-354
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• 2016

The present study was performed to investigate the effects of the colchicine concentrations on chromosome doubling for producing of tetraploid plants of Codonopsis lanceolata, and its effect on plant morphology. A total of 180 individuals germinated from 16 treatment groups, were exposed to various concentrations (0.05-1.0% w/v) of colchicine for different soaking duration (3-24 hour). The highest numbers of tetraploid plants (3) were observed from the lowest concentration of colchicine (0.05%), and one (1) tetraploid plant was obtained from the 0.5% concentration group with a 6 hour treatment. However, no tetraploid individual was observed in any other treatment groups. The plant height of the diploid (18.1 ㎝) was slightly shorter than that of the tetraploid (13.4 ㎝). The fresh weight of the main root in the diploid (0.5 g) was four-fold higher than the tetraploid (2.2 g). The colchicine-treated plant regeneration rate in C. lanceolata was decreased when the plants were subjected to high concentration of colchicine. In particular, the highest number of tetraploid plants (5 and 3) was obtained from the lower concentration (0.05% and 0.1%) of colchicine for 6-hour treatment, which were a higher rate (29.4% and 30%) of regenerated tetraploid plants than other regenerated plants. As in the seed treatment result, the plant height of the diploid was significantly higher (10.4 ㎝) than tetraploid. The higher morphological changes were observed comparatively from tetraploid plants than the diploid.

• 한국자원식물학회지
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• 제28권5호
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• pp.656-664
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• 2015

고품질 수박을 생산하기 위하여 서로 다른 염색체 배수화제를 처리하여 3가지 4배체 육종라인(‘SA03-1’, ‘SA06-1’ and ‘SB01-1’)을 개발하였다. 최적의 4배체 유기조건들을 조사하기 위하여, 3가지 육종라인들의 4배체는 공변세포의 배수화된 엽록체 수를 조사하는 것으로 선발하였다. 4배체 유기율은 배수화제의 종류와 유전자형에 따라 다르게 나타났다. 가장 높은 4배체 유기율은 colchicine 1.0%에서 82.2%로 가장 높게 나타났다. 이들 잠재적인 4배체 라인들의 배수성은 flow cytometer와 염색체 수 분석을 이용하여 재확인하였다. 확보된 4배체 육종라인들의 절간은 그들 2배체와 비교하여 4배체와 유사하거나 짧게 나타난반면, 잎의 크기는 4배체에서 더크게 나타났다. 과중은 ‘SA03-1’, ‘SB01-1’ 라인에서는 다소 감소하였고, 과피 두께와 당도는 ‘SB01-1’라인에서만 2배체와 차이를 보여주었다. 4배체 육종라인은 수정능력을 가지고 있었고 종자는 열매마다 ‘SA03-1’ (21개), ‘SA06-1’ (62개), ‘SB01-1’ (34.7개)로 수확되었으며, 4배체 종자는 그들의 2배체보다 더 크고 두터웠다. 이러한 4배체 품종 육성 결과는 씨없는 수박의 신품종 육성을 위해 유용하게 활용될 것으로 기대된다.

• Journal of Microbiology and Biotechnology
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• 제8권5호
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• pp.536-539
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• 1998

The anti-complementary activity (immuno-stimulating activity) was tested for the exo-polymers (extra-cellular polymer) produced from submerged mycelial cultures of 21 types of higher fungi. Anti-complementary activity of the exo-polymer from Cordyceps militaris showed the highest (69.0%) followed by Pleurotus ostreatus (63.7%) and Trametes suaveolens (61.4%). The mycelial growth rate and biomass doubling time of C. militaris in a 5 I air-lift fermenter were 0.0255 $h^{-1}$ and 27.2 h, respectively. The yield of the exo-polymer produced from the culture broth of C. militaris was 2.95 mg of dry weight/ml of culture broth. Sugar and amino acid compositions of this exo-polymer were analyzed.

• 대한수학회보
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• 제36권1호
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• pp.25-31
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• 1999

Let $\nu$ be a positive Borel measure on a space of homogeneous type (X, d, $\mu$), satisfying the doubling property. A condition on a weight $\omega$ for whixh a maximal operator $M\nu f$(x) defined by M$mu$f(x)=supr>0{{{{ { 1} over {ν(B(x,r)) } INT _{ B(x,r)} │f(y)│d mu (y)}}}}, is of weak type (p,p) with respect to (ν, $omega$), is that there exists a constant C such that C $omega$(y) for a.e. y$\in$B(x, r) if p=1, and {{{{( { 1} over { upsilon (B(x,r) } INT _{ B(x,r)}omega(y) ^ (-1/p-1) d mu (y))^(p-1)}}}} C, if 1$infty$.