• Journal of Information Technology Applications and Management
• /
• v.22 no.2
• /
• pp.219-230
• /
• 2015

Recently, electronic-book (e-book) market is growing rapidly due to the evolution of information technology and e-book standard EPUB. Users can search e-book on-line and download easily to their e-book readers such as amazon's kindle or smartphones. On the other hand, there is lack of e-book contents for the reading disabled people because of high cost of making e-book accessibility for the reading disabled people. If we can translate EPUB specified e-book contents to the alternative e-book contents suitable for the reading disabled people, then there are many advantages to acquire various types and large volumes of e-book contents for the reading disabled people. This paper suggests a new electronic publishing ecosystem for the reading disabled people using e-book translation method. It also suggests a promotion strategy of e-book market for the reading disabled people.

• The Journal of the Convergence on Culture Technology
• /
• v.8 no.1
• /
• pp.245-252
• /
• 2022

This study is significant in explaining the eSports awareness survey and future development direction of deaf people. Therefore, 189 deaf people were selected as the population, and the following conclusions were drawn by frequency analysis and t-test using SPSS 21.0 and Excel 2016. First, 67.7 percent of the 189 deaf people recognized eSports, 61.4 percent recognized it as a new sports system, and 65.6 percent participated directly or indirectly in eSports. Second, smartphones are the most common e-sports participating devices, and most of the participating events are Kartrider, which is recommended by friends. Third, the most inconvenient part of participating in eSports was the lack of eSports programs for deaf people, and the survey on whether to recommend eSports was the most likely. Fourth, the most common reason for not recognizing eSports as a new sport is that they are not actually sports, so they are not interested in participating. Fifth, there are statistically significant differences in eSports awareness, recognition and participation of deaf people by gender.

• Journal of Korea Multimedia Society
• /
• v.16 no.1
• /
• pp.100-107
• /
• 2013

As the eBook market grows fast recently, various eBook viewer solutions such as hardware viewers and software readers came out to the market. We can, however, hardly find mobile eBook interfaces for the reading disabled people who have difficulties in reading for their visual impairment or learning disabilities, or dyslexia. An eBook viewer interfaces for the reading disabled people should be carefully and distinctively designed because the reading disabled people cannot use normal versions of eBook viewer. In this paper, we suggest a eBook viewer interface model to make the reading disabled people read eBooks easily. Depending on the type of the reading disabled people: the full blind, the almost blind, the just learning disabled, our model provides an adaptive interface to make them read eBooks effectively. In addition, unlike the existing simple audio books, we also support annotation systems to make the reading disabled people interact with eBook viewer. To show the effectiveness of our model, we implemented an eBook viewer prototype on an android-based mobile device. We are sure that our model and implementation can make the reading disabled people, who is 10% of all the domestic people, read eBooks effectively.

• The Journal of Information Systems
• /
• v.26 no.4
• /
• pp.355-378
• /
• 2017

Purpose As elderly people are increasing rapidly in the world, consumption of elderly people is also increasing. However, there have been only marketing strategies for elder citizens centered on off-line. Therefore, apply marketing strategies to e-commerce suitable for the elderly in the future through online. This research was conducted to propose some marketing strategies relevant to elder people in the e-commerce context. Design/methodology/approach This study, for the preliminary research, firstly implemented the in-depth interviews based on prior studies, through preliminary research and analysis of previous research and then some research questions were set. With the research questions, we conducted a survey for elderly people and empirically validated the research model, testing given hypotheses. Findings Among the seven hypotheses, three hypotheses were supported by data analysis. Based upon the findings of this study, in order to do this, we have established a marketing strategy that utilizes e-commerce for elderly people who have purchasing power according to the principle of market economy.

• Journal of Microbiology and Biotechnology
• /
• v.31 no.8
• /
• pp.1098-1108
• /
• 2021

The literature indicates that LINC00174 promotes the growth of colorectal cancer (CRC) cells, but its research needs to be enriched. We tried to explore the function and mechanism of LINC00174 in CRC cell proliferation and migration. Bioinformatics analysis predicted the binding relationship and expressions of lncRNA, miRNA and mRNA. Clinical study analyzes the relationship between LINC00174 and clinical data characteristics of CRC patients. The expressions of LINC00174, miR-3127-5p and E2F7 were verified by RT-qPCR, and the combination of the two was verified by dual luciferase analysis and RNA immunoprecipitation as needed. Western blot was used to detect the expression of EMT-related protein and E2F7 protein. Functional experiments were used to evaluate the function of the target gene on CRC cells. LINC00174 was up-regulated in CRC clinical samples and cells and was related to the clinical characteristics of CRC patients. High-expression of LINC00174, contrary to the effect of siLINC00174, promoted cell viability, proliferation, migration and invasion, up-regulated the expressions of N-Cadherin, Vimentin, E2F7, and inhibited the expression of E-Cadherin. MiR-3127-5p was one of the targeted miRNAs of LINC00174 and was down-regulated in CRC samples. In addition, miR-3127-5p mimic partially reversed the malignant phenotype of CRC cells induced by LINC00174. Besides, E2F7 was a target gene of miR-3127-5p, and LINC00174 repressed miR-3127-5p to regulate E2F7. Our research reveals that LINC00174 affected the biological characteristics of CRC cells through regulated miR-3127-5p/ E2F7 axis.

• Asian Pacific Journal of Cancer Prevention
• /
• v.13 no.5
• /
• pp.1793-1797
• /
• 2012

Objective: To analyze the capacity of neurotrophic artemin to promote the motility and invasiveness of MIA PaCa-2 pancreatic cancer cells. Methods: MIA PaCa-2 was cultured in vitro and studied using transwell chambers for motility and invasiveness on treatment with different concentrations of aArtemin or its receptor $GFR{\alpha}3$ were also determined. Expression of matrix metalloproteinase-2 (MMP-2) and epithelial cadherin (E-cadherin) was quantified using RT-PCR and Western blotting. Results: MIA PaCa-2 pancreatic cancer cell motility and invasiveness was significantly increased with artemin and its receptor $GFR{\alpha}3$ with dose dependence (P<0.01). MMP-2 production was also significantly increased (t = 6.35, t = 7.32), while E-cadherin was significantly lowered (t = 4.27, t = 5.61) (P <0.01). Conclusion: Artemin and its receptor $GFR{\alpha}3$ can promote pancreatic cancer cell motility and invasiveness and contribute to aggressive behavior. The mechanism may be related to increased expression of MMP-2 molecule and down-regulation of E-cadherin expression.

• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.5
• /
• pp.2839-2843
• /
• 2013

Objective: To investigate the effects of miR-106b on malignant characteristics of gastric cancer cells, and explore possible mechanisms. Methods: Expression of miR-106b, p21 and E2F was determined by real-time PCR. Transfection with miR-106b mimics was conducted, and gastric cancer cells with miR-106b overexpression were obtained. Cells transfected with mimic mutants and those without transfection served as negative and blank controls, respectively. Flow cytometry and transwell assays were adopted to detect the effects of miR-106b overexpression on cell cycle, migration and invasion of gastric cancer cells. Results:. The expression of miR- 106b in gastric cancer cells was significantly higher than that in normal gastric mucosa cells. Furthermore, the expression level of miR-106b rose according to the degree of malignacy among the three GC cell strains (MKN- 45 > SGC-7901 > MKN-28). Overexpression of miR-106b shortened the G0/G1 phase and accelerated cell cycle progression, while reducing p21 and E2F5, without any significant effects on the capacity for migration and invasion of gastric cancer cells. Conclusions: miR-106b may promote cell cycling of gastric cancer cells through regulation of p21 and E2F5 target gene expression.

• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.11
• /
• pp.6533-6535
• /
• 2013

Background: The purpose of this study was to evaluate a new type of tumor biomarker, eukaryotic elongation factor 2 (eEF2), in serum for the early diagnosis, confirmative diagnosis as well as assessment of treatment of non-small cell lung cancer (NSCLC). Methods: 130 patients with NSCLC and 50 healthy individuals undergoing physical examination in our hospital provided the observation and healthy control groups. An enzyme linked immune sorbent assay (ELISA) method was applied to determine serum eEF2 levels. Serum neuron specific enolase (NSE) and squamous cell carcinoma antigen (SCC) levels in the observation group were assessed with an automatic biochemical analyzer. Results: The median levels of eEF2 in the serum of NSCLC patients was found to be significantly higher than the healthy control group (p < 0.01) and it was markedly higher in stages III, IV than stages I, II (p < 0.05). eEF2 was higher with tumor size ${\geq}2$ cm than <2 cm (P< 0.01). Furthermore, two weeks after surgery patients showed a significant trend for eEF2 decrease (p < 0.05). Conclusions: The eukaryotic elongation factor 2 (eEF2) has certain clinical values for early diagnosis, verification, and prognosis as well as classification of lung cancer patients.

• International Journal of Contents
• /
• v.3 no.2
• /
• pp.30-34
• /
• 2007

This paper concerns with the application of e-based education methodology for people with disabilities targeting to empower them. Instead of the classic educational support such as extended time to take exams, a reader and/or scribe to assist with exams and note taking services, we suggest the use of new pedagogy-the science of educations integrating the state-of-the art. In this paper, we introduce the definition of disabilities for the people who does not fully understand what they means, first, and then possible implementing tools which can empower them with accomplishments. Most of the research in the field of pedagogy has tended to concentrate on the behavioral aspects of instructional sciences. Therefore we would like to point out that we concentrate on the aspects of instructional science particularly related with people with disabilities.

• Proceedings of the Korea Database Society Conference
• /
• 2001.11a
• /
• pp.150-195
• /
• 2001

Only 4% of all customers with problems complain average customer with a problem will: - Tell 7-10 people - Those people will tell another 5-7 - Those people will tell another 3-5 (omitted)