• Structural Engineering and Mechanics
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• v.48 no.1
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• pp.125-150
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• 2013

This paper intends to present an application of isogeometric analysis in crack problems. An isogeometric formula is developed based on NURBS basis functions - enriched and adopted via X-FEM enrichment functions. The proposed method which is represented by the combination of the two above-mentioned methods, first by using NURBS functions models the geometry exactly and then by defining level set function on domain, identifies available discontinuity in elements. Additional DOFs are allocated to elements containing the crack and X-FEM enrichment functions enrich approximate solution. Moreover, a subelement refinement technique is used to improve the accuracy of integration by the Gauss quadrature rule. Finally, several numerical examples are illustrated to demonstrate the effectiveness, robustness and accuracy of the proposed method during calculation of crack parameters.

• Structural Engineering and Mechanics
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• v.76 no.3
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• pp.379-393
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• 2020

In this paper, we propose an automatic procedure to improve the accuracy of finite element solutions using enriched 2D solid finite elements (4-node quadrilateral and 3-node triangular elements). The enriched elements can improve solution accuracy without mesh refinement by adding cover functions to the displacement interpolation of the standard elements. The enrichment scheme is more effective when used adaptively for areas with insufficient accuracy rather than the entire model. For given meshes, an error for each node is estimated, and then proper degrees of cover functions are applied to the selected nodes. A new error estimation method and cover function selection scheme are devised for the proposed adaptive enrichment scheme. Herein, we demonstrate the proposed enrichment scheme through several 2D problems.

• Biomolecules & Therapeutics
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• v.30 no.1
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• pp.98-116
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• 2022

The small GTPase RhoA has been studied extensively for its role in actin dynamics. In this study, multiple bioinformatics tools were applied cooperatively to the microarray dataset GSE64714 to explore previously unidentified functions of RhoA. Comparative gene expression analysis revealed 545 differentially expressed genes in RhoA-null cells versus controls. Gene set enrichment analysis (GSEA) was conducted with three gene set collections: (1) the hallmark, (2) the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, and (3) the Gene Ontology Biological Process. GSEA results showed that RhoA is related strongly to diverse pathways: cell cycle/growth, DNA repair, metabolism, keratinization, response to fungus, and vesicular transport. These functions were verified by heatmap analysis, KEGG pathway diagramming, and direct acyclic graphing. The use of multiple gene set collections restricted the leakage of information extracted. However, gene sets from individual collections are heterogenous in gene element composition, number, and the contextual meaning embraced in names. Indeed, there was a limit to deriving functions with high accuracy and reliability simply from gene set names. The comparison of multiple gene set collections showed that although the gene sets had similar names, the gene elements were extremely heterogeneous. Thus, the type of collection chosen and the analytical context influence the interpretation of GSEA results. Nonetheless, the analyses of multiple collections made it possible to derive robust and consistent function identifications. This study confirmed several well-described roles of RhoA and revealed less explored functions, suggesting future research directions.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.24 no.4
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• pp.405-412
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• 2011

This paper introduces the generalized finite element method with global-local enrichment functions using the preconditioned conjugate gradient method. The proposed methodology is able to generate enrichment functions for problems where limited a-priori knowledge on the solution is available and to utilize a preconditioner and initial guess of good quality with only small addition of computational cost. Thus, it is very effective to analyze problems where a complex behavior is locally exhibited. Several numerical experiments are performed to confirm its effectiveness and show that it is computationally more efficient than the analysis utilizing direct solvers such as Gauss elimination method.

• Mass Spectrometry Letters
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• v.6 no.2
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• pp.31-37
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• 2015

Phosphorylation upon protein is well known to a key regulator that implicates in modulating many cellular processes like growth, migration, and differentiation. Up to date, grafting of multidimensional separation techniques onto advanced mass spectrometry (MS) has emerged as a promising tool for figuring out the biological functions of phosphorylation in a cell. However, advanced MS-based phosphoproteomics is still challenging, due to its intrinsic issues, i.e., low stoichiometry, less susceptibility in positive ion mode, and low abundance in biological sample. To overcome these bottlenecks, diverse techniques (e.g., SCX, HILIC, ERLIC, IMAC, TiO₂, etc.) are continuously developed for on-/off-line enrichment of phosphorylated protein (or peptide) from biological samples, thereby helping qualitative/quantitative determination of phosphorylated protein and its phosphorylated sites. In this review, we introduce to the overall views of enrichment tools that are universally used to selectively isolate targeted phosphorylated protein (or peptide) from ordinary ones before MS-based phospoproteomic analysis.

• Korean Journal of Adult Nursing
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• v.17 no.1
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• pp.128-138
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• 2005

Purpose: As population of elderly people continues to grow, successful aging has risen to the top of the nursing science agenda. The successful aging includes maintenance of the cognitive and physical functions, as well as emotional well-beings. This study was carried out to evaluate effects of the environmental enrichments on cognition of institutionalized elderly. Method: The population was selected among the elderly aging over 65 residing at two of institutions. A quasi experimental design was used with non-equivalent control group. Study subjects were thirteen for each group. For the experimental group, physical, social and symbolic environmental enrichment program was provided for six weeks. The data were analyzed by repeated measure ANOVA and repeated measure ANCOVA using SPSS Win 11.0. Result: Compared to control group, the experimental group showed a significant difference on DSF(F=3.29, p=.046), and TMTA(F=4.76, p=.013) of cognitive function, and depression (F=5.56, p=.007) of emotional distress after 1 and 12 weeks of environmental enrichment program. Conclusion: Findings indicate that physical, social, and symbolic environmental enrichment was effective to partially prevent from cognitive decline, and to decrease emotional distress of elderly. As a nursing intervention, environmental enrichment program for elderly should be expanded for nursing practice to promote healthy aging and to offer support to the growing population of elderly. Further research should be conducted to evaluate the effect on the community elderly.

• 한국정보디스플레이학회:학술대회논문집
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• 2006.08a
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• pp.4-4
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• 2006

Since the introduction of TFT LCDs in portable personal computers (notebooks) in the early 1990's, the TFT LCD industry has experienced several waves of technology revolution: (1) product introduction, (2) performance enrichment, (3) power utilization and material utilization, and (4) human-interface functions.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.26 no.1
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• pp.79-87
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• 2013

An isogeometric topological shape optimization method is developed using the level sets and Heaviside enrichments. In the level set method, the initial domain is kept fixed and its boundary is represented by an implicit moving boundary embedded in the level set functions, which facilitates to handle complicated topological shape changes. The Heaviside enrichment improves the isogeometric analysis by adding some enrichment functions to model the internal boundaries. The proposed topological shape optimization method has several benefits: exact geometric models can be obtained using the isogeometric approach and the limitation of tensor-product patches can be overcome using the Heaviside enrichments to represent the internal voids. Even in a single patch, discontinuous displacement fields as well as smooth stress field can be obtained. Since the level sets offer the implicit moving boundary inside the domain, it is easy to represent the topological shape variations in the isogeometric analysis using Heaviside enrichments.

• Genomics & Informatics
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• v.18 no.4
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• pp.39.1-39.8
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• 2020

Alzheimer's disease (AD) is a chronic, progressive brain disorder that slowly destroys affected individuals' memory and reasoning faculties, and consequently, their ability to perform the simplest tasks. This study investigated the hub genes of AD. Proteins interact with other proteins and non-protein molecules, and these interactions play an important role in understanding protein function. Computational methods are useful for understanding biological problems, in particular, network analyses of protein-protein interactions. Through a protein network analysis, we identified the following top 10 hub genes associated with AD: PTGER3, C3AR1, NPY, ADCY2, CXCL12, CCR5, MTNR1A, CNR2, GRM2, and CXCL8. Through gene enrichment, it was identified that most gene functions could be classified as integral to the plasma membrane, G-protein coupled receptor activity, and cell communication under gene ontology, as well as involvement in signal transduction pathways. Based on the convergent functional genomics ranking, the prioritized genes were NPY, CXCL12, CCR5, and CNR2.

• Nuclear Engineering and Technology
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• v.48 no.3
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• pp.778-784
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• 2016

HyperGam-U was recently developed to determine uranium enrichment based on ${\gamma}$- and X-ray spectroscopy analysis. The $XK_{\alpha}$ region of the uranium spectrum contains 13 peaks for $^{235}U$ and $^{238}U$ and is used mainly for analysis. To describe the X-ray peaks, a Lorentzian broadened shape function was used, and methods were developed to reduce the number of fitting parameters for decomposing the strongly overlapping peaks using channel-energy, energy-width, and energy-efficiency calibration functions. For validation, eight certified reference material uranium samples covering uranium enrichments from 1% to 99% were measured using a high-resolution planar high-purity germanium detector and analyzed using the HyperGam-U code. When corrections for the attenuation and true coincidence summing were performed for the detection geometry in this experiment, the goodness of fit was improved by a few percent. The enrichment bias in this study did not exceed 2% compared with the certified values for all measured samples.